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Association of serum levels of transforming growth factor β1 with disease severity in patients with hepatocellular carcinoma

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Hepatoma Research 2017年第12期3卷 294-301页

作者： mohamed Ahmed Samy Kohla Ahmed Attia Nehad Darwesh Manar Obada Hossam Taha marwa FYoussef Departments of Hepatology National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt Departments of Oncology National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt Departments of Clinical Biochemistry National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt Departments of Epidemiology National Liver InstituteMenoufia UniversityShebeen Al-Kom32511Egypt.

Aim: Transforming growth factor (TGF) is overexpressed by tumor cells like other proteins and growth factors. TGF-β1 is then activated in the extracellular compartment but is unable to control cell proliferation because of the absence or low level of TGF-β1 receptors on the plasma membrane of malignant hepatocytes. This potential mechanism might interrupt the autocrine regulation loop of TGF-β1 and its blocking effect on cell proliferation. TGF-β1 is a multifunctional cytokine involved in the regulation of growth and differentiation of both normal and transformed cells. This study aimed to evaluate the association of serum levels of TGF-β1 with disease severity. Methods: A total of 180 subjects were classified into 6 groups according to Barcelona clinic liver cancer (BCLC) classification, 30 patients each:early (BCLC 0 and A), intermediate (BCLC B), advanced stage (BCLC C), and terminal stage (BCLC D) of hepatocellular carcinoma as well as 1 group of patients with cirrhosis only and 1 control group. Serum levels of TGFβ1 were measured. Results: Serum levels of TGF-β1 were significantly higher in patients with HCC (1,687.47 ± 1,462.81 pg/mL) than cirrhotics (487.98 ± 344.23 pg/mL, P < 0.001) and controls (250.16 ± 284.61 pg/mL, P <0.001). Conclusion: TGF-β1 may have a role in tumor growth and progression.

关键词： Transforming growth factor β1 hepatocellular carcinoma disease severity Egyptian patients

Prevalence of social media addiction among nursing students

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Journal of Integrative Nursing 2023年第2期5卷 145-150页

作者： marwa Mamdouh SHABAN Nagah Mahmoud ABDOU Mahmoud Magdy EID Mostafa Ahmed IBRAHIM Mohammed Saad El Dean METWALY mohamed Abdeltwab SAYED Youmna Magdy Abdulwahab MANSOUR Fatma Saad RAMADAN Department of Community Health Nursing Faculty of NursingCairo UniversityCairoEgypt Department of Nursing Administration Faculty of NursingCairo UniversityCairoEgypt

Objective:The objective of this study was to assess the prevalence and level of social media addiction among nursing students in the Faculty of Nursing,Cairo *** and Methods:A descriptive cross‑sectional research design was conducted on samples of 340 students at the Faculty of Nursing,Cairo *** were collected through demographic background information sheet and Social Networking Addiction ***:All the students were addicted as 6.76%were severely addicted and 60.59%and 32.65%were moderately and mildly addicted,*** relations were found between social media addiction and students’age(χ^(2)=11.331,P=0.003),educational level(χ^(2)=20.239,P=0.003),and grade point average(χ^(2)=19.378,P=0.013).Conclusion:Internet addiction was prevalent among all students but at different levels,so early screening of students for Internet addiction using the Internet Addiction Scale is important to provide early treatment and prevent hazards to health.

关键词： Internet addiction nursing student social media

Antibacterial, Antioxidant Activities and GC-MS Analysis of Dichrostachys cinera (L.) Ethanolic Leaves Extract

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Pharmacology & Pharmacy 2022年第12期13卷 545-557页

作者： Sitelbanat Yassin mohamed Abubker anwar mohamed Selma Omer Salah Humeada Elhadi M. M. Ahmed Mirghani Abd Alrahman Department of Pharmaceutics (Pharmaceutical Microbiology) University of Gezira Wad Madani Sudan Department of Pharmaceutical Chemistry University of Gezira Wad Madani Sudan Central Laboratory University of Gezira Wad Madani Sudan Department of Microbiology Faculty of Medical Laboratory Sciences University of Gezira Wad Madani Sudan Department of Chemistry Faculty of Education West Kordofan University Kordofan Sudan Department of Pharmacognosy University of Gezira Wad Madani Sudan Medicinal and Aromatic Plants Research Center University of Gezira Wad Madani Sudan Department of Clinical Pharmacy and Pharmacy Practice University of Gezira Wad Madani Sudan

Traditional medicinal plants are one of the potential sources of antimicrobial drugs and there is a great concern in the use and development of herbal medicine for the treatment of various infections. This study aimed to evaluate the antibacterial, and antioxidant activities of Dichrostachys cinera ethanolic leaves extract and to determine the components of the crude extract. D. cinera extract was evaluated against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. The antibacterial, antioxidant activities and active constituents were determined using standard methods. Antibacterial activity of the crude extract findings showed that all bacterial candidates were susceptible where S. aureus represent MIC at 12.5 mg/ml and MBC at 25 mg/ml, E. coli and P. aeruginosa both showed MIC 25 mg/ml and MBC 50 mg/ml. In the free radical scavenging assay of the extract and the standard quercetin at concentrations of 250 μg/ml, 125 μg/ml, 50 μg/ml, 10 μg/ml, and 5 μg/ml. The radical scavenging activity for the extract was about 92%, 89.6%, 86.8%, 82.8% and 37.8% respectively, compared to quercetin which gave 89.7%, 85.8%, 62.1%, 55.5%, and 45% radical scavenging activity. The GC-Ms analysis of the total constituents demonstrated that 1,6-Anhydro-2,4-dideoxy-.beta.-D-ribo-hexo (21.26%) with different peaks, followed by Glycerin (11.56%), 1,2,3-Cyclopentanetriol (10.18%), 8,11,14-Eicosatrienoic acid, (Z,Z,Z)-(6.18%), 1H-Pyrrole, 1-methyl-(6.08%), Phytol (5.91%) and 7-Bromo-6-(2-diethylaminoethoxy)-2,3-dihyd (5.44%) as major components in the extract. Finally, this study provided useful information on the therapeutic potential of D. cinera as an antibacterial agent and recommended to be evaluated against a wide range of Bacterial and fungal strains using different solvents and different parts from the plant.

关键词： Dichrostachys cinera Antibacterial Activity Antioxidant GC MS Analysis

Performance of a Proposed Low Cost High Efficiency Solar Cell Structure

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Performance of a Proposed Low Cost High Efficiency Solar Cel...

Effect of Electroless Copper Coating on the Corrosion Behavior of Aluminium Based Metal Matrix Composites Reinforced with Silicon Carbide Particles

2012 International Conference on Power and Energy Systems(ICPES 2012)

作者： marwa S.Salem Ahmed Shaker mohamed Aboulatt A.Zekry d Elsarayat street Abbasia Cairo Egypt

This paper presents a proposed low cost high efficiency solar cell structure. The main advantage of the structure is that it is etched through a p + silicon wafer. Highly doped silicon is considered to be low quality and impure silicon therefore the structure based on low cost starting material. In addition, the proposed structure is etched as strips through the wafer so its series resistance is very low. This result in high fill factor. Simulations for the structure are carried out using advanced TCAD tools. I - V C/C'S is presented. The open circuit voltage (V oc ), short circuit current density (J sc ), fill factor (F.F) and conversion efficiency are calculated. The output results are compared with the high efficiency;high cost single crystalline solar cells. In addition, an important study is carried out to enhance the structure to be responded to the ultraviolet part of the solar radiation spectrum. For this study, external quantum efficiency is presented as this is the best way for measuring the structure performance for each part of the input solar radiation spectrum.

关键词： Low Cost, High Efficiency, Solar Cell, ultraviolet cell

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Journal of Minerals and Materials Characterization and Engineering 2014年第1期2卷 21-25页

作者： mohamed Zakaulla A. R. anwar Khan P. G. Mukunda Ghousia College of Engineering Ramanagaram India Mechanical Engineering Department Ghousia College of Engineering Ramanagaram India Mechanical Engineering Department Nitte Menakshi Institute of Technology Bangalore India

The present paper involves firstly in the studies of corrosion properties of Al 6061 metal matrix composites reinforced with varying percentage of uncoated and Cu coated silicon carbide in 3.5 wt% NaCl solution using weight loss method. The processing route used for the composites was stir casting technique. Mass loss and corrosion rate measurements were utilized as criteria for evaluating the corrosion behavior of composites. The surface morphology of composites after the corrosion test is determined by using scanning electron microscopy. It has been observed that copper as reinforcement coating reduces the corrosion resistance of composites in comparison to uncoated reinforcements and monolithic alloy.

关键词： Stir Casting Al6061 Corrosion Rate Electroless Polarization

Exogenous application of bio-stimulants and growth retardants improve nutrient absorption and fiber quality in upland cotton

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Volumetric Assessment of Corticospinal Tract Infiltration by Astrocytoma Using Diffusion Tensor Tractography

棉花研究(英文) 2024年第2期 137页

作者： AL-KHAYRI Jameel M. ARIF Muhammad KAREEM Shadia Hama Salih anwar Adeel DEHGHANISANIJ Hossein EMAMI Somayeh YASMEEN Azra AFTAB Komal NEGM mohamed

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Open Journal of Medical Imaging 2014年第2期4卷 65-71页

作者： marwa Adel Shaaban Taha Kamel Alloush mohamed Hamdy Ibrahim Ahmed Abd el bar Sherif Hashim Morad Department of Neurology Ain Shams University Cairo Egypt Department of Neurosurgery Ain Shams University Cairo Egypt Department of Radiology Misr University for Science and Technology Cairo Egypt

Objectives: The aim of the study is to assess volumetric Corticospinal Tract infiltration by Astro-cytoma using Diffusion Tensor Tractography. Material and Methods: Preoperative, anatomic (T1- and T2-weighted) and diffusion tensor MRI were performed in 9 patients with supratentorial gliomas (WHO grade II and III). The tumors were manually segmented from the T1- and T2-weighted MRI, and their volume calculated. A three-dimensional tractography was performed in each case. A second segmentation and volume measurement was performed on the tumor regions intersecting adjacent white matter fiber tracts. Results: We identified that white matter tracts were infiltrated by 6 Astrocytoma tumors. The median tumor volume (±standard deviation) in our patient population was 33 ± 26.82 ml. The median tumor volume (±standard deviation) infiltrating white matter fiber tracts was 4.15 ± 9.23 ml. The median fraction of tumor volume infiltrating white matter fiber tracts was 26.3% ± 10.1%. Conclusions: Diffusion tensor MR Tractography is a reliable preoperative assessment tool since it detects extensive white matter infiltration by Astrocytoma irrespective of brain tumors volume. Recommendations: Prospective large population studies are required to clarify how infiltration relates to tumor location.

关键词： Tractography Astrocytoma Brain Tumor Corticospinal Tract Infiltration

Prevalence and Correlates of Obesity and Overweight in Tunisian Bipolar I Patients

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Neuroscience & Medicine 2013年第3期4卷 181-187页

作者： Asma Ezzaher anwar Mechri Dhouha Haj Mouhamed Wahiba Douki Lotfi Gaha mohamed Fadhel Najjar Biochemistry and Toxicology Laboratory Monastir University Hospital Monastir Tunisia Research Laboratory “Vulnerability to Psychotic Disorders LR 05 ES 10” Department of Psychiatry Monastir University Hospital Monastir Tunisia.

Objective: We aim to determine the prevalence of obesity and overweight in bipolar I patients, and to examine their associations with the demographic, clinical and therapeutic characteristics of this population. Patients and Methods: Our study included 120 bipolar I patients (79 men and 41 women, mean age = 39.5 ± 11.9 years). Weight and height were evaluated by body mass index (BMI). Obesity was defined when BMI ≥ 30 kg/m2 and overweight when BMI ≥ 25 kg/m2. Results: The prevalence of obesity and overweight was respectively 32.5% and 30.8%. Obesity was significantly more frequent in women than men. The illness duration was significantly longer in obese patients than in those with normal weight. Moreover, the family history of medical disorders and concomitant medical disorders was significantly more frequent in obese patients than in those with normal weight. However, any significant association between therapeutic characteristics and obesity or overweight was found. Conclusions: Obesity and overweight were frequent in bipolar I patients. Obesity was significantly frequent in women and significantly associated with illness duration, medical disorders, and concomitant medical disorders. These results emphasized the need for specific treatment strategies and programs for weight control for these patients.

关键词： Bipolar I Disorder Obesity Overweight

Antimycobacterial natural products from Moroccan medicinal plants: Chemical composition, bacteriostatic and bactericidal profile of Thymus satureioides and Mentha pulegium essential oils

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 836-840页

作者： marwa Chraibi Abdellah Farah Sara Lebrazi Oumaima El Amine Mohammed Iraqui Houssaini Kawtar Fikri-Benbrahim Laboratory of Microbial Biotechnology Faculty of Science and Technology Sass Sidi Mohamed Ben Abdellah University Laboratory of Aromatic Plants Medicinal and Natural Substances National Institute of Medicinal and Aromatic PlantsPhytochemistry Department

Objective: To evaluate the susceptibility of Mycobacterium aurum and Mycobacterium smegmatis in vitro to the essential oils obtained from two medicinal plants: Thymus satureioides(T. satureioides) and Mentha pulegium(M. pulegium), and to study their chemical ***: The aerial parts of T. satureioides and M. pulegium(leaves and stems) were hydro-distillated using a Clevenger-type apparatus and essential oils were analyzed and identified by gas chromatography-mass spectrometry. Antimycobacterial screening of essential oils was performed on the basis of the inhibition zone diameter by disc diffusion method against two mycobacterial strains whereas the minimal inhibitory concentration and minimal bactericidal concentration were determined by using the micro-dilution ***: Chemical analysis of their aerial part's essential oils gave as major compounds,borneol(34.26%), carvacrol(31.21%) and thymol(3.71%) for T. satureioides and R(+)-pulegone(75.48%), carvone(6.66%) and dihydrocarvone(4.64%) for M. *** their antimycobacterial effect evaluation, using the micro-dilution method,indicated that minimal inhibitory concentration values of T. satureioides essential oil ranged from 0.062% to 0.015%(v/v) and from 0.125% to 0.031%(v/v) for M. pulegium respectively against Mycobacterium aurum and Mycobacterium ***: It is clearly evident from the results obtained that the Moroccan medicinal plants have great potential to be used as anti-tuberculosis agents. These findings may help scientists to undertake several research projects to discover useful natural product as new anti-tuberculosis drug.

关键词： Thymus satureioides Mentha pulegium Essential oil Chemical composition Antimycobacterial activity