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To treat or not to treat Alzheimer’s disease by the ketogenic diet? That is the question

Neural Regeneration Research 2020年第5期15卷 857-858页

作者： marzena ulamek-koziol Ryszard Pluta Laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of SciencesWarsawPoland First Department of Neurology Institute of Psychiatry and NeurologyWarsawPoland

Alzheimer’s disease (AD) and current treatments: AD is a serious neurological disorder worldwide that affects about 26 million people,and whose prevalence has been calculated to quadruple by 2050,thus reaching over 1% of the total population,with the highest prevalence occurring in both adults and elderly (Pluta et al.,2018).Neurodegenerative processes of the sporadic form of AD probably start 20 years before the clinical onset of the disorder (Pluta et al.,2018).This disease is the most important cause of dementia in world aged society (~75%).AD is a disorder that affects not only patients but also their *** social and economic burden associated with AD was calculated as an example in the United States alone;600 billion dollars annually is spent on caring for AD patients (Pluta et al.,2018).AD is the one of the great health-care challenges of the 21st *** incidence of AD,a chronic and progressive neurodegenerative disorder,is increasing,as well as the need for efficient methods of diagnosis,prevention and treatment (Pluta et al.,2018).The characteristic clinical and neuropathological hallmarks of AD are: dementia as the main clinical symptom and in post-mortem neuropathological examination,the presence of amyloid plaques as well as neurofibrillary tangles and loss of neurons in the brain of AD *** role of amyloid and tau protein is questioned in the etiology of AD and other causes such as ischemic etiology are being considered (Pluta and U?amek-Kozio?,2019).There are several treatments that are not causal but symptomatic that are not effective,especially for advanced *** date,only a few drugs are approved,such as acetylcholinesterase inhibitors and *** that regulate partly the activity of neurotransmitters and partly alleviate behavioral *** treatment options include active and passive immunization,anti-aggregation specifics,and secretase *** road to clarity AD etiology,early final ante mortem dia

关键词： diagnosis Alzheimer prevention protein vitamin or cause has

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Unveiling the silent crisis:global burden of suicide‑related deaths among children aged 10–14 years

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World Journal of Pediatrics 2024年第4期20卷 371-391页

作者： Irmina Maria Michalek Pawel Koczkodaj marzena Michalek Florentino Luciano Caetano dos Santos Department of Cancer Epidemiology and Primary Prevention Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland Private Psychiatric Practice-marzena Michalek MDSiedlcePoland Harvard Business School Harvard UniversityBostonMAUSA

Background The rise in suicides among children aged 10–14 years demands urgent attention *** study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and *** The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(YLLs)due to suicide among children aged 10–14 *** analyses,including mortality rates,YLLs,and the sociodemographic index(SDI),were conducted using standardized *** In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,*** rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in South Africa and 7.49(95%UI=5.13–10.57)in *** contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in South Africa to 33.02%(95%UI=24.36%–41.53%)in ***,there were approximately 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,*** association between SDI and suicide-related deaths was evident,with higher contributions observed in countries with higher *** This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 *** progress in reducing mortality rates,suicide remains a significant *** overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.

关键词： Early adolescent Global Burden of Disease Incidence Suicide Years of life lost

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Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan Rey Alexandra Jimenez-Armijo marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

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Wi-Fi的可靠性豪赌

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科技纵览 2024年第1期 48-49页

作者： Michael koziol 不详

Wi-Fi是最令人恼火的成功故事之一。虽然这项技术在我们的生活中无处不在,但人们仍然对它有怨言,比如它时好时坏,或速度缓慢,或不时中断。Wi-Fi的可靠性事关形象问题。2024年,Wi-Fi7问世时将身兼改善形象的新任务。每一代Wi-Fi都会带来... 详细信息

Wi-Fi是最令人恼火的成功故事之一。虽然这项技术在我们的生活中无处不在,但人们仍然对它有怨言,比如它时好时坏,或速度缓慢,或不时中断。Wi-Fi的可靠性事关形象问题。2024年,Wi-Fi7问世时将身兼改善形象的新任务。每一代Wi-Fi都会带来新的功能和焦点领域,通常与吞吐量(从A点到B点获得更多比特)有关。Wi-Fi7的新功能将带来一代更注重可靠性并降低延迟的无线技术,同时仍会寻找新方法来继续提高数据速率。

关键词：数据速率无线技术多比特可靠性吞吐量 Wi-Fi

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Changes in hydrological regime in High Arctic non-glaciated catchment in 1979-2020 using a multimodel approach

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Advances in Climate Change Research 2022年第4期13卷 517-530页

作者： marzena OSUCH Tomasz WAWRZYNIAK Marta MAJERSKA Institute of Geophysics Polish Academy of SciencesWarsaw 01-452Poland

Assessing hydrological consequences of climate change at the catchment scale is recently among key problems in *** study focuses on the estimation of changes in the hydrological regime in the Fuglebekken catchment in SW Spitsbergen(Svalbard).For this purpose,50 rainfll-runoff models were calibrated using available hydrometeorological *** models were validated based on archival flow and SWE observations,and proxy data from time-lapse *** models(FLEX-IS,GSM-SOCONT,PRMS,HBV,Nordic HBV,and GR4J)with the best performance were applied to reconstruct the past hydrological conditions and analyse the trends in flow regime in the period *** significant changes at 0.05 level in the flow regime indicators were detected,including the number of days with the active flow during the calendar year(10.8 d per decade),during the mid-May-November period(9.8 d per decade),the date of the first day with the flow(-4.7 d per decade),and the last day with the flow during mid-May-November(8.4 d per decade).A statistically significant increase in runoff was estimated for two periods from mid-May to the end of June and the second part of August till *** changes in the first period result from increases in air temperature and earlier snowmelt-driven *** estimated runoff increase in the second period corresponds to large increases in *** increase in air temperature,earlier disappearance of snow,and decrease in precipitation in July and the first part of August result in runoff *** presented results show that the Fuglebekken‘catchment's hydrological regime has already *** magnitude of the changes is larger compared to catchments located in lower latitudes.

关键词： Hydrological regime Climate change Svalbard High Aretic catchment hydrology Multimodel approach

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FOCUS： PUNITIVE DAMAGES IN CHINA CHINESE PUNITIVE DAMAGES SEEN IN A COMPARATIVE PERSPECTIVE

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Frontiers of Law in China-Selected Publications from Chinese Universities 2014年第3期9卷 308-320页

作者： Helmut koziol University of Vienna Austria

Whereas common law countries think highly of punitive damages and Chinese law accepts them, continental European countries reject them. This pa_per enumerates and evaluates the various arguments that have periodically been put forward in favour and against punitive damages. It examines why such damages are awarded in some quarters of the globe and not in others and proffers alternative remedies which achieve some of the goals of punitive damages in a manner commensurate with the aims of tort law. To the extent that gaps remain, the author calls for development in other areas of law, particularly criminal and administrative penal law. Punitive damages do not belong in tort law. The author concedes, however, that unjust enrichment and tort law itself could also benefit from development to meet the demands of reasonable compensation and in this way, prevention.

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Simplified Numerical Study of Evaporation Processes Inside Vertical Tubes

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Journal of Thermal Science 2014年第2期23卷 177-186页

作者： Pawe Ocoń marzena Nowak Stanisaw Lopata Cracow University of Technology Faculty of Mechanical EngineeringInstitute of Thermal Power EngineeringAl.Jana PawaII 3731-864 CracowPoland

The paper presents a simplified numerical model of evaporation processes inside vertical *** this model only the temperature fields in the fluid domain(the liquid or two-phase mixture) and solid domain(a tube wall) are *** its performance and efficiency is *** analytical formulas,which allow calculating the pressure drop and the distribution of heat transfer coefficient along the tube length,are used in this *** energy equation for the fluid domain is solved with the Control Volume Method and for the solid domain with the Finite Element Method in order to determine the temperature field for the fluid and solid domains.

关键词： Numerical modeling heat transfer evaporation vertical tubes Finite Element Method

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五问大卫·弗兰克尔

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科技纵览 2024年第5期 23-23页

作者： Michael koziol 不详

他为阻止自动语音电话而不解努力。我们使用电话的习惯在某个时刻悄然发生了变化。过去,如果电话响起,你就会接。随着来电显示的出现,你变成了只在能认出来电者时才会接电话。现在有了欺诈电话和自动语音电话,拿起手机接电话似乎成了一... 详细信息

他为阻止自动语音电话而不解努力。我们使用电话的习惯在某个时刻悄然发生了变化。过去,如果电话响起,你就会接。随着来电显示的出现,你变成了只在能认出来电者时才会接电话。现在有了欺诈电话和自动语音电话,拿起手机接电话似乎成了一次“赌博”。2023年,自动语音电话屏蔽服务商Youmail估计,美国的自动语音电话超过了550亿个。自动语音电话是如何激增到现在主宰了电话网络的?这一切能挽回吗?本刊采访了ZipDX的大卫·弗兰克尔(David Frankel),为了回答这些问题,他已经与自动语音电话斗争了十多年。

关键词：来电显示弗兰克尔自动语音大卫手机服务商

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The role of degenerative pathways in the development of irreversible consequences after brain ischemia

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Neural Regeneration Research 2019年第6期14卷 982-983页

作者： Ryszard Pluta marzena U?amek-Kozio? Laboratory of Ischemic and Neurodegenerative Brain Research Mossakowski Medical Research CentrePolish Academy of Sciences First Department of Neurology Institute of Psychiatry and Neurology

Ischemic stroke and irreversible consequences:Ischemic stroke in humans is the second most common cause of death in the world(Mozaffarian et al.,2016).The outcomes after a stroke are often dependent on complications,including motor disorders,depression and dementia(Pluta et al.,2018a),which causes a high risk of re-hospitalization and/or palliative *** is also the main reason for long-term disability in people after stroke,with up to half of those who survived the stroke will not regain their independence until the end of their lives(Mozaffarian et al.,2016).According to epidemiological forecasts,human ischemic stroke will soon become the dominant cause of death worldwide(Bejot et al.,2016)as well as dementia with the phenotype of Alzheimer’s disease(AD;Kim and Lee 2018).It is suggested that human ischemic stroke and experimental brain ischemia in animals are associated with the possible development of AD neuropathology(Pluta et al.,2018a).

关键词： degenerative pathways irreversible consequences brain ischemia

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五问赛思·弗雷登

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科技纵览 2024年第4期 19-19页

作者： MICHAEL koziol 不详

在大学里开始一个新的工程项目并非易事.不过,这正是位于马萨诸塞州沃尔瑟姆的布兰迪斯大学正在做的事.到2026年,该大学将提供工程学士学位,但不设立工程系.布兰迪斯大学的目标是依靠其强大的人文科学传统,提供与美国工程与技术认证委员... 详细信息

在大学里开始一个新的工程项目并非易事.不过,这正是位于马萨诸塞州沃尔瑟姆的布兰迪斯大学正在做的事.到2026年,该大学将提供工程学士学位,但不设立工程系.布兰迪斯大学的目标是依靠其强大的人文科学传统,提供与美国工程与技术认证委员会(ABET)所认证的3500多个其他工程项目不同的内容.本刊与新项目的临时联合主席之一赛思·弗雷登(Seth Fraden)就启动和运营新的工程项目进行了谈话.

关键词：认证委员会学士学位马萨诸塞州 ABET 工程项目弗雷布兰迪斯大学

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