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Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions

World Journal of Gastroenterology 2018年第11期24卷 1228-1238页

作者： Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama marwa mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader Molecular Virology and Immunology Unit Department of Cancer BiologyNational Cancer InstituteCairo University Department of Zoology Faculty of ScienceCairo University Department of Pathology National Cancer InstituteCairo University Medical Biochemistry and Molecular Biology Department of Cancer BiologyNational Cancer InstituteCairo University Department of Hepatology and Tropical Medicine Faculty of MedicineCairo University Department of Biochemistry Misr University for Science and Technology

AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic *** Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow *** levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by *** Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other *** p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC *** was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC *** was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus NKG2D CD40 interleukin-2 interleukin-10 myeloid dendritic cells plasmacytoid cells natural killer cell Cytokines

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Feature extraction for machine learning-based intrusion detection in IoT networks

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Digital Communications and Networks 2024年第1期10卷 205-216页

作者： mohanad Sarhan Siamak Layeghy Nour Moustafa Marcus Gallagher Marius Portmann University of Queensland BrisbaneQLD4072Australia University of New South Wales CanberraACT2612Australia

A large number of network security breaches in IoT networks have demonstrated the unreliability of current Network Intrusion Detection Systems(NIDSs).Consequently,network interruptions and loss of sensitive data have occurred,which led to an active research area for improving NIDS *** an analysis of related works,it was observed that most researchers aim to obtain better classification results by using a set of untried combinations of Feature Reduction(FR)and Machine Learning(ML)techniques on NIDS ***,these datasets are different in feature sets,attack types,and network ***,this paper aims to discover whether these techniques can be generalised across various *** ML models are utilised:a Deep Feed Forward(DFF),Convolutional Neural Network(CNN),Recurrent Neural Network(RNN),Decision Tree(DT),Logistic Regression(LR),and Naive Bayes(NB).The accuracy of three Feature Extraction(FE)algorithms is detected;Principal Component Analysis(PCA),Auto-encoder(AE),and Linear Discriminant Analysis(LDA),are evaluated using three benchmark datasets:UNSW-NB15,ToN-IoT and *** PCA and AE algorithms have been widely used,the determination of their optimal number of extracted dimensions has been *** results indicate that no clear FE method or ML model can achieve the best scores for all *** optimal number of extracted dimensions has been identified for each dataset,and LDA degrades the performance of the ML models on two *** variance is used to analyse the extracted dimensions of LDA and ***,this paper concludes that the choice of datasets significantly alters the performance of the applied *** believe that a universal(benchmark)feature set is needed to facilitate further advancement and progress of research in this field.

关键词： Feature extraction Machine learning Network intrusion detection system IoT

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Location-Aware Personalized Traveler Recommender System(LAPTA)Using Collaborative Filtering KNN

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Computers, Materials & Continua 2021年第11期69卷 1553-1570页

作者： mohanad Al-Ghobari Amgad Muneer Suliman Mohamed Fati School of Information Technology Asia Pacific UniversityKuala Lumpur57000Malaysia Department of Computer and Information Sciences Universiti Teknologi PETRONASSeri Iskandar32160Malaysia Department of Information Systems Prince Sultan UniversityRiyadh11586Saudi Arabia

Many tourists who travel to explore different cultures and cities worldwide aim to find the best tourist sites,accommodation,and food according to their *** objective makes it harder for tourists to decide and plan where to go and what to *** from hiring a local guide,an option which is beyond most travelers’budgets,the majority of sojourners nowadays use mobile devices to search for or recommend interesting sites on the basis of user ***,this work utilizes the prevalent recommender systems and mobile app technologies to overcome this ***,this study proposes location-aware personalized traveler assistance(LAPTA),a system which integrates user preferences and the global positioning system(GPS)to generate personalized and location-aware *** integration will enable the enhanced recommendation of the developed scheme relative to those from the traditional recommender systems used in customer ***,LAPTA separates the data obtained from Google locations into name and category *** the data separation,the system fetches the keywords from the user’s input according to the user’s past research *** proposed system uses the K-Nearest algorithm to match the name and category tags with the user’s input to generate personalized *** system also provides suggestions on the basis of nearby popular attractions using the Google point of interest feature to enhance system *** experimental results showed that LAPTA could provide more reliable and accurate recommendations compared to the reviewed recommendation applications.

关键词： LAPTA recommender system KNN collaborative filtering users’preference mobile application location awareness

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Effect of vertical stress rest period on deformation behaviour of unbound granular materials:Experimental and numerical investigations

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第1期11卷 172-180页

作者： Ali Alnedawi Kali Prasad Nepal Riyadh Al-Ameri mohanad Alabdullah School of Engineering Deakin University

Repeated load triaxial test is used to assess the deformation behaviour of unbound granular materials(UGMs) in flexible road pavements. Repeated load pulse characteristics(i.e. shape, loading period and rest period) are the stress configurations used in the experimental set-up to simulate the passing axle loads. Some researchers and standard testing protocols suggest a rest period of varying durations after a loading phase. A thorough review of existing literature and practises has revealed that there is no agreement about the effect of the rest period of vertical stress pulse on the deformation behaviour of the UGMs. Therefore,the main objective of this study is to investigate the effect of repeated stress rest period on the deformation behaviour of UGMs experimentally. Experiments are conducted, both with and without rest period, using basalt and granite crushed rocks from Victoria, Australia. Furthermore, in order to gain insight into the effect of the rest period, finite element modelling is also developed. Both the experimental and modelling results show that the rest period has a noticeable effect on both resilient and permanent deformation behaviours of UGMs. It is, therefore, recommended to take extra precautions while adopting a particular standard testing protocol and to supplement the results by additional tests with different loading configurations.

关键词： Flexible pavement Unbound granular materials(UGMs) Repeated load triaxial test Resilient modulus Permanent deformation Finite element modelling

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Enhancing IoT Data Security with Lightweight Blockchain and Okamoto Uchiyama Homomorphic Encryption

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1731-1748页

作者： mohanad A.Mohammed Hala B.Abdul Wahab Computer Science Department The University of TechnologyBaghdadIraq

Blockchain technology has garnered significant attention from global organizations and researchers due to its potential as a solution for centralized system ***,the Internet of Things(IoT)has revolutionized the Fourth Industrial Revolution by enabling interconnected devices to offer innovative services,ultimately enhancing human *** paper presents a new approach utilizing lightweight blockchain technology,effectively reducing the computational burden typically associated with conventional blockchain *** integrating this lightweight blockchain with IoT systems,substantial reductions in implementation time and computational complexity can be ***,the paper proposes the utilization of the Okamoto Uchiyama encryption algorithm,renowned for its homomorphic characteristics,to reinforce the privacy and security of IoT-generated *** integration of homomorphic encryption and blockchain technology establishes a secure and decentralized platformfor storing and analyzing sensitive data of the supply chain *** platformfacilitates the development of some business models and empowers decentralized applications to perform computations on encrypted data while maintaining data *** results validate the robust security of the proposed system,comparable to standard blockchain implementations,leveraging the distinctive homomorphic attributes of the Okamoto Uchiyama algorithm and the lightweight blockchain paradigm.

关键词： Blockchain IoT integration of IoT and blockchain consensus algorithm Okamoto Uchiyama homomorphic encryption lightweight blockchain

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A robust protocol to compute wind load coefficients of telecommunication towers and antennas using numerical simulation for risk and resilience assessment

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Resilient Cities and Structures 2024年第1期3卷 66-83页

作者： mohanad Khazaali Liyang Ma Keivan Rokneddin Matteo Mazzotti Paolo Bocchini Research Engineer Extreme Event Solutions at VeriskLafayette City CenterBostonMA 02111USA Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of TechnologyHarbin 150090PR China Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090PR China Senior Research Scientist RenaissanceRe Risk SciencesUSA Research Associate P.M.Rady Department of Mechanical EngineeringUniversity of Colorado Boulder1111 Engineering Dr UCB 427BoulderCO 80309USA Professor Dept.of Civil and Environmental EngineeringLehigh University117 ATLSS DrBethlehemPA 18015-4729.USA Director Catastrophe Modeling CenterLehigh UniversityBethlehemPAUSA

An accurate estimation of wind loads on telecommunication towers is crucial for design,as well as for perform-ing reliability,resilience,and risk *** particular,drag coefficient and interference factor are the most significant factors for wind load *** tunnel tests and computational fluid dynamics(CFD)are the most appropriate methods to estimate these *** wind tunnel tests are generally preferred in practice,they require dedicated facilities and personnel,and can be expensive if multiple configurations of tower panels and antennas need to be tested under various wind directions(e.g.,fragility curve development for system resilience analysis).This paper provides a simple,robust,and easily accessible CFD protocol with widespread applicability,offering a practical solution in situations where wind tunnel testing is not feasible,such as complex tower configurations or cases where the cost of running experiments for all the tower-antennas configurations is prohibitively *** turbulence models,structural and fluid boundary conditions and mesh types are tested to provide a streamlined CFD modeling strategy that shows good convergence and balances accuracy,computational time,and *** protocol is calibrated and validated with experimental studies available in the *** demonstrate the capabilities of the protocol,three lattice tower panels and antennas with different configurations are analyzed as *** protocol successfully estimates the drag and lateral wind loads and their coefficients under different wind *** differences are observed between the esti-mated wind loads with this protocol and those computed by a simple linear superposition used in most practical applications,indicating the importance of tower-antenna ***,as expected,the wind loads recom-mended by design codes overestimate the simulated *** importantly,the telecommunication design codes inadequate

关键词： Generalized CFD protocol Lattice tower Tower panel Microwave antenna Wind coefficients Tower-antenna interaction

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Simulation of Liquid Argon Flow along a Nanochannel： Effect of Applied Force

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Chinese Journal of Chemical Engineering 2009年第5期17卷 734-738页

作者： YIN Chun-Yang EI-Harbawi mohanad Faculty of Chemical Engineering Universiti Teknologi MARA Shah Alam 40450 Selangor Malaysia Chemical Engineering Department Universiti Teknologi PETRONAS Bandar Seri Iskandar 31750 Tronoh Perak Malaysia

Liquid argon flow along a nanochannel is studied using molecular dynamics (MD) simulation in this ***-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) is used as the MD *** effects of reduced forces at 0.5,1.0 and 2.0 on argon flow on system energy in the form of system potential energy,pressure and velocity profile are *** in the form of three-dimensional visualization of the system at steady-state condition using Visual Molecular Dynamics (VMD) is provided to describe the dynamics of the argon *** equilibrium state is reached after 16000 time *** effects on system energy,pressure and velocity profile due to reduced force of 2.0 (F2) are clearly distinguishable from the other two lower forces where sufficiently high net force along the direction of the nanochannel for F2 renders the attractive and repulsive forces between the argon atoms virtually non-existent.A reduced force of 0.5 (F0.5) provides liquid argon flow that approaches Poiseuille (laminar) flow as clearly shown by the n-shaped average velocity *** extension of the present MD model to a more practical application affords scientists and engineers a good option for simulation of other nanofluidic dynamics processes.

关键词： molecular dynamics large-scale atomic/molecular massively parallel simulator visual molecular dynamics nanofluidics argon

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Evaluation of Novel Chitosan Based Composites Coating on Wettability for Pure Titanium Implants

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Journal of Renewable Materials 2023年第4期11卷 1601-1612页

作者： Qahtan A.Hamad Hanaa A.Al-Kaisy mohanad N.Al-Shroofy Noor K.Faheed Materials Engineering Department University of TechnologyBaghdadIraq Petroleum Engineering Department University of MisanAmaraIraq

This work aims to prepare chitosan(CS)-based coated layers,CS(10 wt%nanosilver/90 wt%CS,10 wt%biotin/90 wt%CS,and 5 wt%nanosilver–5 wt%biotin)/90 wt%CS coatings are prepared,onto pure Ti *** surface morphology of the novel CS composite coating was studied using field emission scanning electron microscopy,atomic force microscopy(AFM),Fourier transforms infrared(FTIR)and wettability *** show that the addition of(biotin,nanosilver)5 Vol.%improves the properties of composite *** different particles’scale size aid in improving the combinations in the alginate,producing a dual effect on film *** surface roughness decreased in the chitosan-based biocomposite with preferable homogeneity and crack-free coating layers,as confirmed by *** increase in surface roughness ensured substitution,which enhanced the surface *** high wettability of the CS-based coating layers was due to the presence of nanoparticles,and the composite coatings with CS,nanosilver,or biotin had excellent wettability because of the good hydrophilic nature of the CS matrix combined with reinforced *** FTIR results showed that peaks of the blending of CS plus nanoparticles,CS plus biotin,or CS plus nanosilver plus biotin were excellent matching with no changes in the structure of the matrix.

关键词： Nano silver biotin chitosan coating bio-composite implants titanium

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Understanding satellite images:a data mining module for Sentinel images

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Big Earth Data 2020年第4期4卷 367-408页

作者： Corneliu Octavian Dumitru Gottfried Schwarz Anna Pulak-Siwiec Bartosz Kulawik mohanad Albughdadi Jose Lorenzo Mihai Datcu Remote Sensing Technology Institute(IMF) Earth Observation Center(EOC)German Aerospace Center(DLR)WeβingGermany SmallGIS KrakowPoland Terranis Ramonville France ATOS SPAIN SA MadridSpain

The increased number of free and open Sentinel satellite images has led to new applications of these *** them is the systematic classification of land cover/use types based on patterns of settlements or agriculture recorded by these images,in particular,the identification and quantification of their temporal *** this paper,we will present guidelines and practical examples of how to obtain rapid and reliable image patch labelling results and their validation based on data mining techniques for detecting these temporal changes,and presenting these as classification maps and/or statistical *** represents a new systematic validation approach for semantic image content *** will focus on a number of different scenarios proposed by the user community using Sentinel *** a large number of potential use cases,we selected three main cases,namely forest monitoring,flood monitoring,and macro-economics/urban monitoring.

关键词： Data mining Earth observation Sentinel-1 Sentinel-2 image semantics classification maps analytics third party mission data

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Provenance and depositional setting of the Late MiocenePleistocene clastic sediments in the eastern Arabian Peninsula and western Iraq using rare earth elements geochemistry

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Acta Geochimica 2024年第2期43卷 399-410页

作者： Salih M.Awadh Zinah S.Al-Ankaz mohanad R.A.Al-Owaidi John S.Armstrong-Altrin Department of Geology College of ScienceUniversity of BaghdadBaghdadIraq Department of Geology College of ScienceUniversity of WasitWasit 52011Iraq Department of Applied Geology College of ScienceUniversity of BabylonBabylon 51001Iraq Unidad de Procesos Oceanicos y Costeros Instituto de Ciencias del Mar y LimnologíaUniversidad Nacional Autonoma de MexicoCiudad Universitaria04510 Mexico CityCDMXMexico Department of Marine Sciences Bharathidasan UniversityTiruchirapalliTamil Nadu 620024India

The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements(REE) and trace elements(Sc, Co, V, and Th) concentrations in these sandstones revealed that they likely derived from a single source. The steep light rare earth elements(LREE) and flat, heavy rare earth element(HREE) patterns, negative Eu anomaly, and high ΣREE contents in sandstones suggest its derivation from a suggests that a passive continental margin environment and originated from felsic source rocks. The average concentration of ΣREE is 93.5 ppm, which is lower than that of the average crustal compositions like Upper Continental Crust and Post Archean Australian Shale. The higher proportion of LREE compared to HREE implies that these sandstones were recycled and derived from a distal source. The Th/Co, Th/Sc, La/Sc, La/Co, Eu/Eu*and(La/Lu)cn elemental ratios indicated that these Late Miocene–Pliocene sandstones were derived from felsic rocks located in the marginal region of the Arabian Shield.

关键词： REE Dibdibba formation Clastic sediments Passive continental margin

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