检索结果-南通市图书馆

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

钠与健康——一致与争议

英国医学杂志中文版 2021年第5期24卷 252-256页

作者： Cook Nancy R He Feng j MacGregor Graham A Graudal Niels 葛进(译) Division of Preventive Medicine Brigham and Women′s HospitalHarvard Medical SchoolBostonMAUSA Centre for Environmental and Preventive Medicine Wolfson Institute of Preventive MedicineBarts and London School of Medicine and DentistryQueen Mary University of LondonUK Copenhagen Lupus and Vasculitis Clinic Copenhagen University HospitalRigshospitaletCopenhagenDenmark 上海交通大学医学院附属仁济医院

Nancy Cook和同事阐述了人们就钠对健康影响有一致及不同意见的原因,以及如何解决这些问题。尽管已有多年对动物和人体的研究,但人们对盐(氯化钠)的作用仍有不同意见。钠存在于细胞外液,调节血容量与物质转运,对生命健康是至关重要的。... 详细信息

Nancy Cook和同事阐述了人们就钠对健康影响有一致及不同意见的原因,以及如何解决这些问题。尽管已有多年对动物和人体的研究,但人们对盐(氯化钠)的作用仍有不同意见。钠存在于细胞外液,调节血容量与物质转运,对生命健康是至关重要的。钠有许多生理功能,包括参与营养吸收及维持体液平衡。

关键词：细胞外液营养吸收体液平衡物质转运血容量氯化钠健康

Remarkable variation of ribosomal（rDNA） DNA in gnetophytes, a distinct lineage of gymnosperms

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remarkable variation of ribosomal（rDNA） DNA in gnetophytes...

微米级薄膜弯曲力学性能测量新技术及装置研制

中国植物学会第十六次全国会员代表大会暨85周年学术年会

作者： Wencai Wang Tao Wan Hannes Becher Alena Kuderova Ilia j.Leitch Sònia Garcia ANDrew R.Leitch Ale? Kova?ík Institute of Clinical Pharmacology Guangzhou University of Chinese Medicine School of Biological and Chemical Sciences Queen Mary University of London Key Laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical GardenShenzhen & Chinese Academy of Science Sino-Africa joint Research Center Chinese Academy of Science Institute of Biophysics Academy of Sciences of the Czech Republic jodrell Laboratory Royal Botanic Gardens

Gnetophytes,comprising genera Ephedra,Gnetum and Welwitschia are an understudied,enigmatic lineage of *** we examined the organization of ribosomal DNA（rDNA） across representative *** applied high throughput sequencing approaches to isolate and reconstruct rDNA units and to determine their intragenomic *** addition,fluorescent in situ hybridization（FISH） and Southern blot hybridization techniques were used to reveal the chromosome and genomic organization of *** found that:（i） the 5 S and 35 S rDNAs were separate in ***,*** and *** and linked in ***;（ii） there was huge variability variability in 5 S rDNA abundance（4,000-100,000 copies per haploid genome） and locus numbers（2-16 sites per diploid genome）;（iii） 5 S rRNA pseudogenes were interspersed between functional genes forming single unit in *** and ***;（iv） in *** internal transcribed spacers（ITS1） of 35 S rDNA were long and intrinsically repetitive while in *** and *** the ITS1 were short without *** conclusion,gnetophytes are distinctive from other gymnosperms and angiosperms as they display a surprisingly high variability in rDNA organization,rDNA copy and locus numbers between genera,with no relationship between copy numbers and genome sizes *** evolution of 5 S rDNA units seems to have led to the amplification of 5 S pseudogenes in both *** and *** patterns of rDNA show both gymnosperm and angiosperm features underlining diversity and distinctness of the group.

关键词： gnetophytes rDNA organization chromosome evolution high through-put sequencing concerted evolution pseudogenes intragenomic diversity

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

微米级薄膜弯曲力学性能测量新技术及装置研制

Ⅳ型胶原和CD44v6在良性卵巢肿瘤、恶性原发性卵巢癌及转移性卵巢癌中的表达:与Ki-67和p53免疫反应性的关系

2018年全国固体力学学术会议

作者：刘大彪李渊何玉明 D.j.Dunstan 华中科技大学力学系工程结构分析与安全评定湖北省重点实验室 School of Physics and Astronomy Queen Mary University of London

本文改进了经典的St?lken-Evans加-卸载微梁弯曲测量方案,基于非接触式表面轮廓仪,发展了一种高精度和宽量程的微梁弯曲测试技术,并研制了相关装置。采用该技术可以有效地消除传统微弯曲实验中的系统误差。装置的弯矩分辨率在0.1μNm量... 详细信息

本文改进了经典的St?lken-Evans加-卸载微梁弯曲测量方案,基于非接触式表面轮廓仪,发展了一种高精度和宽量程的微梁弯曲测试技术,并研制了相关装置。采用该技术可以有效地消除传统微弯曲实验中的系统误差。装置的弯矩分辨率在0.1μNm量级,表面应变的分辨率高达微应变量级。采用该装置对厚度为10-125μm的多晶镍薄膜进行了弯曲实验,结果表明:(1)该装置可以同时获得弹性区域、屈服点处和高塑性应变区域的数据,进而得到完整的弯矩-表面应变关系曲线;(2)对比不同厚度和不同晶粒尺寸的镍薄膜测量结果,发现晶粒尺寸效应和应变梯度效应之间存在相互作用,其关系强烈依赖于晶粒尺寸;(3)利用钝化/非钝化薄膜弯曲实验,验证了"应力跳跃"现象的存在性,为发展合理的应变梯度塑性理论提供了重要实验支撑。

关键词：应变梯度塑性尺度效应弯曲镍薄膜几何必需位错

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 44-45页

作者： Bar j.K. Grelewski P. Popiela A. 张剑萍

Loss of basement membrane(BM)components,such as type IV collagen has been demonstrated in ovarian cancer,but the associations with other mole cules like CD44v6,involved in metastatic process of ovarian carcinoma,have not been fully *** study i nvestigates the ex-pression of type IV collagen,CD44v6molecule in corre-lation with p53and Ki -67presence in primary and metastatic lesion of ovarian carcin oma to define their role in metastases of ovarian *** expression of type IV collagen,CD44v6,p53,and Ki -67was evaluated on frozen tissue sections from primary ovarian tumors(malignant n =37,benign n =16),metastatic lesions(n =29)and ascitic fluid cells(n =28).Protein ex-pression of all studied biomarkersw as evaluated in a subset of specimens using immunohistochem istry(IHC).Type IV collagen expression in the primary o varian carcinoma was positively correlated with International Federation ofGyne-cology andObstetrics(FIGO)-stage and tumor *** difference was observe d for type IV collagen immunoreactivity in carcinoma cell s in effusions when compared to corresponding primary t umors(Pmary ovarian carcinomas(P =0.01),ascitic fluid cells(Pmary carcinomas(51%)and metastatic lesions(52%).In cells isolated from ascitic fluid,CD44v6immunopositivity was observed in 43%of cases.A comparative analysis of primary and metastatic tumors and carcinoma cells in effusion did not reveal differences in expression of *** of CD44v6was found in 2/16(12%)of benign ovarian *** were no significan t differences between CD44v6expression in benign neoplasms compared to pri-mary malignant tumors and metastase s(P>0.05).CD44v6expression in primary ovaria n carcinomas was as-sociated with higher t

关键词：良性卵巢肿瘤转移性卵巢癌 CD44v6 p53 免疫反应性癌转移原发病灶病理学分级组织学分型组织切片

器官移植受者皮肤癌的临床病理特征:一项回顾性病例对照研究

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 57-58页

作者： Harwood C.A. Proby C.M. McGregor j.M. 刘艳 Institute for Cell and Molecular Science Bart' s and the London Queen Mary' s School of Medicine and Dentistry University of London 4 Newark Street London E1 2AT United Kingdom Dr.

Background: Non- melanoma skin cancers (NMSCs) are increased in organ transplant recipients, but transplant and immunocompetent squamous and basal cell carcinomas (SCCs, BCCs) have not been compared previously in a single- center study. Objective: To compare clinicopathologic features of transplant and immunocompetent NMSCs. Methods: Consecutive transplant NMSCs (60 SCCs, 100 BCCs) and immunocompetent NMSCs (40 SCCs, 125 BCCs) presenting between 1995- 1997. Results: Transplant patients were 15 years younger at time of NMSC diagnosis compared with immunocompetent individuals, and transplant tumors were often more multiple and extra cephalic. Spindle cell morphology was more common in transplant SCCs, a superficial component was more common in transplant BCCs, and histologic features of HPV infection were overrepresented in transplant tumors. Outcome was worse for transplant SCCs but not transplant BCCs. Limitations: Histologic features required to identify HPV infection have not been validated. Conclusions: These findings have direct implications for clinical care. The increased frequency and distribution of transplant NMSCs underscore the importance of whole- body surveillance. Transplant SCCs, particularly those with diffuse spindle cell change, may require more aggressive management, whereas transplant BCCs do not. Finally, our data support differences in the pathogenesis of transplant NMSC, which may influence future preventive and therapeutic strategies.

关键词：器官移植受者病例对照研究组织学特征梭形细胞免疫活性单中心临床护理弥漫性发病机制

在线全文

学校读者我要写书评

暂无评论

转非病原病毒基因烟草对同源病毒的抗性研究

中国烟草科学 2000年第1期21卷 31-32页

作者：时焦中国农业科学院烟草研究所中国烟草总公司青州烟草研究所 mary Lou Edwards j.I.Cooper 中国农业科学院烟草研究所中国烟草总公司青州烟草研究所山东青州262500

采用 PAS- EL ISA法就转非病原病毒 (樱桃卷叶病毒 )基因烟草对同源病毒的抗性进行了研究。试验结果表明 ,染病烟叶冰冻后对 PAS- EL ISA检测结果无影响。人工接种试验结果显示 ,转基因烟草发病率较未转基因烟草低。 PAS- EL

关键词：樱桃卷叶病毒转基因烟草 PAS-ELISA 抗性研究

隐性营养不良性大疱性表皮松解症慢性伤口的左旋精氨酸代谢途径基因表达改变

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 23-24页

作者： Wessagowit V. Mallipeddi R. McGrath j.A. South A.F. 王琼 Tumour Biology Laboratory Cancer Research UK Clinical Centre Qu. Mary' s Sch. of Med. and Dent. Charterhouse Square London EC 1M 6BQ United Kingdom

Individuals with the severe, mutilating Hallopeau-Siemens form of recessive dystrophic epidermolysis bullosa (HSRDEB) have trauma-nduced blisters and skin erosions which often progress to wounds that are slow to heal. These chronic wounds cause considerable morbidity and there is an increased risk of squamous cell carcinoma arising in the wound margins. Currently, little is known about the keratinocyte cell biology in these wounds. Therefore, we compared the gene expression profiles of wound edge with nonwounded skin from two individuals with HS-RDEB. Trauma- induced wound sites had been present in both patients for more than 3 months. Hybridizations using DermArray. gene expression filters showed relative differences in gene expression between wounded and unwounded skin. Notably, there was a fivefold increase in expression of arginase-1 (ARG1) in the chronic wound samples. Expression of seven other genes relevant to L-arginine metabolism also showed differences greater than twofold. L- Arginine is known to have a critical role in the synthesis of nitric oxide as part of normal tissue repair. Although alterations in arginase isoenzymes have been detected previously in other chronic wounds (human and animal models),this is the first study to demonstrate differences in several components of the L-arginine metabolism pathway in chronic wounds, and the first to examine chronic wounds in HS-RDEB. The data show that the cascade of L- arginine metabolites is altered in HS-RDEB and the findings may provide new insight into the pathology of chronic wounds in this genodermatosis.

关键词：营养不良性慢性伤口左旋精氨酸代谢途径基因表达遗传性皮肤病皮肤水疱角质形成细胞致残性杂交检测

慢性丙型肝炎病人外周血单个核细胞产生IFN-γ水平的研究

在线全文

学校读者我要写书评

暂无评论

实用肝脏病杂志 1999年第3期4卷 163-164页

作者：戴炜马为民郭亚兵吕晓梅 j.Monjardino 深圳市东湖医院深圳518020 St. mary's Hospital Medical School London UK St.

抗-HCV对清除丙型肝炎病毒（HCV）感染几乎没有什么作用,而肝脏内的细胞毒性T细胞（CTLs）对表达HCV核心和外膜抗原的靶细胞具有溶解作用。在慢性HCV感染中辅助性T细胞1亚型（Th1）产生γ干扰素（IFN-γ）和IL-2促进T细胞增殖和MHC的表... 详细信息

抗-HCV对清除丙型肝炎病毒（HCV）感染几乎没有什么作用,而肝脏内的细胞毒性T细胞（CTLs）对表达HCV核心和外膜抗原的靶细胞具有溶解作用。在慢性HCV感染中辅助性T细胞1亚型（Th1）产生γ干扰素（IFN-γ）和IL-2促进T细胞增殖和MHC的表达,有助于HCV的清除。为探讨Th1细胞产生IFN-γ及其与HCV感染的关系。

关键词：单个核细胞慢性丙型 IFN-γ水平人外周血慢性HCV感染肝炎病毒辅助性T细胞细胞因子联合治疗细胞毒性

在线全文

学校读者我要写书评

暂无评论

Retinal emboli

World journal of Ophthalmology 2014年第4期4卷 124-129页

作者： Michelle j Kim Donald S Fong Kaiser Permanente Southern California Eye Monitoring Center Baldwin Park CA 91706United States

Retinal emboli are opacities identified in retinal arterioles and are often incidental findings on ophthalmic examination. They are generally composed of cholesterol, platelet-fibrin, or calcium and are thought to arise from carotid arteries, coronary arteries, or cardiac valves. In the general population, the estimated prevalence is 0.2% to 1.3%, and the estimated incidence is 0.9% to 2.9%. The transient nature of retinal emboli likely explains the variations between and within these reported figures. The strongest risk factor for retinal emboli is smoking, which has been reported consistently across many studies. Other likely risk factors include older age, hypertension, male sex, total cholesterol, coronary artery disease, and history of coronary artery bypass grafting. The presence of multiple risk factors, as is common in many patients, confers a higher risk for retinal emboli. Several studies suggest that retinal emboli predict an increase in stroke-related, all-cause, and possibly cardiovascular mortality. Due to these sequelae, patients often undergo further workup, most commonly carotid ultrasonography. However, given the low prevalence of significant carotid disease in patients with retinal emboli, further workup, such as carotid ultrasound, should be reserved for those with risk factors for carotid disease. All patients would benefit from medical optimization and coordinated care with the primary care physician.

关键词： Retinal emboli Hollenhorst plaque Stroke Carotid disease Cardiovascular disease