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A Validated Model for the Imaging Diagnosis of cystic Lung Disease

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增加DWI检查可优化MRI对软组织肉瘤肿瘤边缘浸润性的评估

Open Journal of Radiology（放射学期刊） 2023年第1期

作者： Wallace T. Miller1 Karen c. Patterson2 3 Shweta Sood2 James E. Schmitt4 Arshad A. Wani2 Robert Borden5 Maya Galperin-Aisenberg4 mary K. Porteus2 Michelle L. Hershman4 Michael Hewitt4 Jennifer Levy4 Victor D. Babatunde4 Tetiana Glushko6 Timothy J. Niesen4 Sergey Leshchinskiy4 Karine Sahakyan7 Keyur Desai4 Jennifer A. Gillman4 Sandeep Reddy4 Michael Shriver4 Nathaniel B. Linna4 Abass M. Noor4 Aysenur Buz8 Matthew E. Biron4 Scott Simpson4

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国际医学放射学杂志 2019年第4期 497-497页

作者：金莹莹 J.H.Hong W.H.Jee c.K.Jung J.Y.Jung S.H.Shin Y.G.chung Department of Radiology Seoul St.Mary ’s HospitalCollege of Medicine The Catholic University of Korea

摘要目的研究传统3 T MR成像基础上增加扩散加权成像(DWI)在软组织肉瘤(STS)边界浸润性评估中的价值。材料与方法本回顾性研究经机构伦理委员会批准通过。本

关键词： DWI MRI 浸润性肿瘤边缘

东方遇见西方:增龄性骨骼肌肉疾病的临床实践和策略

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中华骨质疏松和骨矿盐疾病杂志 2019年第5期12卷 432-455页

作者：夏维波 cyrus cooper 李梅徐苓 Rene Rizzoli 朱梅林华 John Beard 丁悦余卫 Etienne cavalier 章振林 John A.Kanis 程群王秋梅 Jean-Yves Reginster 冯亦鸣(翻译) 中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室 MRc Lifecourse Epidemiology Unit Southampton General HospitalUniversity of SouthamptonSouthamptonUK NIHR Musculoskeletal Biomedical Research Unit University of OxfordOxfordUK WHO collaborating centre for Public Health Aspects of Musculoskeletal Health and Aging LiegeBelgium 中国医学科学院北京协和医学院北京协和医院妇产科 Division of Bone Diseases Geneva University HospitalsFaculty of MedicineGenevaSwitzerland 天津医科大学总医院内分泌科南京大学医学院附属鼓楼医院骨科 Department of Aging and Lifecourse World Health Organization(WHO)GenevaSwitzerland 中山大学孙逸仙纪念医院骨科中国医学科学院北京协和医学院北京协和医院放射科 Department of clinical chemistry University of LiègeLiegeBelgium 上海交通大学附属第六人民医院骨质疏松和骨病专科 mary McKillop Health Institute Australian Catholic UniversityMelbourneAustralia centre for Metabolic Bone Diseases University of Sheffield Medical SchoolSheffieldUK 复旦大学附属华东医院骨质疏松科中国医学科学院北京协和医学院北京协和医院老年科 Division of Public Health Epidemiology and Health EconomicsUniversity of Liège4000 LiegeBelgium chair for Biomarkers of chronic Diseases Biochemistry DepartmentCollege of ScienceKing Saud UniversityRiyadhKingdom of Saudi Arabia 中国医学科学院北京协和医学院

健康老龄化是指人在维持良好身体功能、保证生活质量前提下的衰老过程。这个过程能否实现取决于机体固有能力,一方面包括心理、生理能力,另一方面包括机体所处环境以及二者的相互作用。在老龄化进程中,骨骼肌肉健康是维持老年人身体功... 详细信息

健康老龄化是指人在维持良好身体功能、保证生活质量前提下的衰老过程。这个过程能否实现取决于机体固有能力,一方面包括心理、生理能力,另一方面包括机体所处环境以及二者的相互作用。在老龄化进程中,骨骼肌肉健康是维持老年人身体功能的重要条件。全球肌少症、骨质疏松症和骨关节炎等老龄化相关的骨骼肌肉疾病及机体失能所致的负担正在增加,因此随着人口老龄化的加剧,防治这类疾病也尤为重要。以此为契机,中华医学会、中华医学会骨质疏松和骨矿盐疾病分会、欧洲骨质疏松和骨关节炎临床经济学会联合开设论坛,共同探讨增龄性肌肉骨骼疾病的现行临床诊治策略。本次会议邀请了中国和欧洲的专家到场,分享这3种疾病的临床诊治经验;双方通过经验交流、讨论异同以取长补短,从而实现对疾病的更佳防治,维持老年人的自身能力、延缓老龄化带来的身体功能退化。展望未来,希望双方经验及最佳临床实践的交流能推进全球战略,以减轻肌肉骨骼疾病的负担,促进符合个体化需求的健康老龄进程。

关键词：骨关节炎骨质疏松症肌少症 FRAX 预防治疗

Robotic versus laparoscopic liver resection for huge (≥10 cm) liver tumors: an international multicenter propensity-score matched cohort study of 799 cases

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 205-215,I0005页

作者： Tan-To cheung Rong Liu Federica cipriani Xiaoying Wang Mikhail Efanov David Fuks Gi-Hong choi Nicholas L.Syn charing c.N.chong Fabrizio Di Benedetto Ricardo Robles-campos Vincenzo Mazzaferro Fernando Rotellar Santiago Lopez-Ben James O.Park Alejandro Mejia Iswanto Sucandy Adrian K.H.chiow Marco V.Marino Mikel Gastaca Jae Hoon Lee TPeter Kingham Mathieu D’Hondt Sung Hoon choi Robert P.Sutcliffe Ho-Seong Han chung-Ngai Tang Johann Pratschke Roberto I.Troisi Go Wakabayashi Daniel cherqui Felice Giuliante Davit L.Aghayan Bjorn Edwin Olivier Scatton Atsushi Sugioka Tran cong Duy Long constantino Fondevila Mohammad Abu Hilal Andrea Ruzzenente Alessandro Ferrero Paulo Herman Kuo-Hsin chen Luca Aldrighetti Brian K.P.Goh International robotic and laparoscopic liver resection study group investigators Department of Surgery Queen Mary HospitalThe University of Hong KongHong Kong SARChina Faculty of Hepatopancreatobiliary Surgery The First Medical Center of Chinese People’s Liberation Army(PLA)General HospitalBeijingChina Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityShanghaiChina Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Scientific CenterMoscowRussia Department of Digestive Oncologic and Metabolic SurgeryInstitute Mutualiste MontsourisUniversite Paris DescartesParisFrance Division of Hepatopancreatobiliary Surgery Department of SurgerySeverance HospitalYonsei University College of MedicineSeoulKorea Department of Hepatopancreatobiliary and Transplant Surgery Singapore General Hospital and Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong Kong SARChina HPB Surgery and Liver Transplant Unit University of Modena and Reggio EmiliaModenaItaly Department of General Visceral and Transplantation SurgeryClinic and University Hospital Virgen de la ArrixacaIMIB-ARRIXACAMurciaSpain HPB Surgery Hepatology and Liver TransplantationFondazione IRCCS Istituto Nazionale Tumori di MilanoMilanItaly HPB and Liver Transplant Unit Department of General SurgeryClinica Universidad de NavarraUniversidad de NavarraPamplonaSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Hepatobiliary and Pancreatic Surgery Unit Department of SurgeryDr.Josep Trueta HospitalIdIBGiGironaSpain Hepatobiliary Surgical Oncology Department of SurgeryUniversity of Washington Medical CenterSeattleWAUSA The Liver Institute Methodist Dallas Medical CenterDallasTXUSA AdventHealth Tampa Digestive Health InstituteTampaFLUSA Hepatopancreatobiliary Unit Department of SurgeryChangi General

Background:The use of laparoscopic(LLR)and robotic liver resections(RLR)has been safely performed in many institutions for liver tumours.A large scale international multicenter study would provide stronger evidence and insight into application of these techniques for huge liver tumours≥10 ***:This was a retrospective review of 971 patients who underwent LLR and RLR for huge(≥10 cm)tumors at 42 international centers between ***:One hundred RLR and 699 LLR which met study criteria were *** comparison between the 2 approaches for patients with huge tumors were performed using 1:3 propensity-score matching(PSM)(73 vs.219).Before PSM,LLR was associated with significantly increased frequency of previous abdominal surgery,malignant pathology,liver cirrhosis and increased median *** PSM,RLR and LLR was associated with no significant difference in key perioperative outcomes including media operation time(242 vs.290 min,P=0.286),transfusion rate rate(19.2%vs.16.9%,P=0.652),median blood loss(200 vs.300 mL,P=0.694),open conversion rate(8.2%vs.11.0%,P=0.519),morbidity(28.8%vs.21.9%,P=0.221),major morbidity(4.1%vs.9.6%,P=0.152),mortality and postoperative length of stay(6 vs.6 days,P=0.435).conclusions:RLR and LLR can be performed safely for selected patients with huge liver tumours with excellent *** was no significant difference in perioperative outcomes after RLR or LLR.

关键词： Laparoscopic liver resection(LLR) robotic liver resection(RLR) hepatocellular carcinoma colorectal liver metastases huge

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使用桡动脉脉搏传输波分析预测动脉增强指数

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 51-51页

作者： Lau E.O.Y. Tse H.-F. c.-P.Lau 雷聪 cardiology Division(Academic) Queen Mary HospitalBlock K102 Pokfulam RoadHong KongProf

Objective: current arterial transfer functions have low capability in predicti ng aortic augmentation index(AIx) from radial pulse contour(RPc), because of the difficulty in accurately identifying the merging point(inflection point) in the derived aortic pulse contour(APc). We hypothesize that the formation time betwe en each characteristic wave in APc is about one-third of ejection duration(ED/3 ). We sought to assess the accuracy of ED/3 in identifying the merging point in APc as compared to the conventional differential method. In addition, we sought to derive the AIx from RPc based on an arterial transfer function and the ED/3 m ethod. Methods: APc and RPc sequences were measured digitally and simultaneously in 60 subjects(37 males; aged 60±10 years). An ensemble-averaged RPcto-APc t ransfer function was determined from 30 randomly selected subjects and was used to derive APc sequences in the 30 additional subjects. The accuracy of AIx predi cted from RPc was determined. Results: In patients with a clearly identifiable m erging point in APc, the ED/3 method identified the merging point of measured AP c within 1.97±0.60 ms of that identified by the conventional differential metho d, with identical AIx. The AIx and merging point of derived APc using the ED/3 m ethod were also within 0.22±1.01%and 1.81±1.64 ms, respectively, of those of the measured APc using the conventional differential method. The accuracy of the predicted AIx was independent of age, sex, body-mass index and presence of hyp ertension. conclusion: In a quiet resting state, the ED/3 is an alternative meth od for identifying the merging point in APc. In conjunction with transfer-funct ion technique, AIx can be derived accurately from RPc.

关键词：脉搏波形增强指数桡动脉预测波分析传统鉴别方法 APc 受试者

与慢性烧伤相关的有长期银屑病病史的原发性cD30+皮肤T细胞淋巴瘤1例

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 28-28页

作者： Yeung c.-K. chan H.H.-L W.Y. Au 牛新武 University Department of Medicine Queen Mary Hospital Pokfulam Road Hong Kong Hong Kong

An increased incidence of lymphoma has been reported in psoriatic patients, but most cases are nodal B-cell lymphoma. We report a unique case of cD30-expressing cutaneous T-cell lymphoma arising from underlying psoriatic plaque after intractable caustic burns and cellulitis in the palm of a patient with generalized chronic plaque psoriasis. Molecular studies confirmed a localized clonal T-cell expansion, and the lesion responded dramatically tomultiagent chemotherapy. The case highlighted the possible role of chronic systemic and local T-cell activation in the pathogenesis of primarycD30+V6 cutaneous T-cell lymphoma, and the importance of histologic assessment in chronic nonhealing skin lesions.

关键词：银屑病 cD30 淋巴瘤克隆增殖慢性系统性化疗药物蜂窝组织炎结节性发病机制

采用前路和后路经肩胛下肌注射时,3.0 TMR关节成像对肩胛下肌肌腱撕裂的诊断能力

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国际医学放射学杂志 2017年第3期 361-361页

作者： J.Y.Jung W.H.Jee c.W.chun Y.S.Kim 王芳 Department of Radiology Seoul St.Mary’s HospitalCollege of Medicine The Catholic University of Korea

摘要目的比较前路和后路经肩胛下肌注射时,3.0 T MR关节成像对肩胛下肌肌腱撕裂(ScT)的诊断能力。方法167例关节镜确诊的病人被纳入研究(84例前路注射,83例后路注射)。2位专家回顾性为肩胛下肌肌腱撕裂评分。计算MR关节成像和关节镜正... 详细信息

摘要目的比较前路和后路经肩胛下肌注射时,3.0 T MR关节成像对肩胛下肌肌腱撕裂(ScT)的诊断能力。方法167例关节镜确诊的病人被纳入研究(84例前路注射,83例后路注射)。2位专家回顾性为肩胛下肌肌腱撕裂评分。计算MR关节成像和关节镜正确分级的比例,进行回顾性误差分析。结果前路注射时,专家1诊断敏感度为80%(24/30),特异度为72%(39/54);专家2诊断敏感度为73%(22/30),特异度为76%(41/54)。后路注射时,专家1诊断敏感度为86%(30/35),特异度为79%(38/48);专家2诊断敏感度为80%

关键词：肩胛下肌后路诊断能力关节运动器官肌腱前路 TMR

VMD2剪接调节子突变导致小眼球和常染色体显性玻璃体视网膜脉络膜病

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世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 40-40页

作者： Yardley J. Leroy B.P. Hart-Holden N. G.c.M. Black 肖颖 Department of clin ical Genetics St Mary's Hospital Hathersage Road Manchester M13 0JH United Kingdom

PURPOSE. To investigate the genetic basis of autosomal dominant vitreoretinoch oroidopathy (ADVIRc), a rare, inherited retinal dystrophy that may be associated with defects of ocular development, including nanophthalmos. METHODS. A combina tion of linkage analysis and DNA sequencing in five families was used to identif y disease-causing mutations in VMD2. The effect of these mutations on splicing was assessed using a minigene system. RESULTS. Three pathogenic sequence alterat ions in VMD2 were identified in five families with nanophthalmos associated with ADVIRc. All sequences showed simultaneousmissense substitutions and exon skippi ng. cONcLUSIONS. VMD2 encodes bestrophin, a transmembrane protein located at the basolateral membrane of the RPE, that is also mutated in Best macular dystrophy . We support that each heterozygous affected individual produces three bestrophi n isoforms consisting of the wild type and two abnormal forms: one containing a missense substitution and the other an in-frame deletion. The data showed that VMD2 mutations caused defects of ocular patterning, supporting the hypothesized role for the RPE, and specifically VMD2, in the normal growth and development of the eye.

关键词：脉络膜病小眼球玻璃体视网膜 VMD2 常染色体调节子卵黄样黄斑变性连锁分析法外显子跳跃测序法

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静脉应用硫酸镁治疗急性哮喘的meta分析

世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 21-21页

作者： cheuk D. K. L. chau T. c. H. Lee S. L. 高蕊 Dept. of Pediat. and Adol. Medicine Queen Mary Hospital University of Hong Kong 121 Pokfulam Road Hong Kong Hong KongDr.

Aim: To evaluate the effectiveness of intravenous magnesium sulphate in the tr eatment of acute asthmatic attacks in children by meta-analysis. Methods: A sys tematic and comprehensive search of the literature was performed to identify con trolled clinical trials of magnesiumsulphate in paediatric acute asthma which ev aluated outcomes of hospitalisation or short term pulmonary function tests or sy mptom scores. Unpublished data were searched by personal contacts with authors a nd specialists. Two reviewers independently assessed trial qualities and synthes ised data. Heterogeneity among studies was evaluated by the cochrane Q test. Out come data were pooled by random or fixed effect models depending on presence or absence of heterogeneity. Results: Five randomised placebo controlled trials inv olving a total of 182 patients were identified. They compared intravenous magnes ium sulphate to placebo in treating paediatric patients with moderate to severe asthmatic attacks in the emergency department, with co-therapies of inhaled β2 agonists and systemic steroids. The studies were of high quality with results j udged to be valid. Four studies showed that magnesium sulphate was effective, wh ile one study found it ineffective. There was no significant heterogeneity in th e primary outcome of hospitalisation. In the fixed effect model, magnesium sulph ate is effective in preventing hospitalisation (OR 0.290, 95%cI 0.143 to 0.5 89). The number needed to treat is 4 (95%cI 3 to 8). Secondary outcomes of shor t term pulmonary function tests and clinical symptom scores also showed signific ant improvement. conclusion: Intravenous magnesium sulphate probably provides ad ditional benefit in moderate to severe acute asthma in children treated with bro nchodilators and steroids.

关键词：硫酸镁治疗 meta分析急性哮喘肺功能检测肺功能检查重度哮喘自身对比随机对照试验临床症状评分安慰剂