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Fate and Movement of Dioxins in the Lake Biwa Basin in Japan

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Fate and Movement of Dioxins in the Lake Biwa Basin in Japan

Impact of ABO Blood Types on Survival after Pancreatectomy for Pancreatic Cancer

持久性有机污染物论坛2008暨第三届持久性有机污染物全国学术研讨会

作者： Yoshihisa Shimizu Keisuke Sato Hiroshi Murata masafumi nakamura Huang Chun-Ching Research Center for Environmental Quality Management Kyoto UniversityOtsu 520-0811Japan Hiyoshi Corporation Omihachiman 523-8555Japan

*** In Japan,the dioxins had been unintentionally produced as the byproducts of Chlorinated Organic Pesticides(COPs)(e.g,PCP and CNP)since 1960s to 1980s,and sprayed on the paddy *** major source of dioxins in Japan i...

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Journal of Cancer Therapy 2013年第10期4卷 7-12页

作者： Tadashi Kayashima masafumi nakamura Kenoki Ohuchida Syunichi Takahata Kohei Nakata Naoki Ikenaga Lin Cui Shingo Kozono Kazuhiro Mizumoto Masao Tanaka Department of Surgery and Oncology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Background/Purpose: A recent genome-wide association study (PanScan) identified significant association between the ABO gene locus and the risk of pancreatic cancer. The aim of this study was to analyze survival of pancreatic cancer patients who underwent surgical resection based on serotype-defined ABO blood types. Methods: In terms of ABO blood types and gemcitabine-based adjuvant therapy, we investigated the survival of 153 patients who underwent pancreatectomy for pancreatic cancer at the Department of Surgery and Oncology,KyushuUniversity(Fukuoka,Japan). Results: Among the four blood type groups, the O serotype group (median survival time (MST): 47.9 months) showed the best prognostic outcome. The A serotype group (MST: 22.5 months) showed the second best prognostic outcome, followed by the AB serotype group (MST: 20.4 months). The B serotype group (MST: 15 months) showed the worst prognostic outcome when considering the MST after the surgical resection. Next, we examined the effect of adjuvant chemotherapy with gemcitabine based on the ABO blood types. The A serotype group showed the greatest improvement in prognosis by adjuvant therapy with gemcitabine after the surgical resection. The other three serotype groups showed no significant differences in the prognostic outcomes between subgroups with and without gemcitabine therapy. Conclusions: The present data suggest the possibility that ABO blood types are prognostic factors for pancreatic cancer patients after surgical treatment and are also predictive factors for the chemosensitivity to gemcitabine of pancreatic cancer patients after pancreatectomy.

关键词： Pancreatic Cancer ABO Blood Type Survival Gemcitabine Adjuvant Chemotherapy

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联合国可持续发展目标的研究方向正在调整

科学观察 2020年第1期15卷 38-47页

作者： masafumi nakamura David Pendlebury Joshua Schnell Martin Szomszor 科睿唯安日本学术研究事业部科睿唯安科学信息研究所

"要意识到,万物相连"——达·芬奇引言联合国可持续发展目标(SDG)是对美好未来的共同愿望,也是协调投入和共同努力的重要议程。2015年9月联合国大会通过了可持续发展议程(A/RES/70/1),其进展可以通过包括17个主要目标的232个具体指标进... 详细信息

"要意识到,万物相连"——达·芬奇引言联合国可持续发展目标(SDG)是对美好未来的共同愿望,也是协调投入和共同努力的重要议程。2015年9月联合国大会通过了可持续发展议程(A/RES/70/1),其进展可以通过包括17个主要目标的232个具体指标进行追踪。可持续发展的推进离不开各个国家和地区政府利用现有资源和知识,组织和推动相关重要工作,许多项目需要在现有的科学知识和新的尝试基础上,开展多学科的研究和创新。

关键词：可持续发展目标专题地图联合国聚类标签

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荧光素酶报告基因法测定飞灰中二噁英类物质

环境污染与防治 2016年第9期38卷 19-24页

作者：籍龙杰陆胜勇杜颖哲陈彤李晓东严建华黄俊卿 masafumi nakamura Hiroshi Murata 浙江大学能源清洁利用国家重点实验室热能工程研究所浙江杭州310027 株式会社日吉日本近江八幡市523-0806

荧光素酶报告基因法(CALUX)相比高分辨气相色谱/质谱法(HRGC/HRMS)测定二噁英浓度时,具有分析周期短、检测成本低、灵敏度高(皮克水平)、能反映样品的毒性总量且可进行高通量检测等优点。实际应用时,可先用CALUX对样品作初步筛选检测,... 详细信息

荧光素酶报告基因法(CALUX)相比高分辨气相色谱/质谱法(HRGC/HRMS)测定二噁英浓度时,具有分析周期短、检测成本低、灵敏度高(皮克水平)、能反映样品的毒性总量且可进行高通量检测等优点。实际应用时,可先用CALUX对样品作初步筛选检测,再将筛选出的阳性样品用化学分析法作进一步定性定量检测。通过对42个垃圾焚烧飞灰样品同时进行HRGC/HRMS和CALUX分析,得到两者的换算系数,从而可以利用快速检测的结果和换算系数来推算HRGC/HRMS的结果。实验表明,CALUX结果与HRGC/HRMS结果具有很好的线性相关性(R=0.96),换算系数为0.332。该换算系数与日本得到的结果不同,表明中国飞灰性质有别于日本飞灰。而且,不同环境介质之间换算系数也不一致。为增加该方法在中国的适用性,必须通过实验方法找出符合中国样品的换算系数。

关键词：二噁英荧光素酶报告基因法高分辨气相色谱/质谱法换算系数

Liver fibrosis markers of nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2015年第24期21卷 7427-7435页

作者： Hirayuki Enomoto Yukihiro Bando Hideji nakamura Shuhei Nishiguchi masafumi Koga Division of Hepatobiliary and Pancreatic Disease Department of Internal Medicine Hyogo College of Medicine Department of Internal Medicine Fukui-ken Saiseikai Hospital Department of Gastroenterology and Hepatology Nissay Hospital Department of Internal Medicine Kawanishi City Hospital

Nonalcoholic fatty liver disease(NAFLD) is one of themajor causes of chronic liver injury. NAFLD includes a wide range of clinical conditions from simple steatosis to nonalcoholic steatohepatitis(NASH), advanced fibrosis, and liver cirrhosis. The histological findings of NASH indicate hepatic steatosis and inflammation with characteristic hepatocyte injury(e.g., ballooning degeneration), as is observed in the patients with alcoholic liver disease. NASH is considered to be a potentially health-threatening disease that can progress to cirrhosis. A liver biopsy remains the most reliable diagnostic method to appropriately diagnose NASH, evaluate the severity of liver fibrosis, and determine the prognosis and optimal treatment. However, this invasive technique is associated with several limitations in routine use, and a number of biomarkers have been developed in order to predict the degree of liver fibrosis. In the present article, we review the current status of noninvasive biomarkers available to estimate liver fibrosis in the patients with NASH. We also discuss our recent findings on the use of the glycated albuminto-glycated hemoglobin ratio, which is a new index that correlates to various chronic liver diseases, including NASH.

关键词： Nonalcoholic fatty liver disease Nonalcoholicsteatohepatitis Liver fibrosis Glycated albumin Glycatedhemoglobin

Two cases of childhood absence epilepsy who showed seizure disappearance after ethosuximide drug eruption

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Acta Epileptologica 2022年第4期5卷 281-285页

作者： Takuji nakamura Keiko Uda Muneaki Matsuo masafumi Zaitsu Department of Pediatrics Faculty of MedicineSaga UniversitySagaJapan Department of Pediatrics National Hospital Organization Ureshino Medical Center4279-3 Shimojuku KouUreshino CitySaga843-0393Japan

Background Recent studies suggest potential roles of immune response in the pathophysiology of ***-seizure medications(ASMs)are known to have side effects of drug eruption caused by immune responses.A few reports in adults have demonstrated disappearance of seizures after an ASM drug eruption *** this paper,we described 2 cases of childhood absence epilepsy(CAE)who showed seizure disappearance after ethosuximide(ESM)drug eruption,suggesting the possibility that the epilepsy disappears due to immune responses to *** presentation Case 1 was an 8-year-old girl diagnosed with *** was treated with valproate acid(VPA)initially,and then ESM was administered as an additional *** epileptic seizure disappeared 4 days after initiation of ***,drug eruption appeared 1 week after the administration of *** after discontinuation of ESM administration,she maintains no seizure after the drug *** 2 was a 5-year-old boy diagnosed as *** was treated with VPA initially,and ESM was administered *** eruption appeared 1 month after the administration of *** after ESM was terminated,he maintained seizure freedom after the appearance of *** Epileptic seizures may have been suppressed due to the immune responses caused by ASM *** studies are needed to elucidate the pathophysiologic effects of drug eruption on epilepsy through immune responses.

关键词： Childhood absence epilepsy Drug eruption Ethosuximide Seizure disappearance

Diffuse gastroduodenitis and pouchitis associated with ulcerative colitis

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World Journal of Gastroenterology 2006年第36期12卷 5913-5915页

作者： Hiroki Ikeuchi Kazutoshi Hori Takashi Nishigami Hiroki Nakano Motoi Uchino Mitsuhiro nakamura Nobuaki Kaibe masafumi Noda Hidenori Yanagi Takehira Yamamura Second Department of Surgery Hyogo College of Medicine Hyogo Japan Department of Gastroenterology Hyogo College of Medicine. Hyogo Japan Second Department of Pathology Hyogo College of Medicine. Hyogo Japan

We experienced a very rare case of ulcerative colitis (UC) accompanied with analogous lesions in the stomach, duodenum, and ileal J -pouch. Ileal J-pouch anal anastomosis was performed on a 29-year old woman in 1996. Six years later, she was admitted again to our hospital because of epigastralgia, nausea, watery diarrhea and low fever. Based on the results of endoscopic examination, we diagnosed it as pouchitis. Moreover, on hypotonic duodenography, expansion of the duodenal bulb and the descending portion were poor. Kerckring folds disappeared with typical lead-pipe appearance. The pathogenesis of the gastric and duodenal lesion in this patient was similar to that of the colonic lesions of UC. For the gastroduodenal lesions in this patient, symptomatic remission was obtained following administration of crushed mesalazine tablets (1500 mg/d) for 14 d with continuous administration of omeprazole. Firstly we used ciprofloxacin to treat pouchitis. On the fifth day, she got a fever because of catheter infection. In the catheter culture, methicillin-resistant Staphylococcus aureus (MRSA) was detected. Therefore we changed ciprofloxacin to vancomycin hydrochloride (Vancomycin?). Vancomycin was very effective, and the stool frequency dramatically improved in three days. Now she continues to take mesalazine, but her condition is stable and there has been no recurrence of pouchitis.

关键词： Ulcerative colitis Pouchitis Gastroduodenal lesions

Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy

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World Journal of Gastroenterology 2005年第1期11卷 89-93页

作者： Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo nakamura Masuji Morita masafumi Taniwaki Molecular Gastroenterology and Hepatology Molecular Hematology and Oncology Department of Internal Medicine Department of Pathology and Clinical Laboratories School of Nursing Clinical Molecular Genetics and Laboratory Medicine

AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of ***: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of ***: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma.

关键词： Helicobacter pylori infection Gastric MALT lymphoma Trisomy 3

Practical applications and limitations of basalt discrimination diagrams

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Big Earth Data 2023年第4期7卷 1081-1093页

作者： Kentaro nakamura Frontier Research Center for Energy and Resources(FRCER) School of EngineeringThe University of TokyoTokyoJapan

Determining the tectonic setting of unknown volcanic rocks continues to be one of the key challenges in *** discrimination diagrams have been successfully employed due to their ease of use,recently,validation with big data has raised questions about their *** this study,the discrimination boundaries of Th/Yb versus(vs.)Nb/Yb and TiO2/Yb ***/Yb diagrams,which are the most used types of discrimination diagrams,were redefined based on a large amount of compiled data and support vector machine,a machine learning *** effectiveness of discrimination diagrams was verified,and the limitations and conditions when using them were *** results show that when using the Th/Yb ***/Yb diagram,only basalts with Th/Yb ratios higher than the discrimination boundary can be identified as volcanic arcs in *** contrast,a significant overlap occurs across boundaries in other cases when using these diagrams,particularly for enriched samples with Nb/Yb ratios higher than ***,when using these diagrams to determine the tectonic setting of unknown samples,their limitations must be considered when interpreting their results.

关键词： Discrimination diagram tectonic setting support vector machine big data large petrological databases