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Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning

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World journal of Gastroenterology 2020年第40期26卷 6207-6223页

作者： Hyun-jong jang Ahwon Lee j Kang In Hye Song Sung Hak Lee Department of Physiology Department of Biomedicine and Health SciencesCatholic Neuroscience InstituteThe Catholic University of KoreaSeoul 06591South Korea Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND Identifying genetic mutations in cancer patients have been increasingly important because distinctive mutational patterns can be very informative to determine the optimal therapeutic strategy. Recent studies have shown that deep learning-based molecular cancer subtyping can be performed directly from the standard hematoxylin and eosin(H&E) sections in diverse tumors including colorectal cancers(CRCs). Since H&E-stained tissue slides are ubiquitously available, mutation prediction with the pathology images from cancers can be a time-and cost-effective complementary method for personalized *** To predict the frequently occurring actionable mutations from the H&E-stained CRC whole-slide images(WSIs) with deep learning-based *** A total of 629 CRC patients from The Cancer Genome Atlas(TCGA-COAD and TCGA-READ) and 142 CRC patients from Seoul St. mary Hospital(SMH) were included. Based on the mutation frequency in TCGA and SMH datasets, we chose APC, KRAS, PIK3CA, SMAD4, and TP53 genes for the study. The classifiers were trained with 360 × 360 pixel patches of tissue images. The receiver operating characteristic(ROC) curves and area under the curves(AUCs) for all the classifiers were *** The AUCs for ROC curves ranged from 0.693 to 0.809 for the TCGA frozen WSIs and from 0.645 to 0.783 for the TCGA formalin-fixed paraffin-embedded *** prediction performance can be enhanced with the expansion of datasets. When the classifiers were trained with both TCGA and SMH data, the prediction performance was *** APC, KRAS, PIK3CA, SMAD4, and TP53 mutations can be predicted from H&E pathology images using deep learning-based classifiers, demonstrating the potential for deep learning-based mutation prediction in the CRC tissue slides.

关键词： Colorectal cancer Mutation Deep learning Computational pathology Computer-aided diagnosis Digital pathology

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Chinese Secret Societies and Popular Religions Revisited： An Introduction

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Frontiers of History in China 2016年第4期11卷 503-509页

作者： Robert j. Antony joseph Tse-Hei Lee Canton's Thirteen Hongs Research Center Guangzhou University Guangzhou 510006 China Department of History and Confucius Institute Pace University New York NY 10038 USA

It has been over forty years since jean Chesneaux published his edited volume Popular Movements and Secret Societies in China, and some twenty years since David Ownby and mary Somers Heidhues published their edited volume Secret Societies Reconsidered On popular religions, both Daniel Overmyer＇s FoItc Buddhist Religion and Susan Naquin＇s Millenarian Rebellion in China were also published almost forty years ago.1 Although there have been a number of important studies published both inside and outside of China on secret societies and popular religions since the 1990s, in recent years there has been a surge in new research, much of it still unpublished, on this important subject in Chinese history.

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不同年龄和部位女性皮肤微循环变化

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中国微循环 2004年第1期8卷 43-46,F002页

作者：李利 S.MAC mary j.M.St HILLIER A.DEGOUY T.GHARBI O.de LACHARRIERE Ph.HUMBERT 四川大学华西医院皮肤性病科四川成都610041 倍桑松孔泰大学医学和药学院工程和皮肤生物实验室倍桑松孔泰大学医学和药学院光学实验室欧莱雅临床研究部

目的观察不同部位皮肤血管结构和形态差异,研究年龄对真皮微循环功能的影响。方法采用活体电视毛细血管镜 (IntravitalVideo-capillaroscopy)和激光多谱勒血流仪(laserDopplerflowmetry)对50名年龄在20～74岁 ,光皮肤类型为II～III型白... 详细信息

目的观察不同部位皮肤血管结构和形态差异,研究年龄对真皮微循环功能的影响。方法采用活体电视毛细血管镜 (IntravitalVideo-capillaroscopy)和激光多谱勒血流仪(laserDopplerflowmetry)对50名年龄在20～74岁 ,光皮肤类型为II～III型白人女性志愿者的前额、眼角、前臂内侧和手背血管作初步观察。并用计算机图象处理技术 ,对前臂和手背活体真皮血管密度作定量分析。结果真皮乳头毛细血管襻在活体电视毛细血管镜下为点状或逗点状 ;乳头下的血管丛表现为线条状或网状 ;年轻人皮肤血管排列整齐 ,年龄较大者血管扩张增粗、扭曲 ,排列不规则。年龄与襻状血管数、襻状血管面积显著负相关 ;与襻状血管间距、平行血管总长正相关 ;真皮血流量面部高于肢端 ;随年龄的增加真皮血流有逐渐增加趋势。结论年龄影响真皮微循环的形态和功能。两种无创性检测技术联合应用能动态研究活体真皮血管的形态和结构 ,在皮肤血管性疾病的诊断和治疗方面有较高的应用前景。

关键词：皮肤微循环电视毛细血管镜激光多谱勒血流仪

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Rainfall Variability under Present and Future Climate Scenarios Using the Rossby Center Bias-Corrected Regional Climate Model

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American journal of Climate Change（美国气候变化期刊） 2020年第3期

作者： jane Wangui Mugo Franklin j. Opijah joshua Ngaina Faith Karanja mary Mburu

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Environmental variation shifts the relationship between trees and scatterhoarders along the continuum from mutualism to antagonism

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Integrative Zoology 2018年第3期13卷 319-330页

作者： Gina M.SAWAYA Adam S.GOLDBERG Michael A.STEELE Harmony j.DALGLEISH Department of Biology College of William and MaryWilliamsburgVirginiaUSA Department of Biology Wilkes UniversityWilkes-BarrePennsylvaniaUSA

The conditional mutualism between scatterhoarders and trees varies on a continuum from mutualism to antagonism and can change across time and space,and among *** examined 4 tree species(red oak[Quercus rubra],white oak[Quercus alba],American chestnut[Castanea dentata]and hybrid chestnut[***×Castanea] mollissima)across 5 sites and 3 years to quantify the variability in this conditional *** used a published model to compare the rates of seed emergence with and without burial to the probability that seeds will be cached and left uneaten by scatterhoarders to quantify variation in the conditional mutualism that can be explained by environmental variation among sites,years,species,and seed provenance within *** species tested had increased emergence when ***,comparing benefits of burial to the probability of caching by scatterhoarders indicated a mutualism in red oak,while white oak was nearly always *** was variable around the boundary between mutualism and antagonism,indicating a high degree of context dependence in the relationship with *** found that different seed provenances did not vary in their potential for *** did not explain microsite differences in seed emergence in any of the species *** hybrid chestnut only,emergence on the surface declined with soil moisture in the *** quantifying the variation in the conditional mutualism that was not caused by changes in scatterhoarder behavior,we show that environmental conditions and seed traits are an important and underappreciated component of the variation in the relationship between trees and scatterhoarders.

关键词： Castanea dentata conditional mutualism Quercus alba Quercus rubra temperate forest

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Distribution characteristics of inertial sediment particles in the turbulent boundary layer of an open channel flow determined using Voronoi analysis

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International journal of Sediment Research 2017年第3期32卷 401-409页

作者： Xin Liu Chunning ji Xiaoli Xu Dong Xu john j.R.Williams State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University Tianjin Research Institute for Water Transport Engineering M.O.T. State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University School of Engineering and Materials Science Queen Mary University of London

This paper presents the numerical investigation of the distribution of inertial sediment particles in the turbulent boundary layer of an open channel flow with the particle Stokes number ranging from 0.6 to 20.4. The methodology is a combination of three numerical approaches, i.e. direct numerical simulation of turbulent flow, the point-particle immersed boundary method, and the discrete particle method. By applying the Vorono analysis, the preferential concentration characteristics of sediment particles were investigated quantitatively. It was found that the normalized area of the Voronoi cells follows a lognormal particle distribution. The inertial sediment particles distributed unevenly in the turbulent boundary layer and the unevenness, governed by the particle Stokes number, was more significant as the particle Stokes number approaches unity. The inertial sediment particles in the turbulent boundary layer accumulated preferentially in streamwise-aligned streaky structures and this pattern was less significant with increasing particle Stokes number.

关键词： Inertial sediment particles Turbulent boundary layers Voronoi analysis Direct numerical simulation

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Becoming mary Sully

Becoming Mary Sully

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作者： Philip j. Deloria.

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Low-cost Free-standing ferroelectric polymer films with high polarization produced via pressing-and-folding

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journal of Materiomics 2022年第3期8卷 640-648页

作者： Nan Meng Xintong Ren jiyue Wu Emiliano Bilotti Michael j.Reece Haixue Yan State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondonE14NSUK Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200433China

Ferroelectric polymer poly(vinylidene fluoride)(PVDF)shows excellent electro-activity and is promising for flexible electronic ***,the processing of PVDF into the favourable ferroelectric structure(β-phase)presents difficulties,while its copolymer with trifluoroethylene(PVDF-TrFE)can directly crystallize into β-phase,but shows limited thermal stability and high-cost *** a result,an easily implementable method,pressing-and-folding(P&F),was used to produce highly compatible blended films of PVDF and PVDF-TrFE without using any hazardous solvent or complex polymer processing ***-pressed PVDF(molecular weight:530 kg/mol)and PVDF-TrFE(molar ratio:51/49)films were firstly stacked before undergoing P&F *** to extrusion-blended films before and after P&F,the P&F stacked films showed isotropic crystalline structure of b-phase,as confirmed using X-ray diffraction and infrared *** ferroelectric remnant polarization of the P&F stacked films is 0.068 C/m^(2),surpassing pure PVDF-TrFE(0.062 C/m^(2))and the simulated value of remnant polarization of pure PVDF(~0.065 C/m^(2)).The above findings promise to provide inspirations for new processing strategy on PVDF-based functional polymers.

关键词： Polymer blends PVDF PVDF-TrFE Ferroelectric Polarization

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Versatile domain mapping of scanning electron nanobeam diffraction datasets utilising variational autoencoders

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npj Computational Materials 2023年第1期9卷 2213-2230页

作者： A.Bridger W.I.F.David T.j.Wood M.Danaie K.T.Butler Inorganic Chemistry Laboratory University of OxfordOxford OX13QRUK ISIS Neutron and Muon Spallation Source STFC Rutherford Appleton LaboratoryOxfordshire OX110QXUK Electron Physical Science Imaging Centre Diamond Light Source Ltd.DidcotUK School of Engineering and Materials Science Queen Mary University of LondonMile End RoadLondon E14NSUK

Characterisation of structure across the nanometre scale is key to bridging the gap between the local atomic environment and macro-scale and can be achieved by means of scanning electron nanobeam diffraction(SEND).As a technique,SEND allows for a broad range of samples,due to being relatively tolerant of specimen thickness with low electron ***,coupled with the capacity for automation of data collection over wide areas,allows for statistically representative probing of the *** paper outlines a versatile,data-driven approach for producing domain maps,and a statistical approach for assessing their *** workflow utilises a Variational AutoEncoder to identify the sources of variance in the diffraction signal,and this,in combination with clustering techniques,is used to produce domain *** approach is agnostic to domain crystallinity,requires no prior knowledge of crystal structure,and does not require simulation of a library of expected diffraction patterns.

关键词： mapping beam dosage

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关于手术中知晓的危险因素、发生原因及后遗症的文献综述

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麻醉与镇痛 2011年第4期7卷 94-102页

作者： Mohamed M. Ghoneim, MD Robert I. Block, PhD mary Haffarnan, CRNA Maya j. Mathews, CRNA 刘梦琳(译) 王祥瑞(校) Department of Anesthesia University of Iowa Iowa City Iowa 不详

背景手术中知晓是一种不常见的临床现象，仅通过一项研究的病例数量不足以证明和评估其危险因素、发生原西及后遗症。对已发表在科学期刊上的大量病例报告进行综合分析可有效表明术中知晓的状况。方法通过检索国家图书馆医学PubMed数据... 详细信息

背景手术中知晓是一种不常见的临床现象，仅通过一项研究的病例数量不足以证明和评估其危险因素、发生原西及后遗症。对已发表在科学期刊上的大量病例报告进行综合分析可有效表明术中知晓的状况。方法通过检索国家图书馆医学PubMed数据库，检索词为“知晓”和“麻醉”，检索起止时间为1950年至2005年8月，同时手工检索了上述报告及其他与知晓相关的参考文献。为进行比较，本文设置了2个外科对照组：Sebel等研究中的无知晓患者和1996年国家门诊外科调查中接受全身麻醉的患者，同时采用了全国卫生统计中心的数据对体重和体重指数进行比较。结果271例出现手术中知晓的患者与19504例无知晓患者进行比较，发现知晓患者中大多为女性（P〈0．05）、青年（P〈0．001），手术种类为心脏或产科手术（P〈0．0001）。麻醉恢复室中报告的知晓发生仅占总数的35％。知晓患者使用的麻醉药剂量较小（P〈0．0001），手术中常出现发作性心跳加速及血压升高（P〈0．0001），手术后主诉知晓（52％，P〈0．0001）、睡眠障碍、对未来麻醉的恐惧感及手术中制动、无助及虚弱感、听到噪音和语音等有关（P〈0．041—0．0003）。22％的患者出现迟发型精神症状。结论本综述提示，麻醉过浅和既往知晓史是发生手术中知晓的危险因素，氧化亚氮或肥胖都不会增加其发生率。其中麻醉过浅是最常见的原因。某些预防性操作或许可以减少其发生。

关键词：术中知晓危险因素文献综述后遗症全身麻醉病例数量 PubMed 体重指数

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