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World Journal of Gastroenterology 2006年第24期12卷 3803-3809页

作者： Kimiyasu Yamazaki Yusuke Tajima Reiko Makino Nobukazu Nishino Shigeo Aoki Masanori Kato masaaki Sakamoto Koji Morohara Tsutomu Kaetsu Mitsuo Kusano Department of Surgery Division of General and Gastroenterological Surgery Showa UniversitySchool of Medicine1-5-8HatanodaiShina-gawa-kuTokyo 142-8666Japan Department of Surgery Division of General and Gastroenterological Surgery Showa UniversitySchool of Medicine1-5-8HatanodaiShina-gawa-kuTokyo 142-8666Japan Clinical Research LaboratoryShowa UniversitySchool of Medicine1-5-8HatanodaiShinagawa-kuTokyo 142-8666Japan

瞄准：在胃的区分类型的肿瘤澄清在肿瘤区别显型和肿瘤侵略或基因改变之间的关系。方法：我们检验了肿瘤区别在 48 个胃的腺瘤和 171 区分类型的癌的显型，在 APC 和 p53 的变化的存在，和微卫星不稳定性(MSI ) 地位。肿瘤区别显型被检... 详细信息

瞄准：在胃的区分类型的肿瘤澄清在肿瘤区别显型和肿瘤侵略或基因改变之间的关系。方法：我们检验了肿瘤区别在 48 个胃的腺瘤和 171 区分类型的癌的显型，在 APC 和 p53 的变化的存在，和微卫星不稳定性(MSI ) 地位。肿瘤区别显型被检验人的表示决定胃粘蛋白(HGM ) ， MUC6， MUC2 和 CD10。肿瘤然后被分类进胃 --(G-) ，胃、肠混合 --( 官方补给 --) ，或肠 --( 我 --) 显型，根据上述标记的免疫确实。在 APC 和 p53 和 MSI 地位的变化的存在也在所有肿瘤被调查。结果：胃的腺瘤显著地与 CD10 表示，我显型肿瘤和 APC 变化的存在被联系，与癌相比(66.7% 对 25.1% ， P < 0.0001；56.3% 对 14.6% ， P < 0.0001；39.6% 对 14.0% ， P < 0.0001，分别地) 并且相反地与 HGM 和 MUC6 和 p53 变化的存在的表情联系了(10.4% 对 62.6% ， P < 0.0001；39.6% 对 64.3% ， P = 0.003；2.0% 对 26.3% ， P = 0.001，分别地) 。APC 变化的频率在比在 HGM 积极的肿瘤， MUC6 积极的肿瘤， CD10 否定的肿瘤和 G 显型肿瘤的 HGM 否定的肿瘤， MUC6 否定的肿瘤， CD10 积极的肿瘤和我显型肿瘤是显著地更高的(32.7% 对 7.1% ， P < 0.0001；27.8% 对 14.0% ， P = 0.0182；37.3% 对 10.4% ， P < 0.0001；并且 38.5% 对 9.5% ， P = 0.0017，分别地) 。MSI 的频率在比在 MUC6 否定的肿瘤， CD10 积极的肿瘤和我显型肿瘤的 MUC6 积极的肿瘤， CD10 否定的肿瘤和 G 显型肿瘤是显著地更高的(24.8% 对 6.7% ， P = 0.0009；22.2% 对 8.0% ， P = 0.0143；并且 28.6% 对 9.6% ， P = 0.0353，分别地) 。结论：肿瘤区别显型是仔细与在胃的区分类型的肿瘤的肿瘤侵略和基因改变有关。

关键词：肿瘤分化基因表型胃肿瘤肿瘤侵入遗传疾病

Comparative Investigation of Alternative Negative Staining Reagents in Bacterial Morphological Study

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Journal of Biosciences and Medicines 2017年第10期5卷 17-24页

作者： masaaki Minami Hiroshi Takase Department of Bacteriology Nagoya City University Nagoya Japan Core Laboratory Graduate School of Medical Sciences Nagoya City University Nagoya Japan

Negative staining is an effective method that can be used for electron microscopic study to observe fine structural morphology without destruction of bacterial structure. Although uranium acetate is used worldwide as a general dyeing solution, it is extremely difficult to use it by a new purchase at a research institution because it falls under the nuclear regulation substance in Japan. Therefore, we examined alternative reagents for negative staining that could replace uranium acetate through bacterial observation with an electron microscope. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes were examined by four stain reagents (phosphotungstic acid (PTA), EMstainer, TI blue, and uranium acetate). Pre cultured bacteria were stained with each stain reagents on a copper grid, washed with PBS, and observed with a transmission electron microscope. In the comparison between bacterial structures, the cell wall structure and bacterial flagella could be observed well in the order of PTA, EMstainer, and uranium acetate. With TI blue staining, flagella could be observed very poorly. In comparison between bacteria, gram negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, could be observed well as compared with gram positive cocci such as Staphylococcus aureus and Streptococcus pyogenes. The uranium acetate looked very coarse in background particles. Since crystals tend to precipitate, TI blue also required filtering, and electron beams were absorbed by the agglomerated crystals, and the frequency of electronic burning occurred high frequency. In this study, there was clear difference in the observation conditions depending on the type of bacteria and the kind of the staining reagents. Especially, it was confirmed that good negative staining features of Pseudomonas aeruginosa by electron microscope were obtained by PTA and EMstainer staining. These alternative reagents are considered to be a candidate for a negative

关键词： Negative Staining Electron Microscope Bacterial Micromorphology Phosphotungstic Acid EMstainer

Formulation of a Preconditioned Algorithm for the Conjugate Gradient Squared Method in Accordance with Its Logical Structure

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Applied Mathematics 2015年第8期6卷 1389-1406页

作者： Shoji Itoh masaaki Sugihara Division of Science School of Science and Engineering Tokyo Denki University Saitama Japan Department of Physics and Mathematics College of Science and Engineering Aoyama Gakuin University Kanagawa Japan

In this paper, we propose an improved preconditioned algorithm for the conjugate gradient squared method (improved PCGS) for the solution of linear equations. Further, the logical structures underlying the formation of this preconditioned algorithm are demonstrated via a number of theorems. This improved PCGS algorithm retains some mathematical properties that are associated with the CGS derivation from the bi-conjugate gradient method under a non-preconditioned system. A series of numerical comparisons with the conventional PCGS illustrate the enhanced effectiveness of our improved scheme with a variety of preconditioners. This logical structure underlying the formation of the improved PCGS brings a spillover effect from various bi-Lanczos-type algorithms with minimal residual operations, because these algorithms were constructed by adopting the idea behind the derivation of CGS. These bi-Lanczos-type algorithms are very important because they are often adopted to solve the systems of linear equations that arise from large-scale numerical simulations.

关键词： Linear Systems Krylov Subspace Method Bi-Lanczos Algorithm Preconditioned System PCGS

Picosecond burst pulse machining with temporal energy modulation

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Chinese Optics Letters 2020年第12期18卷 87-91页

作者： Akinao Nakamura Tomoki Mizuta Yasuhiko Shimotsuma masaaki Sakakura Tomohito Otobe Masahiro Shimizu Kiyotaka Miura Department of Material Chemistry Graduate School of Engineering Kyoto University National Institutes for Quantum and Radiological Science and Technology Kansai Photon Science Institute

Suppression of stress and crack generation during picosecond laser processing in transparent brittle materials such as glass was successfully demonstrated by a picosecond laser pulse with temporal energy modulation. The origin of deterioration in processing accuracy could be interpreted in terms of the discontinuous movement of plasma in the vicinity of the focus. To reveal the effectiveness of the temporal energy modulation for smooth machining, such plasma motion was simulated by the finite-difference time-domain method. Furthermore, photoinduced birefringence was observed using a high-speed polarization camera.

关键词： Burst pulse Energy modulation Material processing Picosecond laser Stress distribution

Gastric adenocarcinoma of the fundic gland(chief cell-predominant type): A review of endoscopic and clinicopathological features

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World Journal of Gastroenterology 2016年第48期22卷 10523-10531页

作者： Masaki Miyazawa Mitsuru Matsuda masaaki Yano Yasumasa Hara Fumitaka Arihara Yosuke Horita Koichiro Matsuda Akito Sakai Yatsugi Noda Department of Internal Medicine Toyama Prefectural Central Hospital

Gastric adenocarcinoma of the fundic gland(chief cellpredominant type, GA-FG-CCP) is a rare variant of welldifferentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis.

关键词： Narrow-band imaging Pepsinogen-I Fundic gland Gastric adenocarcinoma Chief cell

Luminescent Characteristic of Organic Compound-Containing Inorganic Crystal at Room Temperature

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Advances in Chemical Engineering and Science 2015年第4期5卷 441-446页

作者： Norihito Doki masaaki Yokota Department of Chemistry and Bioengineering Faculty of Engineering Iwate University Morioka Japan

The luminescent functional crystal was produced by the organic guest molecules conformation control in the inorganic host crystal matrix. Inorganic host-organic guest crystals were successfully prepared and luminescence spectra were investigated. These crystals had a phosphorescent property in room temperature by 254 nm UV irradiation. In this system, the potassium sulfate host matrix was effectively inhibited the molecular vibration of organic guest molecules by interaction between K+ and π-electrons. In addition, control of the luminescence wavelength (both fluorescence and phosphorescence) was achieved by controlling the structure of organic molecules which were taken in anorganic compound-containing inorganic crystal. Specifically, theorganic compound-containing inorganic crystals with 2-aminobenzenesulfonic acid and 2-naptylamine-1-sulfonic acid as a guest had a phosphorescence band of 455 nm and 510 nm, respectively.

关键词： Phosphorescence Potassium Sulfate 2-Aminobenzenesulfonic Acid

Prostate-specific antigen screening for prostate cancer： benefits for patients with highly aggressive prostate cancer

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Asian Journal of Andrology 2013年第2期15卷 218-220,I0006页

作者： Hui-Jie Jia Yang Li Jin-Guo Wang Ling Zhang Hai-Tao Zhang Xue-Jian Zhao masaaki Kuwahara Department of Pathophysiology Prostate Diseases Prevention and Treatment Research Centre Norman Bethune College of Medicine Jilin University Changchun 130021 China Laboratory of Transplantation and Immunology Xuzhou Medical College Xuzhou 221000 China Department of Pathology and Laboratory Medicine and Tulane Cancer Center Tulane University School of Medicine New Orleans LA 70112 USA Sendal Reno-Urological Clinic 3-1-32 Minami-yoshinari Sendal 9893204 Japan

The US Preventive Services Task Force （USPSTF） analyzed the benefits and harms of prostate specific antigen （PSA）- based screening for prostate cancer （PCa）. The Grade ＇D＇ recommendation of the USPSTF was based mainly on the Prostate, Lung, Colorectal, and Ovarian （PLCO） study in the United States. That result showed only a small reduction in PCa mortality. However, the data from the International Agency for Research on Cancer （IARC） iUustrated the PCa mortality rate （MR） decreased marked. To avoid the over-diagnosis and over-treatment, the American Cancer Society has changed its strategy and updated its guidance. The USPSTF neglected the aggressive PCa accounted for more then 30% of all PCa. Highly aggressive PCa can be diagnosed by PSA screening combined with Gleason grade. We hope that the USPSTF changes the ＇D＇ recommendation for PSA screening.

关键词： UNITED-STATES RISK-FACTORS MORTALITY COMPLICATIONS POPULATION CHINESE LEAD

Intravesical Non-Alkalinized Lidocaine Instillation for Interstitial Cystitis/Bladder Pain Syndrome Patients

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Open Journal of Urology 2012年第4期2卷 223-226页

作者： Teiichiro Aoyagi masaaki Tachibana Tokyo Medical University Ibaraki Medical Center Inashiki Japan

Purpose: The effectiveness of daily or weekly instillation of non-alkalinized lidocaine for patients suffering interstitial cystitis and/or bladder pain syndrome was evaluated retrospectively. Patients and methods: Five female patients (40 - 71 years old) diagnosed as interstitial cystitis by cystoscopic findings and a 68 year-old bladder pain syndrome patient were enrolled. All patients, having interstitial cystitis, had undergone hydrodistention therapy previously and had not improved their symptoms by empirical therapies. Daily or weekly (upon their severity of symptoms) intravesical instillation of 20 ml of 4% non-alkalinized (pH 6.0 - 7.0) lidocaine solution was performed for several times, and patients were asked to keep them in the bladder as long as two hours each time. Previous medications such as anti-cholinergic drugs and analgesics were continued according to patient's requirements and symptoms. The treatment effect was evaluated comparing O'Leary-Sant Symptom Index for interstitial cystitis patients and visual analog pain scale before and after the series of lidocaine therapies. Results: Instillation was made 6 to 16 times. Patients with interstitial cystitis improved their symptoms from O'Leary-Sant Symptom Index 17.5 to 10, Problem Index from 14.8 to 6 in an average. Crouching pain disappeared in all these patients after the instillation therapy. Severe interstitial cystitis findings on cystoscopy disappeared completely in one patient after the therapy. One patient having bladder pain syndrome reduced her analgesics use, and bladder-filling pain decreased from 7 to 3 as a visual analog scale score. One patient complained palpitation at 11th instillation and abandoned treatment thereafter, otherwise, none of these patients showed side effect concerning lidocaine toxicity. Conclusions: Intravesical non-alkalinized lidocaine instillation therapy for interstitial cystitis/bladder pain syndrome patients were an easy, safe and effective treatment.

关键词： Bladder Pain Syndrome Interstitial Cystitis Lidocaine Instillation Therapy

Latest insights into the effects of Helicobacter pylori infection on gastric carcinogenesis

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World Journal of Gastroenterology 2006年第17期12卷 2713-2720页

作者： Kazunari Murakami masaaki Kodama Toshio Fujioka Department of Gastroenterology Oita University Faculty of Medicine OitaJapan

看起来是在 Helicobacter pylori (H pylori ) 和胃的癌症之间的强壮的协会。我们在胃的致癌作用上关于 H pylori 感染的效果考察了最近的证据，分类进传染病学，胃的粘膜变化的动力学， DNA 损坏，毒力因素，主人因素，和胃的恶意的来... 详细信息

看起来是在 Helicobacter pylori (H pylori ) 和胃的癌症之间的强壮的协会。我们在胃的致癌作用上关于 H pylori 感染的效果考察了最近的证据，分类进传染病学，胃的粘膜变化的动力学， DNA 损坏，毒力因素，主人因素，和胃的恶意的来源。通过在对源于 H pylori 紧张之间的差别的毒力因素的研究取得的可观的进步，例如 cagA 确实，以及进主人因素，例如基因多型性，包括胃的癌症， H 联系 pylori 的疾病的一个多样的系列把自己正在借给说明。当发展研究上的胃的恶意的潜在的来源与兴趣尚待分晓，建议骨头髓的 Houghton 等推进的新奇假设的影响导出干细胞(BMDC ) 。进一步作为胃的癌症的可行预防在对 H pylori 根除，以及进胃的致癌作用的机制的研究进行，是急切地被等候当前的年并且在以外。

关键词：胃癌幽门螺杆菌细菌感染病理机制

RECENT DEVELOPMENTS IN LOW-COORDINATE ORGANO PHOSPHORUS COMPOUNDS

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RECENT DEVELOPMENTS IN LOW-COORDINATE ORGANO PHOSPHORUS COMP...