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Nanotechnology in Cancer Diagnosis and Treatment

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Journal of Pharmacy and Pharmacology 2015年第7期3卷 299-315页

作者： Somaia Said Abd E1-Karim Magdy Ibrahim E1-Zahar Manal mohamed anwar Therapeutical Chemistry Department National Research Centre DokM Cairo 12622 Egypt

Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1-100 nanometers range. Objects at this scale, such as ＂nanoparticles,＂ take on novel properties and functions that differ markedly from those seen in the bulk scale. The small size, surface tailor ability, improved solubility, and multifunctional of nanoparticles open many new research avenues for biologists. Nanoparticles are classified into inorganic nanoparticles such as gold nanoparticles and organic nanoparticles such as carbon nanotubes and dendrimers. Different types of nanoparticals such as nanocrystals, liposomes, polymeric nanoparticles, dendrimers, quantum dots and superparamagnetic nanoparticles illustrated different examples of promising nanoparticles for cancer treatment and imaging.

关键词： Nanotechnology cancer nanoparticles toxicity.

Association of XbaI GLUT1 Polymorphism with Susceptibility to Type 2 Diabetes Mellitus and Diabetic Nephropathy

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American Journal of Molecular Biology 2016年第2期6卷 71-78页

作者： Ragaa Abdelkader Ramadan Ahmad mohamed Zaki Gehan Mahmoud Magour Moyassar Ahmad Zaki Sarah Ahmed Aglan marwa Ahmed Madkour Mohammed Mohammed Shamseya Chemical Pathology Department Medical Research Institute Alexandria University Alexandria Egypt Clinical and Experimental Internal Medicine Department Medical Research Institute Alexandria University Alexandria Egypt

Objectives: Diabetic nephropathy (DN) is one of the chronic microangiopathic complications of type 2 diabetes (T2DM) and has become the most frequent cause of end-stage renal disease. The XbaI polymorphism in the glucose transporter (GLUT1) has been suggested in the development of DN. We examined the association between XbaI polymorphism of GLUT1 and susceptibility to T2DM and development of DN. Methods: The study included 227 T2DM patients divided into 107 without DN (DM ? DN) and 120 with DN (DM + DN), in addition to 100 apparently healthy controls. Genotyping was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The GLUT1 XbaI T allele was associated with increased susceptibility to T2DM, when comparing the healthy controls to the whole diabetic group, odds ratio (OR) = 1.899, 95% confidence interval (CI) (1.149 - 3.136), p = 0.011. This association was also significant between healthy controls and DM ? DN OR = 1.997 (1.079 - 3.699), p = 0.026 as well as between healthy controls and DM + DN OR = 1.818 (1.016 - 3.253), p = 0.042. However there was no significant association of XbaI polymorphism with DN when comparing DM ? DN to DM + DN OR = 0.910 (0.474 - 1.747), p = 0.777. Conclusion: XbaI T allele is associated with increased susceptibility to T2DM, but not to development of DN. Further studies are needed to replicate such findings.

关键词： Type 2 Diabetes Mellitus Diabetic Nephropathy Glucose Transporter 1 XbaI Polymorphism

Silent Cerebral Infarctions in Type II Diabetes Mellitus Patients;Could Brain MRI Be a Routine Investigation?

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Open Journal of Medical Imaging 2014年第3期4卷 112-116页

作者： mohamed Hamdy Ibrahim Taha Kamel Alloush marwa Adel Shaaban Mohammed Khalid Abdul Rahim Mohammad Ahmad M. Saad Internal Medicine Department Gulf Medical University Ajman UAE Neurology Department Faculty of medicine Ain shams University Cairo Egypt Radiology Department Fayoom University Fayoom Egypt Radiology Department Misr University for Science and Technology Cairo Egypt

Objective: To study the prevalence of silent cerebral infarction in Type II diabetes mellitus. Patients and Methods: The study was a prospective on 80 patients recruited from neurology, endocrine outpatient clinics. Patients were type II diabetics as described by the American Diabetes Association, 2011 criteria. All patients underwent full metabolic profiles to diagnose diabetes mellitus and MRI brain scans to detect cerebral infarction. Results: Silent cerebral infarctions were detected in 60% of patients (48/80 patients) predominately along periventricular white matter area and subcortical areas (Basal ganglia, Thalamus). Conclusion: Asymptomatic Type II diabetes mellitus patients could have vascular cerebral changes without neurological symptoms. MRI brain scans could be recommended as routine diagnosis (if possible) for early cerebral infarct detection in type II diabetic patients.

关键词： Prevalence Silent Brain Infarction Diabetes Mellitus

Assessment of Physical and Mechanical Properties of Cement Panel Influenced by Treated and Untreated Coconut Fiber Addition

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Assessment of Physical and Mechanical Properties of Cement P...

Plasma D-dimer level in early and late-onset neonatal sepsis

2011 International Conference on Physics Science and Technology (ICPST 2011)

作者： Alida Abdullah Shamsul Baharin Jamaludin mohamed Iylia anwar Mazlee Mohd Noor Kamarudin Hussin School of Materials Engineering Universiti Malaysia Perlis

This project was conducted to produce a cement panel with the addition of treated and untreated coconut fiber in cement panel. Coconut fiber was added to replace coarse aggregate（sand） in this cement panel. In this project, the ratios used to design the mixture were 1:1:0, 1:0.97:0.03, 1:0.94:0.06, 1:0.91:0.09（cement: sand: coconut fiber）. The water cement ratio was constant at 0.55. The sizes of sample tested were, 160 mm x 40 mm x 40 mm for compression test, and 100 mm x 100 mm x 40 mm for density, moisture content and water absorption tests. After curing samples for 28 days, it was found that the addition of coconut fiber, further increase in compressive strength of cement panel with untreated coconut fiber. Moisture content of cement panel with treated coconut fiber increased with increasing content of coconut fiber whereas water absorption of cement panel with untreated coconut fiber increased with increasing content of coconut fiber. The density of cement panel decreased with the addition of untreated and treated coconut fiber.

关键词： Treated coconut fiber cement panel compressive strength density moisture content water absorption

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World Journal of Critical Care Medicine 2022年第3期11卷 139-148页

作者： Mohammed Al-Biltagi Ehab M Hantash Mohammed Ramadan El-Shanshory Enayat Aly Badr mohamed Zahra Manar Hany anwar Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt Department of Pediatrics University Medical CenterArabian Gulf UniversityManama 26671ManamaBahrain Department of Pediatrics University Medical CenterBahrainDr.Sulaiman Al Habib Medical GroupKSAManama 26671ManamaBahrain Department of Anatomy Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Neonatology Unit Department of PediatricsDr.Sulaiman Al Habib Medical GroupRiyadh 11636RiyadhSaudi Arabia Department of Pediatrics Hematol UnitTanta UniversityFaculty of MedicineTanta 31511AlgharbiaEgypt Department of Clinical Pathology Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Clinical Pathology Ministry of HealthEgyptTanta 31511AlghrabiaEgypt

BACKGROUND Neonatal sepsis is a life-threatening *** diagnosis is essential,but no single marker of infection has been *** activates a coagulation cascade with simultaneous production of the D-dimers due to lysis of *** test reflects the activation of the coagulation *** To assess the D-dimer plasma level,elaborating its clinicopathological value in neonates with early-onset and late-onset neonatal *** The study was a prospective cross-sectional study that included ninety neonates;divided into three groups:Group I:Early-onset sepsis(EOS);Group II:Late-onset sepsis(LOS);and GroupⅢ:Control *** diagnosed neonatal sepsis according to our protocol.C-reactive protein(CRP)and D-dimer assays were compared between EOS and LOS and correlated to the causative microbiological *** D-dimer was significantly higher in septic groups with a considerably higher number of cases with positive *** with LOS had substantially higher levels of D-dimer than EOS,with no significant differences in *** with LOS had a significantly longer hospitalization duration and higher gram-negative bacteriemia and mortality rates than EOS(P<0.01).Gramnegative bacteria have the highest D-dimer levels(Acinetobacter,Klebsiella,and Pseudomonas)and CRP(Serratia,Klebsiella,and Pseudomonas);while gram-positive sepsis was associated with relatively lower levels.D-dimer had a significant negative correlation with hemoglobin level and platelet count;and a significant positive correlation with CRP,hospitalization duration,and mortality *** best-suggested cut-off point for D-dimer in neonatal sepsis was 0.75 mg/L,giving a sensitivity of 72.7%and specificity of 86.7%.The D-dimer assay has specificity and sensitivity comparable to CRP in the current *** The current study revealed a significant diagnostic value for D-dimer in neonatal sepsis.D-dimer can be used as an adjunct to other sepsis markers to increase th

关键词： Early-onset neonatal sepsis Late-onset neonatal sepsis C-reactive protein D-dimer

Interplanting Some Soybean Cultivars with Mandarin Trees in Sandy Soil

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Agricultural Sciences 2020年第1期11卷 88-110页

作者： M. A. F. Selim Y. A. A. Hefny Eman I. Abdel-Wahab marwa Kh. A. mohamed Citrus Research Department Horticulture Research Institute Agricultural Research Center Giza Egypt Crop Intensification Research Department Field Crops Research Institute Agricultural Research Center Giza Egypt Food Legumes Research Department Field Crops Research Institute Agricultural Research Center Giza Egypt

Two-year field experiments were carried out at El-Kassasen Horticultural Research Station, Agricultural Research Center (ARC), Ismailia government, Egypt, during 2018 and 2019 summer seasons to evaluate some soybean cultivars for interplanting with mandarin trees to achieve high productivity of both crops, land usage and profitability under sandy soil conditions. The treatments were the combinations of two cropping systems (interplanting and solid cultures) and five soybean cultivars (Giza 21, Giza 22, Giza 35, Giza 82 and Giza 111). A strip plot design with three replications was used. Interplanting soybean cultivar Giza 22 with mandarin trees gave a higher total count of rhizobia in rhizosphere of mandarin roots after 75 days from soybean sowing than the other treatments in both seasons. The highest fruit weight and volume, total soluble solids (T.S.S.), fruit yields per tree and per ha were obtained by growing soybean cultivar Giza 22 or Giza 111 with mandarin compared with the other treatments in both seasons. With respect to soybean crop, interplanting soybean with mandarin trees decreased percentages of light intensity at the middle and bottom of the plant, chlorophylls a and b, as well as, plant dry weight after 75 days from soybean sowing compared with those of solid culture in both seasons. Soybean cultivars Giza 22 and Giza 82 had higher light intensity at the middle and bottom of the plant, as well as chlorophyll a, meanwhile soybean cultivars Giza 22 and Giza 111 had higher plant dry weight than the other soybean cultivars after 75 days from soybean sowing in both seasons. Soybean cultivar Giza 22 and Giza 111 had higher plant dry weight than the other soybean cultivars under interplanting and solid plantings in both seasons. Interplanting soybean with mandarin trees decreased soybean seed yield and its attributes compared with soybean solid culture in both seasons. Soybean cultivars Giza 111 and Giza 22 gave a higher number of pods per plant, seed yield

关键词： Interplanting Mandarin Soybean Cultivars Total Count of Rhizobia Competitive Relationships Financial Return

Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes

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Pharmacology & Pharmacy 2016年第11期7卷 443-458页

作者： marwa E. Sayour Rania M. Abd El Salam mohamed F. Elyamany Abeer M. El Sayed Raafat A. El-Awady National Cancer Institute Cairo University Cairo Egypt Department of Pharmacology & Toxicology Faculty of Pharmacy Cairo University Cairo Egypt Department of Pathology National Cancer Institute Cairo University Cairo Egypt Sharjah Institute for Medical Research and College of Pharmacy University of Sharjah Sharjah UAE

Background: Paracetamol exerts toxic effects on liver cells through its metabolism into N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by conjugation with cellular glutathione (GSH). Once GSH is depleted, NAPQI stimulates a range of oxidative reactions that result in cell necrosis. The aim of the present investigation is to find a new strategy that would selectively protect normal hepatic tissues and sensitize liver cancer cells to the toxic effects of paracetamol or its metabolite. This may lead to the development of a targeted therapy for liver cancer. Methods: The anti-proliferative effects of paracetamol and buthionine sulfoximine BSO (a glutathione depleting agent) alone and in combination on the liver cancer cells HepG2 and normal rat hepatocytes were investigated by sulphorhodamine-B assay. Effects on cell cycle regulation and induction of apoptosis were tested by flow cytometry. The level of prostaglandin expression was measured by ELISA. Results: The present study showed that both agents alone or in combination have anti-proliferative effects on both cell types. Surprisingly, BSO showed a cytoprotective effects on normal hepatocytes treated with high concentrations (1.75 and 2 mM) of paracetamol. This was confirmed by cell cycle analysis that recorded decreased fraction of sub-G1 cells indicating reduction of apoptosis in normal hepatocytes. Analysis of prostaglandin E2 revealed differential effects of paracetamol on normal and liver cancer cells. A significant increase in PGE2 level over the control was observed in normal hepatocytes whereas a significant decrease was seen in HepG2 cells after treatment with paracetamol. Conclusion: These results indicate that combination of paracetamol/BSO has differential effects on liver cancer cells and normal hepatocytes, which opens the avenue for a new effective and selective combination for management of liver cancer.

关键词： Paracetamol Buthionine Sufoximine (BSO) Selective GSH Depletion HepG2 Prostaglandin E2 (PGE2)

Biomarkers and Ultra Structural Evaluation of Marine Pollution by Polycyclic Aromatic Hydrocarbons

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Journal of Environmental Protection 2016年第10期7卷 1283-1304页

作者： Nehad M. Abd El Moneam Nabila E. Abd El Maguid Amany M. El-Sikaily marwa G. Zaki mohamed A. Sheradah Biochemistry and Zoology Department Faculty of Science Alexandria University Alexandria Egypt Marine Pollution Research Lab. National Institute of Oceanography & Fisheries Alexandria Egypt Marine Biotechnology Lab. National Institute of Oceanography & Fisheries Alexandria Egypt

The present study is endeavored to study the oxidative stress and antioxidant response as well as the ultrastructural change of both liver and muscle tissues of Siganus rivulatus collected from polluted region (El-Mex Bay) and control region (Marsa Matrouh) to identify the significance of biomarkers. The results revealed that, El-Mex Bay was polluted by different types of chemicals including hydrocarbons comparing with the reference area (Matrouh area). Where, the concentration range of total hydrocarbons in sediment samples collected from Matrouh coast was 409.24 - 521.26 ng/g, dry weight, where as this range in sediment samples collected from El-MexBay was 4159.77 - 4589.81 ng/g, dry weight. In this context, the induction of antioxidant systems in fish collected from polluted area in response to oxidative stress should be considered as a clear indication of the presence of pollution and environmental health degradation. Also, The increase in lipid peroxidation was a useful indicator of the pollution load in the present study. The results suggest that chemical pollution is capable of inducing morphological alteration in liver offish collected from polluted area. The present study indicated that ultra-structural changes serveas biomarker of stress in aquatic environment.

关键词： Biomarkers Ultra Structural Evaluation Polycyclic Aromatic Hydrocarbons (PAHs)

Deep Learning Methods Used in Remote Sensing Images: A Review

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Journal of Environmental & Earth Sciences 2023年第1期5卷 33-64页

作者： Ekram M.Rewhel Jianqiang Li Amal A.Hamed Hatem M.Keshk Amira S.Mahmoud Sayed A.Sayed Ehab Samir Hind H.Zeyada Sayed A.mohamed marwa S.Moustafa Ayman H.Nasr Ashraf K.Helmy School of Software Engineering Beijing University of Science and TechnologyBeijing100083China Data Reception Analysis and Receiving Station DivisionNational Authority for Remote Sensing and Space ScienceCairo1564Egypt

Undeniably,Deep Learning(DL)has rapidly eroded traditional machine learning in Remote Sensing(RS)and geoscience domains with applications such as scene understanding,material identification,extreme weather detection,oil spill identification,among many *** machine learning algorithms are given less and less attention in the era of big ***,a substantial amount of work aimed at developing image classification approaches based on the DL model’s success in computer *** number of relevant articles has nearly doubled every year since *** in remote sensing technology,as well as the rapidly expanding volume of publicly available satellite imagery on a worldwide scale,have opened up the possibilities for a wide range of modern ***,there are some challenges related to the availability of annotated data,the complex nature of data,and model parameterization,which strongly impact *** this article,a comprehensive review of the literature encompassing a broad spectrum of pioneer work in remote sensing image classification is presented including network architectures(vintage Convolutional Neural Network,CNN;Fully Convolutional Networks,FCN;encoder-decoder,recurrent networks;attention models,and generative adversarial models).The characteristics,capabilities,and limitations of current DL models were examined,and potential research directions were discussed.

关键词： Deep Learning(DL) Satellite imaging Image classification Segmentation and object detection