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Randomized study of lafutidine vs lansoprazole in patients with mild gastroesophageal reflux disease

World Journal of Gastroenterology 2016年第23期22卷 5430-5435页

作者： Ryuta Takenaka Hiroyuki Okada Seiji Kawano Yoshinori Komazawa Fumiya Yoshinaga Shinji Nagata masafumi inoue Hirohisa Komatsu Seiji Onogawa Yoshinori Kushiyama Shinichi Mukai Hiroko Todo Hideharu Okanobu Noriaki Manabe Shinji Tanaka Ken Haruma Yoshikazu Kinoshita Department of Gastroenterology Tsuyama Chuo Hospital Tsuyama 708-0841 Japan Department of Gastroenterology and Hepatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama 708-0841 Japan Division of Internal Medicine Izumo City General Medical Center Izumo 691-0003 Japan Department of Gastroenterology Mihara Red Cross Hospital Mihara 723-0011 Japan Department of Endoscopy Hiroshima City Asa Citizens Hospital Hiroshima 731-0293 Japan Department of Gastroenterology Okayama Red Cross Hospital Okayama 700-0941 Japan Department of Gastroenterology Hiroshima General Hospital Hiroshima 734-8551 Japan Department of Gastroenterology Onomichi General Hospital Onomichi 722-8508 Japan Department of Gastroenterology Matsue Red Cross Hospital Matsue 690-8506 Japan Department of Gastroenterology Miyoshi Central Hospital Miyoshi 728-0023 Japan Department of Gastroenterology Hiroshima-Nishi Medical Center Hiroshima 739-0651 Japan Department of Gastroenterology Chugoku Rosai Hospital Kure 737-0134 Japan Department of Gastroenterology Kawasaki Medical School Hospital Kurashiki 701-0192 Japan Department of Endoscopy Hiroshima University Hospital Hiroshima 734-8551 Japan Department of General Internal Medicine 2 Kawasaki Hospital Kawasaki Medical School Okayama 708-0841 Japan Department of Gastroenterology and Hepatology Shimane University Hospital Izumo 693-0021 Japan

AIM: To compare the clinical efficacy of the secondgeneration H2 RA lafutidine with that of lansoprazole in Japanese patients with mild gastroesophageal reflux disease(GERD). METHODS: Patients with symptoms of GERD and a diagnosis of grade A reflux esophagitis(according to the Los Angeles classification) were randomized to receive lafutidine(10 mg, twice daily) or lansoprazole(30 mg, once daily) for an initial 8 wk, followed by maintenance treatment comprising half-doses of the assigned drug for 24 wk. The primary endpoint was the frequency and severity of heartburn during initial and maintenance treatment. The secondary endpoints were the sum score of questions 2 and 3 in the Gastrointestinal Symptom Rating Scale(GSRS), and the satisfaction ***: Between April 2012 and March 2013, a total of 53 patients were enrolled, of whom 24 and 29 received lafutidine and lansoprazole, respectively. After 8 wk, the frequency and severity of heartburn was significantly reduced in both groups. However, lafutidine was significantly inferior to lansoprazole with regard to the severity of heartburn during initial and maintenance treatment(P = 0.016). The sum score of questions 2 and 3 in the GSRS, and satisfaction scores were also significantly worse in the lafutidine group than the lansoprazole group(P = 0.0068 and P = 0.0048, respectively).CONCLUSION: The clinical efficacy of lafutidine was inferior to that of lansoprazole, even in Japanese patients with mild GERD.

关键词： Gastroesophageal reflux disease Proton pump inhibitors Histamine receptor-2 antagonists Los Angeles classification

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Bipolar I disorder and expressed emotion of families: A cohort study in Japan

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Open Journal of Psychiatry 2012年第4期2卷 258-261页

作者： Shinji Shimodera Yukiko Yonekura Sosei Yamaguchi Aoi Kawamura masafumi Mizuno Shimpei inoue Toshi A. Furukawa Yoshio Mino Department of Cognitive-Behavioral Medicine Kyoto University Graduate School of Medicine/School of Public Health Kyoto Japan Department of Neuropsychiatry Kochi Medical School Kochi University Kochi Japan Department of Neuropsychiatry Toho University School of Medicine Tokyo Japan Department of Psychiatric Rehabilitation National Institute of Mental Health National Center of Neurology and Psychiatry Tokyo Japan Department of Psychiatry Mino Clinic Okayama Japan Department of Social Welfare Kansai University of Social Welfare Hyogo Japan

The relationships between expressed emotion (EE) of the families and the course of bipolar disorder have been examined only in a limited number of cohort studies. No study has yet been reported from Asia. The subjects were 12 patients that had been diagnosed with bipolar I disorder according to DSM-IV and their 12 key family members. The families of the patients were interviewed using the Camberwell Family Interview (CFI) within 2 weeks of the admission of the patients, and their EE were evaluated. The patients were then followed up for 9 months after their discharge from the hospital. The patients were divided into a high-EE group and a low-EE group using the cut-off based on the number of critical comments (CC) and emotional overinvolvement (EOI), and the 9-month relapse risk was compared. When the subjects with 3 or more CC or an EOI score of 3 or more were regarded as the high-EE group, and the others as the low-EE group, the 9-month relapse risk was 100% (3/3) for the high EE group and 0% (0/9) for the low EE group. (Fisher’s exact test p = 0.005) EE based on the CFI appear to be correlated with relapse in bipolar I disorder in Japan.

关键词： Expressed Emotion Family Bipolar Disorder

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组织蛋白酶K与高血压性心脏病心室肌重塑及纤维化关系的初步探讨

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中国临床医学 2008年第4期15卷 449-453页

作者：成宪武宋辉杨光赵萧萧秦孝智井上爱子南勇善关立克金海葛谷雅文室原豊明奧村键二日本名古屋大学医学部循环器内科日本名古屋654668550 延边大学医院手术室吉林延吉133000 延边大学医院心血管内科吉林延吉133000

目的:探讨组织蛋白酶K(cathepsin K,Cat K)在高血压性心脏病心室重塑发生发展中的表达及其活性与心肌纤维化的关系。方法:7周龄雄性Dahl盐敏感(DS)大鼠分别给予高负荷食盐(8%)或正常负荷食盐(0.3%)19周,建立高血压性心脏病心衰(H-HF)模... 详细信息

目的:探讨组织蛋白酶K(cathepsin K,Cat K)在高血压性心脏病心室重塑发生发展中的表达及其活性与心肌纤维化的关系。方法:7周龄雄性Dahl盐敏感(DS)大鼠分别给予高负荷食盐(8%)或正常负荷食盐(0.3%)19周,建立高血压性心脏病心衰(H-HF)模型和对照组(19W-C)。另设人心肌活检标本作研究对象(H-HF患者10例和对照组6例)。用RT-PCR和免疫组化分别检测Cat K mRNA及蛋白表达,酶谱法测定大鼠心肌组织中的组织蛋白酶活性,心脏石蜡切片Azan染色法分析左心室肌间质和血管周围纤维化程度,细胞荧光染色法分析白介素-β1(IL-β1)对培养心肌细胞的Cat K的表达及其胶原蛋白分解能的影响。结果:H-HF组大鼠和患者心肌中的Cat K mRNA的表达显著高于19W-C组和对照组人(P<0.01)。免疫组化法和in situ法分析显示增高的Cat K mRNA和蛋白主要表达于心肌细胞。H-HF组大鼠心肌组织蛋白酶依赖性胶原蛋白分解能显著高于19W-C组。H-HF组大鼠心肌中IL-β1表达也在显著增高。IL-β1刺激心肌细胞的Cat K蛋白及其胶原蛋白分解活性。心肌中的Cat K mRNA表达与左心室肌纤维化面积呈显著正相关(r=0.68,P<0.01)。结论:在心肌中Cat K表达及分泌受IL-β1的调控,并参与高血压性心脏病的发生、发展过程,提示心肌Cat K在H-HF的心肌重塑及纤维化发展中起重要作用。

关键词：组织蛋白酶K 高血压性心脏病心室肌重塑白介素β1

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