检索结果-南通市图书馆

现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, mary E. Flenniken, Ann M. ji, Xiao Teboul, Lydia Wong, Michael D. White, jacqueline K. Meehan, Terrence F. Weninger, Wolfgang j. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, james M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, james Daly, Mark j. Denegre, james M. Doe, Brendan Dolan, mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei johnson, Sara j. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. j. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas j. Ryder, Edward Samocha, Kaitlin E. Seavitt, john R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. justice, Monica j. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David j. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. Dept Mol Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada Mt Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA Med Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England mary Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcome Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinformat Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England Med Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada jackson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy Massachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst MIT & Harvard Program Med & Populat Genet Cambridge MA 02142 USA German Res Ctr Environm Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany German Mouse Clin D-85764 Neuherberg Germany Baylor Coll Med Dept Mol & Human Genet Houston TX 77030 USA Nanjing Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA IMPC San Anselmo CA 94960 USA Tech Univ Munich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany German Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developmental phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

引用

2015中国遗传学会大会

作者：贾仲林 Elizabeth j.Leslie Margaret E.Cooper Azeez Butali jennifer Standley jennifer Rigdon Satoshi Suzukil Ayana Gongorjav T.Enkhtur Shonkhuuz Nagato Natsume 石冰 mary L.Marazita jeffrey C.Murray 四川大学华西口腔医学院口腔疾病国家重点实验室 Department of Pediatrics University of Iowa 四川大学华西口腔医院唇腭裂外科 Center for Craniofacial and Dental Genetics Department of Oral BiologySchool of Dental MedicineUniversity of Pittsburgh Department of Oral Pathology Radiologyand MedicineCollege of DentistryUniversity of Iowa Divisionof Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of DentistryAichi-Gakuin University

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验... 详细信息

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验证唇腭裂全基因组关联研究Meta分析发现的6个显著相关的位点:rs742071(1p36),rs7590268(2p21),rs7632427(3p11.1),rs12543318(8q21.3),rs8001641(13q31.1)和rs7179658(15q22.2);同时对来自美国,蒙古,和菲律宾三个人群的713个病例,438个正常对照及485个核心家系在SPRY2基因下游200Kb的三个非编码保守区进行直接测序。我们发现rs8001641位点显著与欧洲人群非综合征型唇裂伴腭裂的发生相关((p=4 x 10-5,ORtransmission=1.86和95%CI:1.38-2.52)。我们还在亚洲和欧洲的病例中发现了一些位于保守区域的遗传变异,它们可帮助定位与唇腭裂发生风险相关的常见遗传变异。这项研究进一步证实了先前报道的rs8001641和欧洲人群唇腭裂之间的关联。

关键词：全基因组关联研究非综合征型口面裂

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Rolapitant预防术后恶心呕吐：一项前瞻性、双盲、安慰剂对照的随机试验

引用

麻醉与镇痛 2012年第4期8卷 23-30页

作者： Tong j. Gan jiezhun Gu Neil Singla Frances Chung Michael H. Pearman Sergio D. Bergese Ashraf S. Habib Keith A. Candiotti Yi Mo Susan Huyck mary R. Creed Marc Cantillon Rolapitant Investigation group 黄礼兵(译) 崔苏扬(校) Department of Anesthesiology Duke University Medical Center Durham North Carolina Department of Clinical Trials Statistics Duke Clinical Research Institute Durham North Carolina Lotus Clinical Research Inc. Arcadia California Department of Anesthesia University Health Network University of Toronto Toronto Ontario Canada Department of Anesthesia Jane Phillips Medical Center Bartlesville Oldahoma Department of Anesthesiology and Neurological Surgery Ohio State University Columbus Ohio Department of Anesthesiology Duke University Medical Center Durham North Carolina University of Miami Miami Florida tt Schering-Plough Research Institute Kenilworth New Jersey Duke Clinical Research Institute Durham North Carolina See the Appendix for a full listing of Rolapitant Investigation group participating investigators 不详

背景术后恶心呕吐（postoperativenauseaandvomiting，PONV）是一种常见的术后并发症。研究证实神经激肽．1（neurokinin一1，NK，）受体拮抗剂可以安全有效地用于预防和治疗人类PONV。Rolapitant（罗纳吡坦）为一种吸收迅速、半衰期相... 详细信息

背景术后恶心呕吐（postoperativenauseaandvomiting，PONV）是一种常见的术后并发症。研究证实神经激肽．1（neurokinin一1，NK，）受体拮抗剂可以安全有效地用于预防和治疗人类PONV。Rolapitant（罗纳吡坦）为一种吸收迅速、半衰期相当长（达180小时）的强效选择性NK、受体拮抗剂，潜在的药物相互作用低。我们对Rolapitant用于预防PONV高危人群的量效关系以及术后5天的预防迟发性IK）NV的效果进行了研究。方法这项关于Rolapitant的随机、多中心、双盲、有效剂量范围的研究设有安慰剂组和阳性对照组。纳入619例行开腹手术的成年妇女，基于PONV或晕动病史进行分层，分为6个研究组：Rolapitant口服剂量5mg组、20mg组、70nag组或200mg组；静注昂丹司琼4mg组或安慰剂组。主要研究终点：不考虑补救用药，拔管后24小时的无呕吐发生率。结果Rolapitant20mg、70mg或200mg组患者的术后24小时无呕吐发生率高于安慰剂组。Rolapitant剂量与主要转归呈线性相关。与安慰剂组相比，Rolapitant70mg和200mg组的呕吐次数明显更低（P≤0．001，对数秩和检验）。尽管术后24小时无呕吐次数在Rolapitant组和昂丹司琼对照组没有明显差异，但Rolapitant200mg组和70mg组的术后72小时和120小时无呕吐发生率更高（不考虑补救用药）。结论Rolapitant降低术后呕吐的疗效优于安慰剂，呈剂量依赖性地降低呕吐发生率。而且Rolapitant与安慰剂在不良反应方面没有差异。

关键词：术后恶心呕吐安慰剂对照随机试验预防双盲受体拮抗剂阳性对照组 PONV

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Validated Model for the Imaging Diagnosis of Cystic Lung Disease

引用

Open journal of Radiology 2023年第1期13卷 42-57页

作者： Wallace T. Miller Karen C. Patterson Shweta Sood james E. Schmitt Arshad A. Wani Robert Borden Maya Galperin-Aisenberg mary K. Porteus Michelle L. Hershman Michael Hewitt jennifer Levy Victor D. Babatunde Tetiana Glushko Timothy j. Niesen Sergey Leshchinskiy Karine Sahakyan Keyur Desai jennifer A. Gillman Sandeep Reddy Michael Shriver Nathaniel B. Linna Abass M. Noor Aysenur Buz Matthew E. Biron Scott Simpson Department of Radiology University of Botswana Gaborone Botswana Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia USA Brighton and Sussex Medical School Brighton England Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia USA Department of Radiologic Sciences Drexel University College of Medicine Philadelphia USA Department of Radiology Mercy Catholic Medical Center Philadelphia USA Department of Diagnostic Imaging School of Alpert Medical Brown University Providence USA Department of Radiology Goztepe Research and Training Hospital Istanbul Medeniyet University Istanbul Türkiye

Rationale and Objectives: Cystic lung disease may be accurately diagnosed by imaging interpretation of specialist radiologists, without other information. We hypothesized that with minimal training non-specialists could perform similarly to specialist physicians in the diagnosis of cystic lung disease. Methods: 72 cystic lung disease cases and 25 cystic lung disease mimics were obtained from three sources: 1) a prospective acquired diffuse lung disease registry, 2) a retrospective search of medical records and 3) teaching files. Cases were anonymized, randomized and interpreted by 7 diffuse lung disease specialists and 15 non-specialist radiologists and pulmonologists. Clinical information other than age and sex was not provided. Prior to interpretation, non-specialists viewed a short PDF training document explaining cystic lung disease interpretation. Results: Correct first choice diagnosis of 85%-88% may be achieved by high-performing specialist readers and 71%-80% by non-specialists and lower-performing specialists, with mean accuracies in the diagnosis of LAM (91%, p Conclusion: With specific but limited training, non-specialist physicians can diagnose cystic lung diseases from CT appearance alone with similar accuracy to specialists, correctly identifying approximately 75% of cases.

关键词： Lymphangioleiomyomatosis Histiocytosis Langerhans-Cell Idiopathic Interstitial Pneumonias Birt-Hogg-Dube Syndrome Lung Diseases Interstitial Diagnoses Differential

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

长期应用硫唑嘌呤的克罗恩病患者的随机、双盲、对照停药试验

引用

世界核心医学期刊文摘（胃肠病学分册） 2005年第10期1卷 26-26页

作者： Lémann M. mary j.-Y. Colombel j.-F. 王铮 Service de Gastroentérologie 1 Avenue Claude Vellefaux 75010 Paris France Dr.

Background&Aims: An open study reported that patientswith Crohn’s disease in remission who have taken azathioprine for longer than 3.5 years are at low risk of relapse when azathioprine is discontinued. To confirm this observation, we performed a multicenter, double-blind, noninferiority withdrawal study. Methods: Patients who were in clinical remission on azathioprine formary end point was clinical relapse at 18 months. Results: Forty patients were randomly assigned to receive azathioprine and 43 to receive placebo. Characteristics of patients at entry were similar in the 2 study groups. At 18 months, 3 patients had a relapse in the azathioprine group, and 9 had a relapse in the placebo group. Kaplan-Meier estimates of the relapse rate at 18 months were 8%±4%and 21%±6%, respectively. The hypothesis that placebo was inferior to azathioprine was not rejected (P =. 195). Among the baseline variables, C-reactive protein level >20 mg/L, time without steroids < 50 months, and hemoglobin level< 12 g/dL were found to be predictive of relapse in the multivariate analysis. Conclusions: This study shows that azathioprine withdrawal is not equivalent to continued therapy with azathioprine for maintenance of remission in patients with Crohn’s disease who have been in remission on azathioprine for < 3.5 years. Thus, azathioprine maintenance therapy should be continued beyond 3.5 years.

关键词：克罗恩病硫唑嘌呤复发率安慰剂临床缓解治疗疗程研究设计多变量分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

VISUAL DISABILITIES RELATED TO INTRAOCULAR LENS DESIGN

引用

Eye Science 1990年第Z1期15卷 36-39页

作者： Gerri Goodman Walter j.Stark john D.Gottsch Daniel Goodman Steven Olkowski A.E.Maumenee Ivan Escape Wilmer Ophthalmological Institute johns Hopkins University School of Medccine Baltimore Maryland U. S. A.

Intraoeular. lens implantation after cataract extraction has become a common practice in the United States. However, unwanted optical images can correet an otherwise successful surgery into one that causes patient dissatisfaction. Refinements in manufacturing design and finishing have greatly improved the quality of present day intraocular lenses, but there is continued interest in simulating the optics of the human crystalline *** will discuss the optical requirements of intraocular lenses and how these are influenced by optic design and dimension, and spectral transmission characteristics.

关键词： intraocular cataract otherwise implantation crystalline optic VISUAL continued finishing aberration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

非增强CT与和双能量CT结合可提高早期痛风的诊断

引用

国际医学放射学杂志 2019年第3期 369-370页

作者：曹娜娜 S.K.Lee j.Y.jung W.H jee j.j.Lee S.H.Park Department of Radiology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

摘要目的探讨痛风早期出现症状的第一跖趾关节的非增强CT(NCCT)对双能CT(DECT)的增值。方法连续记录115例有关节疼痛的病人,根据2015年EULAR/ACR标准

关键词： CT

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

乳腺特异性伽玛成像特征预测乳腺恶性病变

引用

国际医学放射学杂志 2019年第1期 126-127页

作者： E.K.Choi j.j.Im C.S.Park Y.A.Chung K.Kim j.K.Oh 周健 Department of Radiology Incheon St. Mary ’s HospitalCollege of MedicineThe Catholic University of Korea

摘要目的本研究旨在探讨近期诊断为恶性乳腺癌病人的乳腺特异性伽玛成像(BSGI)摄取特征。方法回顾性分析231例近期诊断为乳腺癌病人的术前BSGI数据。特征分

关键词：恶性病变乳腺钼靶摄影特异性

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Phase 3 trial of first generation protease inhibitor therapy for hepatitis C virus/human immunodeficiency virus coinfection

引用

World journal of Hepatology 2017年第4期9卷 217-223页

作者： Kenneth E Sherman Minhee Kang Richard Sterling Triin Umbleja Kristen Marks jennifer j Kiser Beverly Alston-Smith Wayne Greaves Adeel A Butt 无 Division of Digestive Diseases University of Cincinnati College of Medicine harvard T.h. Chan School of Public health Department of Gastroenterology Virginia Commonwealth University Division of Infectious Disease Weill Cornell Medical School University of Colorado School of Pharmacy NIAID-Division of AIDS Merck and Co Inc. University of Pittsburgh School of Medicine hamad healthcare Quality Institute the ACTG 5294 BIRTH Study Team

AIMTo evaluate efficacy/safety of hepatitis C virus (HCV) protease inhibitor boceprevir with pegylated interferon (PEG-IFN) alfa and weight-based ribavirin (RBV) in a phase 3 trial. METHODSA prospective, multicenter, phase 3, open-label, single-arm study of PEG-IFN alfa, weight-based RBV, and boceprevir, with a PEG-IFN/RBV lead-in phase was performed. The HCV/human immunodeficiency virus coinfected study population included treatment naïve (TN) and treatment experienced (TE) patients. Treatment duration ranged from 28 to 48 wk dependent upon response-guided criteria. All patients had HCV Genotype 1 with a viral load > 10000 IU/mL. Compensated cirrhosis was allowed. Sample size was determined to establish superiority to historical (PEG-IFN plus RBV) rates in sustained viral response (SVR). RESULTSA total of 257 enrolled participants were analyzed (135 TN and 122 TE). In the TN group, 81.5% were male and 54.1% were black. In the TE group, 76.2% were male and 47.5% were white. Overall SVR12 rates (HCV RNA P = 0.002). Among the TN, SVR12 was 42.1% among whites and 27.4% among blacks (P = 0.09). CONCLUSIONThe trial met its hypothesis of improved SVR compared to historical controls but overall SVR rates were low. All-oral HCV treatments will mitigate these difficulties.

关键词： Human immunodeficiency virus Hepatitis C virus Boceprevir Pegylated interferon alfa Ribavirin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自发性脑出血管理指南美国心脏协会／美国卒中协会针对医疗专业人员的指南

引用

国际脑血管病杂志 2015年第10期23卷 721-739页

作者： j. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok mary Cushman Gordon L. Fung joshua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆徐欣不详南京大学医学院附属鼓楼医院神经内科 210008

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定... 详细信息

目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索，检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见，采用美国心脏协会／美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南，重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。

关键词：美国心脏协会科学声明血压凝血功能障碍诊断脑出血脑室出血外科手术治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：