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Prote.tive.e.fe.ts ofLactobacillus plantarum against e.ithe.ial barrie. dysfunction of human colon ce.l line.NCM460

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World Journal of Gastroe.te.ology 2010年第45期16卷 5759-5765页

作者： mary Pat Moye. INCe.L Corporation San AntonioTX 78249United States

AIM: To inve.tigate.the.e.fe.ts of Lactobacillus plantarum (L. plantarum ) in the.inte.tinal pe.me.bility and e.pre.sion of tight junction (TJ) using the.normal human colon ce.l line.NCM460. Me.HODS: Parace.lular pe.me.bility of NCM460 monolaye.s was de.e.mine. by transe.ithe.ial e.e.trical re.istance.and de.tran pe.me.bility. e.pre.sion of TJ prote.ns in NCM460 ce.l monolaye.s was de.e.te. by We.te.n blotting and quantitative.re.l-time.polyme.ase.chain ***: L. plantarum playe. an important role.in incre.sing transe.ithe.ial e.e.trical re.istance.and de.re.sing the.pe.me.bility to macromole.ule. of NCM460 monolaye.s against the.disruption cause. by e.te.opathoge.ic e.che.ichia coli (e. coli ) or e.te.oinvasive.e. coli . L. plantarum also pre.e.te. the.de.re.se.in the.e.pre.sion of TJ prote.ns and F-actin in NCM460 ***: L. plantarum can prote.t against dysfunction of NCM460 inte.tinal e.ithe.ial barrie. cause. by e.te.opathoge.ic e. coli or e.te.oinvasive.e. coli , and thus can be.a pote.tial candidate.of the.ape.tic age.ts for the.tre.tme.t of inte.tinal dise.se..

关键词： Lactobacillus plantarum NCM460 Tight junction Inte.tinal barrie.

LIVe.IMAGING OF e.RLY De.e.OPMe.TAL PROCe.Se. IN MAMMALIAN e.BRYOS WITH OPTICAL COHe.e.Ce.TOMOGRAPHY

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Journal of Innovative.Optical He.lth Scie.ce. 2009年第3期2卷 253-259页

作者： KIRILL V.LARIN IRINA V.LARINA MICHAe. LIe.LING mary e.DICKINSON De.artme.t of Biome.ical e.gine.ring Unive.sity of Houston HoustonTXUSA De.artme.t of Mole.ular Physiology and Biophysics Baylor Colle.e.of Me.icine HoustonTXUSA De.artme.t of e.e.trical and Compute. e.gine.ring Unive.sity of California Santa BarbaraCAUSA

e.rly e.bryonic imaging of cardiovascular de.e.opme.t in mammalian mode.s re.uire. a me.hodthat can pe.e.rate.through and distinguish the.many tissue.laye.s with high spatial and te.poralre.olution. In this pape. we.e.aluate.the.capability of Optical Cohe.e.ce.Tomography (OCT)te.hnique.for structural 3D e.bryonic imaging in mouse.e.bryos at diffe.e.t stage. of the.e.e.opme.tal proce.s ranging from 7.5 dpc up to 10.5 dpc. Obtaine. re.ults sugge.t that the.olle.te. data is suitable.for quantitative.and qualitative.me.sure.e.ts to asse.s cardiovascularfunction in mouse.mode.s, which is like.y to e.pand our knowle.ge.of the.comple.ity of the.mbryonic he.rt, and its de.e.opme.t into an adult he.rt.

关键词： Optical Cohe.e.ce.Tomography non-invasive mouse.e.bryos cardiovascular function.

The.comparative.e.ficacy of e.e.imibe.adde. to atorvastatin 10 mg ve.sus uptitration to atorvastatin 40 mg in subgroups of patie.ts age. 65 to 74 ye.rs or gre.te. than or e.ual to 75 ye.rs

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Journal of Ge.iatric Cardiology 2011年第1期8卷 1-11页

作者： Ori Be.-Ye.uda Nane.te.K. We.ge. Christian Constance.Franklin Zie.e.mary e. Hanson Jian-Xin Lin Arvind K. Shah Charlotte.Jone.-Burton Andrew M. Te.shakove. Unive.sity of California San Die.o 200 West Arbor Drive La Jolla CA 92103 USA e.ory Unive.sity School of Me.icine 49 Jess Hill Jr Dr SE Atlanta GA 30303 USA SHopital Maisonne.ve.Rose.ont Re.he.che.Clinique.Polyclinique 5415 Boulevard de l＇Assomption Suite 295 Montreal Quebec QC H1T2M4 Canada McGuire.VA Me.ical Ce.te. 1201 Broad Rock Blvd （151） Richmond VA 23249 USA Me.ck-Sharp ＆ Dohme One Merck Drive Whitehouse Station NJ 08889 USA

Background Coronary he.rt dise.se.（CHD） risk incre.se. with age. ye. lipid-lowe.ing the.apie. are.significantly unde.-utilize. in patie.ts 〉 65 ye.rs. The.obje.tive.was to e.aluate.the.safe.y and e.ficacy of lipid-lowe.ing the.apie. in olde. patie.ts tre.te. with atorvastatin 10 nag ＋ e.e.imibe.10 mg （e./Atorva） vs. incre.sing the.atorvastatin dose.to 40 mg, Me.hods Patie.ts 〉 65 ye.rs with athe.oscle.otic vascular dise.se.（LDL-C ≥1.81 mmol/L） or at high risk for coronary he.rt dise.se.（LDL-C 〉 2.59 mmol/L） we.e.randomize. to e./Atorva for 12 wk vs. uptitration to atorvastatin 20 nag for 6 wk followe. by atorvastatin 40 nag for 6 wk. The.pe.ce.t change.in LDL-C and othe. lipid parame.e.s and pe.ce.t patie.ts achie.ing pre.pe.ifie. LDL-C le.e.s we.e.asse.se. afte. 12 wk. Re.ults e./Atorva produce. gre.te. re.uctions in most lipid parame.e.s vs. uptitration of atorvastatin in patie.ts 〉 75 ye.rs （n = 228）, ge.e.ally consiste.t with patie.ts 65-74 ye.rs （n = 812）. More.patie.ts achie.e. LDL-C targe.s with combination the.apy vs. monothe.apy in both age.groups at 6 wk and in patie.ts 〉 75 ye.rs at 12 wk. At 12 wk, more.patie.ts 〉 75 ye.rs achie.e. LDL-C targe.s with monothe.apy vs. combination the.apy. e./Atorva produce. more.favorable.improve.e.ts in most lipids vs. doubling or quadrupling the.atorvastatin dose.in patie.ts 〉 75 ye.rs, ge.e.ally consiste.t with the.findings in patie.ts 65-74 ye.rs. Conclusions Our re.ults e.te.de. pre.ious findings de.onstrating that e.e.imibe.adde. to a statin provide. a ge.e.ally we.l-tole.ate. the.ape.tic option for improving the.lipid profile.in patie.ts 65 to 74 ye.rs and 〉 75 ye.rs of age.

关键词： chole.te.ol absorption inhibitor LDL-C hype.chole.te.ole.ia statin

Pre.e.tion of me.abolic de.ompe.sation in an infant with mutase.de.icie.t me.hylmalonic aciduria unde.going cardiopulmonary bypass

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World Journal of Pe.iatrics 2014年第1期10卷 83-85页

作者： Raymond Y Wang Richard C Chang mary e.Sowa Anthony C Chang Jose.e.Abde.ur Division of Me.abolic Disorde.s CHOC Children's FoundationDepartment of PediatricsUniversity of California Irvine School of MedicineOrangeCAUSA De.artme.t of Clinical Nutrition and Lactation CHOC Children'sOrangeCAUSA Division of Cardiology Pediatric Subspecialty FacultyHeart InstituteCHOC Children'sOrangeCAUSA

Background:e.fe.ts of circulatory arre.t upon an inborn e.ror of me.abolism patie.t are.***:A re.rospe.tive.chart re.ie. was pe.forme. of outcome.and bioche.ical parame.e.s obtaine. during palliative.cardiac surge.y for a mutase.de.icie.t me.hylmalonic aciduria patie.t with e.ste.n’s cardiac anomaly was ***:The.le.e.s of ammonia,me.hylmalonic acid,fre. carnitine.and propionylcarnitine.of the.patie.t we.e.*** patie.t survive. surge.y following institution of four me.abolic tre.tme.t principle.:1)re.triction of toxic substrate.2)promotion of anabolism via administration of carbohydrate.and lipid calorie.;3)administration of de.oxifying le.ocarnitine.and sodium be.zoate.and 4)cobalamin e.zymatic co-factor *** patie.t die. from post-ope.ative.dysrhythmia and was posthumously de.e.mine. to have.compound he.e.ozygosity for mutations pre.icting se.e.e.cobalamin non-re.ponsive.dise.se.c.322C>T/c.1233de.3(p.R108C/p.ΔI412).Conclusion:Me.abolic de.ompe.sation is pre.e.table.during cardiopulmonary bypass and cardiople.ia using four principle. of me.abolic tre.tme.t.

关键词： bypass manage.e.t me.hylmalonic aciduria

Advance. in he.lthcare.we.rable.de.ice.

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npj Fle.ible.e.e.tronics 2021年第1期5卷 73-86页

作者： She.kh M.A.Iqbal Imade.din Mahgoub e.Du mary Ann Le.vitt Wase.m Asghar De.artme.t of Compute. and e.e.trical e.gine.ring&Compute. Scie.ce Florida Atlantic UniversityBoca RatonFLUSA Asghar-Lab Micro and Nanotechnology in MedicineCollege of Engineering and Computer ScienceBoca RatonFLUSA De.artme.t of Oce.n and Me.hanical e.gine.ring Florida Atlantic UniversityBoca RatonFLUSA Christine.e.Lynn Colle.e.of Nursing Florida Atlantic UniversityBoca RatonFLUSA De.artme.t of Biological Scie.ce.(Courte.y appointme.t) Florida Atlantic UniversityBoca RatonFLUSA

We.rable.de.ice. have.found nume.ous applications in he.lthcare.ranging from physiological dise.se.,such as cardiovascular dise.se.,hype.te.sion and muscle.disorde.s to ne.rocognitive.disorde.s,such as Parkinson’s dise.se.Alzhe.me.’s dise.se.and othe. psychological *** type. of we.rable. are.use. for this purpose.for e.ample.skin-base. we.rable. including tattoobase. we.rable.,te.tile.base. we.rable.,and biofluidic-base. ***,we.rable. have.also shown e.couraging improve.e.ts as a drug de.ive.y syste.;the.e.ore.e.hancing its utility towards pe.sonalize. *** we.rable. contain inhe.e.t challe.ge.,which ne.d to be.addre.se. be.ore.the.r comme.cialization as a fully pe.sonalize. he.lthcare.*** pape. re.ie.s diffe.e.t type. of we.rable.de.ice. curre.tly be.ng use. in the.he.lthcare.*** also highlights the.r e.ficacy in monitoring diffe.e.t dise.se. and applications of he.lthcare.we.rable.de.ice.(HWDs)for diagnostic and tre.tme.t ***,curre.t challe.ge. and limitations of the.e.we.rable. in the.fie.d of he.lthcare.along with the.r future.pe.spe.tive. are.also re.ie.e..

关键词： we.r he.lthcare challe.ge.

Iodoace.ic acid e.posure.alte.s the.transcriptome.in mouse.ovarian antral follicle.

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Journal of e.vironme.tal Scie.ce. 2022年第7期34卷 46-57页

作者： Andre.sa Gonsioroski mary Laws Vasiliki e.Mourike. Alison Ne.f Je.ny Drne.ich Michae. J.Ple.a Jodi A.Flaws De.artme.t of Comparative.Bioscie.ce. University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA Roy J.Carve. Biote.hnology Ce.te. University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA De.artme.t of Crop Scie.ce. and the.Safe.Global Wate. Institute University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA

Iodoace.ic acid(IAA) is an unre.ulate. wate. disinfe.tion byproduct that is an ovarian toxicant. Howe.e., the.me.hanisms of action unde.lying IAA toxicity in ovarian follicle. re.ain uncle.r. Thus, we.de.e.mine. whe.he. IAA alte.s ge.e.e.pre.sion in ovarian follicle. in mice. Adult fe.ale.mice.we.e.dose. with wate. or IAA(10 or 500 mg/L) in the.wate. for 35-40 days. Antral follicle. we.e.colle.te. for RNA-se.ue.cing analysis and se.a we.e.colle.te. to me.sure.e.tradiol. RNA-se.ue.cing analysis ide.tifie. 1063 diffe.e.tially e.pre.se. ge.e.(De.s) in the.10 and 500 mg/L IAA groups(false.discove.y rate.FDR e.pe.tive.y, compare. to controls. Ge.e.Ontology e.richme.t analysis showe. that De.s we.e.involve. with RNA proce.sing and re.ulation of angioge.e.is(10 mg/L) and the.ce.l cycle.and ce.l division(500 mg/L). Pathway e.richme.t analysis showe. that De.s we.e.involve. in the.phosphatidylinositol 3-kinase.and prote.n kinase.B(PI3K-Akt), gonadotropin-re.e.sing hormone.Gn RH), e.troge., and insulin signaling pathways(10 mg/L). Pathway e.richme.t analysis showe. that De.s we.e.involve. in the.oocyte.me.osis, Gn RH, and oxytocin signaling pathways(500 mg/L). RNA-se.ue.cing analysis ide.tifie. 809 De.s whe. comparing the.500 and 10 mg/L IAA groups(FDR e.s we.e.re.ate. to ribosome. translation, m RNA proce.sing, oxidative.phosphorylation, chromosome. ce.l cycle. ce.l division, prote.n folding, and the.oxytocin signaling pathway. More.ve., IAA e.posure.significantly de.re.se. e.tradiol le.e.s(500 mg/L) compare. to control. This study ide.tifie. ke. candidate.ge.e. and pathways involve. in IAA toxicity and can he.p to furthe. unde.stand the.mole.ular me.hanisms of IAA toxicity in ovarian follicle..

关键词： Disinfe.tion byproducts Iodoace.ic acid Ovary Ovarian follicle. Ste.oidoge.e.is e.docrine.disruptors

Baye.ian Optimization for Fie.d-Scale.Ge.logical Carbon Storage

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e.gine.ring 2022年第11期18卷 96-104页

作者： Xue.ing Lu Kirk e.Jordan mary F.Whe.le. e.ward O.Pyze.-Knapp Matthe. Be.atan Ce.te. for Subsurface.Mode.ing Oden Institute for Computational Engineering and SciencesThe University of Texas at AustinAustinTX 78712USA IBM Re.e.rch Unite. Kingdom Warrington WA44ADUK

We.pre.e.t a frame.ork that couple. a high-fide.ity compositional re.e.voir simulator with Baye.ian optimization(BO)for inje.tion we.l sche.uling optimization in ge.logical carbon *** work re.re.e.ts one.of the.first at te.pts to apply BO and high-fide.ity physics mode.s to ge.logical carbon *** implicit paralle. accurate.re.e.voir simulator(IPARS)is utilize. to accurate.y capture.the.unde.lying physical proce.se. during CO_(2)*** provide. a frame.ork for se.e.al flow and me.hanics mode.s and thus supports both stand-alone.and couple. *** this work,we.use.the.compositional flow module.to simulate.the.ge.logical carbon storage.*** compositional flow mode.,which include. a hyste.e.ic thre.-phase.re.ative.pe.me.bility mode.,accounts for thre. major CO_(2)trapping me.hanisms:structural trapping,re.idual gas trapping,and solubility ***,IPARS is couple. to the.Inte.national Busine.s Machine.(IBM)Corporation Baye.ian Optimization Acce.e.ator(BOA)for paralle. optimizations of CO_(2)inje.tion strate.ie. during fie.d-scale.CO_(2)*** builds a probabilistic surrogate.for the.obje.tive.function using a Baye.ian machine.le.rning algorithm-the.Gaussian proce.s re.re.sion,and the. use. an acquisition function that le.e.age. the.unce.tainty in the.surrogate.to de.ide.whe.e.to *** IBM BOA addre.se. the.thre. we.kne.se. of standard BO that limits its scalability in that IBM BOA supports paralle.(batch)e.e.utions,scale. be.te. for high-dime.sional proble.s,and is more.robust to *** de.onstrate.the.e.me.its by applying the.algorithm in the.optimization of the.CO_(2)inje.tion sche.ule.in the.Cranfie.d site.in Mississippi,USA,using fie.d *** optimize. inje.tion sche.ule.achie.e. 16%more.gas storage.volume.and 56%le.s wate./surfactant usage.compare. with the.*** pe.formance.of BO is compare. with that of a ge.e.ic algorithm(GA)and a covariance.matrix adaptation(CMA)-e

关键词： Compositional flow Baye.ian optimization Ge.logical carbon storage CCUS Machine.le.rning AI for scie.ce

Tunne. ge.me.ry of the.subte.rane.n te.mite.Re.iculite.me. grasse. （Isopte.a： Rhinote.mitidae.in re.ponse.to sand bulk de.sity and the.pre.e.ce.of food

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Inse.t Scie.ce 2007年第6期14卷 511-518页

作者： TANIA NOBRe.LINA NUNe. DAVID e. BIGNe.L Laboratorio Nacional de.e.ge.haria Civil Nucleo de Estruturas de Madeira Lisboa Portugal Que.n mary University of London School of Biological and Chemical Sciences London UK Institute.of Tropical Biology and Conse.vation Universiti Malaysia Sabah Kota Kinabalu Sabah Malaysia

The.cryptic habits of subte.rane.n te.mite. re.tricts de.aile. analysis of the.r foraging patte.ns in situ, but the.proce.s is e.ide.tly dominate. by tunne. constructions conne.ting the.ne.t with woody re.ource. discove.e. within the.te.ritory of e.ch colony. In this study, tunne. formation and orie.tation we.e.studie. e.pe.ime.tally in the.te.mite.Re.iculite.me. grasse. （Cle.e.t）, using 2-dime.sional laboratory foraging are.as con- taining fine.sand as the.substratum. The.building of e.ploratory tunne.s ove. a 10-day pe.iod and the.ge.me.ry of the.re.ulting ne.work are.de.cribe.. Fractal analysis showe. that tunne. ge.me.ry had a fractal dime.sion, re.ardle.s of the.total le.gth tunne.le. whe.he. forage.s e.counte.e. the.food source.or not. The.bulk de.sity of the.sand in the.are.as affe.te. the.distance. tunne.le., with highe. de.sity re.ucing construction, but did not affe.t tunne. ge.me.ry. Tunne.s we.e.not disce.nibly orie.tate. with re.pe.t to the.positioning of the.food source. e.e. in a situation whe.e.te.mite. had faile. to find the.food source.at a distance.of le.s than 50 mm, sugge.ting that volatile. from wood are.not attractants.

关键词： foraging galle.y fractal analysis Re.iculite.me. grasse. se.rch patte.n,subte.rane.n te.mite. tunne. ge.me.ry

Nurse.’ pe.spe.tive.of the.re.e.rch-practice.gap in nursing

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Ope. Journal of Nursing 2014年第2期4卷 95-100页

作者： Clara Agbe.ia Ije.ma Okoronkwo e. Onokaye.gho mary Ann Agbo De.artme.t of Nursing Scie.ce Delta State University Abraka Nigeria De.artme.t of Nursing Scie.ce University of Nigeria Enugu Campus Enugu State Nigeria

This work aims to e.plore.the.vie.s of Nige.ian nurse. on re.e.rch-practice.gap in the.clinical practice.and the.challe.ge. in the.utilization of nursing re.e.rch. The.re.ults from in-de.th inte.vie. and focus group discussion de.onstrate. that a re.e.rch-practice.gap e.iste. in the.clinical se.ting. The.nurse. ge.e.ally did not utilize.re.e.rch findings in the.r practice. Some.use.ul sugge.tions we.e.re.omme.de. to solve.the.proble..

关键词： Nursing The.ry Re.e.rch Practice Re.e.rch Utilization