检索结果-南通市图书馆

Association between Serum Glutathione Peroxidases and Superoxide Dismutases mRNA Level with Coronary Artery Disease

Health 2017年第2期9卷 252-260页

作者： Ali Reza Abaspour Mohammad Taghikhani Mohamad Reza Parizade Mohsen Moohebati Fahime Ghafoori Mehraneh Mehramiz maryam tayefi Amir Avan Marzeye Ghalandari Gordon A. A. Ferns Majid Ghayour-Mobarhan Department of Molecular Science Faculty of Medicine North Khorasan University of Medical Science Bojnurd Iran Department of Clinical Biochemistry Tarbiat Modares University Tehran Iran Department of Biochemistry and Nutrition Faculty of Medicine Mashhad University of Medical Science (MUMS) Mashhad Iran Cardiovascular Research Center Avicenna Research Institute Mashhad University of Medical Science (MUMS) Mashhad Iran Department of Modern Sciences and Technologies School of Medicine Mashhad University of Medical Sciences Mashhad Iran Department of Biochemistry Faculty of Basic Science Payame Noor University Mashhad Iran Division of Medical Education Brighton & Sussex Medical School Brighton UK

Background: Oxidative stress plays a crucial role in the pathogenesis and progression of many diseases, including cardiovascular disease (CVD) and diabetes mellitus. Oxidative stress results from an imbalance between free radical formation and the protective antioxidant mechanisms. The latter mechanisms include superoxide dismutases (SODs) and glutathione peroxidases (GPx) that scavenge excessive ROS and protect cells against excess ROS production. The aim of current study was to determine the serum levels of SOD and serum GPx mRNA as well as the serum prooxidant-antioxidant balance in CVD patients. Method: A total of 103 subjects were recruited, with ≥50% stenosis (Angio+) or –). The expression levels of SOD and GPx in serum were measured using real time PCR. Biochemical-analyses (e.g., triglycerides;high-density lipo-protein cholesterol;low-density lipoprotein cholesterol;fasting-blood-glucose) were determined in all the subjects. Associations of SOD and GPx levels with biochemical and anthropometric characteristics were assessed together with evaluation of the serum pro-oxidant-antioxidant balance (PAB). Results: CVD subjects had a significantly higher level of fasting blood glucose (FBG), TC, LDL-C, TG and hs-CRP levels, as compared to control subjects. The level of serum PAB was significantly higher in the CVD group, 117.92 ± 35.51 and 110.65 ± 27.65 μg/dl in the angio– and angio+ groups, respectively compared to the control group (54.26 + 23.25). Additionally we observed that the SOD-3 level was higher in angio+ group versus control subjects. Conclusion: We have found that patients with CVD had a significantly higher prooxidant-antioxidant and SOD-3 levels. Further studies in larger multi-center setting are warranted to explore the value of emerging biomarker in CVD patients.

关键词： Coronary Artery Disease Glutathione Peroxidases Superoxide Dismutases Real Time PCR Angiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A meshless local Petrov–Galerkin method for solving the neutron diffusion equation

引用

Nuclear Science and Techniques 2018年第11期29卷 304-322页

作者： Shima tayefi Ali Pazirandeh Mohsen Kheradmand Saadi Department of Nuclear Engineering Science and Research BranchIslamic Azad University

The goal of this study is to solve the neutron diffusion equation by using a meshless method and evaluate its performance compared to traditional methods. This paper proposes a novel method based on coupling the meshless local Petrov–Galerkin approach and the moving least squares approximation. This computational procedure consists of two main steps. The first involved applying the moving least squares approximation to construct the shape function based on the problem domain. Then, the obtained shape function was used in the meshless local Petrov–Galerkin method to solve the neutron diffusion equation.Because the meshless method is based on eliminating the mesh-based topologies, the problem domain was represented by a set of arbitrarily distributed nodes. There is no need to use meshes or elements for field variable interpolation. The process of node generation is simply and fully automated, which can save time. As this method is a local weak form, it does not require any background integration cells and all integrations are performed locally over small quadrature domains. To evaluate the proposed method,several problems were considered. The results were compared with those obtained from the analytical solution and a Galerkin finite element method. In addition, the proposed method was used to solve neutronic calculations in thesmall modular reactor. The results were compared with those of the citation code and reference values. The accuracy and precision of the proposed method were acceptable. Additionally, adding the number of nodes and selecting an appropriate weight function improved the performance of the meshless local Petrov–Galerkin method. Therefore, the proposed method represents an accurate and alternative method for calculating core neutronic parameters.

关键词： Neutron diffusion equation Meshless local Petrov–Galerkin(MLPG) Moving least squares approximation(MLSA) Meshless methods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and Physicochemical Characterization of Biodegradable Star-Shaped Poly Lactide-Co-Glycolide-<i>β</i>-Cyclodextrin Copolymer Nanoparticles Containing Albumin

引用

Advances in Nanoparticles 2014年第1期3卷 14-22页

作者： Soodabeh Davaran Akbar Rezaei Somayeh Alimohammadi Amir Ahmad Khandaghi Kazem Nejati-Koshki Hamid tayefi Nasrabadi Abolfazl Akbarzadeh Department of Medical Nanotechnology Faculty of Advanced Medical Science Tabriz University of Medical Sciences Tabriz Iran Department of Medicine Tabriz University of Medical Sciences Tabriz Iran Department of Science Ahar Branch Islamic Azad University Ahar Iran

The purposes of this research were to synthesize and characterize star-shaped poly lactide-co-glycolide-β-cyclo-dextrin (PLGA-β-CD) copolymer by reacting L-lactide, glycolide and β-cyclodextrin in the presence of stannous octoate as a catalyst. The structure of PLGA-β-CD copolymer was confirmed with 1H-NMR, 13C-NMR and FT-IR spectra. Albumin as a model peptide drug was encapsulated within nanoparticles made of PLGA-β-CD with a modified double emulsion method. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) photomicrographs showed that the nanoparticles have the mean diameter within the range of 80 - 210 nm. Also they were almost spherical in shape. Effects of the experimental parameters, such as copolymer composition, copolymer concentration, and reaction temperature, on particular size and encapsulation efficiency were investigated.

关键词： Albumin Star-Shaped Poly Lactide-Co-Glycolide β-Cyclodextrin Nanoparticles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：