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Heparin-induced thrombocytopenia occurring early after living donor liver transplantation:a case report

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Emergency and Critical Care Medicine 2023年第4期3卷 198-202页

作者： Naoya Iwasaki Motohiro Sekino Takanobu Hara Akihiko Soyama masaaki Hidaka Yusuke Kasai Miki Suzumura Hiroshi Araki Rintaro Yano Sojiro Matsumoto Taiga Ichinomiya Ushio Higashijima Susumu Eguchi Tetsuya Har Department of Anesthesiology and Intensive Care Medicine Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan Department of Surgery Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan

Background:Thrombocytopenia commonly occurs early after liver ***,usually administered as anticoagulant ther-apy for thrombosis,a common complication after liver transplantation,may cause heparin-induced ***-induced thrombocytopenia is a rare but life-threatening complication,and its diagnosis after liver transplantation is *** presentation:We report a case of heparin-induced thrombocytopenia after living donor liver transplantation with a good out-come because of early diagnosis and discontinuation of *** liver transplantation,the platelet count usually reaches a nadir on postoperative days 3–5 and gradually *** contrast,heparin-induced thrombocytopenia typically occurs 5–10 days after heparin administration;therefore,if heparin is started intraoperatively,then thrombocytopenia will occur on postoperative days 5–***:Monitoring the trend and timing of thrombocytopenia and detailed examination for thrombosis may help confirm the diag-nosis of heparin-induced thrombocytopenia in the early stage after liver transplantation.

关键词： Case report Heparin Heparin-induced thrombocytopenia Liver transplantation Thrombocytopenia Thrombosis

Environmental agricultural policy in Japan in harmony with WTO agricultural agreements: current situation and its development (Ⅱ)

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Agricultural Science & Technology 2005年第1期6卷 2-9页

作者： masaaki ISHIDA Faculty of Bioresources Mie University

(To be continued)The development of environmental agricultural policy in JapanEnvironmental agricultural policies based on collaboration between central and local governments

关键词：日本 WTO农业协定农业生态环境政策 GAP 环境保护

A Study on Flow Structure around a Bridge Beam and Behavior of Sea Water Mist

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Open Journal of Fluid Dynamics 2017年第3期7卷 340-347页

作者： masaaki Ishikawa Mechanical Engineering Program University of the Ryukyus Okinawa Japan

Okinawa in the subtropical islands enclosed in the ocean has a problem that corrosion of structures progresses quickly because of high temperature, high humidity and adhesion of sea-water mists flying from sea. Author is interested in corrosion of bridge made of weatherability steel. Therefore, it needs to investigate the flow structure around bridge beams and behavior of sea-water mist (droplet). In this paper, flow visualization and PIV are attempted to understand the flow structures around bridge beams and, furthermore, numerical approach of motion of droplets is attempted to understand the collision of sea-water mists on the bridge wall.

关键词： Flow Visualization PIV Behavior of Sea-Water Mist

Association of non-synonymous variants in WIPF3 and LIPA genes with ab- dominal aortic aneurysm： an autopsy study

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Journal of Geriatric Cardiology 2016年第12期13卷 960-967页

作者： Yuko Maeda Noriko Sato Makiko Naka-Mieno Seijiro Mori Tomio Arai Masashi Tanaka masaaki Muramatsu Motoji Sawabe Department of Molecular Epidemiology Medical Research Institute Tokyo Medical and Dental University Tokyo Japan Department of Medical Informatics Center of Inormation Jichi Medical University Tochigi Japan Center for Promotion of Clinical Investigation Tokyo Metropolitan Geriatric Hospital Tokyo Japan Department of Pathology Tokyo Metropolitan Geriatric Hospital Tokyo Japan Research Teams for Geriatric Pathology Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Genomics for Longevity and Health Tokyo Metropolitan Institute of Gerontology Tokyo Japan Department of Molecular Pathology Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan

腹的大动脉的动脉瘤(AAA ) 是有强壮的基因部件的 multifactorial 疾病。各种各样的基因 loci 与临床的 AAA 被联系了，但是很少研究调查了病理学的 AAA， *** 的中间的显型在日本个人(JG-SNP 学习) 在衰老老人疾病上从研究检验了更老... 详细信息

腹的大动脉的动脉瘤(AAA ) 是有强壮的基因部件的 multifactorial 疾病。各种各样的基因 loci 与临床的 AAA 被联系了，但是很少研究调查了病理学的 AAA， *** 的中间的显型在日本个人(JG-SNP 学习) 在衰老老人疾病上从研究检验了更老的日本题目的 2263 具连续尸体。AAA 的存在在尸体期间与病理学的诊断被决定。与 AAA 联系的单个核苷酸变体(SNV ) 与一个 Illumina HumanExome Beadchip 数组被决定。逻辑回归分析被执行决定基因协会。当有 AAA 的 ***118 题目和没有 AAA 的 2145 个题目在一个盒子控制背景被分析，年龄，性，和 AAA 的另外的风险因素被分析。没有变体在使用 Bonferroni 修正以后到达了意义(P < 2.05 ???????  ???????????????????? 瀠瑡敩瑮 ? 潃据畬楳湯味敨 ?????????????? 吗？？

关键词：腹的大动脉的动脉瘤 Lysosomal 酸脂肪分解酵素 A WAS/WASL 交往蛋白质家庭 3

Improved anti-Stokes energy transfer between rare earth ions in Er(0.5)Yb(9.5):FOV oxyfluoride vitroceramics explains the strong color reversal

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Chinese Physics B 2009年第12期18卷 5523-5533页

作者：陈晓波王策 Gregory J.Salamo Naruhito Sawanobori 康栋国 masaaki Ohtsuka 杨国建彭芳麟 Applied Optics Beijing Area Major Laboratory Beijing Normal University University of Arkansas Department of PhysicsFayettevilleAR 72701USA Sumita Optical Glass Inc.4-7-25 HarigayaUrawaSaitama338Japan Beijing Institute of Applied Physics and Computational Mathematics Applied Optics Beijing Area Major Laboratory and Physics Department Beijing Normal University

The widely used energy transfer theory is a foundation of luminescence, in which the rates of Stokes and anti-Stokes processes have the same calculation formula. An improvement on the anti-Stokes energy transfer to explain the fluorescence intensity reversal between the red and green fluorescence of Er（0.5）Yb（9.5）：FOV is reported in the present article. The range of the intensity reversal Z was measured to be 877. Dynamic processes for 16 levels were simulated. A coefficient, the improvement factor of the intensity ratio of Stokes to anti-Stokes processes in quantum Raman theory compared to classical Raman theory, is introduced to successfully describe the anti-Stokes energy transfer. A new method to calculate the distance between the rare earth ions, which is critical for the energy transfer calculation, is proposed. The validity of these important improvements is also proved by experiment.

关键词： improvement of anti-Stokes energy transfer nanomaterial Era+yb^3+ co-doped rare earth ion material

The clinical signifi cance of circulating tumor cells in gastrointestinal cancer

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Journal of Cancer Metastasis and Treatment 2015年第1期1卷 130-137页

作者： masaaki Iwatsuki Junji Kurashige Takatsugu Ishimoto Keisuke Kosumi Yoshifumi Baba Yasuo Sakamoto Yuji Miyamoto Naoya Yoshida Masayuki watanabe Hideo Baba Department of Gastroenterological Surgery Graduate School of Medical SciencesKumamoto University1-1-1 HonjoChuo-kuKumamoto 860-8556Japan Department of Gastroenterological Surgery Esophageal Cancer DivisionCancer Institute Hospital of Japanese Foundation for Cancer Research3-8-31 AriakeKoto-kuTokyo 135-8550Japan

Circulating tumor cells(CTCs)are originated from the primary tumor lesion into the blood *** could lead to recurrence of gastrointestinal(GI)cancers,even after a curative resection and colonizing in the distant organs to facilitate tumor distant metastasis;however,it has been challenging in clinic to detect CTCs for a long time,such as detection methodology or molecular markers for identifi cation of *** review discussed the recent technical advances and biomarkers in the detection of CTCs and the molecular mechanism of CTC in cancer progression and ***,novel concepts,such as cancer stem cells and epithelial-mesenchymal transition,could lead to CTCs and tumor progression and ***,the involvement of CTCs varies greatly among cancer types in the GI and much remains to be ***,further study will provide more insightful information from a clinical and translational viewpoint to use CTCs for cancer early diagnosis or prediction of tumor recurrence and investigation of tumor progression and metastasis as well.

关键词： Cancer stem cells circulating tumor cells epithelial-mesenchymal transition gastrointestinal cancer tumor progression and metastasis

Effect of Peptidase Inhibitors on Dynorphin A (1-17) or (1-13)-Induced Antinociception and Toxicity at Spinal Level

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Pharmacology & Pharmacy 2017年第2期8卷 33-51页

作者： Mitsumasa Matsuda Masanobu Yoshikawa Takugi Kan Mariko watanabe Junko Ajimi Shigeru Takahashi masaaki Miura Kenji Ito Hiroyuki Kobayashi Toshiyasu Suzuki Department of Anesthesiology School of Medicine Tokai University Isehara Japan Department of Clinical Pharmacology School of Medicine Tokai University Isehara Japan Department of Anesthesiology Hiratsuka City Hospital Hiratsuka Japan

Our group has earlier demonstrated that three enzymes sensitive to peptidase inhibitors (PIs), amastatin (A)-, captopril (C)-, and phosphoramidon (P), played an important role in inactivation of enkephalins at the spinal level. Dynorphin-converting enzyme (DCE) hydrolyzes dynorphin (Dyn) A (1-17) or Dyn A (1-13) mainly at the Arg6-Arg7 bond. Dynorphin A and its derived peptides interact with opioid and glutamate receptors at their N- and C-terminals, respectively. The purpose of the present study was to evaluate the antinociceptive potency and toxicity of intrathecal administered Dyn A (1-17), Dyn A (1-13), or Dyn A (1-6) under pretreatment with ACP and/or the DCE inhibitor p-hydroxymercuribenzoate (PHMB). The effect of these PIs on Dyn A (1-17)-induced inhibition of electrically-evoked contractions in mouse vas deferens was also investigated. The inhibitory potency of Dyn A (1-17) on electrically-evoked contractions in mouse vas deferens under pretreatment with ACP was higher than that with AC, AP, or CP. Pretreatment with ACP augmented Dyn A (1-17) or (1-13)-induced antinociception by approximately 50- or 30-fold with no sign of allodynia when administered intrathecally at low doses. Pretreatment with ACP and PHMB induced neuropathy. These findings showed that intrathecal administration of low-dose Dyn A (1-17) or DynA (1-13) increased antinociception under pretreatment with ACP, but without signs of allodynia in rat.

关键词： Dynorphin A Peptidase Dynorphin-Converting Enzyme Antinociception Allodynia

Time course of expression of intermediate filament protein vimentin,nestin and desmin in rat renal glomerular injury

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Chinese Medical Journal 2007年第13期120卷 1203-1205页

作者： ZOU Jun CHANG Tian-hui CHANG He Eishin Yaoita Yutaka Yoshida masaaki Nameta Tadashi Yamamoto JIN Xin Department of Pharmacy School of Medical Sciences Xiamen University Xiamen 361005 China Department of Clinical Pharmacology School of Pharmaceutical Sciences China Medical University Shengyang 110001 China Division of Cardiology Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori Niigata 951-8510 Japan Department of Structural Pathology Institute of NephrologyNiigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-dori Niigata 951-8510 Japan

Podocytes in renal glomemlus express unusual intermediate filament proteins （IFs） for visceral epithelial cells. IFs cytoskeleton is mainly composed of vimentin, nestin and desmin. Tissue injury is often accompanied by changes in gene expression of IFs. Enhanced desmin staining in variety of rat experimental including 2 4 puromycin nephrosis. It has not podocytes are observed in a models of podocyte injury aminonucleoside （PAN） been elucidated whether expression of vimentin and nestin is up-regulated in podocyte injury. To further gain insight into expression of IFs in podocytes, we investigated the time course of vimentin, nestin and desmin in PAN nephrosis.

关键词： intermediate filament vimentin nestin desmin kidney

Spontaneous regression of hepatocellular carcinoma: A mini-review

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World Journal of Gastroenterology 2017年第21期23卷 3797-3804页

作者： Akira Sakamaki Kenya Kamimura Satoshi Abe Atsunori Tsuchiya masaaki Takamura Hirokazu Kawai Satoshi Yamagiwa Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University

Spontaneous tumor regression is an extremely rare phenomenon in the oncology field. However, there are several case reports resulted in the regression of hepatocellular carcinoma(HCC) and the accumulation of clinical information and analyses of the mechanism can contribute to the development of a novel therapy. For this purpose, we have carefully reviewed 23 cases of spontaneously regressed HCC published in recent 5 years and our case. The information regarding the tumor size, tumor marker, treatments, etc., have been summarized. The mechanism of spontaneous regression has been discussed to date and presumed to be due to many factors, including hypoxia and immunological reactions. In this careful review of the 24 cases based on the clinical information, hypoxia, systemic inflammation, and both upon spontaneous regression were seen in 3, 8, and 4 cases, respectively amo ng t he 15 c as e s f or w hic h t he inf o r mat io n regarding the proposed mechanisms are available. Recent development of immunotherapeutic approaches in oncology shows promising results, therefore, accumulation of additional cases and analysis of mechanisms underlying the spontaneous regression of HCC are essential and could lead to the development of a new generation of immunotherapies including antibodies directed against immune reactions.

关键词：自发的回归 Hepatocellular 癌免疫学的反应免疫疗法组织缺氧