Cancer cells are highly proliferative,invasive,metastatic and initiate *** activities demand plentiful energy and bountiful stores of anabolic precursors,a situation that puts significant strain on metabolic pathways ...
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Cancer cells are highly proliferative,invasive,metastatic and initiate *** activities demand plentiful energy and bountiful stores of anabolic precursors,a situation that puts significant strain on metabolic pathways and necessitates juggling of finite ***,the location and erratic structural organisation of tumours means they reside in a nutrient-poor *** glycolytic phenotype has evolved in cancer cells to provide a suitable balance between bioenergetic and biosynthetic *** this adopted strategy also support the overexpression of an ATP-dependent transporter(P-glycoprotein)to maintain resistance against chemotherapy?This article highlights the metabolic adaptations used by cancer cells to maintain both a glycolytic phenotype and sustain the activity of *** argue that these cells negotiate an energy precipice to achieve these ***,we advocate the use of compounds that place resistant cells expressing P-glycoprotein under further metabolic strain and how uncoupling protein-2 may provide an ideal target for them.
Biochar,an environmentally friendly soil conditioner,is produced using several thermochemical *** has unique characteristics like high surface area,porosity,and surface *** paper reviews the fertilizer value of biocha...
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Biochar,an environmentally friendly soil conditioner,is produced using several thermochemical *** has unique characteristics like high surface area,porosity,and surface *** paper reviews the fertilizer value of biochar,and its effects on soil properties,and nutrient use efficiency of *** serves as an important source of plant nutrients,especially nitrogen in biochar produced from manures and wastes at low temperature(≤400℃).The phosphorus,potassium,and other nutrient contents are higher in manure/waste biochars than those in crop residues and woody *** nutrient contents and pH of biochar are positively correlated with pyrolysis temperature,except for nitrogen *** improves the nutrient retention capacity of soil,which depends on porosity and surface charge of *** increases nitrogen retention in soil by reducing leaching and gaseous loss,and also increases phosphorus availability by decreasing the leaching process in ***,for potassium and other nutrients,biochar shows inconsistent(positive and negative)impacts on *** addition of biochar,porosity,aggregate stability,and amount of water held in soil increase and bulk density ***,biochar increases soil pH and,thus,influences nutrient availability for *** also alters soil biological properties by increasing microbial populations,enzyme activity,soil respiration,and microbial ***,nutrient use efficiency and nutrient uptake improve with the application of biochar to ***,biochar can be a potential nutrient reservoir for plants and a good amendment to improve soil properties.
Hematological malignancies are usually life-limiting *** of care need to be decided early,based on acceptability to the patient,family,physician,and *** intensive care unit(ICU)admission is likely to result in signifi...
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Hematological malignancies are usually life-limiting *** of care need to be decided early,based on acceptability to the patient,family,physician,and *** intensive care unit(ICU)admission is likely to result in significant physical,psychological,and economic *** is little published on the impact of non-acute preadmission disease factors on ICU outcomes in hematological ***:To identify baseline performance and disease-associated factors before admission to ICU in patients with hematological malignancy that contribute to subsequent ICU ***:A retrospective analysis of electronic medical records,laboratory results,and Intensive Care data for all patients(n=184)with hematological malignancy admitted to the Calvary Mater Hospital ICU between January 1,2013 and June 30,2017 was *** age,gender,condition,Eastern Cooperative Oncology,and Charlson Comorbidity scores were compared to ICU outcome and overall ***-specific prognostic risk scores were compared to ICU ***:Overall,73.9%survived the ICU admission,with 31.6%surviving at 12 *** ejection fractions(>55%)and prognosis>12 months(based on disease-specific risk scores)were significantly associated with overall survival(P=0.024 and P=0.001).Induction and posttransplantation therapy were predictive of poor ICU survival outcome(P<0.0001 and P=0.041).APACHE scores were significant predictors of ICU mortality(P=0.002 for APACHE II and P<0.0001 for APACHE III).Conclusion:Survival outcomes for patients with hematological malignancy admitted to the ICU correlate with functional and comorbidity ***-specific prognostic scores can assist in recognizing patients likely to benefit from ICU admission.
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