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Alveolar macrophage functions and DNA damage in cigarette smoke-exposed mice

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Advances in Bioscience and Biotechnology 2013年第8期4卷 1-7页

作者： Yuriko Hirono Yasuyuki Tanahashi Kazuma Sasaki Kenjiro Konno Yuki Shirai Kengo Kobayashi Azusa Someya Sumire Inaga masaaki Sakura Kent E. Pinkerton Minoru Takeuchi Center for Health and the Environment University of California Davis Davis USA Department of Animal Medical Science Faculty of Life Sciences Kyoto Sangyo University Kyoto Japan Division of Genome Morphology Department of Functional Morphological and Regulatory Science Faculty of Medicine Tottori University Yonago Japan

Alveolar macrophages (AM) are known to play an essential role in lung defense through their ability to remove the foreign matters reaching the lung alveoli. Cigarette smoke (CS) is a critical risk factor for many lung diseases. CS is inhaled into the lung by respiretion and affects AM. It has been previously reported that CS induces inhibition of cytokine production, cell surface receptor expression and antigen presentation in AM. However, the relationship of immune suppression and DNA damage caused by CS in AM is still unclear. Therefore, in this study, we investigated AM immune function and DNA damage in CS-exposed mice. Mice were exposed to CS of 20 cigarettes/day during 10 days using a HambrugⅡsmoking machine. After exposure, AM were obtained by bronchoalveolar lavage. The number of AM was significantly increased in CS-exposed mice compared with non-CS-exposed mice. Phagocytic activity of AM was significantly inhibited by CS exposure. Percentage of CD11b-, CD14-, Toll-like receptor (TLR)2- or TLR4-positive cells was significantly decreased in CS-exposed mice compared with non-CS-exposed mice. Interleukin-1β mRNA expression in lipopolysaccharide-stimulated AM was significantly inhibited by CS exposure. Intracellular reactive oxygen species (ROS) (, H2O2) production of AM was significantly increased, and DNA damage was induced by CS exposure. These results suggest that impaired immune functions by CS exposure may be related to DNA damage via excessive ROS induced by CS. These alterations of AM caused by CS could be associated with infection and development of pulmonary diseases.

关键词： Alveolar Macrophages Phagocytic Activity ROS Production DNA Damage Cigarette Smoke

分子吸附对聚乙烯醇在氧化铝粉末压缩体中扩散系数的影响

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硅酸盐学报 1998年第1期26卷 47-52页

作者：赵亮金斗满山崎丰张耀内田希植松敬三河南省科学院化学研究所长冈技术科学大学化学系

利用氧化铝粉末压缩球状体和Ｆｉｃｋ第二扩散定律，系统地研究了聚乙烯醇在多孔介质和实验系统ｐＨ值为８．４０±０．２条件下的扩散行为，以及聚乙烯醇在球体外表面吸附对扩散系数的影响．实验结果和相应计算得到的扩散系数表明：发... 详细信息

利用氧化铝粉末压缩球状体和Ｆｉｃｋ第二扩散定律，系统地研究了聚乙烯醇在多孔介质和实验系统ｐＨ值为８．４０±０．２条件下的扩散行为，以及聚乙烯醇在球体外表面吸附对扩散系数的影响．实验结果和相应计算得到的扩散系数表明：发生在氧化铝表面的分子吸附，不仅导致扩散平衡状态时的Ｍｔ（聚乙烯醇在时间ｔ的扩散量）高于理论计算值Ｍ∞，而且使实验初始阶段计算的扩散系数远大于其它过程扩散系数．由分子吸附产生的实验误差和扩散系数计算误差，可通过修正浓度分配系数Ｋ，或者直接从Ｍｔ中去除可能存在的吸附量得到解决．

关键词：吸附扩散系数聚乙烯醇氧化铝陶瓷胶粘剂

肝细胞癌、肝内胆管细胞癌与肝样癌的鉴别中BSEP和MDR3是一种非常有用的免疫组化标志物

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临床与实验病理学杂志 2016年第3期32卷 317-317页

作者： Fujikura K yamasaki T Otani K 魏建国刘勇浙江省绍兴市人民医院病理科绍兴312000 江西省人民医院病理科南昌330006

作者分析两种肝细胞特异性转运蛋白：胆汁盐输出蛋白（BSEP）和多药耐药蛋白3（MDR3）在肝细胞癌（n=54）、肝内胆管细胞癌（n=34）、混合性肝细胞和胆管细胞癌（n=23）及起源于肝外器官的肝样癌（rt=27）中免疫组化中的表达情况，并比... 详细信息

作者分析两种肝细胞特异性转运蛋白：胆汁盐输出蛋白（BSEP）和多药耐药蛋白3（MDR3）在肝细胞癌（n=54）、肝内胆管细胞癌（n=34）、混合性肝细胞和胆管细胞癌（n=23）及起源于肝外器官的肝样癌（rt=27）中免疫组化中的表达情况，并比较它们与精氨酸酶1（ARGl）、HepPar-1在这些肿瘤中的诊断价值。

关键词：肝内胆管细胞癌免疫组化标志物肝细胞癌肝样癌 MDR3 BSEP HepPar-1 多药耐药蛋白

日本百年石质文物保护:从技术演进到大遗址保护的全景探析

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华夏考古 2024年第3期 125-129页

作者： [日]泽田正昭雷欣怡(译) 日本奈良文化财研究所成都博物馆四川成都市610015

人类创造并传承至今的历史,启示着人类社会的理想状态和前进方向。此中,文化遗产更被誉为人类社会的指南针,是历史的重要物证。尤其近年来,政府极力主张它们应作为旅游资源被有效利用,许多地方率先加强行政效能到地方文化的振兴中,依托... 详细信息

人类创造并传承至今的历史,启示着人类社会的理想状态和前进方向。此中,文化遗产更被誉为人类社会的指南针,是历史的重要物证。尤其近年来,政府极力主张它们应作为旅游资源被有效利用,许多地方率先加强行政效能到地方文化的振兴中,依托当地历史文化,通过世界遗产名录活动的开展和文化遗产的认定,达到地方振兴的目的。像这样将文化遗产作为媒介,举办地域认同感的文化活动也成为近年的趋势。

关键词：世界遗产名录文化遗产石质文物保护日本百年大遗址保护技术演进重要物证指南针

纳米硬度法研究颗粒形状对SiCp/LD2复合材料塑性的影响

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纳米硬度法研究颗粒形状对SiCp/LD2复合材料塑性的影响

Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study

2000年中国材料研讨会

作者：刘澂张国定 masaaki Naka 上海交通大学材料学院金属基复合材料国家重点实验室日本大阪大学接合科学研究所

本文采用纳米硬度法研究了钝化处理的SiC颗粒增强LD2基复合材料和未钝化处理的具有尖角的SiC颗粒增强LD2基复合材料中颗粒附近的微观力学性能的分布对SiC/LD2复合材料的塑性的影响。研究结果表明:两种类型颗粒的周围都存在纳米硬度和塑... 详细信息

本文采用纳米硬度法研究了钝化处理的SiC颗粒增强LD2基复合材料和未钝化处理的具有尖角的SiC颗粒增强LD2基复合材料中颗粒附近的微观力学性能的分布对SiC/LD2复合材料的塑性的影响。研究结果表明:两种类型颗粒的周围都存在纳米硬度和塑性变形能力分布不均匀的区域,且硬度与塑性变形能力的分布趋势相反。在尖角颗粒附近纳米硬度要高于钝化颗粒附近的纳米硬度,而塑性变形能力则低于钝化颗粒附近的塑性变形能力,因此未钝化处理的SiC颗粒增强LD2基复合材料具有较低的塑性。

关键词：纳米硬度塑性变形能力颗粒形状

来源： cnki会议评论

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1070-1077页

作者： Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa yamasaki Takashi Kondo Fumihiko Toyoshima Jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto Miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine NishinomiyaHyogo 663-8501 Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Division of Gastroenterology Department of Internal Medicine Hyogo College of MedicineNishinomiyaHyogo 663-8501 Japan

AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD.

关键词： Gastric cancer Signet ring cell carcinoma Narrow-b

日本工程试验卫星ETS—Ⅶ交会对接的光学敏感器系统

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控制工程（北京） 1997年第1期 27-34页

作者： masaaki Mokuno Isao Kawano Hiroshi Horiguchi Koichi Kibe 余四祥

ETS-Ⅶ卫星(日本工程试验卫星Ⅶ)的任务之一是在轨演示和验证从相对逼近阶段(20km～600m)经最后逼近阶段(600～2m)直至对接段(2m～对接)整个过程的自动交会对接(RVD)系统及其飞行操作。在最后逼近阶段及对接阶段,导航敏感器选用RVD光学... 详细信息

ETS-Ⅶ卫星(日本工程试验卫星Ⅶ)的任务之一是在轨演示和验证从相对逼近阶段(20km～600m)经最后逼近阶段(600～2m)直至对接段(2m～对接)整个过程的自动交会对接(RVD)系统及其飞行操作。在最后逼近阶段及对接阶段,导航敏感器选用RVD光学敏感器,NASDA从1986年开始就着手研究RVD光学敏感器(包括逼近段摄像敏感器PXS和交会激光雷达RVR等),现阶段PXS和RVR敏感器均处于工程样机(EM)阶段。本文讨论了制导、导航和控制(GNC)系统以及对接系统对RVD光学敏感器的性能要求,并描述其研制状态。

关键词：人造卫星交会对接日本敏感器光学式

特发性肺纤维化患者中肺泡巨噬细胞不同辅助细胞功能

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中华结核和呼吸杂志 1997年第Z1期20卷 33-33页

作者： Furuie H yamasaki H Suga M Ando M 曾小明(译) FirstDepartmentofInternalMedicine KumamotoUniversityschoolofMedicine1—1—1HonjoKumamotoJapan FirstDepartmentofInternalMedicine KumamotoUniversityschoolofMedicineHonjoKumamotoJapan

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用新式双通道进行抓取钳辅助的早期胃癌内镜下黏膜切除术

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世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 29-30页

作者： Kume K. yamasaki M. Kanda K. M. Otsuki 王晓君 Current affiliations: Third Department of Internal Medicine University of Occupational and Environmental Health School of Medicine Kitakyusyu Japan Dr.

Background: Endoscopic mucosal resection with a cap-fitted panendoscope (EMRC) such as a soft prelooped hood is a useful, effective, and safe technique. One problem with this method is that the lesion cannot always be maintained in the center of the cap because the procedure is performed blindly after aspiration. Objective: We developed a 2-channel prelooped hood that facilitates EMRC while simultaneously allowing both grip of the center in the lesion and irrigation of the aspiration site and evaluated the usefulness of this end hood for early gastric cancer. Design: Retrospective study. Setting: Between August 2003 and October 2004, patients underwent our novel EMR. Patients: Twelve cases of early gastric cancer. Interventions: Two side holes were fabricated by drilling in the cap portion of a conventional soft prelooped hood, and then the irrigation tube and the accessory channel tube were glued to the exterior surface of the holes. We placed the fabricated transparent hood at the tip of the endoscope and performed grasping forceps-assisted endoscopic aspiration mucosectomy. Main Outcome Measurements: Accurate aspiration and the rate of en bloc resection. Results: We obtained a satisfactory field of view and accurate aspiration in the center of the tumor in all lesions. The rate of en bloc resection was 91.7%(11/12). Limitations: Gastric intramucosal cancer. Conclusion: Grasping forceps-assisted endoscopic mucosal resection with a novel 2-channel prelooped hood is safe and useful for mucosal resection of intramucosal cancers less than 20 mm and may help center the lesion in the cap before resection.

关键词：早期胃癌黏膜内癌圈套器黏膜切除术病变中心端罩效用性结果指标操作过程外表面