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Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 342-346页

作者： Elton Lik Tong Tay Vernon Khet Yau Yong Boon Ang Lim Stelson Sia elizabeth Poh Ying Wong leonard Wei Leon Yip Department of Ophthalmology Tan Tock Seng Hospital Republic of Singapore Air Force Aeromedical Centre Cardinal Santos Medical Center

AIM: To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography(AS-OCT), as well as gonioscopy and spectral domain OCT(SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT ***: Seventeen consecutive subjects(33 eyes)were recruited from the study hospital’s Glaucoma *** was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other’s analyses of OCT ***: Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively(P <0.01). The agreement for angle closure between AS-OCT and gonioscopy was fair at k =0.31(95% confidence interval, CI: 0.03-0.59) and k =0.35(95%CI: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k =0.21(95% CI: 0.07-0.49) and slight at k =0.17(95% CI: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51(95% CI: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18(95% CI: 0.08-0.45).CONCLUSION: Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. Identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively.

关键词： anterior segment imaging spectral domain imaging angle closure assessment

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PET/MRI改善癌症患儿管理

中华核医学与分子影像杂志 2024年第2期44卷 124-128页

作者： Lucia Baratto K.elizabeth Hawk Lisa States Jing Qi Sergios Gatidis Louise Kiru Heike E.Daldrup-Link 陈素芸(译) 王辉(审校) Department of Radiology Stanford UniversityStanfordCalifornia Department of Radiology Children′s Hospital of PhiladelphiaPhiladelphiaPennsylvania Department of Radiology Children′s WisconsinMilwaukeeWisconsin Department of Diagnostic and Interventional Radiology University Hospital TübingenTübingenGermany Department of Pediatrics Stanford UniversityStanfordCalifornia 上海交通大学医学院附属新华医院核医学科上海200092

一体化PET/MRI通过一站式成像提供肿瘤解剖学及功能评估,且与^(18)F-FDG PET/CT相比其辐射暴露量减少80%,因此对癌症患儿的分期与再分期具有显著临床价值。该文回顾了^(18)F-FDG PET/MRI在小儿肿瘤中的临床应用,尤其关注PET/MRI在患儿... 详细信息

一体化PET/MRI通过一站式成像提供肿瘤解剖学及功能评估,且与^(18)F-FDG PET/CT相比其辐射暴露量减少80%,因此对癌症患儿的分期与再分期具有显著临床价值。该文回顾了^(18)F-FDG PET/MRI在小儿肿瘤中的临床应用,尤其关注PET/MRI在患儿管理中的价值。来自4个不同机构的PET/MRI应用先行者分享了他们对PET/MRI技术在癌症患儿评估中特殊优势的见解。文章作者讨论了全身PET/MRI在评估某些解剖区域(如软组织和骨髓)中的价值以及儿童特殊的PET/MRI影像学特征,并强调了全身PET/MRI如何通过在不失去诊断准确性的同时减少所需放射学检查次数(因此减少辐射暴露),改善淋巴瘤、肉瘤和神经纤维瘤病患儿的临床管理。文章论述了PET/MRI如何帮助区分恶性肿瘤与感染性或炎性疾病;另外,简要探讨了PET/MRI用于接受免疫治疗的患儿疗效评估以及对不同诊疗一体化药物评估的未来研究方向。从儿童应用中所获得的经验也可拓展至成人患者的评估中。

关键词：肿瘤学儿科学 PET/MRI 癌症儿科肿瘤学

Molecular Characterization of the Calvin Cycle Enzyme Phosphoribulokinase in the Stramenopile Alga Vaucheria litorea and the Plastid Hosting Mollusc Elysia chlorotica

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Molecular Plant 2009年第6期2卷 1384-1396页

作者： mary E. Rumpho Sirisha Pochareddy Jared M. Worful elizabeth J. Summer Debashish Bhattacharya Karen N. Pelletreau mary S. Tyler Jungho Lee James R. Manhart Kara M. Soule Department of Biochemistry Microbiology and Molecular Biology 5735 Hitchner Halt University of Maine Orono ME 04469 USA Department of Biology Texas A&M University College Station TX 77843 USA Department of Ecology Evolution and Natural Resources Institute of Marine and Coastal Sciences Rutgers University New Brunswick NJ 08901 USA School of Biology and Ecology University of Maine Orono ME 04469 USA Green Plant Institute #2-202 Bio Valley Seoul National University 103-2 Seodun Gwonseon Suwon Gyeonggi 441-853 Korea Department of Biochemistry and Biophysics Texas A&M University College Station TX 77843 USA

Phosphoribulokinase （PRK）, a nuclear-encoded plastid-localized enzyme unique to the photosynthetic carbon reduction （Calvin） cycle, was cloned and characterized from the stramenopile alga Vaucheria litorea. This alga is the source of plastids for the mollusc （sea slug） Elysia chlorotica which enable the animal to survive for months solely by photoautotrophic CO2 fixation. The 1633-bp V. litorea prk gene was cloned and the coding region, found to be interrupted by four introns, encodes a 405-amino acid protein. This protein contains the typical bipartite target sequence expected of nuclearencoded proteins that are directed to complex （i.e. four membrane-bound） algal plastids. De novo synthesis of PRK and enzyme activity were detected in E. chlorotica in spite of having been starved of V. litorea for several months. Unlike the algal enzyme, PRK in the sea slug did not exhibit redox regulation. Two copies of partial PRK-encoding genes were isolated from both sea slug and aposymbiotic sea slug egg DNA using PCR. Each copy contains the nucleotide region spanning exon 1 and part of exon 2 of V litorea prk, including the bipartite targeting peptide. However, the larger prk fragment also includes intron 1. The exon and intron sequences of prk in E. chlorotica and V/itorea are nearly identical. These data suggest that PRK is differentially regulated in V. litorea and E. chlorotica and at least a portion of the V. litorea nuclear PRK gene is present in sea slugs that have been starved for several months.

关键词： Alga Calvin cycle Elysia chlorotica kleptoplast mollusc phosphoribulokinase photosynthesis plastid redox regulation stramenopile symbiosis Vaucheria litorea.

淮北煤田中高阶煤储层物性表征及深部有利区预测研究

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非常规油气 2024年

作者：侯海海 elizabeth Cruz Pérez 陈泓圳胡博何倩黄乡琴辽宁工程技术大学矿业学院

为定量表征淮北煤田中高阶煤储层物性特征，采用工业分析、显微煤岩组分定量、低温氮吸附、高压压汞、核磁共振等实验手段，对淮北煤田7个煤样的物性特征进行了研究。结果表明，淮北煤田煤显微组分以镜质组为主，最大镜质组反射率变化... 详细信息

为定量表征淮北煤田中高阶煤储层物性特征，采用工业分析、显微煤岩组分定量、低温氮吸附、高压压汞、核磁共振等实验手段，对淮北煤田7个煤样的物性特征进行了研究。结果表明，淮北煤田煤显微组分以镜质组为主，最大镜质组反射率变化较大，在0.7%-2.5%之间，可能受燕山期郯庐和太行山岩浆活动的共同影响。该煤质具有中-高灰分、低-极低硫含量、低磷、中高热值的特点。从低阶煤到中阶煤，由于脱水作用较强，煤基质收缩，吸附孔隙和渗流孔隙体积减小，裂隙体积增大；从中阶煤到高阶煤，吸附孔具有明显的优势，表明其对甲烷的吸附能力增强。预测淮北煤田宿县矿区的南坪深部、桃园祁南深部、彭桥深部、朱仙庄北部，临涣矿区的任楼赵集深部、许疃深部，濉萧矿区的萧西深部为该区煤层气勘探的较有利区，

关键词：淮北煤田煤储层物性孔裂隙结构煤层气有利区优选

Crystal Structure of the MAP3K TAO2 Kinase Domain Bound by an Inhibitor Staurosporine

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Acta Biochimica et Biophysica Sinica 2006年第6期38卷 385-392页

作者： elizabeth J.GOLDSMITH USA TX 75390-9038 Department of Biochemistry University of Texas Southwestern Medical Center at Dallas

Mitogen-activated protein kinase (MAPK) signal transduction pathways are ubiquitous ineukaryotic cells,which transfer signals from the cell surface to the nucleus,controlling multiple *** are activated by MAPK kinases [MAP2Ks or MAP/extracellular signal-regulated kinase(ERK) kinases (MEK)],which in turn are activated by MAPK kinase kinases (MAP3Ks).TAO2 is a MAP3Klevel kinase that activates the MAP2Ks MEK3 and MEK6 to activate p38 *** p38 MAPKs arekey regulators of expression of inflammatory cytokines,they appear to be involved in human diseases suchas asthma and *** an upstream activator of p38s,TAO2 represents a potential drug *** we report the crystal structure of active TAO2 kinase domain in complex with staurosporine,a broad-range protein kinase inhibitor that inhibits TAO2 with an ICof 3 μ*** structure reveals that staurosporineoccupies the position where the adenosine of ATP binds in TAO2,and the binding of the inhibitor mimicsmany features of ATP *** polar and nonpolar interactions contribute to the *** induces conformational changes in TAO2 residues that surround the inhibitormolecule,but causes very limited global changes in the *** structure provides atomic details forTAO2-staurosporine interactions,and explains the relatively low potency of staurosporine against *** structure presented here should aid in the design of inhibitors specific to TAO2 and related kinases.

关键词： TAO2 MAP3K inhibitor staurosporine crystal structure

ntegrated approach to winery waste： waste generation and data consolidation

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Frontiers of Environmental Science & Engineering 2016年第1期10卷 168-176页

作者： Margarida OLIVEIRA elizabeth DUARTE Instituto Superior de Agronomia (ISA) University of Lisbon 1349-017 Lisboa Portugal Escola Superior Agrairia de Santarem (ESAS) Instituto Superior Politecnico de Santarem 2001-904 Santarem Portugal

The winemaking process involves the genera- tion of a significant amount of waste and wastewater. These residues should be addressed for recycling or treatment before being returned to environment. As each winery is unique in waste generation and disposal, plans for environmentally friendly waste management are not universal and should be tested for their effectiveness. In this study, a diagnostic was made during three years, in different wineries, throughout Portugal, in order to quantify and characterize the waste and the wastewater produced. The results showed that solid waste and wastewater are mainly produced during the harvest period, corresponding to 74% and 87%, respectively. One ton of processed grape approximately produce 0.13 t marc, 0.06 t lees, 0.03 t of stalks and 1.65 m3 of wastewater. No significant differences （P≤0.05） were observed for grape marc, lees and wastewater ratios, between years or wineries. With respect to the stalk ratio, there was no effect of year but the winery significantly affected this ratio （P ≤ 0.05）. During the study period the treated wastewater, since diluted, revealed suitable characteristics for irrigation representing an additional source of water. In this regard, the data acquisition and consolidation ensure the transfer of information and experience which constitute an essential step in a support decision tool design.

关键词： waste management wastewater reuse winerywastewater

Muscles: Testing and Function, with Posture and Pain 5th Edition 5th ed.

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Crouzon syndrome mouse model exhibits cartilage hyperproliferation and defective segmentation in the developing trachea

丛书名： Kendall, Muscles

2005年

作者： Florence Peterson Kendall elizabeth Kendall McCreary Patricia Geise Provance mary McIntyre Rodgers William Anthony Romani

来源：畅想之星图书光盘版（南... 评论

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Science China(Life Sciences) 2019年第10期62卷 1375-1380页

作者： elizabeth A. Hines mary-Kayt N. Jones Julie F. Harvey Chad Perlyn David M. Ornitz Xin Sun Jamie M. Verheyden Laboratory of Genetics University of WisconsinMadisonWI 53706USA Department of Surgery Florida International University College of MedicineMiamiFL 33199USA Department of Developmental Biology Washington University School of MedicineSt. LouisMO 63110USA Department of Pediatrics University of California-San DiegoLa JollaCA 92093USA

Crouzon syndrome is the result of a gain-of-function point mutation in FGFR2. Mimicking the human mutation, a mouse model of Crouzon syndrome(Fgfr2342Y) recapitulates patient deformities, including failed tracheal cartilage segmentation, resulting in a cartilaginous sleeve in the homozygous mutants. We found that the Fgfr2C342Y/C^342Y mutants exhibited an increase in chondrocytes prior to segmentation. This increase is due at least in part to over proliferation. Genetic ablation of chondrocytes in the mutant led to restoration of segmentation in the lateral but not central portion of the trachea. These results suggest that in the Fgfr2C342Y/C342Y mutants, increased cartilage cell proliferation precedes and contributes to the disruption of cartilage segmentation in the developing trachea.

关键词： trachea lung mouse development

The Sendai Framework for Disaster Risk Reduction at Five:Lessons from the 2011 Great East Japan Earthquake and Tsunami

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International Journal of Disaster Risk Science 2020年第2期11卷 167-178页

作者： elizabeth Maly Anawat Suppasri International Research Institute of Disaster Science Tohoku UniversitySendai 980-8579.Japan

The Sendai Framework for Disaster Risk Reduction 2015–2030(SFDRR) represents an inclusive approach to disaster risk reduction, linked to development and recovery. Building on previous international guidelines, the SFDRR promotes practical and measurable outcomes for reducing disaster losses, including indicators to measure progress towards seven specific global *** in the context of the priorities and global targets of the SFDRR, the article considers the case of the Great East Japan Earthquake and Tsunami of 2011 to illustrate advances and limitations in pre-disaster tsunami hazard engineering and post-disaster recovery. With respect to the targets set out in the Sendai Framework related to risk reduction and tsunami engineering, especially Priority 1,understanding disaster risk, there have been significant advances in hazard assessment and systems for tsunami detection and warning. Although the SFDRR emphasizes actions in the recovery phase through Priority 4, enhancing disaster preparedness with an emphasis on the concept of build back better, on its own this does not function as a clear directive for guiding recovery. However, the overall people-centered and inclusive approach of the SFDRR, as well as the global targets and several sub-priorities, can be a useful way to shape good practices in recovery and evaluate recovery progress.

关键词： Build back better Disaster recovery Great East Japan Earthquake Sendai Framework Tsunami risk