检索结果-南通市图书馆

Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

引用

Bioactive Materials 2019年第1期4卷 43-55页

作者： Abdulrahman A.Balhaddad Anmar A.Kansara Denise Hidan Michael D.Weir Hockin H.K.Xu mary anne s.melo Ph.D.Program in Biomedical sciences University of Maryland School of DentistryBaltimoreMD21201USA Division of Biomaterials&Tissue Engineering Department of Advanced Oral Sciences and TherapeuticsUniversity of Maryland School of DentistryBaltimoreMD21201USA Department of Restorative Dental sciences Imam Abdulrahman Bin Faisal UniversityCollege of DentistryDammamSaudi Arabia Department of Restorative Dentistry Umm Al-Qura UniversityCollege of DentistryMakkahSaudi Arabia Division of Operative Dentistry Dept.of General DentistryUniversity of Maryland School of DentistryBaltimoreMD21201USA

Millions of people worldwide suffer from a toothache due to tooth cavity,and often permanent tooth *** caries,also known as tooth decay,is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings(tooth colored fillings).Until now,restorative polymeric fillings present no *** complexity of oral biofilms contributes to the difficulty in developing effective novel dental *** has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related ***-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative *** bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against caries-related *** has been suggested that this bioactivity could minimize the incidence of caries around restorations(CARs)and increase the longevity of such filling *** last few years witnessed growing numbers of studies on the preparation evaluations of these novel ***,the caries disease process and the role of pathogenic caries-related biofilm,the increasing incidence of CARs,and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are *** highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.

关键词： Dental materials Bioactive Nanoparticles Dental caries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Revisiting cerebral endothelial cells in Alzheimer’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

引用

Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extended Evolutionary Fast Learn-to-Walk Approach for Four-Legged Robots

引用

Journal of Bionic Engineering 2007年第4期4卷 255-263页

作者： Muh. Anshar mary-anne Williams Innovation and Technology Research Laboratory Faculty of Information Technology University of Technology Sydney City Campus 15 Broadway Ultimo NSW 2007 Australia

Robot locomotion is an active research area. In this paper we focus on the locomotion of quadruped robots. An effective walking gait of quadruped robots is mainly concerned with two key aspects, namely speed and stability. The large search space of potential parameter settings for leg joints means that hand tuning is not feasible in general. As a result walking parameters are typically determined using machine learning techniques. A major shortcoming of using machine learning techniques is the significant wear and tear of robots since many parameter combinations need to be evaluated before an optimal solution is found. This paper proposes a direct walking gait learning approach, which is specifically designed to reduce wear and tear of robot motors, joints and other hardware. In essence we provide an effective learning mechanism that leads to a solution in a faster convergence time than previous algorithms. The results demonstrate that the new learning algorithm obtains a faster convergence to the best solutions in a short run. This approach is significant in obtaining faster walking gaits which will be useful for a wide range of applications where speed and stability are important. Future work will extend our methods so that the faster convergence algorithm can be applied to a two legged humanoid and lead to less wear and tear whilst still developing a fast and stable gait.

关键词： legged-robots locomotion learning genetic convergence walking gaits

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vortex quasi-crystals in mesoscopic superconducting samples

引用

Chinese Physics B 2016年第8期25卷 361-368页

作者：王璟琨张威 sde melo C A R Department of Physics Renmin University of China Beijing Key Laboratory of Opto-electronic Functional Materials and Micro-nano Devices Renmin University of China school of Physics Georgia Institute of Technology

There seems to be a one to one correspondence between the phases of atomic and molecular matter（AMOM） and vortex matter（VM） in superfluids and superconductors. Crystals, liquids, and glasses have been experimentally observed in both AMOM and VM. Here, we propose a vortex quasi-crystal state which can be stabilized due to boundary and surface energy effects for samples of special shapes and sizes. For finite sized pentagonal samples, it is proposed that a phase transition between a vortex crystal and a vortex quasi-crystal occurs as a function of magnetic field and temperature as the sample size is reduced.

关键词： vortex matter quasi-crystal mesoscopic superconductor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Proximal and distal esophageal sensitivity is decreased in patients with Barrett’s esophagus

引用

World Journal of Gastroenterology 2011年第4期17卷 514-521页

作者： anne L Kraru sφren s Olesen Peter Funch-Jensen Hans Gregersen Asbjφrn M Drewes Mech-sense Department of Gastroenterology Aalborg Hospital Aarhus University Hospital Department of surgery L Aarhus University Hospital

AIM: To investigate sensations to multimodal pain stimulation in the metaplastic and normal parts of the esophagus in patients with Barrett’s esophagus (BE). METHODs: Fifteen patients with BE and 15 age-matched healthy volunteers were subjected to mechanical, thermal and electrical pain stimuli of the esophagus. Both the metaplastic part and the normal part (4 and 14 cm, respectively, above the esophago-gastric junction) were examined. At sensory thresholds the stimulation intensity, referred pain areas, and evoked brain potentials were recorded. REsULTs: Patients were hyposensitive to heat stimulation both in the metaplastic part [median stimulation time to reach the pain detection threshold: 15 (12-34) s vs 14 (6-23) s in controls; F = 4.5, P = 0.04] and the normal part of the esophagus [median 17 (6-32) s vs 13 (8-20) s in controls; F = 6.2, P = 0.02]. Furthermore, patients were hyposensitive in the metaplastic part of the esophagus to mechanical distension [median volume at moderate pain: 50 (20-50) mL vs 33 (13-50) mL in controls; F = 5.7, P = 0.02]. No indication of central nervous system abnormalities was present, as responses were comparable between groups to electrical pain stimuli in the metaplastic part [median current evoking moderate pain: 13 (6-26) mA vs 12 (9-24) mA in controls; F = 0.1, P = 0.7], and in the normal part of the esophagus [median current evoking moderate pain: 9 (6-16) mA, vs 11 (5-11) mA in controls; F = 3.4, P = 0.07]. Furthermore, no differences were seen for the referred pain areas (P-values all > 0.3) or latencies and amplitudes for the evoked brain potentials (P-values all > 0.1). CONCLUsION: Patients with BE are hyposensitive both in the metaplastic and normal part of esophagus likely as a result of abnormalities affecting peripheral nerve pathways.

关键词： Barrett’s esophagus Heat Multimodal Pain sensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Heterogeneity of mature oligodendrocytes in the central nervous system

引用

Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo anne stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

s1P: the elixir of life for naive T cells

引用

Cellular & Molecular Immunology 2018年第7期15卷 657-659页

作者： Michaël Pérès anne Montfort Nathalie Andrieu-Abadie Céline Colacios Bruno ségui INsERM UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouse 31037France Facultéde pharmacie UniversitéToulouse III Paul-SabatierToulouse 31062France Laboratoire d’hématologie CHU de ToulouseToulouse 31059France Equipe Labellisée Ligue Contre Le Cancer Toulouse 31037France Correspondence:Professor B SéguiPhDINSERMUMR1037 CRCTCentre de Recherches en Cancérologie de Toulouse2 avenue Hubert CurienToulouse 31037France

During their life,T cells are constantly circulating throughout the ***-1-phosphate(s1P),a sphingolipid metabolite,triggers T cell egress from the thymus and secondary lymphoid organs(sLO)into the lymph and the *** phenomenon is dependent on the s1P gradient between lymphoid organs(including thymus and sLO)and the lymphatic and blood vessels,which exhibit low,intermediate and high s1P levels,respectively.T cells follow the s1P gradient via the engagement of the G-protein-coupled receptor s1P receptor 1(s1P1)expressed on T cells.1 s1P production is regulated by various sphingolipid-metabolizing *** sphingosine kinases 1 and 2(sKs),encoded by sphk1 and sphk2,phosphorylate the sphingosine(sph)into ***,s1P can be dephosphorylated to sph by s1P phosphatases 1 and 2,encoded by sgpp1 and ***,s1P can be irreversibly degraded by the s1P Lyase(sPL),encoded by sgpl1,into phosphoethanolamine and hexadecenal.

关键词： organs al. lymphoid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Coarse corn particles cause a negative effect on eggshell quality of semi-heavy laying hens

引用

Animal Nutrition 2019年第4期5卷 432-434页

作者： Vanessa R.M.Oliveira Alex M.V.Arruda Aurora s.melo Davyd H.souza Joao B.F.souza-Junior Raimunda T.V.Fernandes Joao P.A.F.Queiroz Department of Animal sciences Universidade Federal Rural do Semi-AridoMossoro 59625900Brazil Department of Animal science Federal University of CearaFortalezaCEP 60455-760Brazil

One of the possible ways to optimize the productive performance of poultry is through the physical processing of ingredients,which can improve the use of nutrients in these *** this context,this study was to evaluate the effects of different corn particle sizes in diets on the productive performance and egg quality of semi-heavy laying *** naked neck laying hens were used from 24 weeks of age and distributed in a completely randomized *** diets in different treatments contained corn grain ground into sieves with a diameter of 2,4,or 8 mm to provide corn particles with a geometric mean diameter(GMD) of 605(fine),1,030(medium),and 2,280 μm(coarse),*** feed and leftovers were weighed daily throughout the experimental period to determine the feed intake and feed *** corn particle sizes did not affect any aspect of the productive performance of hens,except for feed *** fed fine and medium corn particles exhibited higher values for egg yolk color,eggshell weight,and eggshell *** is suggested that semi-heavy laying hens should be fed mash diets containing corn particles with GMD from 605 to 1,030 μm,because coarse corn particles cause a negative effect on eggshell quality.

关键词： Egg quality Geometric mean diameter Productive performance Poultry nutrition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：