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Monkeypox: A Viral Zoonotic Disease of Rising Global Concern

Infectious Diseases & Immunity 2024年第3期4卷 121-131页

作者： Sukumaran Ani Betsy Joseph mary thomas Vishnupriya K.Sweety Nandita Suresh Tumos Waltimo Department of Dentistry Oral Health InstituteHamad Medical CorporationPost Box 3050DohaQatar College of Dental Medicine Qatar UniversityPost Box 2713DohaQatar Department of Periodontology Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesSaveetha UniversityChennai 600077India Department of Oral and Maxillofacial Diseases Helsinki University and University HospitalHelsinki 00014Finland Pushpagiri Institute of Medical Sciences and Research Centre MedicityPerumthuruthyTiruvallaKerala 689101India Clinic for Oral Health and Medicine University Center for Dental Medicine Basel UZBUniversity of Basel4058 BaselSwitzerland.

Monkeypox(mpox)is a rare viral zoonotic disease,endemic to Central and West Africa,caused by the monkeypox virus,an orthopoxvirus similar to the variola virus(smallpox).Although sporadic travel-associated cases have historically occurred outside Africa,in May 2022,mpox began spreading globally in multiple nonendemic countries across several *** 2024,there has been an increase in globally reported confirmed cases of mpox and deaths from mpox,making it a public health emergency of international *** reasons for the unusual global spread are under investigation but likely relate to increased travel and waning population immunity to *** now appears to be mainly through close,intimate contact,especially among men who have sex with *** is usually a self-limited *** limited approved antiviral treatments are available,such as tecovirimat,which the European Medicines Agency approved in January 2022 for the treatment of mpox,their widespread availability and effectiveness in the current outbreak remain to be *** health control measures include surveillance,case identification/isolation,contact tracing,and targeted vaccination of contacts at high risk of ***,challenges remain in curtailing the current unprecedented *** knowledge gaps include animal reservoir(s)responsible for initial spillover events,viral mutations that may enhance transmissibility,optimal diagnostics for noninvasive specimens,effective antiviral therapies,next-generation vaccines providing longer-term immunity,and building global capacity for outbreak *** review summarizes the current literature on mpox virology,epidemiology,pathogenesis,clinical manifestations,diagnostics,treatment,prevention,and public health control *** investigation and research are needed to better understand mpox’s evolving epidemiology,pathogenicity,transmissibility,and ecology to guide strategies for containin

关键词： Antiviral agents Disease outbreaks Epidemiology Mpox Smallpox vaccine Zoonoses

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真菌和花卉保护并赞颂大自然

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空中英语教室（高级版．彭蒙惠英语） 2024年第8期 20-22,43-45页

作者： mary Ann thomas Norman Winter 不详

每个人都可以是博物学家查尔斯·毕尔是那种会把蛇放进口袋里的孩子。郊区可能会很无聊。草坪和道路无法为好奇的男孩提供多样的生物。不过,不久之前退休的宾夕法尼亚州西部自然资源保护协会保护科学资深主任毕尔却找到了在野外消磨时... 详细信息

每个人都可以是博物学家查尔斯·毕尔是那种会把蛇放进口袋里的孩子。郊区可能会很无聊。草坪和道路无法为好奇的男孩提供多样的生物。不过,不久之前退休的宾夕法尼亚州西部自然资源保护协会保护科学资深主任毕尔却找到了在野外消磨时间的方式。

关键词：自然资源保护宾夕法尼亚州博物学家大自然

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Efficient Approach for Resource Allocation in WPCN Using Hybrid Optimization

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Computers, Materials & Continua 2022年第7期72卷 1275-1291页

作者： Richu mary thomas Malarvizhi Subramani Department of Electronics and Communication Engineering SRMISTKattankulathur603203India

The recent aggrandizement of radio frequency(RF)signals in wireless power transmission combined with energy harvesting methods have led to the replacement of traditional battery-powered wireless networks since the blooming RF technology provides energy renewal of wireless devices with the quality of service(QoS).In addition,it does not require any unnecessary alterations on the transmission hardware side.A hybridized global optimization technique uniting Global best and Local best(GL)based particle swarm optimization(PSO)and ant colony optimization(ACO)is proposed in this paper to optimally allocate resources in wireless powered communication networks(WPCN)through coordinated operation of communication groups,in which the wireless energy transfer and information sharing take place concomitantly by the aid of a cooperative relay positioned in between the communicating *** designed algorithm assists in minimizing power consumption and maximizes the weighted sum rate at the end-user *** the principal target of the system is coordinated optimization of energy beamforming along with time and energy allocation to reduce the total energy consumed combined with assured information rates of the communication *** outputs are presented to manifest the proposed system’s performance to verify the analytical results via simulations.

关键词： Wireless powered communication networks cooperative communication relay hybrid optimization technique ant colony optimization particle swarm optimization

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Seguin Form Board as an intelligence tool for young children in an Indian urban slum

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Family Medicine and Community Health 2017年第4期5卷 275-281页

作者： Beena Koshy Hannah mary thomas T Prasanna Samuel Rajiv Sarkar Scott Kendall Gagandeep Kang Developmental Paediatrics Christian Medical CollegeVelloreIndia Department of Biostatistics Christian Medical CollegeVelloreIndia Department of Gastrointestinal Sciences Christian Medical CollegeVelloreIndia University of California IrvineCAUSA

Objective:The present study evaluates the concurrent and predictive validity of the Seguin Form Board Test(SFBT)as an intelligence tool for children in low-and middle-income ***:In a cohort of normal children,followed up in South India,two cross-sectional analyses were done at 3 and 7 years of age on 95 *** SFBT and Vineland Social Matu-rity Scale(VSMS)were done at 3 years of age and Malin’s Intelligence Scale for Indian Children(MISIC)and the VSMS were done at 7 years of age,and the results were compared for concurrent and predictive validity for the ***:Intelligence quotient and social quotient had positive correlations at 3 years of age,indicating fair concurrent *** SFBT done at around 3 years of age had good positive cor-relation with MISIC at 7 years of age,indicating good predictive ***:This study shows the utility of the SFBT as a community-based intelligence tool with acceptable concurrent and predictive validity.

关键词： Intelligence tests Seguin Form Board Test Malin’s Intelligence Scale for Indian Children Vineland Social Maturity Scale

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High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4320-4337页

作者： Zhi-Wei Mo Yue-Ming Peng Yi-Xin Zhang Yan Li Bi-Ang Kang Ya-Ting Chen Le Li mary GSorci-thomas Yi-Jun Lin Yang Cao Si Chen Ze-Long Liu Jian-Jun Gao Zhan-Peng Huang Jia-Guo Zhou Mian Wang Guang-Qi Chang Meng-Jie Deng Yu-Jia Liu Zhen-Sheng Ma Zuo-Jun Hu Yu-Gang Dong Zhi-Jun Ou Jing-Song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases NHC Key Laboratory of Assisted Circulation(Sun Yat-sen University)Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular DiseasesGuangzhouChina Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Division of Hypertension and Vascular Diseases Department of CardiologyHeart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Medical College of Wisconsin MilwaukeeWIUSA Center for Translational Medicine Institute of Precision MedicineThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Cardiology Heart CenterThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of Medicine of Sun Yat-sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080P.R.China

Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy ***,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote ***,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by *** this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor *** contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of *** was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of *** expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of *** together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis.

关键词： angiogenesis lipoprotein inhibited

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Oesophageal cancer metastases:An observational study of a more aggressive approach

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 997-1007页

作者： Lianne Pickett mary Dunne Orla Monaghan Liam Grogan Oscar Breathnach thomas N Walsh Department of Surgery Connolly HospitalBlanchardstownDublin D15 X40DIreland Clinical Trials Resource Unit St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland Department of Radiation Oncology St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland Department of Medical Oncology Beaumont HospitalDublin D09 V2N0Ireland Department of Surgery RCSI BahrainAdliya 15503Bahrain

BACKGROUND The prognosis for oesophageal carcinoma is poor,but once distant metastases emerge the prognosis is considered *** is no consistent protocol for the early identification and aggressive management of *** To examine the outcome of a policy of active postoperative surveillance with aggressive treatment of confirmed *** A prospectively maintained database of 205 patients diagnosed with oesophageal carcinoma between 1998 and 2019 and treated with curative intent was interrogated for patients with metastases,either at diagnosis or on follow-up surveillance and treated for *** cohort was compared with incomplete clinical responders to neoadjuvant chemoradiotherapy(nCRT)who subsequently underwent surgery on their primary *** survival was estimated using the Kaplan-Meier method,and the log-rank test was used to compare survival differences between *** Of 205 patients,11(5.4%)had metastases treated for cure(82%male;median age 60 years;9 adenocarcinoma and 2 squamous cell carcinomas).All had undergone neoadjuvant chemotherapy or chemoradiotherapy,followed by surgery in all but 1 *** the 11 patients,4 had metastatic disease at diagnosis,of whom 3 were successfully downstaged with nCRT before definitive surgery;2 of these 4 also developed oligometastatic recurrence and were treated with curative *** definitive treatment,7 had treatment for metachronous oligometastatic disease;5 of whom underwent metastasectomy(adrenal×2;lung×2;liver×1).The median overall survival was 10.9 years[95%confidence interval(CI):0.7-21.0 years],which was statistically significantly longer than incomplete clinical responders undergoing surgery on the primary tumour without metastatic intervention[n=62;median overall survival=1.9(95%CI:1.1-2.7;P=0.012].The cumulative proportion surviving 1,3,and 5 years was 100%,91%,and 61%,respectively compared to 71%,36%,and 25%for incomplete clinical responders undergoing surge

关键词： Oesophageal metastases Oligometastases Active surveillance Treatment for cure Metastasectomy Survival

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Late endocarditis of Amplatzer atrial septal occluder device in a child

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World Journal of Cardiology 2015年第10期7卷 703-706页

作者： Neerod K Jha Laszlo Kiraly John SK Murala Csaba Tamas Haitham Talo Hazem El Badaoui Magdi Tofeig Malaika Mendonca Sameer Sajwani mary A thomas Sura Ahmed Al Doory Mohammad D Khan Department of Pediatric Cardiac Surgery Sheikh Khalifa Medical City (managed by Cleveland Clinic) Department of Pediatric Cardiology Sheikh Khalifa Medical City (managed by Cleveland Clinic) Department of Critical Care Sheikh Khalifa Medical City (managed by Cleveland Clinic) Department of Cardiology Latifa Hospital Department of Pathology Sheikh Khalifa Medical City (managed by Cleveland Clinic)

Bacterial endocarditis following atrial septal defect closure using Amplatzer device in a child is extremely rare. We report a 10-year-old girl who developed late bacterial endocarditis, 6 years after placement of an Amplatzer atrial septal occluder device. Successful explantation of the device and repair of the resultant septal defect was carried out using a homograft patch. The rare occurrence of this entity prompted us to highlight the importance of a closed long-term follow up, review the management and explore preventive strategies for similar patients who have multiple co-morbidities and a cardiac device. A high index of suspicion is warranted particularly in pediatric patients.

关键词： Endocarditis Atrial Septal Device

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Promises and pitfalls of targeted agents in chronic lymphocytic leukemia

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Cancer Drug Resistance 2020年第3期3卷 415-444页

作者： thomas E.Lew mary Ann Anderson John F.Seymour Department of Clinical Haematology The Royal Melbourne Hospital and Peter MacCallum Cancer CentreParkville 3050Australia. Blood Cells and Blood Cancer Division Walter and Eliza Hall Institute of Medical ResearchParkville 3050Australia. Faculty of Medicine Dentistry and Health SciencesThe University of MelbourneParkville 3050Australia.

Targeted agents have significantly improved outcomes for patients with chronic lymphocytic leukemia,particularly high-risk subgroups for whom chemoimmunotherapy previously offered limited *** classes of agent in particular,the Bruton tyrosine kinase inhibitors(e.g.,ibrutinib)and the B-cell lymphoma 2 inhibitor,venetoclax,induce high response rates and durable remissions in the relapsed/refractory and frontline ***,maturing clinical data have revealed promises and pitfalls for both *** drugs induce remissions and disease control in the majority of patients,often in situations where modest efficacy would be expected with traditional chemoimmunotherapy ***,in the relapsed and refractory setting,both agents appear to be associated with an inevitable risk of disease relapse and *** patterns of resistance are being described for both agents but a common theme appears to be multiple sub-clonal drivers of disease *** these mechanisms and developing effective and safe methods to circumvent the emergence of resistance will determine the longer-term utility of these agents to improve patients’quality and length of *** drug combinations,optimised scheduling and sequencing of therapy will likely hold the key to achieving these important goals.

关键词： Chronic lymphocytic leukemia drug resistance venetoclax B-cell lymphoma 2 ibrutinib bruton tyrosine kinase idelalisib phosphatidylinositol 3-kinase

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Identification and Characterization of Genes Responsible for Drought Tolerance in Rice Mediated by Pseudomonas fluorescens

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Rice science 2017年第5期24卷 291-298页

作者： Manjesh SAAKRE Thirthikar Meera BABURAO Abida Puthenpeedikal SALIM Rose mary FFANCIES Valasala Poothecty ACHUTHAN George thomas Sajeevan Radha SIVARAJAN Centre for Plant Biotechnology and Molecular Biology/Department of Genetics and Plant Breeding/Department of Agronomy College of Horticulture Kerala Agricultural University Vellanikkara Thrissur 680656 Kerala India

Drought is one of the major abiotic stresses which adversely affect crop plants limiting growth and yield *** and functional characterization of drought stress-induced genes has contributed to a better understanding of how plants respond and adapt to the drought *** the present study,differential display technique was employed to study the gene expression of rice plants at the reproductive stage that were subjected to drought stress by withholding water,Pseudomonas fluorescens strain(Pf1) treated plants subjected for drought stress by withholding water and control(well-watered).Differentially expressed c DNAs of six genes(COX1,PKDP,b ZIP1,AP2-EREBP,Hsp20 and COC1) were identified,cloned and ***-time q PCR analysis showed that all the six genes were upregulated in drought-stressed plants treated with *** revealed that the remarkable influence of Pf1 colonization leads to drought tolerance at the reproductive *** results showed that high levels of gene expression in plants lacking adequate water can be remarkably influenced by Pf1 colonization,which might be a key element for induced systemic tolerance by microbes.

关键词： rice drought tolerance Pseudomonas fluorescens differential display reverse transcription polymerase chain reaction quantitative real-time PCR transcript derived fragment

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System Identification Modeling and Unstable Behavior of the Dynamics of Flows within the Tip Region of an Axial Compressor Blade Passage

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Journal of Thermal Science 2016年第2期25卷 109-116页

作者： STERBENTZ Dane M. PRASAI Sujan HOFLE mary M. WALTERS thomas LIN Feng LI Ji-chao BOSWORTH Ken SCHOEN Marco P. Idaho State University Measurement and Control Engineering Research Center Institute of Engineering Thermophysics Chinese Academy of Sciences

In recent years, the correlation coefficient of pressure data from the same blade passage in an axial compressor unit has been used to characterize the state of flow in the blade passage. In addition, the correlation coefficient has been successfully used as an indicator for active control action using air injection. In this work, the correlation coefficient approach is extended to incorporate system identification algorithms in order to extract a mathematical model of the dynamics of the flows within a blade passage. The dynamics analyzed in this research focus on the flow streams and pressure along the rotor blades as well as on the unsteady tip leakage flow from the rotor tip gaps. The system identification results are used to construct a root locus plot for different flow coefficients, starting far away from stall to near stall conditions. As the compressor moves closer to stall, the poles of the identified models move towards the imaginary axis of the complex plane, indicating an impending instability. System frequency data is captured using the proposed correlation based system identification approach. Additionally, an oscillatory tip leakage flow is observed at a flow coefficient away from stall and how this oscillation changes as the compressor approaches stall is an interesting result of this research. Comparative research is analyzed to determine why the oscillatory flow behavior occurs at a specific sensor location within the tip region of the rotor blade.

关键词：系统识别方法压气机叶片流动力学不稳定通道辨识建模行为轴流

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