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Ubiquitin C gene: Structure, function, and transcriptional regulation

Advances in Bioscience and Biotechnology 2013年第12期4卷 1057-1062页

作者： Lucia Radici marzia bianchi Rita Crinelli Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biol-ogy Section University of Urbino “Carlo Bo” Urbino Italy

Ubiquitin C (UbC) is one of the four genes encoding for ubiquitin in the mammalian genome. It has been described as the most responsive gene to cellular treats such as UV irradiation, heat shock, oxidative stress and translational impairment;it was also reported to contribute to maintaining ubiquitin steady state levels under physiological conditions. Despite the bulk of knowledge concerning its function, little is known about the molecular mechanisms modulating UbC expression. Here we review the state of the art of UbC structure, function and transcriptional regulation. Starting from the first evidences which circumscribed the genomic region, pointing out both basic promoter marks (such as transcription start site and TATA-like element), and transcript structure (exonintron boundaries) we go through more detailed molecular studies performed by Marinovic in 2002 and by bianchi et al. in 2009 and 2013. Herein, the key players orchestrating UbC gene basal activity are underlined.

关键词： Ubiquitin C Transcriptional Regulation YY1 Sp1 Ubiquitin Homeostasis

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Intranasal nerve growth factor bypasses the blood-brain barrier and affects spinal cord neurons in spinal cord injury

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Neural Regeneration Research 2014年第10期9卷 1025-1030页

作者： Luigi Aloe Patrizia bianchi Alberto De Bellis marzia Soligo Maria Luisa Rocco Cellular Biology and Neurobiology Institute National Research Council(CNR) Maria Rosaria Maglione Foundation Onlus NapoliItaly Intitute of Translational Pharmacology National Research Council(CNR)

The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of spinal cord injury. Adult Sprague-Dawley rats with intact and injured spinal cord received daily intranasal nerve growth factor administration in both nostrils for 1 day or for 3 consecutive weeks. We found an in-creased content of nerve growth factor and enhanced expression of nerve growth factor receptor in the spinal cord 24 hours after a single intranasal administration of nerve growth factor in healthy rats, while daily treatment for 3 weeks in a model of spinal cord injury improved the deifcits in locomotor behaviour and increased spinal content of both nerve growth factor and nerve growth factor receptors. These outcomes suggest that the intranasal nerve growth factor bypasses blood-brain barrier and affects spinal cord neurons in spinal cord injury. They also suggest exploiting the possible therapeutic role of intranasally delivered nerve growth factor for the neuroprotection of damaged spinal nerve cells.

关键词： nerve regeneration spinal cord injury nerve growth factor intranasal delivery blood-brain barrier motor function leptin neuroprotection rats neural regeneration

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