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Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study

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World Journal of Gastroenterology 2016年第16期22卷 4191-4200页

作者： I jane cox Abil E Aliev mary ME crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson Institute of Hepatology London Foundation for Liver Research Department of chemistry University College London Division of Digestive Diseases Department of Surgery and Cancer Imperial College London Department of Hepatology Bangabandhu Sheikh Mujib Medical University Department of Medical Sciences Toshiba General Hospital

AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma (Hcc) patients compared to cirrhosis patients and ***: Urine samples from 42 Bangladeshi patients with Hcc (39 patients with hepatitis-B Hcc), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance (NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis (PcA) and orthogonal partial least squared discriminant analysis (OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PcA and OPLS-DA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance (ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the Mann-Whitney U test was used to compare metabolite levels depending on hepatitis B e-antigen (HBeAg) status and treatment with anti-viral therapy. A Benjamini-Hochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < ***: There were significant differences in age (P < 0.001), weight (P < 0.001), and body mass index (P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase (ALT) was significantly higher in the Hcc group compared to controls (P < 0.001); serum α-fetoprotein was generally markedly elevated in Hcc compared to controls; and serum creatinine levels were significantly reduced in the Hcc group compared to the cirrhosis group (P = 0.004). A three-factor PcA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgr

关键词： Urinary metabolic profiling Hepatocellular carcinoma Nuclear magnetic resonance spectroscopy Hepatitis B Bangladesh

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Algebra II :

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2010年

作者： by mary jane Sterling.

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清华英语自然拼读故事屋A1

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2013年

作者： Anne Miranda mary jane Martin

《清华英语自然拼读故事屋》是儿童英语教育专家Anne Miranda及Marry jane Martin根据4—12岁孩子的语言水平与特点，为他们量身定做的英语自然拼读读物。根据不同年龄段孩子们需要掌握的英语语音、词汇、句型与阅读技巧，分为A1、A2、B... 详细信息

ISBN: (纸本)9787302319269

《清华英语自然拼读故事屋》是儿童英语教育专家Anne Miranda及Marry jane Martin根据4—12岁孩子的语言水平与特点，为他们量身定做的英语自然拼读读物。根据不同年龄段孩子们需要掌握的英语语音、词汇、句型与阅读技巧，分为A1、A2、B1、B2、c1、c2六个级别，每个级别6套书，每套书（2本故事书+1本活动手册+1张多媒体互动光盘）包含一个主题，孩子可以通过读故事、分享故事、游戏、歌曲、手指游戏、贴画、表演等活动，同时学习听说读写4种语言技能。　　配套的多媒体互动光盘包含热身活动、故事、歌曲、语音、单词闪卡、语音等7个菜单项，动画栩栩如生、充满活力，活动和游戏的设计形式多样，充满创造力、奇思妙想和趣味性，深深吸引孩子的兴趣，让孩子在玩中学，在做中学。

关键词：英语课

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全球重要农业文化遗产——中国浙江青田稻鱼共生系统项目实施框架

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资源科学 2009年第1期31卷 10-20页

作者：闵庆文孙业红 Frank van Schoubroeck 梁洛辉 mary jane Dela cruz 中国科学院地理科学与资源研究所北京100101 中国科学院研究生院北京100049 Wageningen International 6700 AB WageningenThe Netherlands Environment and Sustainable Development Programme United Nations University53-70 Jingumae Shibuya-kuTokyo 150-8925Japan Land and Water Division Natural Resources and Environment Management DepartmentFAORomeItaly

水稻是世界上最主要的农作物之一。长期以来,亚洲许多地方一直有在稻田中养鱼(并作或连作)的传统。据历史记录和考古研究成果,中国稻田养鱼的历史可以追溯到2000多年以前。稻鱼共生系统不仅是一种独特的生产方式,而且还是一种具有丰富... 详细信息

水稻是世界上最主要的农作物之一。长期以来,亚洲许多地方一直有在稻田中养鱼(并作或连作)的传统。据历史记录和考古研究成果,中国稻田养鱼的历史可以追溯到2000多年以前。稻鱼共生系统不仅是一种独特的生产方式,而且还是一种具有丰富内涵的传统文化。稻鱼共生系统可以提供多种产品和服务功能:保障粮食安全,提高营养水平,增加农民收入,防止疟疾传染,生物多样性保护,病虫害控制,促进授粉过程,促进碳氮循环,水土保持,以及文化传承和休憩等。但是,正像其他许多传统农业技术一样,由于受到快速经济增长、城市化和现代农业技术的影响,稻鱼共生系统也面临着严峻威胁。中国是联合国首批农业文化遗产保护试点国家之一,浙江省青田县龙现村的传统稻鱼共生系统被列为首批试点之一,其目的就是开发出一种农业文化遗产"动态保护和适应性管理"的方法论并进行推广。本文是按照粮农组织要求所编制的项目实施的国家框架,在全面分析中国,特别是青田稻鱼共生系统发展历史和基本特征的基础上,确定了项目实施的总体目标和具体目标。根据项目的总体要求和稻鱼共生系统在我国的发展前景,预期的主要成果包括:建立国家农业文化遗产认定标准体系,确定国家农业文化遗产名录,并作为推荐为全球重要农业文化遗产的基础;促进将全球重要农业文化遗产中具有重要意义的农业生物多样性的保护和适应性管理纳入国家有关部门的保护和发展规划与政策中;通过对社区广泛参与,促进试点地方的具有全球意义的农业生物多样性得到可持续的利用与保护,并通过采取适当的技术和政策手段促进传统农业系统生态过程与文化过程的发展;将试点所得到的经验向更大范围进行推广,建立国家农业文化遗产保护网络,促进全球农业文化遗产网络的建立。此外,还介绍了为达到这些目标所应采取的措施和开展的具体活动,提出了促进机制建设、资金支持、社会发展、生态保护的可持续性途径,给出了促进项目实施的具体执行框架和各利益相关方的责任与义务。

关键词：稻鱼共生系统全球重要农业文化遗产传统生态农业浙江省青田县龙现村

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Management information systems : managing the digital firm / 9th ed. 9th ed.

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2006年

作者： Kenneth c. Laudon jane P. Laudon.

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comparing posture induced intraocular pressure variations in normal subjects and glaucoma patients

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 399-404页

作者： Onyekachi jane Ireka chimdia E Ogbonnaya Obinna c Arinze Nneka Ogbu chimdi M chuka-Okosa Department of Ophthalmology Alex Ekwueme Federal University Teaching HospitalAbakalikiEbonyi State 48028Nigeria Department of Ophthalmology University of Nigeria Teaching HospitalItuku OzallaEnugu 01129Nigeria

AIM:To compare the posture-induced variations in intraocular pressure(IOP)between the primary open angle glaucoma(POAG)and non-glaucomatous ***:A case-controlled age matched study was conducted in 55 successive newly diagnosed POAG and 56 non-glaucomatous patients seen in glaucoma clinic and general outpatient eye clinic in the Alex Ekwueme University Teaching Hospital,*** IOPs of eligible correspondents were measured with Perkin’s hand-held tonometer in the sitting,supine flat and supine with pillow positions *** of IOP in each position was done after 15 min of assuming such ***:The IOP difference between the sitting and supine flat position was significantly higher in the POAG than non-glaucoma subjects(7.68±2.08 vs 4.03±0.13 mm Hg,Pce between the sitting and supine with pillow positions was 2.61±1.49 mm Hg for POAG and 1.44±0.70 mm Hg in non-glaucoma(Pce between supine flat and supine with pillow positions was 5.07±2.24 mm Hg in POAG and 2.59±0.66 mm Hg in non-glaucomatous patients(PcONcLUSION:Greater variations in posture induced IOP occurred in POAG patients than *** posture induced IOP variation is lowest in the sitting position and highest in the supine flat *** of posture induced IOP changes may be an important tool in the management of glaucoma.

关键词： primary open angle glaucoma non-glaucoma intraocular pressure sitting position supine position

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Algebra I :

Algebra I :

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2010年

作者： mary jane Sterling.

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Rangeland hillslope lengths:A case study at the Walnut Gulch Experimental Watershed,southeastern Arizona

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International Soil and Water conservation Research 2022年第4期10卷 597-609页

作者： Li Li Mark A.Nearing Philip Heilman mary H.Nichols D.P.Guertin c.J.Williams School of Natural Resources and the Environment University of ArizonaTucsonAZ85705USA USDA-Agricultural Research Service Southwest Watershed Research CenterTucsonAZ85719USA

Rangeland hillslopes provide much of the sediment supplied to channel systems and their lengths exert a fundamental constraint on hillslope diffusive ***,information regarding lengths of rangeland hillslopes,and how best to estimate them,is *** this study,three groups of watersheds(10 in total)were selected from the Walnut Gulch Experimental Watershed according to their geology,soil and vegetation *** 1 watersheds were at lower elevations dominated by shrubs,Group 3 were at high elevations dominated by grass,and Group 2 were mixed shrub and *** hillslope lengths were calculated from 1 m-resolution DEMs using three methods:a flow routing algorithm,slope-area relationships,and inverted relationship with drainage *** that characterize the current watersheds,including Hack's exponent and coefficient,watershed shape coefficient,channel concavity and steepness,and surface roughness,were quantified and related to hillslope *** shows:(1)estimated hillslope lengths were different for the three methods and between the three groups of watersheds;(2)hillslope lengths that measured from the flow routing algorithm for the ten selected watersheds primarily ranged from 30 to 100 m,with a median value of 63.0 m,which was 20%e50%greater than those derived from slope-area plots or drainage densities;(3)hillslope lengths estimated from the flow routing method were greater in Group 3 watersheds than in Group 2 and then in Group 1 *** attributed these differences in hillslope lengths to the historic epeirogenic pulses,watershed and drainage network morphology,and differences in vegetation characteristics;(4)measured hillslope lengths from the flow routing algorithm were best correlated with hillslope relief,then surface roughness,channel steepness and *** results would benefit the applications of hydrological and erosion models in rangelands.

关键词： Rangeland hillslope Slope length Drainage density Slope-area relationship Hillslope hydrology

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Potato aphid Macrosiphum euphorbiae performance is determined by aphid genotype and not mycorrhizal fungi or water availability

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Insect Science 2017年第6期24卷 1015-1024页

作者： Alison jane Karley Matthew Emslie-Smith Alison Elizabeth Bennett Ecological Sciences The James Hutton Institute Invergowrie Dundee UK School of Biology University of St. Andrews St Andrews UK

Intra- and interspecific variation in plant and insect traits can alter the strength and direction of insect-plant interactions, with outcomes modified by soil biotic and abiotic conditions. We used the potato aphid （Macrosiphum euphorbiae Thomas） feeding on cultivated Solanum tuberosum and wild Solanurn berthaulti to study the impact of water availability and plant mutualistic arbuscular mycorrhizal （AM） fungi on aphid performance and susceptibility to a parasitoid wasp （Aphidius ervi Haliday）. Plants were grown under glass with live or sterile AM fungal spores and supplied with sufficient or reduced water supply. Plants were infested with 1 of 3 genotypes ofM. euphorbiae or maintained as aphidfree controls; aphid abundance was scored after 1 week, after which aphid susceptibility to A. ervi was assayed explanta. Solarium tuberosum accumulated c. 20% more dry mass than S. berthaultii, and root mass of S. berthaultii was smallest under reduced water supply in the presence of AM fungi. Aphid abundance was lowest on S. berthaultii and highest for genotype ＂2＂ aphids; genotype ＂1＂ aphid density was particularly reduced on S. berthaultii. Aphid genotype ＂1＂ exhibited low susceptibility to parasitism and was attacked less frequently than the other two more susceptible aphid genotypes. Neither AM fungi nor water availability affected insect performance. Our study suggests a fitness trade-offin M. euphorbiae between parasitism resistance and aphid performance on poor quality Solarium hosts that warrants further exploration, and indicates the importance of accounting for genotype identity in determining the outcome of multitrophic interactions.

关键词： Aphidius ervi arbuscular mycorrhizal fungi multitrophic interaction parasitism resistance Solanum spp.

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characterization of Fusobacterium nucleatum ATcc 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis

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International Journal of Oral Science 2016年第3期8卷 138-144页

作者： jane Park Bhumika Shokeen Susan K Haake Renate Lux School of Dentistry University of California at Los Angeles Los Angeles USA

Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral biofilm architecture by acting as a bridge between early Gram-positive and late Gram-negative colonizers that do not otherwise adhere to each other. In this study, we survey a key adherence interaction of F. nucleatum with Porphyromonas gingivalis, and present evidence that multiple fusobacterial adhesins have a role in the attachment of F. nucleatum ATcc 23726 to P. gingivalis in a highly strain-dependent manner. Interaction between these species displayed varying sensitivities to arginine, galactose and lactose. Arginine was found to hamper coaggregation by at least 62% and up to 89% with several P. gingivalis strains and galactose inhibition ranged from no inhibition up to 58% with the same P. gingivalis strains. Lactose consistently inhibited F. nucleatum interaction with these P. gingivalis strains ranging from 40% to 56% decrease in coaggregation. Among the adhesins involved are the previously described Fap2 and surprisingly, RadD, which was described in an earlier study for its function in attachment of F. nucleatum to Gram-positive species. We also provide evidence for the presence of at least one additional adhesin that is sensitive to arginine but unlike Fap2 and RadD, is not a member of the autotransporter family type of fusobacterial large outer membrane proteins. The strain-specific binding profile of multiple fusobacterial adhesins to P. gingivalis highlights the heterogeneity and complexity of interspecies interactions in the oral cavity.

关键词： adhesin bio?lm coaggregation Fusobacterium nucleatum Porphyromonas gingivalis

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