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一组高效稳定纤维素分解菌复合系MC1的筛选及功能

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环境科学 2002年第3期23卷 36-39页

作者：崔宗均李美丹朴哲黄志勇 masaharu ishii Yasuo Igarashi 中国农业大学作物学院北京100094 中国科学院微生物研究所北京100080 东京大学农学部应用生命工学

从 4种堆肥样品中分别筛选出纤维素分解能力较强的 4组混合菌 ,再以酸碱反应互补的原则重新优化组合并驯化成 1组纤维素分解能力非常强而稳定的纤维素分解菌复合系MC1 .1 0 0mL培养物在 5 0℃静止培养 72h ,分别可分解 0 48g滤纸、0 ... 详细信息

从 4种堆肥样品中分别筛选出纤维素分解能力较强的 4组混合菌 ,再以酸碱反应互补的原则重新优化组合并驯化成 1组纤维素分解能力非常强而稳定的纤维素分解菌复合系MC1 .1 0 0mL培养物在 5 0℃静止培养 72h ,分别可分解 0 48g滤纸、0 49g脱脂棉、0 1 9g麦秆和 0 0 8g锯末 .分解滤纸时 ,第 2 4hCMC糖化力最高 ,为1 2 2 3U·mL- 1.在初始pH4～ 1 0的不同培养基上接种 ,均能把 pH调到中性 ,最后稳定在 8 0～ 8 5之间 .在连续投放滤纸情况下纤维素分解能力稳定保持 2 0d以上 ,其发酵液的 pH在有滤纸时稳定在 6 0～ 6 5之间 ,没有滤纸时稳定在 8 0～ 8

关键词：纤维素分解菌复合系功能稳定

Effects of Anthropogenic CO2 and Thermally-Induced CO2 on Global Warming

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Atmospheric and Climate Sciences 2024年第3期14卷 317-327页

作者： masaharu Nishioka Retired Chicago IL USA

Changes in CO2 and temperature are correlated, but it is difficult to observe which is the cause and which is the effect. The release of CO2 dissolved in the ocean into the atmosphere depends on the atmospheric temperature. However, examining the relationship between changes in CO2 caused by other phenomena and temperature is difficult. Studies of soil respiration (Rs) since the late 20th century have shown that CO2 emissions from soil respiration (Rs) are overwhelmingly greater than CO2 emissions from fossil fuel combustion. This is also noted in the IPCC carbon budget assessment. In this paper, the dependences of Rs on temperature, time, latitude, precipitation, seasons, etc., were investigated using the latest NASA database. The changes in temperature and Rs correlated well. There is also a good correlation between Rs and CO2 generation. Therefore, an increase in temperature results in an increase in CO2. On the other hand, there is no evidence other than model calculations that an increase in anthropogenic CO2 is mainly linked to a rise in temperature. The idea that global warming is caused by anthropogenic CO2 production is still a hypothesis. For these reasons, the relationship between global warming and anthropogenic CO2 should be reconsidered based on physical evidence without preconceptions. .

关键词： Global Warming Anthropogenic CO2 Thermally-Induced CO2 Soil Respiration Carbon Cycles

The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

Optimized operation scheme of flash-memory-based neural network online training with ultra-high endurance

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Journal of Semiconductors 2024年第1期45卷 33-37页

作者： Yang Feng Zhaohui Sun Yueran Qi Xuepeng Zhan Junyu Zhang Jing Liu masaharu Kobayashi Jixuan Wu Jiezhi Chen School of Information Science and Engineering(ISE) Shandong UniversityQingdao 266200China Neumem Co. LtdHefei 230093China Key Laboratory of Microelectronic Devices and Integrated Technology Institute of Microelectronics of Chinese Academy of SciencesBeijing 100084China Institute of Industrial Science The University of TokyoTokyoJapan

With the rapid development of machine learning,the demand for high-efficient computing becomes more and more *** break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attracted increasing attention in recent *** this work,to provide a feasible CIM solution for the large-scale neural networks(NN)requiring continuous weight updating in online training,a flash-based computing-in-memory with high endurance(10^(9) cycles)and ultrafast programming speed is *** the one hand,the proposed programming scheme of channel hot electron injection(CHEI)and hot hole injection(HHI)demonstrate high linearity,symmetric potentiation,and a depression process,which help to improve the training speed and *** the other hand,the low-damage programming scheme and memory window(MW)optimizations can suppress cell degradation effectively with improved computing *** after 109 cycles,the leakage current(I_(off))of cells remains sub-10pA,ensuring the large-scale computing ability of *** characterizations are done on read disturb to demonstrate its robust *** processing CIFAR-10 tasks,it is evident that~90%accuracy can be achieved after 109 cycles in both ResNet50 and VGG16 *** results suggest that flash-based CIM has great potential to overcome the limitations of traditional Von Neumann architectures and enable high-performance NN online training,which pave the way for further development of artificial intelligence(AI)accelerators.

关键词： NOR flash memory computing-in-memory endurance neural network online training

Overspeeding characteristics of turbomachinery for gas generator cycle air turbo ramjet engine

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Propulsion and Power Research 2022年第4期11卷 444-456页

作者： Ryojiro Minato Daisuke Nakata masaharu Uchiumi Ryoji Imai Kazuyuki Higashino Department of Engineering Muroran Institute of Technology MuroranHokkaido050-8585Japan Aerospace Plane Research Center Muroran Institute of Technology MuroranHokkaido050-8585Japan

The main interest in the current study focuses on the possibility of overspeeding for the gas-generator cycle air turbo ramjet(GG-ATR)*** authors developed the air turbo ramjet engine and investigated its compressor *** on those data,the authors developed the analytical code for the air turbo ramjet engine,which calculates the performances of turbomachinery,gas-generator,and ram *** previous study described that the rotor overspeeding would not occur in the air turbo rocket ***,the current results show that degraded ram combustion can decrease the compressor pressure ratio and the compressor *** reduced compressor power can cause overspeeding for the air turbo ramjet *** experimental results of compressor power and turbine inlet pressure support those analytical results.

关键词： Air turbo ramjet engine Compressor map Overspeeding Combustion efficiency

From cradle to grave:seamless management of chronic pancreatitis but consider the special requests for children

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 585-589页

作者： Hiroyuki Isayama Shigeto ishii Mitsuyoshi Suzuki Toshiaki Shimizu Department of Gastroenterology Graduate School of MedicineJuntendo UniversityTokyoJapan Department of Pediatrics Juntendo University Graduate School of MedicineTokyoJapan

We have read the position paper by *** Freeman and the members of the Pancreas Nutrition Committee of the North American and the European Societies for Pediatric Gastroenterology,Hepatology,and Nutrition(NASPGHAN and ESPGHAN)(1).That paper focused on chronic pancreatitis(CP)in children and endoscopic procedures about which NASPGHAN published a second position paper(2).There are clinical practice guidelines for the management of CP in adults but not for CP in children(3).

关键词： Chronic pancreatitis pediatrics endoscopic retrograde cholangiopancreatography(ERCP) endoscopic ultrasound(EUS) pancreatic enzyme replacement therapy(PERT)

Development of conversion therapy for advanced hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 453-456页

作者： Ryota Matsuki masaharu Kogure Nobuhiro Hasui Hirokazu Momose Yutaka Suzuki Yoshihiro Sakamoto Department of Hepato-Biliary-Pancreatic Surgery Kyorin University HospitalShinkawaMitaka CityTokyoJapan

Although the number of hepatocellular carcinoma(HCC)patients is decreasing due to the development of hepatic anti-virus therapy,it remains a leading cause of cancer-related death *** recent development of systemic or locoregional therapy for advanced or unresectable HCC has enabled advanced HCC to be downstaged,and reports of conversion therapy have increased;however,many clinical and scientific subjects rely on the therapeutic strategies of advanced *** is a need to assess the evidence and develop clinical guidelines for conversion therapy for HCC;therefore,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition),consisting of 16 statements,has been developed for clinical practice(1).This consensus addresses treatment strategies for both technically and oncologically unresectable *** applaud Chinese establishment of this comprehensive and cutting-edge consensus on the treatment of advanced HCC.

关键词： Hepatocellular carcinoma(HCC) conversion therapy Chinese expert consensus

Characteristics of In-Hospital Patients with Congenital Heart Disease Requiring Rapid Response System Activations: A Japanese Database Study

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Congenital Heart Disease 2022年第1期17卷 31-43页

作者： Taiki Haga Tomoyuki Masuyama Yoshiro Hayashi Takahiro Atsumi Kenzo ishii Shinsuke Fujiwara Department of Pediatric Critical Care Medicine Osaka City General HospitalOsaka534-0021Japan Department of Emergency and Critical Care Medicine Jichi Medical University Saitama Medical CenterSaitama330-8503Japan Department of Intensive Care Medicine Kameda Medical CenterChiba296-8602Japan Department of Emergency Medicine Seirei Hamamatsu General HospitalShizuoka430-8558Japan Department of Anesthesiology Intensive Care UnitFukuyama City HospitalHiroshima721-8511Japan Department of Emergency Medicine NHO Ureshino Medical CenterSaga843-0393Japan

Objectives:This study aimed to study the characteristics of in-hospital deterioration in patients with congenital heart disease who required rapid response system activation and identify risk factors associated with 1-month ***:We retrospectively analysed data from a Japanese rapid response system registry with 35 participating *** included consecutive patients with congenital heart disease who required rapid response system activation between January 2014 and March *** regression analyses were performed to examine the associations between 1-month mortality and other patient-specific ***:Among 9,607 patients for whom the rapid response system was activated,only 82(0.9%)had congenital heart *** few patients with congenital heart disease were being treated at the cardiology and cardiovascular surgery departments(12.3%and 9.9%,respectively).Moreover,the incidences of rapid-response events after intensive care unit discharge or surgery were low(6.8% and 12.2%,respectively).The most common reason for rapid response system activation was respiratory dysfunction(desaturation:35.4%,tachypnoea:25.6%,and new dyspnoea:19.5%).Rapid response system interventions and intensive care unit transfers were required for 65.9% and 20.7%of patients,*** mortality rate was 1.2% at the end of the rapid response system intervention and 11.0% after 1 ***,decreased respiratory rate and decreased heart rate at rapid response system activation were associated with increased 1-month *** adjusted odds ratio was 1.10(95% confidence interval 1.02–1.19)and 1.02(95% confidence interval,1.00–1.04) for respiratory rate and heart rate,***:Rapid response systems were rarely activated after cardiac surgery and intensive care unit discharge,which were situations with a high risk of sudden deterioration in patients with congenital heart ***,encouraging the use of the rapid response sys

关键词： Heart defects congenital emergencies clinical deterioration hospital rapid response team critical care This