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Practice patterns and outcomes of equivocal bone scans for patients with castration-resistant prostate cancer: Results from SEARCH

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Asian journal of Urology 2019年第3期6卷 242-248页

作者： Brian T.Hanyok mary M.Everist Lauren E.Howard Amanda M.De Hoedt William j.Aronson Matthew R.Cooperberg Christopher j.Kane Christopher L.Amling Martha K.Terris Stephen j.Freedland Urology Section Department of SurgeryVeterans Affairs Medical CenterDurhamNCUSA New York Medical College ValhallaNYUSA Department of Biostatistics and Bioinformatics Duke University School of MedicineDurhamNCUSA Urology Section Department of SurgeryVeterans Affairs Medical CenterGreater Los AngelesLos AngelesCAUSA Department of Urology University of California at Los Angeles Medical CenterLos AngelesCAUSA Departments ofUrology and Epidemiology&Biostatistics University of CaliforniaSan FranciscoCAUSA Urology Section Department of SurgeryVeterans Affairs Medical CenterSan FranciscoCAUSA Division of Urology Department of SurgeryUniversity of California at San Diego Medical CenterSan DiegoCAUSA Division of Urology Department of SurgeryOregon Health&Science UniversityPortlandORUSA Urology Section Division of SurgeryVeterans Affairs Medical CenterAugustaGAUSA Division of Urologic Surgery Department of SurgeryMedical College of GeorgiaAugustaGAUSA Division of Urology Department of SurgerySamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Center for Integrated Research in Cancer and Lifestyle Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA

Objective:To review follow-up imaging after equivocal bone scans in men with castration resistant prostate cancer(CRPC)and examine the characteristics of equivocal bone scans that are associated with positive follow-up ***:We identified 639 men from five Veterans Affairs Hospitals with a technetium-99m bone scan after CRPC diagnosis,of whom 99(15%)had equivocal *** with equivocal scans were segregated into“high-risk”and“low-risk”subcategories based upon wording in the bone scan *** follow-up imaging(bone scans,computed tomography[CT],magnetic resonance imaging[MRI],and X-rays)in the 3 months after the equivocal scan were *** were compared between patients with a positive *** follow-up imaging after an equivocal bone ***:Of 99 men with an equivocal bone scan,43(43%)received at least one follow-up imaging test,including 32/82(39%)with low-risk scans and 11/17(65%)with high-risk scans(p=0.052).Of follow-up tests,67%were negative,14%were equivocal,and 19%were *** those who underwent follow-up imaging,3/32(9%)low-risk men had metastases vs.5/11(45%)high-risk men(p=0.015).Conclusion:While 19%of all men who received follow-up imaging had positive follow-up imaging,only 9%of those with a low-risk equivocal bone scan had metastases versus 45%of those with *** preliminary findings,if confirmed in larger studies,suggest follow-up imaging tests for low-risk equivocal scans can be delayed while high-risk equivocal scans should receive follow-up imaging.

关键词： Castration-resistant prostate cancer Equivocal test result Bone scan Radiology report Follow-up imaging Neoplasm metastasis

Thalidomide ameliorates portal hypertension via nitric oxide synthase independent reduced systolic blood pressure

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World journal of Gastroenterology 2015年第14期21卷 4126-4135页

作者： Nicholas G Theodorakis Yining N Wang Vyacheslav A Korshunov mary A Maluccio Nicholas j Skill Division of Transplant Surgery Department of SurgerySchool of MedicineIndiana University School of Medicine University of Rochester

AIM: Portal hypertension is a common complication of liver cirrhosis and significantly increases mortality and *** reports have suggested that the compound thalidomide attenuates portal hypertension(PHT).However, the mechanism for this action is not fully *** hypothesis is that thalidomide destabilizes tumor necrosis factor α(TNFα) mR NA and therefore diminishes TNFα induction of nitric oxide synthase(NOS) and the production of nitric oxide(NO).To examine this hypothesis, we utilized the murine partial portal vein ligation(PVL) PHT model in combination with endothelial or inducible NOS isoform gene knockout ***: Wild type, inducible nitric oxide synthase(i NOS)-/- and endothelial nitric oxide synthase(e NOS)-/-mice received either PVL or sham surgery and were given either thalidomide or *** nitrate(total nitrate, NOx) was measured daily for 7 d as a surrogate of NO *** TNFα level was quantified by enzyme-linked immunosorbent ***α m RNA was quantified in liver and aorta tissue by reverse transcription-polymerase chain *** was determined by recording splenic pulp pressure(SPP) and abdominal aortic flow after 0-7 *** to thalidomide was determined by measurement of SPP and mean arterial pressure(MAP).RESULTS: SPP, abdominal aortic flow(Qao) and plasma NOx were increased in wild type and i NOS-/-PVL mice when compared to sham operated control *** contrast, SPP, Qao and plasma NOx were not increased in e NOS-/- PVL mice when compared to sham *** TNFα level in both sham and PVL mice was below the detection limit of the commercial ELISA ***, the effect of thalidomide on serum TNFα levels was undetermined in wild type, e NOS-/-or i NOS-/- *** acutely increased plasma NOx in wild type and e NOS-/- mice but not i NOS-/-***, thalidomide temporarily(0-90 min) decreased mean arterial pressure, SPP and Qao in wild type, e NOS-/- and i NOS-/- PVL mice, aft

关键词： Portal hypertension Thalidomide Nitric oxide Knock

Oxidative DNA Damage Is Elevated in Renal Patients Undergoing Haemodialysis

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Open journal of Preventive Medicine 2014年第6期4卷 421-429页

作者： Twyla Moffitt Florence Hariton Megan Devlin Peter j. Garrett mary P. A. Hannon-Fletcher A School of Health Sciences University of Ulster Newtownabbey UK Renal Unit Western Health and Social Care Trust Tyrone County Hospital Omagh UK

Background: End stage renal disease (ESRD) is associated with an increase in oxidative stress, cardiovascular disease and cancer. The main treatment for ESRD is haemodialysis (HD), which itself induces repetitive bouts of oxidative stress through membrane biocompatibility and endotoxin challenge. The resulting higher levels of reactive oxygen species in turn produce increased levels of oxidative DNA damage leading to genomic instability which may influence the higher risk of cancer reported in HD patients. Our aims were to measure levels of oxidative DNA damage in HD patients and in age and gender matched control volunteers. Methods: Thirty eight patients receiving HD in the Western Health and Social Services Trust (WHSCT) and 8 healthy volunteers were recruited. Volunteers gave informed consent and non-fasting morning blood samples were taken and assessed for DNA disruption using the comet assay modified to identify oxidative specific damage. Results: The HD patients had significantly elevated levels of alkaline DNA damage (19.46% ± 1.37% vs 3.86% ± 1.36% tail DNA, p < 0.05) and oxidative DNA damage formamidepyrimidine DNA glycosilase (5.81% ± 1.08% vs 1.23% ± 0.43% tail DNA, p < 0.01) and endonuclease III (6.04% ± 1.00% vs 1.98% ± 0.70% tail DNA, p < 0.01) compared to controls, respectively. A positive correlation was observed between the duration on dialysis (months) and levels of Endo III specific damage (p = 0.041). Conclusion: The significant increase in oxidative DNA damage and the positive correlation with duration of HD treatment and Endo III damage may contribute to the increased cancer risk observed in this patient group. Studies are required to investigate the best way to reduce this damage.

关键词： Haemodialysis Modified Comet Assay Oxidative DNA Damage

Effects of Planting Methods and Seed Density on Vegetable Yield and Nutrient Composition of <i>Solanum macrocarpon</i>and <i>Solanum scabrum</i>in Southwest Nigeria

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Food and Nutrition Sciences 2014年第13期5卷 1185-1195页

作者： mary K. Idowu Durodoluwa j. Oyedele Ojo Kolawole Adekunle Oluwole Olalekan Akinremi Bob Eilers Department of Crop Production and Protection Faculty of Agriculture Obafemi Awolowo University Ile-Ife Nigeria Department of Soil Science and Land Resources Management Faculty of Agriculture Obafemi Awolowo University Ile-Ife Nigeria Department of Soil Science University of Manitoba Winnipeg Canada

Two field studies were carried out using Solanum macrocarpon and Solanum scabrum to investigate the effects of planting methods and seed density required for optimum biomass yield and nutrient content in southwest Nigeria. Two planting methods (drilling and broadcasting), and two seed densities (4 and 8 table spoon full) were investigated as a 2×2×3 factorial experiment in randomized complete block design and replicated three times. Four seed spoons gave 25.78 kg seeds ha-1 for S. macrocarpon and 20.67 kg·seeds·ha-1 for S. scabrum. Significant highest S. macrocarpon shoots (2.75 kg·m-2) and Ca, K, Fe and Zn contents and S. scabrum (2.95 kg·m-2) and Zn content, were obtained with drilling and four spoons of seeds compared with broadcasting and 8 spoons of seeds. This treatment gave average values for N, P, K, Mg, Ca, Na, Fe, Zn, Mn, Cu, Ca/P and Na/K ratio were 2.79%, 0.03%, 3.37%, 1.64%, 0.02%, 300 mg·kg-1, 100 mg·kg-1, 300 mg·kg-1, 8 mg·kg-1, 1.22 and 0.008 for S. macrocarpon and 2.05%, 0.27%, 5.81%, 3.27%, 2.91%, 0.09%, 280 mg·kg-1, 52.99 mg·kg-1, 359.35 mg·kg-1 and 22.42 mg·kg-1, 11.63 and 0.016 for S. scabrum. It was concluded that planting in drilling made weeding, fertilizer application, irrigation and harvesting more effective rather than by broadcasting, and four spoons of seeds per 9 m-2 produced deep green and broader leaves and balanced nutrient contents than eight spoons of seeds.

关键词： Solanum macrocarpon Solanum scabrum Planting Method Seed Density and Nutrient Contents

Launching the imagination : 1st ed.

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Understanding the agronomic impacts of defoliation strategies in“Bulldog 805”Alfalfa+“Tifton 85”bermudagrass mixed stands

2002年

作者： mary Stewart.

CD-ROM entitled: Launching the imagination, volumes I, II, & combined / mary Stewart.

ISBN: (纸本)0072482842

CD-ROM entitled: Launching the imagination, volumes I, II, & combined / mary Stewart.

关键词： Design.

来源：畅想之星图书光盘版（南... 评论

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Grassland Research 2023年第4期2卷 251-259页

作者： Lisa L.Baxter justin C.Burt mary Kimberly Mullenix Sydney L.Payne Kaylyn R.Reagin Katie M.Mason Chris G.Prevatt jennifer j.Tucker Department of Crop and Soil Science University of GeorgiaTiftonGeorgiaUSA Department of Animal Science Auburn UniversityAuburnAlabamaUSA Department of Animal Science University of TennesseeKnoxvilleTennesseeUSA Beef Cattle and Forage Commodity Director Alabama Farmers Federation MontgomeryMontgomeryAlabamaUSA Department of Animal and Dairy Science University of GeorgiaTiftonGeorgiaUSA

Background:The incorporation of legumes,specifically alfalfa(Medicago sativa L.),into bermudagrass(Cynodon spp.)-based pasture systems in the southeastern United States has increased in recent years as an alternative to synthetic nitrogen(N)***:A small plot evaluation was conducted in Shorter,Alabama,and Tifton,Georgia,USA,to evaluate the impact of harvest height(HH)and harvest frequency(HF)on agronomic characteristics of alfalfa+bermudagrass mixtures in southeastern United ***:Results from both locations revealed that the longer the HF and the shorter the HH,the greater the alfalfa retention was in the stand(p<0.01).HH did not impact any of the reported nutritive value parameters,while longer HF resulted in lower total digestible nutrients,lower crude protein,higher acid detergent fiber,and lower 48 h in vitro dry matter digestibility(p<0.01).Both HH and HF impacted forage accumulation at both locations(p<0.01).HH resulted in different trends at each location,while longer frequencies generally increased forage ***:This research confirmed recent findings from comparable evaluations in the southeastern United States,in that increasing HH and decreasing HF improved alfalfa retention while having a negligible effect on nutritive value or forage accumulation.

关键词： alfalfa+bermudagrass mixtures defoliation management forage management

Inflammation,infection and coronary heart disease

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老年心脏病学杂志：英文版 2007年第3期4卷 135-136页

作者： Matthew j. Sorrentino Section of Cardiology Department of MedicineUniversity of Chicago Pritzker School of Medicine. 5841 S. Mary-land AveMC 6080ChicagoIllinois 60637 USA

　　It has become clear that inflammation is an important component of coronary heart disease. Atherosclerotic disease usually begins with injury to endothelial cells.……

关键词： LDL

Assessment of the knowledge, attitude and practice of rural women of northeast Nigeria on risk factors associated with cancer of the Cervix

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Health 2013年第9期5卷 1367-1371页

作者： Babatunji A. Omotara Shuaibu j. Yahya mary O. Amodu john S. Bimba Department of Community Medicine College of Medical Sciences University of Maiduguri Maiduguri Nigeria

Cervical cancer is the leading cancer-related cause of death among women in Nigeria. An estimated 70,700 new cases occur each year, representing one quarter of all female cancers in sub Saharan Africa. The magnitude of the problem has been under recognised and under prioritised compared with the competing health priorities of infectious diseases such as HIV/ AIDS, tuberculosis and malaria. Studies in the United States and Nigeria have indicated that the disease has the highest incidence among the lowest socio-economic groups especially residing in rural areas. The peak age for the disease has been shown to be within 35-45 years age group. Knowledge of the risk factors of the disease is deemed important in its early detection and prevention. The objective of this study was to assess the knowledge, attitude and practice of rural women with cancer of the cervix. A cross sectional descriptive study was conducted among 1600 rural women aged 15-55 years (randomly selected from 28 villages) who were interviewed using a structured questionnaire between April and june, 2010. The majority (82.2%) were married before the age of 20 years and 19.3% before 15 years, 40% in polygamous union, 22.6% have had 2 or more sexual partners, 71.3% were primi and grand multiparous, 7.5% have had previous treatment for STIs and 10.1% were on various types of contraceptive. 454 (28.4%) have heard of Ca cervix, 358 (22.4%) knew the location of the cervix. 2.3% had Pap smear test of which 72.6% were within 2 years. The majority (89.9%) will avail themselves for screening.

关键词： Risk Factors Cervical Cancer Rural Women North-Eastern Nigeria

Wastewater surveillance provides 10-days forecasting of COVID-19 hospitalizations superior to cases and test positivity:A prediction study

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Infectious Disease Modelling 2023年第4期8卷 1138-1150页

作者： Dustin T.Hill Mohammed A.Alazawi E.joe Moran Lydia j.Bennett Ian Bradley mary B.Collins Christopher j.Gobler Hyatt Green Tabassum Z.Insaf Brittany Kmush Dana Neigel Shailla Raymond Mian Wang Yinyin Ye David A.Larsen Department of Public Health Syracuse UniversitySyracuseNY13244USA Center for Environmental Health New York State Department of HealthAlbanyNYUSA CDC Foundation AtlantaGAUSA Department of Civil Structural and Environmental EngineeringUniversity at BuffaloBuffaloNYUSA School of Marine and Atmospheric Sciences Sustainability Studies DivisionStony Brook UniversityStony BrookNYUSA Institute for Advanced Computational Science Stony Brook UniversityStony BrookNYUSA New York State Center for Clean Water Technology Stony Brook UniversityStony BrookNYUSA School of Marine and Atmospheric Sciences Stony Brook UniversityStony BrookNYUSA Department of Environmental Biology State University of New York College of Environmental Science and ForestrySyracuseNYUSA Department of Epidemiology and Biostatistics School of Public HealthUniversity at AlbanyRensselaerNYUSA Department of Civil Engineering College of Engineering and Applied SciencesStony Brook UniversityStony BrookNYUSA

Background:The public health response to COVID-19 has shifted to reducing deaths and hospitalizations to prevent overwhelming health *** amount of SARS-CoV-2 RNA fragments in wastewater are known to correlate with clinical data including cases and hospital admissions for *** developed and tested a predictive model for incident COVID-19 hospital admissions in New York State using wastewater ***:Using county-level COVID-19 hospital admissions and wastewater surveillance covering 13.8 million people across 56 counties,we fit a generalized linear mixed model predicting new hospital admissions from wastewater concentrations of SARS-CoV-2 RNA from April 29,2020 to june 30,*** included covariates such as COVID-19 vaccine coverage in the county,comorbidities,demographic variables,and holiday ***:Wastewater concentrations of SARS-CoV-2 RNA correlated with new hospital admissions per 100,000 up to ten days prior to *** that included wastewater had higher predictive power than models that included clinical cases only,increasing the accuracy of the model by 15%.Predicted hospital admissions correlated highly with observed admissions(r¼0.77)with an average difference of 0.013 hospitalizations per 100,000(95%CI¼[0.002,0.025])Interpretation:Using wastewater to predict future hospital admissions from COVID-19 is accurate and effective with superior results to using case data *** lead time of ten days could alert the public to take precautions and improve resource allocation for seasonal surges.

关键词： COVID-19 hospitalizations Wastewater-based epidemiology Forecasting Prediction SARS-CoV-2