检索结果-南通市图书馆

Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications

Bioactive Materials 2020年第3期5卷 659-666页

作者： Wei Xu Chenjin Hou Yuxuan Mao Lei Yang maryam tamaddon Jianliang Zhang Xuanhui Qu Chaozong Liu Bo Su Xin Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsInstitute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijingChina Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalStanmoreHA74LPUK Center for Health Science and Engineering Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control TechnologySchool of Materials Science and EngineeringHebei University of TechnologyTianjin300130China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Bristol Dental School University of BristolBristolBS12LYUK

When biomaterials are implanted in the human body,the surfaces of the implants become favorable sites for microbial adhesion and biofilm formation,causing peri-implant infection which frequently results in the failure of prosthetics and revision ***-Mo alloy is one of the commonly used implant materials for load-bearing bone replacement,and the prevention of infection of Ti-Mo implants is therefore *** this study,bacterial inhibitory copper(Cu)was added to Ti-Mo matrix to develop a novel Ti-Mo-Cu alloy with bacterial inhibitory *** effects of Cu content on microstructure,tensile properties,cytocompatibility,and bacterial inhibitory ability of Ti-Mo-Cu alloy were systematically *** revealed that Ti-10Mo-1Cu alloy consisted ofαandβphases,while there were a few Ti2Cu intermetallic compounds existed for Ti-10Mo-3Cu and Ti-10Mo-5Cu alloys,in addition toαandβ*** tensile strength of Ti-10Mo-xCu alloy increased with Cu content while elongation ***-10Mo-3Cu alloy exhibited an optimal tensile strength of 1098.1 MPa and elongation of 5.2%.Cytocompatibility study indicated that none of the Ti-10Mo-xCu alloys had a negative effect on MC3T3-E1 cell *** inhibitory rates against *** and *** increased with the increase in Cu content of Ti-10Mo-xCu alloy,within the ranges of 20-60%and 15-50%,*** together,this study suggests that Ti-10Mo-3Cu alloy with high strength,acceptable elongation,excellent cytocompatibility,and the bacterial inhibitory property is a promising candidate for biomedical implant applications.

关键词： Ti-10Mo-xCu alloy Microstructure Mechanical properties Cytocompatibility Bacterial inhibitory property

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eularian wall film model for predicting dynamic cell culture process to evaluate scaffold design in a perfusion bioreactor

引用

Medicine in Novel Technology and Devices 2022年第1期13卷 12-21页

作者： Ziyu Liu Chunjing Tao Shanshan Yuan Wei Wang maryam tamaddon Liqi Ng Hao Huang Xiaodan Sun Chaozong Liu Division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmore HA74LPUK School of Medical Science and Engineering Beihang UniversityChina Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijingChina Department of Cardiology Qingdao Municipal HospitalShandongChina School of Science and Engineering The Chinese University of Hong KongShenzhenChina

In tissue engineering field,it is important to develop a suitable numerical model to evaluate scaffold geometry *** experimental evaluation of the effect of each specific scaffold parameter on tissue regeneration requires large cost and long time *** cell culture is commonly used for generating tissues which could replace damaged tissues.A perfusion bioreactor model is developed which is able to simulate dynamic cell culture,to evaluate scaffold *** wall-film model is used to simulate cell attachment with the assumption that cells could be seen as liquid *** the process of cell attachment,the cells could impinge to a solid surface and form a liquid film which were considered as cell attached on the scaffold *** types of cell-scaffold interactions were involved in numerical models including trap model and Stanton-Rutland(Cell impinge model—CIM)*** trap model,all cells impinged the scaffold are seen as *** Stanton-Rutland model,four regimes of cell-scaffold interaction are involved in the cell attachment,including stick,rebound,spread,and splash,and only stick and spread are seen as *** comparison with two different numerical methods,the results showed that CIM model result is more related to the experimental results than trap model,which indicated that four regimes of cell-scaffold interaction occurred in cell attachment *** evaluating two different geometry scaffold's cells seeding by these two models,the results further indicated that this model are able to use for assessing the scaffold design.

关键词： Scaffold structure Computational fluid dynamics Cell attachment Cell impinge model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

组织工程中细胞实验和动物实验的替代计算模型

引用

Chinese Medical Sciences Journal 2021年第4期36卷 323-332页

作者：黄皓刘朝宗易腾 maryam tamaddon 苑姗姗史震云刘子钰北京航空航天大学工程医学院北京航空航天大学机械工程及自动化学院英国伦敦大学学院外科与介入科学系英国伦敦斯坦莫尔市英国皇家国家骨科医院国防科技创新研究院青岛市立医院心内科

在骨科植入物和再生医学研究领域,为了得到合适的产品需要经过反复实验分析优化材料、结构、机械性能等指标,从细胞实验到临床试验的整个过程既昂贵又耗时。计算模拟方法是组织工程产品开发的设计工具,可以有效降低开发成本和时耗。本... 详细信息

在骨科植入物和再生医学研究领域,为了得到合适的产品需要经过反复实验分析优化材料、结构、机械性能等指标,从细胞实验到临床试验的整个过程既昂贵又耗时。计算模拟方法是组织工程产品开发的设计工具,可以有效降低开发成本和时耗。本文综述了一系列组织工程模型,他们能模拟从细胞附着到组织再生的全过程。从细胞黏附到组织再生的一体化模型的建立能优化组织工程产品设计和评价过程。然而,目前模拟组织工程过程的模型均各自独立。本文重点介绍了组织工程中细胞黏附、营养物质运输和细胞增殖、分化、迁移的模型,试图将所有独立模型串联在一起以供读者使用。在细胞黏附模型中,离散相模型能最精确地模拟控制细胞运动过程,Stanton-Rutland模型能模拟细胞黏附过程。营养盐运输模型能是一种能将流体体积模型和组分传输模型耦合的数值模型,在组织工程中被应用于营养盐运移过程的预测。有限元以及随机游走算法被用于细胞增殖、分化和迁移的模拟。大多数模型的准确性和有效性还有待进一步研究证实。由于尚缺乏检测营养物质扩散速率的技术,在凝血领域模型分析方法的研究尤其少。因此,组织工程全过程建模方法的研究还有很多工作要做。在未来,数值模型将被视为研究组织工程产品生物性能的最佳方法,并能够优化组织工程产品的参数和材料类型。

关键词：组织工程支架计算机辅助设计计算流体力学有限元模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Redox-sensitive, PEG-shielded carboxymethyl PEI nanogels silencing MicroRNA-21, sensitizes resistant ovarian cancer cells to cisplatin

引用

Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 69-82页

作者： Sanaz Javanmardi Ali Mohammad tamaddon Mahmoud Reza Aghamaali Ladan Ghahramani Samira Sadat Abolmaali Department of Biology Faculty of ScienceUniversity of Guilarij Rasht 64891Iran Center for Nanotechnology in Drug Delivery Shiraz University of Medical SciencesShiraz 71345Iran School of Pharmacy Shiraz University of Medical SciencesShiraz 71345Iran

A series of branched polyethylenimine(PEI) modifications including PEGylation(PEG2 k-PEI) for steric shielding, redox-sensitive crosslinking for synthesis PEG2 k-PEI-ss nanogels and subsequent carboxymethylation(PEG2 k-CMPEI-ss) for modulation of the polymer pk a have been introduced for cellular delivery of Anti-mi R-21. The synthesis was characterized using 1 H NMR, FTIR, TNBS, potentiometric titration, particle size and ζ potential. Loading of Anti-mi R-21 at various N/P ratios was investigated by gel retardation, ethidium bromide dye exclusion, heparin sulfate competition and DNase I digestion experiments. The mi R-21 silencing was measured by stem-loop RT PCR in A2780 ovarian cancer cell lines whether it is sensitive to resistant to cisplatin. It has been shown that PEG2 k-CMPEI-ss was well suited for delivery of Anti-mi R-21 in terms of nucleic acid loading, preservation against extracellular matrix and nucleases and sequence-specific silencing of mi RNA-21 in vitro. Moreover, it has been demonstrated that pre-treating cells with Anti-mi R-21 loaded nanogels can sensitize them to cis-Pt even at non-toxic concentraions. The results indicate that PEG2 k-CMPEIss mediated micro RNA delivery can be considered as a novel strategy for ovarian cancer therapy.

关键词： MicroRNA PEI nanogels Anti-miR-21 Gene delivery Cisplatin resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Predicting numerically the large increases in extra pressure drop when boger fluids flow through

引用

Natural Science 2010年第1期2卷 1-11页

作者： H. R. tamaddon-Jahromi M. F. Webster K. Walters 不详

Recent numerical studies on pressure-drops in contraction flows have introduced a variety of constitutive models to compare and contrast the competing influences of extensional vis-cosity, normal stress and shear-thinning. Early work on pressure-drops employed the constant viscosity Oldroyd-B and Upper Convected Max- well (UCM) models to represent the behavior of so-called Boger fluids in axisymmetric contrac-tion flows, in (unsuccessful) attempts to predict the very large enhancements that were ob-served experimentally. In more recent studies, other constitutive models have been employed to interpret observed behavior and some pro-gress has been made, although finding a (re-spectable) model to describe observed contrac-tion-flow behavior, even qualitatively, has been frustratingly difficult. With this in mind, the present study discusses the ability of a well- known FENE type model (the so-called FENE- CR model) to describe observed behavior. For various reasons, an axisymmetric (4:1:4) con-traction/expansion geometry, with rounded corners, is singled out for special attention, and a new hybrid finite element/volume algo-rithm is utilized to conduct the modeling, which reflects an incremental pressure-correction time-stepping structure. New to this algo-rithmic formulation are techniques in time discretization, discrete treatment of pressure terms, and compatible stress/velocity-gradient representation. We shall argue that the current simulations for the FENE-CR model have re-sulted in a major improvement in the sort-for agreement between theory and experiment in this important bench-mark problem.

关键词： Contraction Flows Extra Pressure Drop Numerical Simulation Extensional Viscosity Normal Stress Differences

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

(P_2O_5/SiO_2):固相Ritter反应的一个有效试剂

引用

中国医药工业杂志 2009年第1期40卷 63-63页

作者： tamaddon F 孙桂芳

苯甲腈、乙腈或丙烯腈（RCN）与苯甲醇类或叔丁醇（R′OH）在P2O5／SiO2（60％，w／w）存在下加热至80～100℃反应2～4．5h，获得相应的酰胺（RCONHR′）。19N收率68％～93％。微波可加速反应，杂环腈类不反应。

关键词：加速反应试剂固相 P2O5 苯甲腈叔丁醇丙烯腈乙腈

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：