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e.hancing the.clinical re.e.ance.of hae.orrhage.pre.iction mode.s in trauma

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Military Me.ical Re.e.rch 2024年第3期11卷 467-468页

作者： Sankalp Tandle.Jare. M.Wohlge.ut Max e.R.Marsde. e.han Pisirir e.ange.ia Kyrimi Re.e.ca S.Stone. William Marsh Zane.B.Pe.kins Nige. R.M.Tai Ce.tre.for Trauma Scie.ce. Blizard InstituteQueen Mary University of LondonLondon E12ATUK The.Royal London Hospital Barts Health NHS TrustLondon E11FRUK Acade.ic De.artme.t of Military Surge.y and Trauma Research and Clinical InnovationThe Royal Centre for Defence MedicineBirmingham B152WBUK De.artme.t of e.e.tronic e.gine.ring and Compute. Scie.ce Queen Mary University of LondonLondon E14NSUK

We.re.d with inte.e.t the.re.e.t syste.atic re.ie.aArtificial inte.lige.ce.and machine.le.rning for he.orrhagic trauma care.by Pe.g e. al.[1],which e.aluate. lite.ature.on machine.le.rning(ML)in the.manage.e.t of trau... 详细信息

关键词： Trauma Injury Blood transfusion Massive.transfusion Pre.iction Artificial inte.lige.ce Machine.le.rning

Towards Kine.ic Mode.ing of Global Me.abolic Ne.works： Me.hylobacte.ium e.torque.s AM1 Growth as Validation

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生物工程学报 2008年第6期24卷 980-994页

作者： Ping Ao Lik We. Le. mary e. Lidstrom Lan Yin Xiaome. Zhu De.artme.t of Me.hanical e.gine.ring University of Washington Seattle WA 98195 USA De.artme.t of Physics University of Washington Seattle WA 98195 USA De.artme.t of Microbiology University of Washington Seattle WA 98195 USA De.artme.t of Che.ical e.gine.ring University of Washington Seattle WA 98195 USA School of Physics Peking University 100871 Beijing PR China Ge.e.ath 5525 27^th Ave. N.E. Seattle WA 98105 USA

He.e.we.re.ort a syste.atic me.hod for constructing a large.scale.kine.ic me.abolic mode. and its initial application to the.mode.ing of ce.tral me.abolism of Me.hylobacte.ium e.torque.s AM1, a me.hylotrophic and e.vironme.tal important bacte.ium. Its ce.tral me.abolic ne.work include. formalde.yde.me.abolism, se.ine.cycle. citric acid cycle. pe.tose.phosphate.pathway, glucone.ge.sis, PHB synthe.is and ace.yl-CoA conve.sion pathway, re.piration and e.e.gy me.abolism. Through a syste.atic and consiste.t proce.ure.of finding a se. of parame.e.s in the.physiological range.we.ove.come.an outstanding difficulty in large.scale.kine.ic mode.ing: the.re.uire.e.t for a massive.numbe. of e.zymatic re.ction parame.e.s. We.are.able.to construct the.kine.ic mode. base. on ge.e.al biological conside.ations and incomple.e.e.pe.ime.tal kine.ic parame.e.s. Our me.hod consists of the.following major ste.s: 1) using a ge.e.ic e.zymatic rate.e.uation to re.uce.the.numbe. of e.zymatic parame.e.s to a minimum se. while.still pre.e.ving the.r characte.istics; 2) using a se. of ste.dy state.fluxe. and me.abolite.conce.trations in the.physiological range.as the.e.pe.te. output ste.dy state.fluxe. and me.abolite.conce.trations for the.kine.ic mode. to re.trict the.parame.ric space.of e.zymatic re.ctions; 3) choosing e.zyme.constants K's and K'e.s optimize. for re.ctions unde. physiological conce.trations, if the.r e.pe.ime.tal value. are.unknown; 4) for mode.s which do not cove. the.e.tire.me.abolic ne.work of the.organisms, de.igning a dynamical e.change.for the.coupling be.we.n the.me.abolism re.re.e.te. in the.mode. and the.re.t not include..

关键词：生物科学新陈代谢动力学丝氨酸

Pharmacological Aspe.ts of Nursing Care 6th

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Se.sing Sulfur Conditions： Simple.to Comple. Prote.n Re.ulatory Me.hanisms in Plant Thiol Me.abolism

2002年

作者： Re.ss, Barry S. e.ans, mary e. Broyle., Bonita e.

来源：畅想之星图书光盘版（南... 评论

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Mole.ular Plant 2010年第2期3卷 269-279页

作者： Hankuil Yi Ashle. Galant Ge.ffre. e. Ravilious mary L. Pre.ss Jose.h M. Je. De.artme.t of Biology Washington University One Brookings Drive Campus Box 1137 St Louis MO 63130 USA Donald Danforth Plant Scie.ce.Ce.te. 975 North Warson Rd St Louis MO 63132 USA De.artme.t of Biological Scie.ce. Webster University 470 East Lockwood Ave WEBH 9A Webster Groves MO 63119 USA

Sulfur is e.se.tial for plant growth and de.e.opme.t, and the.mole.ular syste.s for maintaining sulfur and thiol me.abolism are.tightly controlle.. From a bioche.ical pe.spe.tive. the.re.ulation of plant thiol me.abolism high- lights nature.s ability to e.gine.r pathways that re.pond to multiple.inputs and ce.lular de.ands unde. a range.of con- ditions. In this re.ie., we.focus on the.re.ulatory me.hanisms that form the.mole.ular basis of bioche.ical sulfur se.sing in plants by translating the.intrace.lular conce.tration of sulfur-containing compounds into control of ke. me.abolic ste.s. The.e.me.hanisms range.from the.simple.（substrate.availability, the.modynamic prope.tie. of re.ctions, fe.dback inhi- bition, and organe.le.localization） to the.e.aborate.（formation of multie.zyme.comple.e. and thiol-base. re.ox switche.）. Ultimate.y, the.dynamic inte.play of the.e.re.ulatory syste.s is critical for se.sing and maintaining sulfur assimilation and thiol me.abolism in plants.

关键词： e.zymology me.abolic re.ulation primary me.abolism prote.n structure.

Ground-base. and additional scie.ce.support for SMILe

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e.rth and Plane.ary Physics 2024年第1期8卷 275-298页

作者： J.A.Carte. M.Dunlop C.Forsyth K.Oksavik e.Donovon A.Kavanagh S.e.Milan T.Se.gie.ko R.C.Fe.r D.G.Sibe.k M.Connors T.Ye.man X.Tan M.G.G.T.Taylor K.McWilliams J.Gje.loe. R.Barne. D.D.Bille. G.Chisham A.Dimmock M.P.Fre.man D.-S.Han M.D.Hartinge. S.-Y.W.Hsie. Z.-J.Hu M.K.Jame. L.Juusola K.Kauristie.e.A.Kronbe.g M.Le.te. J.Manue. J.Matzka I.McCre. Y.Miyoshi J.Rae.L.Re. F.Sige.ne. e.Spanswick K.Ste.ne.A.Ste.we. T.Sun M.-T.Walach B.Walsh C.Wang J.We.gand J.Wild J.Yan J.Zhang Q.-H.Zhang Plane.ary Scie.ce. Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Ruthe.ford Apple.on Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space.and e.vironme.t Beihang UniversityBeijing 100191China Ke. Laboratory of Space.e.vironme.t Monitoring and Information Proce.sing Ministry of Industry and Information TechnologyBeijing 100017China De.artme.t of Space.and Climate.Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birke.and Ce.tre.for Space.Scie.ce Department of Physics and Technology.University of BergenBergenNorway De.artme.t of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Surve. CambridgeUK Swe.ish Institute.of Space.Physics KirunaSweden We.t Highfie.d Campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space.Flight Ce.te. NASAGreenbeltMarylandUSA Athabasca Unive.sity AthabascaCanada e.Te. European Space AgencyNetherlands Unive.sity of Saskatche.an SaskatoonCanada The.Johns Hopkins Unive.sity Applie. Physics Laboratory LaurelMarylandUSA Swe.ish Institude.of Space.Physics UppsalaSE 75121Sweden Tongji Unive.sity Shanghai 200092China Ce.te. for Space.Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Re.e.rch Institute.of China Shanghai 200136China Finnish Me.e.rological Institute.FMI) Finland De.artme.t of e.rth and e.vironme.tal Scie.ce.(Ge.physics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space.Age.cy MontrealCanada GFZ Ge.man Re.e.rch Ce.tre.for Ge.scie.ce. PotsdamGermany Nagoya Unive.sity Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria Unive.sity Newcastle upon TyneTyne and WearUK NE18ST National Space.Scie.ce.Ce.te. Chinese Academy SciencesBeijing 100190China Arctic Ge.physics University Centre in Svalbard

The.joint e.rope.n Space.Age.cy and Chine.e.Acade.y of Scie.ce. Solar wind Magne.osphe.e.Ionosphe.e.Link e.plore.(SMILe.mission will e.plore.global dynamics of the.magne.osphe.e.unde. varying solar wind and inte.plane.ary magne.ic fie.d conditions,and simultane.usly monitor the.auroral re.ponse.of the.Northe.n He.isphe.e.*** the.e.large.scale.re.ponse. with me.ium and fine.scale.me.sure.e.ts at a varie.y of cade.ce. by additional ground-base. and space.base. instrume.ts will e.able.a much gre.te. scie.tific impact be.ond the.original goals of the.SMILe.***,we.de.cribe.curre.t community e.forts to pre.are.for SMILe.and the.be.e.its and conte.t various e.pe.ime.ts that have.e.plicitly e.pre.se. support for SMILe.can offe..A de.icate. group of inte.national scie.tists re.re.e.ting many diffe.e.t e.pe.ime.t type. and ge.graphical locations,the.Ground-base. and Additional Scie.ce.Working Group,is facilitating the.e.*** include.constructing an online.SMILe.Data Fusion Facility,the.discussion of particular or spe.ial mode. for e.pe.ime.ts such as cohe.e.t and incohe.e.t scatte. radar,and the.conside.ation of particular obse.ving strate.ie. and space.raft *** anticipate.growing inte.e.t and community e.gage.e.t with the.SMILe.mission,and we.we.come.nove. ide.s and insights from the.solar-te.re.trial community.

关键词： magne.osphe.e ionosphe.e magne.osphe.e.ionosphe.e.coupling ground-base. e.pe.ime.tation SMILe conjunctions missions

Mutation of autophagy-re.ate. ge.e.ATG7 incre.se. the.risk of se.e.e.dise.se.in patie.ts with non-alcoholic fatty live. dise.se

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Live. Re.e.rch 2023年第4期7卷 365-366页

作者： mary Miu Ye. Waye The.Ne.he.sole.School of Nursing Croucher Laboratory for Human GenomicsThe Chinese University of Hong KongHong KongChina

Non-alcoholic fatty live. dise.se.NAFLD)is the.most common chronic live. dise.se.*** me.hanism of NAFLD has be.n we.l studie. and it has be.n pre.iously re.orte. that the.e.are.some.pre.isposing ge.e.ic polymorphisms of NAFLD,e.g.,ge.e. such as fat mass and obe.ity-associate.(FTO)ove.e.pre.sion,le.ding to triglyce.ide.accumulation,via upre.ulation of lipoge.ic ge.e. has be.n re.orte..1 An e.rlie. study of a 20-ge.e.se. publishe. in 2014 has be.n corre.ate. with NAFLD se.e.ity.2 Adiposity plays an important role.in the.amplification of the.ge.e.ic risk of NAFLD-including thre. variants:PNPLA3,TM6SF2,and GCKR ge.e..

关键词： NAFLD live. patie.ts

Tuning inte.facial inte.actions for bottom-up asse.bly of surface.anchore. me.al-organic frame.orks to tailor film morphology and patte.n surface.fe.ture.

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Aggregate

Aggre.ate 2022年第4期3卷 131-140页

作者： Christine.D.Fasana Fabiola G.Gonzale. Jonathan W.Wade.Ashle. M.We.ks B.Dulani Dhanapala mary e.Ande.son De.artme.t of Che.istry Furman UniversityGreenvilleSouth CarolinaUSA

Surface.anchore. me.al-organic frame.orks(surMOFs)inte.rate.nanoporous supramole.ular MOF mate.ials dire.tly into archite.ture. for applications such as gas storage.che.ical se.sing,and e.e.gy ***-by-laye. solution-phase.de.osition of the.MOF-14 compone.ts(1,3,5-tris(4-carboxyphe.yl)be.ze.e.and coppe.(II)dime.s,re.pe.tive.y)produce. a porous and conformal film on carboxylte.minate. se.f-asse.ble. monolaye.s(SAMs).In this re.e.rch,the.formation of ultrathin(le.s than 25 nm)surMOF films on code.osite. bicompone.t SAMs and microcontact printe. SAMs is inve.tigate. by atomic force.microscopy,e.lipsome.ry,infrare. spe.troscopy,and contact angle.*** compose. of me.hyl-te.minate. alkane.hiols asse.ble. on gold substrate. inhibit surMOF formation,whe.e.s carboxyl-te.minate. alkane.hiols promote.MOF-14-base. film *** tune.the.de.sity of carboxyl groups that anchor the.film,me.hyl-and carboxylte.minate. alkane.hiols of varying conce.trations are.code.osite. on *** syste.atic study de.onstrate. how surMOF film formation and morphology are.impacte. by the.e.SAMs with mixe. surface.*** patte.ning me.hods for SAMs,such as microcontact printing(μCP),commonly have.mixe. che.ical functionalitie. within ce.tain re.ions of the.*** gaine. re.arding how mixe. surface.functionalitie. affe.t surMOF film formation are.applie. he.e.n to optimize.the.CP me.hod to produce.che.ically patte.ne. SAMs that se.e.tive.y dire.t surMOF asse.bly to produce.high-quality surMOF film fe.ture..

关键词： atomic force.microscopy microcontact printing MOF-14 se.f-asse.ble. monolaye.s surface.anchore. me.al-organic frame.orks

Impact loading in fe.ale.runne.s with single.and multiple.bone.stre.s injurie. during fre.h and e.e.te. conditions

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Journal of Sport and He.lth Scie.ce 2023年第3期12卷 406-413页

作者： Kristin L.Popp Je.e.e.Oute.le.s Sarah Ge.man Margare. Garrahan Sara Rudolph e.izabe.h Lorange. Kathryn e.Acke.man Adam S.Te.forde.mary L.Bouxse.n Ire.e.S.Davis Military Pe.formance.Division United States Army Research Institute of Environmental MedicineNatickMA 01760USA e.docrine.Unit Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA De.artme.t of Physical Me.icine.and Re.abilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolCambridgeMA 02138USA De.artme.t of Sports Me.icine Boston Children's HospitalHarvard Medical SchoolBostonMA 02115USA Ce.te. for Advance. Orthope.ic Studie. Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA

Background:Bone.stre.s injurie.(BSIs)are.common in fe.ale.runne.s,and re.urre.t BSI rate. are.*** work sugge.ts an association be.we.n highe. impact loading during running and tibial ***,it is unknown whe.he. impact loading and fatigue.re.ate. loading change. discriminate.wome. with a history of multiple.*** study compare. impact variable. at the.be.inning of a tre.dmill run to e.e.tion andthe.change. in those.variable. with e.e.tion among fe.ale.runne.s with no history of BSI as we.l as among those.with a history of single.or multiple.***:We.e.rolle. 45 fe.ale.runne.s(age. 18-40 ye.rs)for this cross-se.tional study:having no history of diagnose. lowe. e.tre.ity BSI(N-BSI,n=14);a history of 1 lowe. e.tre.ity BSI(1-BSI,n=16);and diagnose. by imaging,or a history of multiple.>3)lowe. e.tre.ity BSIs(M-BSI,n=15).Participants comple.e. a 5-km race.spe.d run on an instrume.te. tre.dmill while.we.ring an Ine.tial Me.sure.e.t *** ve.tical ave.age.loading rate.VALR),ve.tical instantane.us loading rate.VILR),ve.tical stiffne.s during impact via instrume.te. tre.dmill,and tibial shock de.e.mine. as the.pe.k po sitive.tibial acce.e.ation via Ine.tial Me.sure.e.t Unit we.e.me.sure. at the.be.inning and the.e.d of the.***:The.e.we.e.no diffe.e.ce. be.we.n groups in VALR,VILR,ve.tical stiffne.s,or tibial shock in a fre.h or e.e.te. ***,compare. to N-BSI,wome. with M-BSI had gre.te. incre.se.with e.e.tion in VALR(-1.8%vs.6.1%,p=0.01)and VILR(1.5%vs.4.8%,p=0.03).Similarly,compare. to N-BSI,ve.tical stiffne.s incre.se. more.with e.e.tion among wome. with M-BSI(-0.9%vs.7.3%,p=0.006)and 1-BSI(-0.9%vs.1.8%,p=0.05).Finally,compare. to N-BSI,the.incre.se.in tibial shock from fre.h to e.e.te. condition was gre.te. among wome. with M-BSI(0.9%vs.5.5%,p=0.03)and 1-BSI(0.9%vs.11.2%,p=0.02).Conclusion:Wome. with 1-BSI or M-BSIs e.pe.ie.ce.gre.te. e.e.tion-re.ate. incre.se. in impact loading than wome. with *** obse.vations impl

关键词： Biome.hanics Bone.stre.s injurie. Fatigue Runne.s Stre.s fracture

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A Room of His Own

中国翻译 1995年第2期 62-63页

作者： mary e.Potte.

Unmistakable.noise. are.coming throughmy be.room wall. Now a scuffling, now abumping, a long, drawn-out scraping"John, are.you moving furniture.in the.e. A-gain?" I call. The.wall muffle. his "ye." butdoe. not filte. ... 详细信息

关键词： A Room of His Own