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World journal of Gastroenterology 2006年第22期12卷 3461-3465页

作者： Scott Grier Adrian KP Lim Nayna Patel jeremy FL Cobbold Howard C Thomas Isobel j Cox Simon D Taylor-Robinson Liver Unit St mary's Hospital Campus Faculty of MedicineImperial College LondonLondonUnited Kingdom Department of Imaging Sciences Hammersmith Hospital Campus Faculty of MedicineImperial College LondonLondonUnited Kingdom

Patients who are chronically infected with the hepatitis C virus often develop chronic liver disease and assessment of the severity of liver injury is required prior to considering viral eradication therapy. This article examines the various assessment methods currently available from gold standard liver biopsy to serological markers and imaging. Ultrasound is one of the most widely used imaging modalities in clinical practice and is already a first-line diagnostic tool for liver disease. Microbubble ultrasound contrast agents allow higher resolution images to be obtained and functional assessments of microvascular change to be carried out. The role of these agents in quantifying the state of hepatic injury is discussed as a viable method of determining the stage and grade of liver disease in patients with hepatitis C. Although currently confined to specialist centres, the availability of microbubble contrast-enhanced ultrasound will inevitably increase in the clinical setting.

关键词： Hepatitis C Microbubble contrast agents Ultrasound

Diversity in global gene expression and morphology across a watercress (Nasturtium officinale R. Br.) germplasm collection: first steps to breeding

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Horticulture Research 2015年第1期2卷 175-182页

作者： Adrienne C.Payne Graham j.j.Clarkson Steve Rothwell Gail Taylor Centre for Biological Sciences Institute for Life SciencesUniversity of SouthamptonSouthamptonSO171BJUK Vitacress Salads Ltd Lower Link FarmSt Mary BourneAndoverHampshireSP116DBUK

Watercress(Nasturtium officinale ***.)is a nutrient intense,leafy crop that is consumed raw or in soups across the globe,but for which,currently no genomic resources or breeding programme *** morphological,biochemical and functional genomic variation was identified for the first time in a newly established watercress germplasm collection,consisting of 48 watercress accessions sourced from contrasting global *** length,stem diameter and anti-oxidant(AO)potential varied across the *** variation was used to identify three extreme contrasting accessions for further *** in global gene expression was investigated using an Affymetrix Arabidopsis ATH1 microarray gene chip,using the commercial control(C),an accession selected for dwarf phenotype with a high AO potential(dwarfAO,called‘Boldrewood’)and one with high AO potential alone.A set of transcripts significantly differentially expressed between these three accessions,were identified,including transcripts involved in the regulation of growth and development and those involved in secondary *** particular,when differential gene expression was compared between C and dwarfAO,the dwarfAO was characterised by increased expression of genes encoding glucosinolates,which are known precursors of phenethyl isothiocyanate,linked to the anti-carcinogenic effects well-documented in *** study provides the first analysis of natural variation across the watercress genome and has identified important underpinning information for future breeding for enhanced anti-carcinogenic properties and morphology traits in this nutrient-intense crop.

关键词： breeding dwarf germplasm

Application of finite integration method: large deformations of tapered beam

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Application of finite integration method: large deformations...

在2个老年人群中线粒体DNA序列变异与血压水平相关

力学与工程——数值计算和数据分析2019学术会议

作者： j.j.Yang Y.Yuan j.L.Zheng P.H.Wen School of Traffic and Transportation Engineering Changsha University of Science and Technology School of Engineering and Materials Science Queen Mary University of London

The large deformations of tapered beams subjected to different kinds of forces are investigated by using the finite integration method in this paper. The geometry of the beams is assumed to be any functions of the natural coordinate. The nonlinear ordinary differential equation is numerically solved by using the finite integration method with iterative technique. The numerical scheme demonstrates that this direct integration scheme is of high accuracy and excellent convergence.

关键词： Nonlinear ordinary differential equation large deformations tapered beams finite integration method Lagrange series interpolation

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中华高血压杂志 2018年第11期26卷 1077-1077页

作者：刘青叶鹏 Thomas W Todd M Manini john A Kairalla mary M McDermott Carlos A. Vaz Fragoso Haiying Chen Roger A Fielding Abby C King Anne B Newman Gregory j

年龄相关的血压变化与多种不良健康转归有关。遗传因素被认为是与年龄相关的血压升高的影响因素,但仅有很少的基因位点被确定。研究者通过对线粒体基因组进行测序来检查线粒体基因组变异对血压的影响作用。

关键词：线粒体DNA 血压水平序列变异老年人群线粒体基因组基因组变异血压变化血压升高

Asia's first combined liver transplant and aortic valve replacement

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 86-87页

作者： chung yeung cheung kenneth s.h.chok oswald j.lee kevin s.lo see ching chan chung mau lo department of surgery queen mary hospitalhong kongChina department of surgery the university of hong konghong kongChina state key laboratory for liver research the university of hong konghong kongChina department of cardiothoracic surgery queen mary hospitalhong kongChina department of anesthesiology queen mary hospitalhong kongChina

To the editor:Liver transplantation is the only cure for patients with endstage liver *** is however an ultra-major surgery which is physiologically challenging to the cardiopulmonary function of the ***,in patients w... 详细信息

关键词： Asia’s first combined liver transplant and aortic valve replacement

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对华加征关税对美国意味着什么?

金融市场研究 2019年第8期79卷 96-97页

作者：玛丽·阿米蒂斯蒂芬·雷丁大卫·温斯坦谢华军纽约联邦储备银行研究和统计组

评估美对华新征关税的影响,一种方法是借鉴2018年美对华关税的最新经验。近期研究表明,2018年美对华加征关税致使美国普通家庭每年负担增加419美元。增加的负担由两部分组成,一是消费者面临的额外税收,二是无谓损失或效率损失。负担大... 详细信息

评估美对华新征关税的影响,一种方法是借鉴2018年美对华关税的最新经验。近期研究表明,2018年美对华加征关税致使美国普通家庭每年负担增加419美元。增加的负担由两部分组成,一是消费者面临的额外税收,二是无谓损失或效率损失。负担大小取决于关税如何影响中国出口商品的价格以及美国对进口商品的需求。

关键词：商品价格无谓损失

Reconsidering Melt-water Pulses 1A and 1B: Global Impacts of Rapid Sea-level Rise

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journal of Ocean University of China 2004年第2期3卷 183-190页

作者： j. Paul Liu john D. Milliman Department of Marine Earth and Atmosphere Sciences North Carolina State University Raleigh NC 27695 USASchool of Marine Science College of William and Mary Gloucester Point VA. 23062 USA

Re-evaluation of the post-glacial sea level derived from the Barbados coral-reef borings suggests slightly revised depth ranges and timing of melt-water pulses MWP-1A (96-76 m, 14.3-14.0 ka cal BP) and 1B (58-45 m, 11.5-11.2 ka cal BP), respectively. Ages of non-reef sea-level indicators from the Sunda Shelf, the East China Sea and Yellow Sea for these two intervals are unreliable because of the well-documented radiocarbon ( 14C) plateau, but their vertical clustering corresponds closely with MWP-1A and 1B depth ranges. Close correlation of the revised sea-level curve with Greenland ice-core data suggests that the 14C plateau may be related to oceanographic-atmospheric changes due to rapid sea-level rise, fresh-water input, and impaired ocean circulation. MWP-1A appears to have occurred at the end of Blling Warm Transition, suggesting that the rapid sea-level rise may have resulted from lateral heat transport from low to high-latitude regions and subsequent abrupt ice-sheet collapses in both North America-Europe and Antarctica. An around 70 mm a -1 transgression during MWP-1A may have increased freshwater discharge to the North Atlantic by as much as an order of magnitude, thereby disturbing thermohaline circulation and initiating the Older Dryas global cooling.

关键词： melt-water pulse MWP-1A sea-level 14C plateau coral reef Blling Transition

Global blue carbon accumulation in tidal wetlands increases with climate change

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National Science Review 2021年第9期8卷 145-155页

作者： Faming Wang Christian j.Sanders Isaac R.Santos jianwu Tang Mark Schuerch Matthew L.Kirwan Robert E.Kopp Kai Zhu Xiuzhen Li jiacan Yuan Wenzhi Liu Zhian Li Xiaoliang Research Station for Tropical Coastal Ecosystems Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems and the CAS Engineering Laboratory for Ecological Restoration of Island and Coastal Ecosystems South China Botanical Garden Chinese Academy of Sciences Center of Plant Ecology Core Botanical Gardens Chinese Academy of Sciences Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) State Key Laboratory of Estuarine and Coastal Research and Institute of Eco-Chongming East China Normal University National Marine Science Centre School of Environment Science and Engineering Southern Cross University Department of Marine Sciences University of Gothenburg Lincoln Centre for Water and Planetary Health School of Geography University of Lincoln Virginia Institute of Marine Science College of William and Mary Department of Earth and Planetary Sciences and Rutgers Institute of Earth Ocean and Atmospheric Sciences Rutgers University Department of Environmental Studies University of California Department of Atmospheric and Oceanic Sciences Fudan University CAS Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of Sciences

Coastal tidal wetlands produce and accumulate significant amounts of organic carbon(C) that help to mitigate climate change. However, previous data limitations have prevented a robust evaluation of the global rates and mechanisms driving C accumulation. Here, we go beyond recent soil C stock estimates to reveal global tidal wetland C accumulation and predict changes under relative sea level rise, temperature and precipitation. We use data from literature study sites and our new observations spanning wide latitudinal gradients and 20 countries. Globally, tidal wetlands accumulate 53.65(95%CI: 48.52–59.01)Tg C yr-1, which is ～30% of the organic C buried on the ocean floor. Modeling based on current climatic drivers and under projected emissions scenarios revealed a net increase in the global C accumulation by2100. This rapid increase is driven by sea level rise in tidal marshes, and higher temperature and precipitation in mangroves. Countries with large areas of coastal wetlands, like Indonesia and Mexico, are more susceptible to tidal wetland C losses under climate change, while regions such as Australia, Brazil, the USA and China will experience a significant C accumulation increase under all projected scenarios.

关键词： coastal wetlands blue C C burial rate global change

Twenty years of human immunodeficiency virus care at the Mayo Clinic:Past,present and future

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World journal of Virology 2016年第2期5卷 63-67页

作者： Nathan W Cummins Andrew D Badley mary j Kasten Rahul Sampath Zelalem Temesgen jennifer A Whitaker john W Wilson joseph D Yao john Zeuli Stacey A Rizza Division of Infectious Diseases Mayo ClinicRochester

The Mayo human immunodeficiency virus(HIV) Clinic has been providing patient centered care for persons living with HIV in Minnesota and beyond for the past 20 years. Through multidisciplinary engagement, vital clinical outcomes such as retention in care, initiation of antiretroviral therapy and virologic suppression are maximized. In this commentary, we describe the history of the Mayo HIV Clinic and its best practices, providing a "Mayo Model" of HIV care that exceeds national outcomes and may be applicable in other settings.

关键词： Human immunodeficiency virus/acquired immune deficiency syndrome Patient engagement Care Cascade Multidisciplinary care Minimally disruptive medicine

Structure of protein O-mannose kinase reveals a unique active site architecture

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Structure of protein O-mannose kinase reveals a unique activ...