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Neuromyelitis optica spectrum disorders and anti-myelin oligodendrocyte glycoprotein positive optic neuropathies

International Journal of Ophthalmology(English edition) 2022年第7期15卷 1095-1107页

作者： Patrick Murtagh Amy Coman Kirk stephenson Maria Gaughan David Ryan Graeme McNeill Christopher McGuigan lorraine Cassidy Royal Victoria Eye and Ear Hospital Adelaide RoadDublin 2D02 XK51Republic of Ireland st Vincent’s University Hospital Elm ParkDublin 4D04 N2E0Republic of Ireland

AIM: To describe the clinical characteristics and treatments associated with antibody positive optic neuropathies including anti-myelin oligodendrocyte glycoprotein(MOG) and anti-aquaporin 4(AQP4), alongside diagnostic modalities, investigations, and outcomes. METHODs: A cross-sectional single-centre retrospective case series consisting of 16 patients including 12 antiMOG positive patients and 4 anti-AQP4 positive patients. Each of these patients had clinical signs and symptoms of optic neuritis and consisted of all patients who had a positive blood antibody result in our centre. Clinical findings including presence of a relative afferent pupillary defect, colour vision and disc assessment were recorded. structured clinical exam and multimodal imaging was undertaken sequentially on each. Optical coherence tomography(OCT) scanning was preformed to examine the correlation between ganglion cell layer(GCL) thickness and visual acuity(VA) at presentation and as a determinant of final visual outcome in both groups. Initial and long-term treatment is also summarised. REsULTs: A total of 16 patients were included in the study consisting of 12 anti-MOG and 4 anti-AQP4 positive patients. Nine of the 16 patients were female and the average age of onset was 29.2 y in the MOG group and 42 y in the AQP4 group. There was no statistically significant correlation(Pearson correlation) between GCL thickness and presenting and final VA [r(10)=0.081, P=0.08 and r(10)=0.089, P=0.34 respectively]. The same statistical analysis was performed for the correlation between retinal nerve fibre layer(RNFL) and VA and similar outcomes wereobserved [r(10)=0.04, P=0.22 and r(10)=0.09, P=0.04]. No correlation was seen for initial RNFL thickness and final visual outcome in this group either [r(2)=0.19, P=0.38]. Visual field testing and radiological findings for each group are described. CONCLUsION: No correlation between initial VA or RNFL and final visual outcome is identified. A broad range of visu

关键词： neuromyelitis anti-myelin oligodendrocyte glycoprotein antibody anti-aquaporin 4

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Reflections on Advanced Practice of Nurse Administered ECT as a Treatment Resource during the COVID-19 Pandemic

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Open Journal of Nursing 2021年第11期11卷 909-919页

作者： lorraine Bastick Tracey shrimpton The Treatment Centre Northampton Healthcare NHS foundation Trust Berrywood Hospital Northampton UK

Background: With Electro-Convulsive Therapy (ECT) during the COVID-19 pandemic at risk, nurse administered ECT has become a treatment resource. This study aims to investigate the experiences of two senior ECT nurses p... 详细信息

strong>Background:strong> With Electro-Convulsive Therapy (ECT) during the COVID-19 pandemic at risk, nurse administered ECT has become a treatment resource. This study aims to investigate the experiences of two senior ECT nurses practicing Nurse Administered ECT. strong>Method: strong>Qualitative reflective interviews were conducted;the data was then analyzed and presented as corresponding themes for inductive data driven analysis. Each nurse was asked to recall positive and negative events from their practice and describe how their experiences have enabled them to cope. strong>Results:strong> Theme 1: The nurse’s competence is positively influenced by feedback, leading to enhancement of personal and professional development. Theme 2: During the COVID-19 pandemic, nurses report an increased sense of teamwork among staff, and feel that “we are all in this together”. Theme 3: The nurse’s ability to manage difficult situations is dependent on their education, individual knowledge, and experience.strong> Limitations: strong>The authors had the role of both researcher and participant.strong> Conclusion: strong>This study found that both nurses valued feedback above any medical and technical skills they had acquired. This strengthened their advanced practice enabling them to handle difficult situations with confidence. The COVID 19 pandemic has led to advanced nursing practice replacing the junior doctor role within ECT treatment. The nurses felt this had been recognised by their organisation and has led to an increased pride in their work. This paper would suggest that Nurse administered ECT is a valuable resource and that, future nurses could be at the forefront of delivering ECT services.

关键词： ECT Nurse Administered ECT

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A sea Turtle＇s Quiet Miracle

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英语沙龙（高中） 2014年第5期 56-57页

作者： lorraine A. Jay

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Atypical electrocardiographic manifestations of ischemia: a case of dynamic Wellens patterns

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Journal of Geriatric Cardiology 2018年第11期15卷 710-712页

作者： Alex Tsz Lai Ngan RN Cynthia Yeung lorraine Chiang Tong LIU Gary Tse Ka Hou Christien Li Department of Medicine and Therapeutics Faculty of Medicine Chinese University of Hong Kong Hong Kong China Li Ka shing Institute of Health sciences Faculty of Medicine Chinese University of Hong Kong Hong Kong China Department of Medicine Queen's University Kingston Ontario Canada Li Ka shing Faculty of Medicine University of Hong Kong Hong Kong China Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University Tianjin China Faculty of Medicine Newcastle University NewcastleUK

A 55-year-old male with hypertension, hyperlipidemia, impaired fasting glucose, obesity, gout, and osteoarthritis, statin-induced myopathy, but no known cardiac disease, presented with a one day history of intermittent exertional chest discomfort without radiation. symptoms included sweating, dyspnea, dizziness, and upper limb numbness.

关键词： Dynamic pattern Ischemia Wellens

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Cross-scale modeling of surface temperature and tree seedling establishment in mountain landscapes

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Ecological Processes 2013年第1期2卷 313-327页

作者： John R Dingman Lynn C sweet Ian McCullough Frank W Davis Alan Flint Janet Franklin lorraine E Flint Earth Research Institute University of California Santa BarbaraSanta BarbaraCA 93106USA U.s.Geological survey California Water Science CenterSacramentoCA 95819USA Bren school of Environmental science&Management University of California Santa BarbaraSanta BarbaraCA93106USA school of Geographical sciences and Urban Planning Arizona State UniversityTempeAZ85287USA

Introduction:Estimating surface temperature from above-ground field measurements is important for understanding the complex landscape patterns of plant seedling survival and establishment,processes which occur at heights of only several ***,future climate models predict temperature at 2 m above ground,leaving ground-surface microclimate not well ***:Using a network of field temperature sensors and climate models,a ground-surface temperature method was used to estimate microclimate variability of minimum and maximum *** lapse rates were derived from field temperature sensors and distributed across the landscape capturing differences in solar radiation and cold air drainages modeled at a 30-m spatial ***:The surface temperature estimation method used for this analysis successfully estimated minimum surface temperatures on north-facing,south-facing,valley,and ridgeline topographic settings,and when compared to measured temperatures yielded an R2 of 0.88,0.80,0.88,and 0.80,*** surface temperatures generally had slightly more spatial variability than minimum surface temperatures,resulting in R2 values of 0.86,0.77,0.72,and 0.79 for north-facing,south-facing,valley,and ridgeline topographic ***-Poisson regressions predicting recruitment of Quercus kelloggii(black oak)seedlings from temperature variables were significantly improved using these estimates of surface temperature compared to air temperature modeled at 2 ***:Predicting minimum and maximum ground-surface temperatures using a downscaled climate model coupled with temperature lapse rates estimated from field measurements provides a method for modeling temperature effects on plant *** methods could be applied to improve projections of species’range shifts under climate *** of complex topography can provide intricate microclimates that may allow species to redistribute locally as climate

关键词： Black oak Climate change Generalized linear models Microclimate Topography spatial scale surface temperature

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Mass data processing of time series Landsat imagery:pixels to data products for forest monitoring

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International Journal of Digital Earth 2016年第11期9卷 1035-1054页

作者： Txomin Hermosilla Michael A.Wulder Joanne C.White Nicholas C.Coops Geordie W.Hobart lorraine B.Campbella Integrated Remote sensing studio Department of Forest Resources ManagementUniversity of British ColumbiaVancouverBCCanada Canadian Forest service(Pacific Forestry Centre) Natural Resources CanadaVictoriaBCCanada

Free and open access to the Landsat archive has enabled the implementation of national and global terrestrial monitoring ***,we summarize a project characterizing the change history of Canada’s forested ecosystems with a time series of data representing *** the Composite2Change approach,we applied spectral trend analysis to annual best-available-pixel(BAP)surface reflectance image composites produced from Landsat TM and ETM+imagery.A total of 73,544 images were used to produce 29 annual image composites,generating∼400 TB of interim data products and resulting in∼25 TB of annual gap-free reflectance composites and change *** average,10%of pixels in the annual BAP composites were missing data,with 86%of pixels having data gaps in two consecutive years or *** detection overall accuracy was 89%.Change attribution overall accuracy was 92%,with higher accuracy for standreplacing wildfire and *** were assigned to the correct year with an accuracy of 89%.Outcomes of this project provide baseline information and nationally consistent data source to quantify and characterize changes in forested *** methods applied and lessons learned build confidence in the products generated and empower others to develop or refine similar satellite-based monitoring projects.

关键词： Remote sensing big data forest change monitoring image processing

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Plain cigarette packaging: A policy analysis of Australia’s integrated “whole-of-system” model for smoking cessation

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Health 2012年第12期4卷 1271-1275页

作者： lorraine Davies Erica Bell University Department of Rural Health University of Tasmania Hobart Australia

Introduction: Plain cigarette packaging as a tobacco control measure is to be implemented in Australia on December 1st 2012. There is mounting evidence for its likely impact on smokers and potential smokers. Yet Australia’s integrated model of smoking cessation and the particular role and opportunities it has created for primary healthcare have not yet been subject to policy analysis in leading international journals. This policy analysis paper explores these new Australian policy developments and debates in ways that identify their international relevance to primary healthcare. Policy analysis: There are 57 studies about plain cigarette packaging published since 2002. Of these, 27 looked at the impact of health warnings. These studies support the introduction of plain packaging as a tobacco control measure, by increasing the efficacy of health warnings and reducing misconceptions about cigarettes. However, the Australian tobacco control reforms are not limited to plain cigarette packaging. They include other evidence-based tobacco control measures as part of its primary health care strategy: for example, increasing tobacco excises, a mass media campaign focusing on high-risk and hard-to-reach groups, and a national summit on smoking in prisons. The Australian government has acknowledged the key role of primary health care in health promotion activities, establishing a network of regional primary health care organisations (“medicare locals”) in 2011-2012, and expanding the role of nurses in general practice. These initiatives offer general practice a chance to seize “golden opportunities to intervene with smoking patients”. Conclusions: Whether the combined impact of the Australian government’s recent tobacco control reforms and its previous measures will be sufficient to reduce daily smoking prevalence to 10% or less by 2020, only time will tell. What is more certain is that the Australian experience of plain packaging offers international colleagues in general pra

关键词： Tobacco Control Measures Primary Healthcare smoking Interventions smoking Cessation

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Postpartum meloxicam administration alters plasma haptoglobin, polyunsaturated fatty acid, and oxylipid concentrations in postpartum ewes

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Journal of Animal science and Biotechnology 2020年第4期11卷 1047-1060页

作者： Katie EOlagaray Barry J.Bradford lorraine M.sordillo Jeffery C.Gandy Laman K.Mamedova Turner H.swartz Trey D.Jackson Emma K.Persoon Caitlin s.shugart Curtis R.Youngs Department of Animal sciences and Industry Kansas State UniversityManhattan 66506USA College of Veterinary Medicine Michigan State University2265K Anthony HallEast LansingMI 48824-1225USA Department of Animal science Iowa State UniversityAmesIAUSA.

Background: Postpartum inflammation is a natural and necessary response;however, a dysfunctional inflammatory response can be detrimental to animal productivity. The objective of this study was to determine the effects of a non-steroidal anti-inflammatory drug(meloxicam) on ewe postpartum inflammatory response, ewe plasma polyunsaturated fatty acid and oxylipid concentrations, and lamb ***: After lambing, 36 Hampshire and Hampshire × suffolk ewes were sequentially assigned within type of birth to control(n = 17) or meloxicam orally administered on d 1 and 4 of lactation(MEL;90 mg, n = 19). Milk and blood samples were collected on d 1(prior to treatment) and d 4. Milk glucose-6-phosphate was not affected by MEL. Plasma haptoglobin(Hp) concentrations were less for MEL ewes;control ewes with greater d 1 Hp concentrations had elevated Hp on d 4, but this was not the case for MEL-treated ewes. Treatment with MEL increased plasma arachidonic acid concentration by more than 4-fold in ewes rearing singles but decreased concentrations of 9,10-dihydroxyoctadecenoic acid, prostaglandin F2α, 8-iso-prostaglandin E2, and 8,9-dihydroxyeicosatetraenoic acid. Nine oxylipids in plasma had interactions of treatment with d 1 Hp concentration,all of which revealed positive associations between d 1 Hp and d 4 oxylipid concentrations for CON, but neutral or negative relationships for MEL. MEL decreased 13-hydroxyoctadecadienoic acid:13-oxooctadecadienoic acid ratio and tended to increase 9-hydroxyoctadecadienoic acid:9-oxooctadecadienoic acid ratio(both dependent on d 1 values), indicating progressive metabolism of linoleic acid-derived oxylipids occurred by enzymatic oxidation after MEL treatment. Meloxicam reduced oxylipids generated across oxygenation pathways, potentially due to an improved redox ***: Postpartum MEL treatment of ewes decreased plasma concentrations of Hp and several oxylipids,with the greatest impact in ewes with biomarkers reflecting a greate

关键词： Eicosanoid Inflammation Lactation Nonsteroidal anti-inflammatory drug sheep

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高校外语教师概述策略教学元认知知识研究 1

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丛书名：上海外国语大学规划基金项目

2013年

作者：徐蔚 lorraine dagostino jamescarifio

本书梳理和总结了以高校外语教师用论说文教授概述策略时应具备的元认知知识为研究内容的学术专著建构与验证过程。

ISBN: (纸本)9787560851839

本书梳理和总结了以高校外语教师用论说文教授概述策略时应具备的元认知知识为研究内容的学术专著建构与验证过程。

关键词：外语教学教学研究高等学校

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使用NexION 300 ICP-Ms按照加利福尼亚州65号法案测定钙制酸剂和膳食补充剂中的铅

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岩矿测试 2010年第5期29卷 631-632页

作者： lorraine Foglio Lee Davidowski 美国PerkinElmer公司康涅狄格州谢尔顿06484

按照美国加利福尼亚州65号法案中对钙制酸剂和膳食补充剂中Pb的控制要求,分析方法对这类固体物质中铅的检出限要求低于0.05g/g。电感耦合等离子体质谱仪（ICP-Ms）的分析能力使其成为常规检测中低含量Pb测定的最佳仪器。但是,如果不采... 详细信息

按照美国加利福尼亚州65号法案中对钙制酸剂和膳食补充剂中Pb的控制要求,分析方法对这类固体物质中铅的检出限要求低于0.05g/g。电感耦合等离子体质谱仪（ICP-Ms）的分析能力使其成为常规检测中低含量Pb测定的最佳仪器。但是,如果不采用特定的预防措施消除潜在的问题，将是这些类型样品的分析挑战。

关键词：加利福尼亚州膳食补充剂 ICP-Ms 电感耦合等离子体质谱仪制酸测定法案铅

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