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Beneficial effect of an omega-6 PUFA-rich diet in non-steroidal anti-inflammatory drug-induced mucosal damage in the murine small intestine

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World Journal of Gastroenterology 2015年第1期21卷 177-186页

作者： Toshihide Ueda Ryota Hokari masaaki higashiyama Yuichi Yasutake Koji Maruta Chie Kurihara Kengo Tomita Shunsuke Komoto Yoshikiyo Okada Chikako Watanabe Shingo Usui Shigeaki Nagao Soichiro Miura Department of Internal Medicine National Defense Medical CollegeSaitama 359-8513Japan

AIM: To investigate the effect of a fat rich diet onnon-steroidal anti-inflammatory drug(NSAID)-induced mucosal damage in the murine small ***: C57BL6 mice were fed 4 types of diets with or without *** group was fed standard laboratory *** other groups were fed a fat diet consisting of 8% w/w fat,beef tallow(rich in SFA),fish oil,(rich in omega-3 PUFA),or safflower oil(rich in omega-6 PUFA).Indomethacin(3 mg/kg) was injected intraperitoneally from day 8 to day *** day 11,intestines and adhesions to submucosal microvessels were ***: In the indomethacin-treated groups,mucosal damage was exacerbated by diets containing beef tallow and fish oil,and was accompanied by leukocyte infiltration(P < 0.05).The mucosal damage induced by indomethacin was significantly lower in mice fed the safflower oil diet than in mice fed the beef tallow or fish oil diet(P < 0.05).Indomethacin increased monocyte and platelet migration to the intestinal mucosa,whereas safflower oil significantly decreased monocyte and platelet recruitment(P < 0.05).CONCLUSION: A diet rich in SFA and omega-3 PUFA exacerbated NSAID-induced small intestinal damage via increased leukocyte ***,a diet rich in omega-6-PUFA did not aggravate inflammation as monocyte migration was blocked.

关键词： Non-steroidal anti-inflammatory drugs Small intest

Dendritic Learning-Incorporated Vision Transformer for Image Recognition

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 539-541页

作者： Zhiming Zhang Zhenyu Lei masaaki Omura Hideyuki Hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan IEEE

Dear Editor,This letter proposes to integrate dendritic learnable network architecture with Vision Transformer to improve the accuracy of image *** this study,based on the theory of dendritic neurons in neuroscience,we design a network that is more practical for engineering to classify visual *** on this,we propose a dendritic learning-incorporated vision Transformer(DVT),which out-performs other state-of-the-art methods on three image recognition benchmarks.

关键词： Image network image

Dendritic Deep Learning for Medical Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 803-805页

作者： Zhipeng Liu Zhiming Zhang Zhenyu Lei masaaki Omura Rong-Long Wang Shangce Gao the Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan the Faculty of Engineering University of FukuiFukui-shi 910-8507Japan IEEE

Dear Editor,This letter presents a novel segmentation approach that leverages dendritic neurons to tackle the challenges of medical imaging *** this study,we enhance the segmentation accuracy based on a SegNet variant including an encoder-decoder structure,an upsampling index,and a deep supervision ***,we introduce a dendritic neuron-based convolutional block to enable nonlinear feature mapping,thereby further improving the effectiveness of our approach.

关键词： thereby Deep enable

Principals’and Teachers’Awareness,Knowledge,and Differentiation of Privatization-A Secondary Publication

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Journal of Contemporary Educational Research 2024年第2期8卷 183-186页

作者： masaaki Katsuno Department of School Improvement and Policy Studies School of EducationUniversity of TokyoJapan

Based on the keynote report by Professor Martin Thrupp,this paper discusses the hollowing out of education provision by the state and the permeation of *** was pointed out that principals and boards of trustees in socioeconomically advantaged areas may not be willing to share their benefits with schools in less advantaged *** new liberal policies have hollowed out state provision of education,so the education system has come to rely heavily on private *** paper also presents the current stage of privatization in Japan and the principals’and teachers’perceptions of privatization.

关键词： Privatization Education Principals and teachers

Formation and Properties of Organic Long Persistent Luminescence Crystals Containing Benzidine Derivatives by Melt Crystallization

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Advances in Chemical Engineering and Science 2024年第1期14卷 1-7页

作者： Norihito Doki Kiyoka Maruyama masaaki Yokota Department of Chemistry and Bioengineering Faculty of Engineering Iwate University Morioka Japan

Organic molecules that exhibit long persistent luminescence (LPL) are rapidly gaining attention for a variety of applications. In this study, organic molecules with simple structures were selected and organic long persistent luminescence (OLPL) crystals were prepared. The crystal structure of the prepared OLPL crystal was elucidated and the guideline for the design of OLPL crystal was clarified. LPL was observed in OLPL crystals prepared with TMB as the guest molecule and 1,2-bis(diphenylphosphino)ethane as the host molecule. XRD measurements of the OLPL crystals suggest that the guest molecule is a solid solution substituted in the stable crystal structure of the host molecule in a lattice-shrinking direction.

关键词： Melt Crystallization Host-Guest Chemistry

日本百年石质文物保护:从技术演进到大遗址保护的全景探析

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华夏考古 2024年第3期 125-129页

作者： [日]泽田正昭雷欣怡(译) 日本奈良文化财研究所成都博物馆四川成都市610015

人类创造并传承至今的历史,启示着人类社会的理想状态和前进方向。此中,文化遗产更被誉为人类社会的指南针,是历史的重要物证。尤其近年来,政府极力主张它们应作为旅游资源被有效利用,许多地方率先加强行政效能到地方文化的振兴中,依托... 详细信息

人类创造并传承至今的历史,启示着人类社会的理想状态和前进方向。此中,文化遗产更被誉为人类社会的指南针,是历史的重要物证。尤其近年来,政府极力主张它们应作为旅游资源被有效利用,许多地方率先加强行政效能到地方文化的振兴中,依托当地历史文化,通过世界遗产名录活动的开展和文化遗产的认定,达到地方振兴的目的。像这样将文化遗产作为媒介,举办地域认同感的文化活动也成为近年的趋势。

关键词：世界遗产名录文化遗产石质文物保护日本百年大遗址保护技术演进重要物证指南针

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E8粒子的自旋动力学研究（英文）

Science Bulletin 2024年第19期 2974-2977页

作者：王骁 Konrad Puzniak Karin Schmalzl Christian Balz masaaki Matsuda Akira Okutani Masayuki Hagiwara 马杰吴建达 Bella Lake Tsung-Dao Lee Institute Shanghai Jiao Tong University Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Institut für Festk?rperphysik Technische Universit?t Berlin Jülich Centre for Neutron Science JCNS Forschungszentrum Jülich GmbH ISIS Neutron and Muon Source STFC Rutherford Appleton Laboratory Neutron Scattering Division Oak Ridge National Laboratory Center for Advanced High Magnetic Field Science Graduate School of ScienceOsaka University School of Physics&Astronomy Shanghai Jiao Tong University Collaborative Innovation Center of Advanced Microstructures Nanjing University Shanghai Branch Hefei National Laboratory

Unlike the classical phase transition driven by thermal fluctuations,the quantum phase transition arises at zero temperature when the system is tuned by a non-thermal parameter[1].For a continuous quantum phase transition,novel physics with higher symmetry may emerge at the quantum critical point (QCP).As the system is driven away from the QCP with a relevant perturbation,exotic physics may further emerge due to the strong renormalization of the almost infinite low-lying excitations[2].The transverse-field Ising chain (TFIC) is a paradigmatic model[1–3]:when an Ising chain is tuned to its QCP by a magnetic field applied transverse to its Ising anisotropy,

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Enhancing mechanism of intestinal absorption of highly lipophilic compounds using microemulsion e Quantitative analysis of the partitioning to the mesenteric lymph in intestinal cells

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Asian Journal of Pharmaceutical Sciences 2015年第3期10卷 186-193页

作者： Kazunori Iwanaga Yoichi higashiyama Makoto Miyazaki Masawo Kakemi Division of Pharmaceutics Osaka University of Pharmaceutical Sciences4-20-1 NasaharaTakatsukiOsaka 569-1094Japan

The purpose of this study was to quantify the effect of the fatty acid alkyl-chain length of a polyethylene glycol(PEG)glyceryl ester,which was used as a microemulsion oil component,on the partitioning of highly lipophilic compounds to the mesenteric lymph after oral *** blue N,a highly lipophilic anthraquinone derivative,was orally administered to lymph duct-cannulated and untreated rats in two kinds of different ***®50/13 and Gelucire®44/14 were used as the oil component with long chain and medium chain fatty acid portions,respectively,of PEG glyceryl esters in *** cumulative amount of oil blue N in lymph fluid was almost the same between the two microemulsions,although the transferred amount of oil component(triglyceride)in the lymph after administration of the Gelucire®50/13 microemulsion was significantly higher than that of the Gelucire®44/14 *** the other hand,the solubility of oil blue N in Gelucire®44/14 was much higher than that in Gelucire®50/*** significant differences were observed between microemulsions in the bioavailability of oil blue *** these data,the partitioning of oil blue N to the lymph was calculated using a mathematical model,showing that the partitioning ratios of oil blue N to the lymph fluid were almost the same for both *** solubility of oil blue N to the oil component of the microemulsions and the transfer of triglycerides to the lymph after administration of the microemulsions counteract each other,leading to similar partitioning ratios of oil blue N to the lymph.

关键词： Microemulsion Intestinal absorption Mesenteric lymph Partition Quantitative analysis

Creep and creep-fatigue behavior of high chromium steel weldment

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 175-182页

作者： Yukio TAKAHASHI masaaki TABUCHI Materials Science Laboratory Central Research Institute of Electric Power Industry National Institute of Material Sciences

Strength of welded joints of high chromium steels is one of the important concerns for fabricators and operators of ultra supercritical thermal power plants. A number of creep as well as creep-fatigue tests with tensile hold have been carried out on the welded joints of two types of high chromium steels widely used in Japan, i.e. Grade 91 and 122 steels. It was found that failure occurred in fine grain heat-affected zone in all the creep-fatigue tests, even at a relatively low temperature and fairly short time where failure occurred in plain base metal region in simple creep testing. Four procedures were used to predict failure lives and their results were compared with the test results. A newly proposed energy-based approach gave the best estimation of failure life, without respect of the material and temperature.

关键词： Creep Creep-fatigue High chromium steel Life prediction Welded joint