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Fetal stem cells are effective in the treatment of Grade Ⅰ and Ⅱrespiratory failure in amyotrophic lateral sclerosis and muscular dystrophy

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Translational Neuroscience and Clinics 2015年第1期1卷 10-16页

作者： Nataliia.S..Sych Olena.v..Ivankova Mariya.O..Klunnyk Iryna.G..Matiyashchuk Andrey.A..Sinelnyk Mariya.P..Demchyk maryna.v..skalozyb Dario.Siniscalco Department of Clinical Cell Therapy Center Em Cell Department of skalozyb‐Biotechnology Cell Therapy Center Em Cell Department of Experimental Medicine Second University of Naples via S.Maria di Costantinopoli 16

Objectives: To study the effect of fetal stem cell(FSC) therapy on Grade Ⅰ and Ⅱrespiratory failure in patients with amyotrophic lateral sclerosis(ALS) and muscular dystrophy(MD). Methods: A comparative study was conducted on 41 patients with Grade Ⅰ or Ⅱrespiratory failure(RF) resulting from ALS or MD. The patients were divided into 4 groups according to the underlying disease and the degree of RF. Patients underwent combined treatment, including the experimental application of FSC therapy, and were examined before FSC treatment, and 6 months and 12 months after treatment. Results: FSC treatment improved both subjective and objective breathing parameters as early as 6 months post‐treatment. A significant increase in the forced vital capacity(FvC) and forced expiratory volume in 1 second(FEv1) was reported by all patients with grade Ⅰ RF linked to ALS and MD compared to baseline. Patient respiratory improvement was maintained over the next 6 months. Grade Ⅱ RF patients with MD reported a significant improvement in FvC 12 months after treatment. Conclusions: Evidence for respiratory improvement was observed as early as 6 months in all patients after combined treatment including FSC therapy, and this was maintained for a further 6 months after therapy. In MD patients with Grade Ⅱ RF, treatment resulted in a significant FvC and FEv1 increase within 6 months and downgrading to Grade Ⅰ RF within a year after FSC treatment.

关键词： respiratory failure amyotrophic lateral sclerosis muscular dystrophy fetal stem cells forced vital capacity forced expiratory volume

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Human chemerin induces eryptosis at concentrations exceeding circulating levels

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BIOCELL 2024年第8期48卷 1197-1208页

作者： maryna TKACHENKO ANATOLII ONISHCHENKO LILIYA TRYFONYUK DMYTRO BUTOv KATERYNA KOT vIKTORIIA NOvIKOvA LIWEI FAN vOLODYMYR PROKOPIUK YURII KOT ANTON TKACHENKO Department of Internal Medicine No.2 Clinical Immunology and AllergologyKharkiv National Medical UniversityKharkiv61022Ukraine Research Institute of Experimental and Clinical Medicine Kharkiv National Medical UniversityKharkiv61022Ukraine Institute of Health National University of Water and Environmental EngineeringRivne61022Ukraine Department of Infectious Diseases and Phthisiology Kharkiv National Medical UniversityKharkiv61022Ukraine Biochemistry Department V.N.Karazin Kharkiv National University Ministry of Education and Science of UkraineKharkiv61022Ukraine Department of Chemistry BiochemistryMicrobiology and Food HygieneState Biotechnological UniversityKharkiv61022Ukraine Clinical Research Innovation Lab Floor 26 Block D Qidi Technology Building 8Tsinghua Technology ParkBeijing100084China Department of Cryobiochemistry Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of UkraineKharkiv61015Ukraine

Introduction:Human chemerin is an adipokine that regulates chemotaxis,inflammation,and glucose *** addition,accumulating evidence suggests that chemerin promotes apoptosis,autophagy,and ***,there are no data on its impact on *** current study aimed to analyze the effects of human active Glu^(21)-Ser^(157) chemerin on eryptosis in *** and Methods:Human chemerin 0-2-10-50μg/mL was incubated for 24 h with human erythrocytes(hematocrit 0.4%)obtained from eight healthy *** cytometry-based determination of phospholipid scrambling,reactive oxygen species(ROS)production,and intracellular Ca^(2+)levels was *** supplement data on ROS and Ca^(2+)signaling in chemerin-mediated eryptosis,incubation in the presence or absence of antioxidants vitamin C and N-acetylcysteine and Ca^(2+)-binding agent EGTA was carried out,*** microscopy-based techniques were used to detect reactive nitrogen species(RNS)generation,involvement of caspase-3 and caspase-8,as well as the state of lipid order in cell membranes of erythrocytes exposed to human Glu^(21)-Ser^(157) ***:Our observations suggest that human Glu^(21)-Ser^(157) chemerin had no impact on eryptosis parameters at 2μg/***,chemerin stimulated phosphatidylserine externalization,ROS production,and Ca^(2+)accumulation at higher concentrations suggesting activation of ***^(2+)uptake turned out to be at least partly required for chemerin-mediated ***-mediated erythrotoxicity was additionally mediated by RNS,caspase-3,and ***,Glu^(21)-Ser^(157) chemerin promoted reduction in the liquid-ordered phase of cell membranes in ***:The present study first discloses that human chemerin can induce eryptosis via Ca^(2+)-dependent mechanisms at concentrations noticeably exceeding circulating ***,chemerin-induced eryptosis can hardly contribute to eryptosis-mediated anemia in disease

关键词： Adipokine Cell death Chemerin Oxidative stress Eryptosis

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Can glucagon-like peptide-1(GLP-1) analogues make neuroprotection a reality?

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Neural Regeneration Research 2020年第10期15卷 1852-1853页

作者： maryna v.Basalay Sean M.Davidson Derek M.Yellon The Hatter Cardiovascular Institute University College London

Currently,ischemic stroke remains one of the most costly and devastating clinical syndromes,accounting for 9%of all deaths and being the second leading cause of death in the world(Davidson et al.,2018).Approximately 20%of strokes are caused by intracerebral hemorrhage,while the other^80%are classified as *** the discovery of thrombolysis,reperfusion therapy became an option for the treatment of ischemic *** recently,endovascular recanalization with mechanical thrombectomy has brought about a paradigm shift in the optimal management of patients with large vessel ***,early reperfusion is the only therapy that is proven to limit infarct size in patients with acute ischemic ***,despite a successful recanalization being achieved in more than 70% of patients treated with mechanical thrombectomy+/–intravenous tissue recombinant plasminogen activator,functional independence(modified Rankin score 0–2 at 3 months after ischemic stroke)is obtained only in^45% of *** reveals the further need to develop new adjunctive neuroprotective treatment strategies alongside reperfusion therapy.

关键词： protective treatment independence

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