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Detection accuracy for epithelial dysplasia using an objective autofluorescence visualization method based on the luminance ratio

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International Journal of Oral Science 2017年第4期9卷 200-209页

作者： nanami yamamoto koji kawaguchi hisako fujihara mitsuhiko hasebe yuta kishi masaaki yasukawa kenichi kumagai yoshiki hamada department of oral and maxillofacial surgery school of dental medicinetsurumi universityYokohamaJapan department of oral hygiene tsurumi junior collegeYokohamaJapan

The autofluorescence visualization method （AVM） uses blue excitation light to assist in the diagnosis of epithelial dysplasia. It detects epithelial dysplasia as a black area, which is known as fluorescence visualization loss （FVL）. In this study, we evaluated the detection accuracy for epithelial dysplasia of the tongue using the objective AVM and assessed its possible clinical utility. Seventy-nine tongue specimens clinically suspected to have leukoplakia or squamous cell carcinoma （SCC） were analyzed. First, the AVM was subjectively performed using the Visually Enhanced Lesion scope （VELscope）, and the iodine-staining method was then performed. After biopsy, the histopathological results and the luminance ratio between the lesion and healthy tissue were compared, and a receiver operating characteristic curve was created. The cutoff value for the objective AVM was determined; the lesion was considered FVL-positive or -negative when the luminance ratio was higher or lower than the cutoff value, respectively. The histopathological diagnoses among the 79 specimens were SCC （n = 30）, leukoplakia with dysplasia （n = 34）, and leukoplakia without dysplasia （n= 15）. The cutoff value of the luminance ratio was 1.62, resulting in 66 FVL-positive and 13 FVL-negative specimens. The luminance ratio was significantly higher in the epithelial dysplasia-positive than -negative group （P〈O.O00 1）. The objective AVM showed much higher consistency between histopathological results than did the two methods （kappa statistic = 0.656）. In conclusion, objective autofluorescence visualization has a potential as an auxiliary method for diagnosis of epithelial dysplasia.

关键词： autofluorescence epithelial dysplasia oral cancer Visually Enhanced Lesion scope

Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients

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World Journal of Gastroenterology 2019年第15期25卷 1817-1827页

作者： Kenya Kamimura Akira Sakamaki Hiroteru Kamimura Toru Setsu Takeshi Yokoo masaaki Takamura Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore,management of the various symptoms of liver cirrhosis is essential, and agingrelated parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging.

关键词： Liver cirrhosis Elderly patients Quality of life Aging

A body mass index ≥25 kg/m2 is associated with a poor prognosis in patients with acute pancreatitis: a study of Japanese patients

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 645-651页

作者： Tsukasa Ikeura Kota Kato Makoto Takaoka masaaki Shimatani Masanobu Kishimoto Kenichiro Nishi Shuji Kariya Kazuichi Okazaki Department of Gastroenterology and Hepatology Kansai Medical University 2-5-1 Shinmachi Hirakata Osaka 5731010 Japan Department of Emergency and Critical Care Medicine Kansai Medical University 2-5-1 Shinmachi Hirakata Osaka 5731010 Japan Department of Anesthesiology Kansai Medical University 2-5-1 Shinmachi Hirakata Osaka 5731010 Japan Department of Radiology Kansai Medical University 2-5-1 Shinmachi Hirakata Osaka 5731010 Japan

BACKGROUND:In Asian population, there is limited infor mation on the relevance between obesity and poor outcomes in acute pancreatitis(AP). The objective of this study was to examine the clinical impact of obesity based on body mass index(BMI) on prognosis of AP in Japanese ***:A total of 116 patients with AP were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to examine relations between BMI and patients’ outcomes. Additionally, to investigate whether including obesity as a prognostic factor improved the predic tive accuracy of a Japanese prognostic factor score(PF score)a receiver-operating characteristic(ROC) curve analysis of mortality was ***:Multiple logistic regression analyses revealed that BMI ≥25 kg/m2was associated with a significant higher mor tality [odds ratio(OR)=15.8; 95% confidence interval(CI):1.1-227; P=0.043]. The area under the ROC curve(AUC) for the combination of PF score and BMI ≥25 kg/m2(AUC=0.881;95% CI:0.809-0.952) was higher than that for the PF score alone(AUC=0.820; 95% CI:0.713-0.927)(P=0.034).CONCLUSIONS:The negative impact of a high BMI on the prognosis of AP was confirmed in a Japanese population Including BMI ≥25 kg/m2 as an additional parameter to PF score enhanced the predictive value of the PF score for AP-related mortality.

关键词： acute pancreatitis obesity body mass index severity criteria prognostic factor score

Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B

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World Journal of Gastroenterology 2006年第27期12卷 4310-4317页

作者： Yasuteru Kondo Koju Kobayashi Yoshiyuki Ueno masaaki Shiina Hirofumi Niitsuma Noriatsu Kanno Tomoo Kobayashi Tooru Shimosegawa Tohoku University Graduate School of Medicine 1-1 Seiryo-machiAoba-kuSendai 980-8574Japan Tohoku University School of Health Sciences 2-1 Seiryo-machiAoba-kuSendai 980-8575Japan Department of Gastroenterology Sendai Medical Center2-8-8 MiyaginoMiyagino-kuSendai 983-0045Japan Department of Internal Medicine Furukawa City HospitalSenjujimae-machiFurukawa 919-6183Japan

AIM： To study the mechanisms of hyporesponsiveness of HBV-specific CD4^＋ T cells by testing TH1 and TH2 commitment and regulatory T cells. METHODS： Nine patients with chronic hepatitis B were enrolled. Peripheral blood mononuclear cells were stimulated with HBcAg or HBsAg to evaluate their potential to commit to TH1 and TH2 differentiation. HBcAg-specific activity of regulatory T cells was evaluated by staining with antibodies to CD4, CD25, CTLA-4 and interleukin-10. The role of regulatory T cells was further assessed by treatment with anti-interleukin-10 antibody and depletion of CD4^＋CD25^＋ cells. RESULTS： Level of mRNAs for T-bet, IL-12R β2 and IL-4 was significantly lower in the patients than in healthy subjects with HBcAg stimulation. Although populations of CD4^＋CD25^highCTLA-4^＋ T cells were not different between the patients and healthy subjects, IL-10 secreting cells were found in CD4^＋ cells and CD4^＋CD25^＋ cells in the patients in response to HBcAg, and they were not found in cells which were stimulated with HBsAg. Addition of anti-IL-10 antibody recovered the amount of HBcAgspecific TH1 antibody compared with control antibody （P 〈 0.01, 0.34% ± 0.12% vs 0.15% ± 0.04%）. Deletion of CD4^＋CD25^＋ T cells increased the amount of HBcAgspecific TH1 antibody when compared with lymphoo/tes reconstituted using regulatory T cells （P 〈 0.01, 0.03% ± 0.02% vs 0.18% ± 0.05%）.CONCLUSION： The results indicate that the mechanism of T cell hyporesponsiveness to HBcAg includes activation of HBcAg-induced regulatory T cells in contrast to an increase in TH2-committed cells in response to HBsAg.

关键词： Hepatitis B virus Regulatory T cells IL-10 FOXP3 TH1

Hydrogen promotes the activation of Cu, Zn superoxide dismutase in a rat corneal alkali-burn model

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International Journal of Ophthalmology(English edition) 2020年第8期13卷 1173-1179页

作者： Takeshi Arima Tsutomu Igarashi masaaki Uchiyama Maika Kobayashi Ikuroh Ohsawa Akira Shimizu Hiroshi Takahashi Department of Ophthalmology Nippon Medical SchoolTokyo1138602Japan Department of Analytic Human Pathology Nippon Medical SchoolTokyo1138602Japan Biological Process of Aging Tokyo Metropolitan Institute of GerontologyTokyo173-0015Japan

AIM: To investigate the effects of hydrogen(H2) on Cu, Zn superoxide dismutase(SOD1) activation in a rat model of corneal alkali burn. METHODS: In each rat, one cornea was subjected to alkali exposure. Physiological saline(saline group) or H2-dissolved saline(H2 group) was instilled continuously on the cornea for 5 min before and after alkali exposure. Inflammatory cells, neovascularization, and cytoplasmic SOD1 levels were evaluated immunohistochemically in enucleated eyes from both groups. Three-dimensional ultrastructural tissue changes in the eyes were analyzed using low-vacuum scanning electron ***: The numbers of both inflammatory and vascular endothelial cells were significantly reduced in the corneas of the H2 group(P<0.01). Furthermore, H2 treatment increased both cytoplasmic SOD1 levels(P<0.01) and activity in corneal epithelial cells(P<0.01). Notably, the SOD1 activity level in the H2 group was approximately 2.5-fold greater than that in the saline ***: H2 treatment suppresses inflammation and neovascularization in the injured cornea and indirectly suppresses oxidative insult to the cornea by upregulating the SOD1 enzyme protein level and activity.

关键词： hydrogen alkali burn Cu,Zn superoxide dismutase low-vacuum scanning electron microscopy rats

Environmental agricultural policy in Japan in harmony with WTO agricultural agreements: current situation and its development (Ⅱ)

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Agricultural Science & Technology 2005年第1期6卷 2-9页

作者： masaaki ISHIDA Faculty of Bioresources Mie University

(To be continued)The development of environmental agricultural policy in JapanEnvironmental agricultural policies based on collaboration between central and local governments

关键词：日本 WTO农业协定农业生态环境政策 GAP 环境保护

A Study on Flow Structure around a Bridge Beam and Behavior of Sea Water Mist

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Open Journal of Fluid Dynamics 2017年第3期7卷 340-347页

作者： masaaki Ishikawa Mechanical Engineering Program University of the Ryukyus Okinawa Japan

Okinawa in the subtropical islands enclosed in the ocean has a problem that corrosion of structures progresses quickly because of high temperature, high humidity and adhesion of sea-water mists flying from sea. Author is interested in corrosion of bridge made of weatherability steel. Therefore, it needs to investigate the flow structure around bridge beams and behavior of sea-water mist (droplet). In this paper, flow visualization and PIV are attempted to understand the flow structures around bridge beams and, furthermore, numerical approach of motion of droplets is attempted to understand the collision of sea-water mists on the bridge wall.

关键词： Flow Visualization PIV Behavior of Sea-Water Mist

Effect of PEGylation on the physicochemical and pharmacokinetic characteristics of bovine serum albumin-encapsulated liposome

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 112-113页

作者： Yuko Okamoto Kazuaki Taguchi Keishi yamasaki Mina Sakuragi Shun’ichi Kuroda Masaki Otagiri Faculty of Pharmaceutical Sciences Sojo UniversityKumamoto 860-0082Japan Department of Nanoscience Sojo UniversityKumamoto 860-0082Japan The Institute of Scientific and Industrial Research Osaka UniversityOsaka 567-0047Japan Graduate School of Bioagricultural Sciences Nagoya UniversityNagoya 464-8601Japan

There is now little doubt that PEGylation is useful and is in widespread use because it provides a prolonged half-life,a higher stability and a lowerimmunogenicity[1].However,it is of concern that PEGylation may affect the physicochemical and pharmacokinetic characteristics of protein-encapsulated ***,we prepared the bovine serum albumin(BSA)-encapsulated liposome(BSA-liposome)with or without PEG and then compared their physicochemical and pharmacokinetic characteristics(Fig.1).BSA-liposomes were prepared by the thin-film hydration method.

关键词： Liposome PEGylation Bovine serum albumin

Tuning Polymer-Grafted Particle Monolayer Structure at the Air-Water Interface by Introducing Anisotropic Features

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Journal of Materials Science and Chemical Engineering 2018年第1期6卷 11-18页

作者： Emiko Mouri Yo yamasaki Motokazu Terada Department of Applied Chemistry Kyushu Institute of TechnologyKyushu Institute of TechnologyFukuokaJapan

Fabrication of anisotropic material is one of the important topics and we examined to introduce “anisotropic” nature by spreading polymer-grafted particle on the medium with polymer-reactive potential. Poly (tert-butyl methacrylate) (PtBMA) was polymerized from polystyrene latex (PSL) surface by ATRP to give PtBMA-grafted PSL (PSL-PtBMA). Particle monolayer was formed at air-water and air-acidic water interfaces and the monolayer characteristics were compared by π-A isotherm measurements, SEM observations, and contact angle measurements. π-A isotherms, in particular, indicates that the interaction between polymer chains become stronger by changing the subphase condition, which suggests that anisotropicparticle monolayer formation.

关键词： Anisotropic Particle Polymer-Grafted Particle Air-Water lnterface Polymer Brush Particle Monolayer