检索结果-南通市图书馆

Steroids, Tri- and Meroterpenoids with a Quinone Structure—A Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Organic Chemistry 2024年第1期14卷 32-68页

作者： maryam S. M. Aghaei Thies Thiemann Department of Chemistry College of Science United Arab Emirates University Al Ain United Arab Emirates

Terpenoids with quinoid structures are found as natural products. This includes steroidal quinones, quinones with a secosteroid structure and meroterpenoid quinones. Importantly, catechol estrogens as endogenous metabolites of estradiol and estrone are precursors of reactive quinones and semiquinones, which are thought to contribute to estrogen-induced carcinogenesis. On the other hand, a number of quinones that include substituted naphthoquinones and anthraquinones are highly cytotoxic and have been used in cancer treatment. This makes the structures interesting synthetic targets. The following is a review of important natural and synthetic terpenoid and steroid quinone hybrids.

关键词： Steroid Secosteroid Meroterpenoid Triterpenoid Quinone Anti-Tumour Agent Antibiotic Natural Product

Spatial analysis of animal bites in Iran(2015-2020):A cross-sectional study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Acute Disease 2024年第2期13卷 67-73页

作者： Hoda Amiri Khadijeh Yazdanparast Mohsen Pourkhosravani maryam Rastegar Department of Environmental Health Engineering School of HealthShiraz University of Medical SciencesShirazIran Department of Geography and Urban Planning Shahid Bahonar University of KermanIran Department of Biostatistics School of HealthMashhad University of Medical SciencesMashhadIran

Objective:To investigate the distribution pattern of animal bites in Mirjaveh,Iran from 2015 to ***:The data on animal bites were collected from the Department of Infectious Diseases,the provincial health *** climatic data on precipitation and temperature during the study period were also *** correlation between incidence and temperature,precipitation rate,land type,and altitude was also ***:The results showed that men were more affected by animal bites than women(76.4%,P<0.001),and the highest incidence rate occurred in the age group of 5-19 *** incidence rate of animal bites was found to be correlated with temperature and *** increase in temperature was associated with a rise in the incidence rate of animal *** number of animal bites increased until 2019,possibly due to an increase in the number of dogs in the ***:Targeted interventions should be implemented to reduce the incidence of animal bites,particularly among children,housewives,and *** access to appropriate treatments,increasing public awareness of the hazards of animal bites,and increasing the number of vaccinated dogs in the area are essential strategies to be considered.

关键词： Animal bites Epidemiology Zoonotic disease Iran

Isoimperatorin alleviates acetic acid-induced colitis in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 147-153页

作者： Saied Goodarzi Amir Hossein Abdolghaffari Behnaz Najafi Mostafa Pirali Hamedani Saeed Tavakoli Mahshad Marvi maryam Baeeri Narguess Yassa Abbas Hadjiakhoondi Mohammad Abdollahi Zahra Tofighi Medicinal Plants Research Center Faculty of PharmacyTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran Medical SciencesIslamic Azad UniversityTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran Medicinal Plants Research Center Institute of Medicinal PlantsACECRKarajIran International Campus School of Pharmacy Tehran University of Medical SciencesTehranIran Toxicology and Diseases group The Pharmaceutical Sciences Research CenterTehran University of Medical SciencesTehranIran Department of Toxicology and Pharmacology Faculty of PharmacyTehran University of Medical SciencesTehranIran

Objective:To investigate the effect of isoimperatorin on histopathological and biochemical changes in acetic acid-induced colitis ***:Colitis was induced by intracolonic administration of acetic acid solution(4%v/v)in *** were divided into six groups including the sham group,the negative control group,the dexamethasone-treated group,and the groups treated with isoimperatorin(0.1,1,and 10 mg/kg/d by gavage).The treatments were administered for three days and then colonic status was assessed by macroscopic,histopathological,and biochemical ***:Isoimperatorin significantly alleviated colonic damage in a dose-dependent manner and improved histological changes in rats with acetic acid-induced *** also significantly reduced myeloperoxidase,TNF-α,IL-1β,and malodialdehyde ***:Isoimperatorin alleviates acetic acid-induced colitis in rats and may be a potential therapeutic agent for the treatment of colitis.

关键词： Isoimperatorin Inflammatory bowel disease Acetic acid Colitis TNF-α IL-1β

Splenic Vein Thrombosis as a Complication of Hypertriglyceridemia-Induced Acute Pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2024年第7期13卷 260-267页

作者： Qonitah Gibrata Fedaa Housen Bashar Almasri maryam AlKhatry Emirate Health Services Ras Al-Khaimah United Arab Emirates Ibrahim Obaid Allah Hospital Ras Al-Khaimah United Arab Emirates

Background: Acute pancreatitis (AP) is an extensive inflammation condition that may lead to local and systemic complications, ranging from mild edematous peripancreatic fluid collection to multiorgan failure and death. Aim: To report the case of the patient with the complications that happened and the presented management. Case presentation: A 37-year-old female patient presented with acute necrotizing pancreatitis secondary to hypertriglyceridemia. During hospitalization, the patient developed severe ileus with splenic vein thrombosis. She was treated conservatively with Intravenous (IV) fluids, insulin infusion, anticoagulant, pain relief medication and antibiotics. Discussion: This case of pancreatitis induced splenic vein thrombosis (PIVST) was treated supportively with outstanding improvement of the patient’s symptoms. Conclusion: Acute pancreatitis can be complicated by splenic vein thrombosis that can be self-limited and treated with conservative measures.

关键词： Hypertriglyceridemia Acute Pancreatitis

Structural optimization of a reusable seismic frame active link

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Welding 2024年第3期33卷 1-7页

作者： Károly Jármai maryam Hasanali Kaveh Andisheh University of Miskolc Miskolc H-3515Hungary New Zealand Heavy Engineering Research Association HERAAuckland 2104New Zealand

Circular design encompasses the use of inventive construction methodologies that possess the capability to be readily dismantled,repurposed,or recycled upon reaching the conclusion of their functional *** work specifically examines the creation of a reusable design case-study idea for seismic frame design,which is commonly employed in steel-frame constructions in New Zealand.A reusable optimized design for the full seismic frame was proposed in the *** the dimensions of welded structures,whether in terms of weight or cost,leads to a decrease in the weight of the steel *** decrease in weight is directly associated with a decrease in environ-mental impact,as the environmental impact is directly proportional to the mass of the *** environmental consequences associated with welding technique are contingent upon the dimensions of the weld,hence exerting an indirect influence on the overall mass of the *** the presence of mass dependence in all three areas,albeit in distinct manners,this work employed a multi-objective function optimization strategy to simultaneously address these areas while also partially evaluating them *** this way substantial reductions can be achieved both at structural mass and environmental effects.

关键词： welded frame design structural optimization environmental effects cost calculations

Navigating AI Cybersecurity: Evolving Landscape and Challenges

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Intelligent Learning Systems and Applications 2024年第3期16卷 155-174页

作者： maryam Roshanaei Mahir R. Khan Natalie N. Sylvester IST Department Pennsylvania State University Abington Abington USA

The rapid integration of artificial intelligence (AI) into critical sectors has revealed a complex landscape of cybersecurity challenges that are unique to these advanced technologies. AI systems, with their extensive data dependencies and algorithmic complexities, are susceptible to a broad spectrum of cyber threats that can undermine their functionality and compromise their integrity. This paper provides a detailed analysis of these threats, which include data poisoning, adversarial attacks, and systemic vulnerabilities that arise from the AI’s operational and infrastructural frameworks. This paper critically examines the effectiveness of existing defensive mechanisms, such as adversarial training and threat modeling, that aim to fortify AI systems against such vulnerabilities. In response to the limitations of current approaches, this paper explores a comprehensive framework for the design and implementation of robust AI systems. This framework emphasizes the development of dynamic, adaptive security measures that can evolve in response to new and emerging cyber threats, thereby enhancing the resilience of AI systems. Furthermore, the paper addresses the ethical dimensions of AI cybersecurity, highlighting the need for strategies that not only protect systems but also preserve user privacy and ensure fairness across all operations. In addition to current strategies and ethical concerns, this paper explores future directions in AI cybersecurity.

关键词： AI Cybersecurity Adversarial Attacks Defensive Strategies Ethical AI

Enhancing Cybersecurity through AI and ML: Strategies, Challenges, and Future Directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Information Security 2024年第3期15卷 320-339页

作者： maryam Roshanaei Mahir R. Khan Natalie N. Sylvester Information Sciences and Technology Department Pennsylvania State University Abington USA

The landscape of cybersecurity is rapidly evolving due to the advancement and integration of Artificial Intelligence (AI) and Machine Learning (ML). This paper explores the crucial role of AI and ML in enhancing cybersecurity defenses against increasingly sophisticated cyber threats, while also highlighting the new vulnerabilities introduced by these technologies. Through a comprehensive analysis that includes historical trends, technological evaluations, and predictive modeling, the dual-edged nature of AI and ML in cybersecurity is examined. Significant challenges such as data privacy, continuous training of AI models, manipulation risks, and ethical concerns are addressed. The paper emphasizes a balanced approach that leverages technological innovation alongside rigorous ethical standards and robust cybersecurity practices. This approach facilitates collaboration among various stakeholders to develop guidelines that ensure responsible and effective use of AI in cybersecurity, aiming to enhance system integrity and privacy without compromising security.

关键词： Artificial Intelligence Machine Learning Cybersecurity Data Privacy and Security Ethical Standards

Governance of noncommunicable diseases in Afghanistan

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chronic Diseases and Translational Medicine 2024年第3期10卷 238-246页

作者： Narges Neyazi Ali M.Mosadeghrad maryam Tajvar Najibullah Safi International Campus School of Public HealthTehran University of Medical SciencesTehranIran Department of Health System Development World Health OrganizationAfghanistan Department of Health Management Policy and EconomicsSchool of Public HealthTehran University of Medical SciencesTehranIran

Background Noncommunicable diseases(NCDs)are the main reasons of mortality *** of every two person is dying due to NCDs in *** policy actors,mainly the World Health Organization(WHO),published several reports and declarations on controlling and preventing *** study aimed to provide a situation for governance of NCDs in Afghanistan and proper solutions for identified *** We conducted qualitative research utilizing interpretive phenomenology.A self-developed questionnaire was developed to conduct the semi-structured interviews with 39 experts from *** results were analyzed using a deductive framework *** building block framework of health system developed by the WHO was used as predefined framework for this *** The governance building block of health system consists of five subthemes including policy making,planning,organizing,stewardship,and *** identified main strengths,weaknesses,opportunities,and challenges for these *** experts also provided key recommendations to address the *** Management of NCDs is a neglected part of the health system in *** evidence-based policy making with technical and indigenous planning,establishing responsive units with adequate financial and human resources within different ministries to address“health in all policies”concept,passing and implementing national laws and regulations to support national strategies for prevention and control of NCDs,and establishing decentralized monitoring systems to control the implementation of these strategies are the main recommendations of this *** government and international policy actors should invest and support the development of a multisectoral coordination system at national level for Afghanistan.

关键词： governance health in all policies health system multisectoral coordination noncommunicable diseases

Hypokalemia Havoc: Unraveling the Mystery of Unexplained Potassium Depletion

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Case Reports in Clinical Medicine 2024年第8期13卷 292-296页

作者： Justin David Tse maryam Shams Mushgan Nassiri Jackson Wang Department of Graduate Medical Education Internal Medicine Residency Sutter Roseville Medical Center Roseville CA USA Summit Nephrology Roseville CA USA

Hypokalemia, defined as serum potassium below 3.5 mEq/L, can lead to severe complications such as arrhythmias and muscle paralysis, potentially resulting in rhabdomyolysis. The etiology of hypokalemia is often multifactorial, involving but not limited to gastrointestinal losses, renal losses, medication effects, and inadequate dietary intake. Chronic heavy alcohol use, obstructive sleep apnea (OSA), and the use of diuretics such as hydrochlorothiazide (HCTZ) are also significant contributing factors. Effective management requires thorough evaluation and investigation to effectively treat a patient. This case report aims to illustrate the diagnostic challenges and comprehensive treatment approach required in a patient with multiple comorbidities and severe hypokalemia, emphasizing the need for a multidisciplinary and comprehensive approach to address all underlying causes.

关键词： Severe Hypokalemia Electrolyte Derangements Thiazide Diuretic Complications Potassium Repletion