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Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database

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Cancer Communications 2019年第1期39卷 548-556页

作者： Gary D.Lewis Yan Xing Waqar Haque Tejal Patel mary schwartz Albert Chen Andrew Farach Sandra S.Hatch E.Brian Butler Jenny Chang Bin S.Teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA

Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast *** studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the ***-rank test was performed to evaluate associations of clinical characteristics with overall survival(OS).Cox proportional hazards model was used to determine variables associated with ***:Overall,2660 patients with IMPC met the selection criteria;the 5-year OS rate was 87.5%and 24.9%of patients had nodal involvement at *** with≥4 positive lymph nodes had shorter OS than node-negative patients,whereas patients with 1-3 positive nodes had similar OS to node-negative ***<65 years,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged *** benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included age<65 years,<4 positive lymph nodes,receipt of radiotherapy,and estrogen receptor *** results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy.

关键词： Breast cancer Invasive micropapillary carcinoma Radiotherapy Surgery Survival Hormone receptor

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Turning teawaste particles into magnetic bio-sorbents particles for arsenic removal from wastewater:Isotherm and kinetic studies

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Particuology 2024年第4期87卷 179-193页

作者： mary McGeogh Hamza Annath Chirangano Mangwandi School of Chemistry and Chemical Engineering Queen's University BelfastDavid Kier BuildingBT95AGUnited Kingdorm Department of Chermnistry Lancaster UniversityBailrigsLancasterLA14YBUnited Kingdom

The primary objective of this research was to assess the potential of magnetic bleached biochar(MBBC)as a cost-effective adsorbent for arsenic *** achieve this,locally collected tea wastes underwent meticulous cleaning,bleaching,and modifications via thermal and chemical *** non-magnetic and magnetic biochar adsorbents were thoroughly characterized using Fourier transform-infrared spectroscopy(FT-IR)and thermo-gravimetric analysis(TGA).Subsequently,the adsorptive performance of MBBC in removing arsenic from wastewater samples was investigated,considering various crucial parameters such as adsorbent-adsorbate contact time,concentration of As,temperature,adsorbent dosage,and the regeneration-ability of the *** experimental data for the adsorption process were best represented by the Langmuir isotherm,indicating its suitability for the MBBC ***,the MBBC demonstrated a maximum Langmuir adsorption capacity of approximately 714 mg/g at room temperature,highlighting its efficiency as an arsenic ***,the Lagergren's Pseudo-second order kinetic model proved to be the most suitable for describing the adsorption kinetics,confirming the chemisorption nature of the *** results also indicated that the adsorption process is endothermic and feasible,suggesting its viability for practical *** all findings into account,the comprehensive analysis strongly supports the potential use of MBBC as a highly promising and cost-effective adsorbent for efficiently removing arsenic from aqueous *** research contributes valuable insights to the field of wastewater treatment and offers a sustainable and environmentally friendly solution for tackling arsenic contamination in water sources.

关键词： Arsenics Wastewater Adsorption Magnetic bio-char Teawaste

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A toast to a zebrafish germ cell induction cocktail

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Science China(Life Sciences) 2024年第6期67卷 1314-1315页

作者： mary C.Mullins Department of Cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGCs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

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Geothermo-mechanical alterations due to heat energy extraction in enhanced geothermal systems: Overview and prospective directions

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Deep Underground Science and Engineering 2024年第3期3卷 256-268页

作者： mary C.Ngoma Oladoyin Kolawole Olufemi Olorode John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkUSA Department of Petroleum Engineering Louisiana State UniversityBaton RougeUSA

Geothermal energy from deep underground (or geological) formations,with or without its combination with carbon capture and storage (CCS),can be a key technology to mitigate anthropogenic greenhouse gas emissions and meet the 2050 net‐zero carbon emission *** resources in low‐permeability and medium‐and high‐temperature reservoirs in sedimentary sequence require hydraulic stimulation for enhanced geothermal systems (EGS).However,fluid migration for geothermal energy in EGS or with potential CO_(2) storage in a CO_(2)‐EGS are both dependent on the in situ flow pathway network created by induced fluid *** thermo‐mechanical interactions can be complex and induce varying alterations in the mechanical response when the working fluid is water (in EGS) or supercritical CO_(2)(in CO_(2)‐EGS),which could impact the geothermal energy recovery from geological ***,there is a need for a deeper understanding of the heat extraction process in EGS and CO_(2)‐*** study presents a systematic review of the effects of changes in mechanical properties and behavior of deep underground rocks on the induced flow pathway and heat recovery in EGS reservoirs with or without CO_(2) storage in CO_(2) ‐***,we proposed waterless‐stimulated EGS as an alternative approach to improve heat energy extraction in ***,based on the results of our literature review and proposed ideas,we recommend promising areas of investigation that may provide more insights into understanding geothermo‐mechanics to further stimulate new research studies and accelerate the development of geothermal energy as a viable clean energy technology.

关键词： CO_(2)-EGS enhanced geothermal systems geomechanics geothermal energy underground thermal energy

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Adenoid cystic carcinoma of breast: Recent advances

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World Journal of Clinical Cases 2014年第12期2卷 732-741页

作者： Kosuke Miyai mary R schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro Department of Pathology and Genomic Medicine Houston Methodist Hospital Weill Medical College of Cornell UniversityHouston TX 77030 United States Department of Basic Pathology National Defense Medical College Saitama 359-0042 Japan Department of Pathology Hanyang University Guri Hospital 153 Gyeongchun-ro Guri Gyeonggi-do 471-701 South Korea

Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.

关键词： Adenoid cystic carcinoma Breast Triplenegative and basal-like phenotype Histology Molecular genetic features

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Directives and references in selected coronavirus-motivated internet memes

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Language and Semiotic Studies 2024年第2期10卷 245-266页

作者： Ayo Osisanwo Toluwalope mary Falade Department of English University of IbadanIbadanNigeria Institute of English Studies Leuphana UniversitätLüneburgGermany Department of English and General Studies Ladoke Akintola UniversityOgbomosoNigeria

The use of directives in communicating the nature of the pandemic and reference to social experiences were promoted using images on social media *** images or memes are used to create awareness and reinforce the criteria for safety during the *** studies on internet memes have concentrated on humor generation,speaker-hearer shared knowledge,neologism,and multimodality among others,with insufficient attention paid to the use of directives and references in such coronavirus-motivated *** paper,therefore,examines how directives and references are employed in conveying expected social responsibilities through coronavirus-motivated internet memes in Nigeria and other socio-cultural *** data,one hundred coronavirus-motivated memes were purposively selected from Facebook,and eight representative memes were subjected to pragmatic analysis using aspects of Jacob Mey’s(***:An introduction,2nd ***:Blackwell Publishing)pragmatic acts theory to unearth insights from *** paper observes that the various spheres of life that are relatable to an online audience help to express what the pandemic is about and enhance the meaning of the pandemic with the context of the use of the memes,giving clearer perspectives on the *** and references are useful tools for conveying social responsibilities to online audience.

关键词： directives references coronavirus internet memes social responsibilities

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Assessment of nano-to-micro-scale geomechanical properties and their time-dependent behavior: Current status and progressive perspectives

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2024年第1期3卷 1-15页

作者： mary C.Ngoma Oladoyin Kolawole John A.Reif Jr.Department of Civil and Environmental EngineeringNew Jersey Institute of TechnologyNewarkNJ07102USA

Rocks can deform at varying scales(nano-,micro-and macro-scale)under different temperatures,pressures,stresses,and time ***-core scale(nano-to micro-scale)changes in rock properties can influence local(fine-scale)and bulk scale(macro-scale)rock ***,there is a lack of comprehensive knowledge on how rock deformation at sub-core scale(i.e.,nano-to micro-scale)is assessed and its potential to accurately predicte and estimate the macro-scale mechanical behavior of *** study presents a comprehensive and forward-leaning review of the assessment of nano-scale and micro-scale rock mechanical parameters,their timedependent behavior,and potential applications in rock ***,we highlighted the key findings based on experimental and numerical methods for evaluating rock mechanical parameters,and presented the limitations of these ***,we discussed the reliability of sub-core scale mechanical assessments in predicting macromechanical(larger-scale)properties and the behavior of rocks in ***,we offer recommendations to advance investigations focused on rock mechanical assessments at these smaller scales and provide a more accurate characterization at the sub-core scale.

关键词： Rock mechanics Rock deformation Nanomechanics Rock creep Rock engineering

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采用美国国家癌症数据库数据分析淋巴浸润性微乳头状乳腺癌的预后

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癌症 2020年第2期39卷 77-86页

作者： Gary DLewis Yan Xing Waqar Haque Tejal Patel mary schwartz Albert Chen Andrew Farach Sandra SHatch EBrian Butler Jenny Chang Bin S.Teh Department of Radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Houston Methodist HospitalHoustonTX 77030USA Department of Pathology and Genomic Medicine Houston Methodist HospitalHoustonTX 77030USA Department of Radiation Oncology Baylor College of MedicineHoustonTX 77030USA Department of Radiation Oncology The University of Texas Medical BranchGalvestonTX 77555USA.

背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(Nat... 详细信息

背景与目的浸润性微乳头状癌(invasive micropapillary carcinoma,IMPC)是乳腺癌中一种罕见的亚型。已有研究表明,与浸润性导管癌(invasive ductal carcinoma,IDC)相比,该亚型更易发生淋巴结转移。本研究旨在明确美国国家癌症数据库(National Cancer Database,NCDB)中记录的乳腺IMPC患者的临床特征、结局和淋巴结转移倾向性。方法从NCDB中检索2004–2014年之间诊断为IMPC患者的病历,并对其进行log-rank检验以评估临床特征与总生存期(overall survival,OS)的相关性。采用Cox比例风险模型确定OS相关因素。结果本研究共纳入2660例IMPC患者。5年OS率为87.5%,24.9%患者出现淋巴结转移。阳性淋巴结数≥4的患者的OS短于阴性淋巴结的患者,而阳性淋巴结数为1–3的患者的OS与阴性淋巴结患者相似。年龄<65岁、接受放疗和雌激素受体阳性也与OS延长有关。放疗仅对接受肿块切除术的IMPC患者有效,对进行乳房切除术的患者无效(无论淋巴结阳性/阴性)。结论IMPC患者的有利预后因素包括年龄<65岁、阳性淋巴结数<4、接受放疗和雌激素受体阳性。本研究结果表明,IMPC患者的生存获益与放疗相关,但可能仅限于经肿块切除术治疗的患者。

关键词：乳腺癌浸润性微乳头状癌放疗手术生存激素受体

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DeepRice: A deep learning and deep feature based classification of Rice leaf disease subtypes

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Artificial Intelligence in Agriculture 2024年第1期11卷 34-49页

作者： P.Isaac Ritharson Kumudha Raimond X.Anitha mary Jennifer Eunice Robert Andrew J Department of CSE Karunya Institute of Technology and Sciences CoimbatoreTamilnaduIndia Department of Robotics Engineering Karunya Institute of Technology and SciencesCoimbatoreIndia Department of Mechatronics Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India Department of Computer Science and Engineering Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India

Rice stands as a crucial staple food globally,with its enduring sustainability hinging on the prompt detection of rice leaf ***,efficiently detecting diseases when they have already occurred holds paramount importance for solving the cost of manual visual identification and chemical *** the recent past,the identification of leaf pathologies in crops predominantly relies on manual methods using specialized equipment,which proves to be time-consuming and *** study offers a remedy by harnessing Deep Learning(DL)and transfer learning techniques to accurately identify and classify rice leaf diseases.A comprehensive dataset comprising 5932 self-generated images of rice leaves was assembled along with the benchmark datasets,categorized into 9 classes irrespective of the extent of disease spread across the *** classes encompass diverse states including healthy leaves,mild and severe blight,mild and severe tungro,mild and severe blast,as well as mild and severe brown *** meticulous manual labelling and dataset segmentation,which was validated by horticulture experts,data augmentation strategies were implemented to amplify the number of *** datasets were subjected to evaluation using the proposed tailored Convolutional Neural Networks *** performance are scrutinized in conjunction with alternative transfer learning approaches like VGG16,Xception,ResNet50,DenseNet121,Inception ResnetV2,and Inception *** effectiveness of the proposed custom VGG16 model was gauged by its capacity to generalize to unseen images,yielding an exceptional accuracy of 99.94%,surpassing the benchmarks set by existing state-of-the-art ***,the layer wise feature extraction is also visualized as the interpretable AI.

关键词： Rice leaf disease Deep learning CNN Crop yield Agriculture Food security

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Nobel Prize Winner Alice Munro One of the best writers you may not know about

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空中英语教室（高级版．彭蒙惠英语） 2024年第11期 28-29,46,47页

作者： mary Rourke 不详

Alice Munro,the Canadian,writer considered by many to be the finest short-fiction writer of her generation,died[earlier this year].She was *** was awarded the Nobel Prize in literature in 2013,only months after publishing a collection of stories that she said would be her *** had already received the Man Booker International Prize,the National Book Critics Circle Award in the United States and every top literary prize offered in her native Canada,including its most prestigious,the Governor General's Award.

关键词： Nobel Canada writer

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