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PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis

World Journal of Hepatology 2017年第1期9卷 18-29页

作者： Aline awad Ama Gassama-Diagne Inserm Unite 1193 Hopital Paul Brousse Univ Paris-Sud UMR-S 1193Univsite Paris-Saclay

Hepatitis C virus(HCV) infects hepatocytes, polarized cells in the liver. Chronic HCV infection often leads to steatosis, fibrosis, cirrhosis and hepatocellular carcinoma, and it has been identified as the leading cause of liver transplantation worldwide. The HCV replication cycle is dependent on lipid metabolism and particularly an accumulation of lipid droplets in host cells. Phosphoinositides(PIs) are minor phospholipids enriched in different membranes and their levels are tightly regulated by specific PI kinases and phosphatases. PIs are implicated in a vast array of cellular responses that are central to morphogenesis, such as cytoskeletal changes, cytokinesis and the recruitment of downstream effectors to govern mechanisms involved in polarization and lumen formation. Important reviews of the literature identified phosphatidylinositol(Ptd Ins) 4-kinases, and their lipid products Ptd Ins(4)P, as critical regulators of the HCV life cycle. SH2-containing inositol polyphosphate 5-phosphatase(SHIP2), phosphoinositide 3-kinase(PI3K) and their lipid products Ptd Ins(3,4)P2 and Ptd Ins(3,4,5)P3, respectively, play an important role in the cell membrane and are key to the establishment of apicobasal polarity and lumen formation. In this review, we will focus on these new functions of PI3 K and SHIP2, and their deregulation by HCV, causing a disruption of apicobasal polarity, actin organization and extracellular matrix assembly. Finally we will highlight the involvement of this pathway in the event of insulin resistance and nonalcoholic fatty liver disease related to HCV infection.

关键词： Hepatitis C virus Phosphoinositide 3-kinase SH2-containing inositol polyphosphate 5-phosphatase Epithelial cell polarity Phosphoinositides

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Applying Neural Networks for Tire Pressure Monitoring Systems

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Structural Durability & Health Monitoring 2019年第3期13卷 247-266页

作者： Alex Kost Wael A.Altabey Mohammad Noori Taher awad Mechanical Engineering Department California Polytechnic State UniversitySan Luis ObispoCA 93405USA International Institute for Urban Systems Engineering(IIUSE) Southeast UniversityNanjingChina Nanjing Zhixing Information Technology Co. Ltd.NanjingChina Mechanical Engineering Department Faculty of EngineeringAlexandria UniversityAlexandria21544Egypt

A proof-of-concept indirect tire-pressure monitoring system is developed using artificial neural networks to identify the tire pressure of a vehicle tire.A quarter-car model was developed with MATLAB and Simulink to generate simulated accelerometer output *** data are used to train and evaluate a recurrent neural network with long short-term memory blocks(RNN-LSTM)and a convolutional neural network(CNN)developed in Python with *** Optimization via SigOpt was used to optimize training and model *** predictive accuracy and training speed of the two models with various parameters are ***,future work and improvements are discussed.

关键词： RNN-LSTM CNN artificial neural networks tire pressure monitoring systems

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GIS-Based Assessment of Soil Chemical and Physical Properties as a Basis for Land Reclamation in Toshka Area, Aswan, EGYPT

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Open Journal of Geology 2023年第7期13卷 697-719页

作者： Ahmed A. M. awad Mostafa M. A. Al-Soghir Department of Soil and Natural Resources Faculty of Agriculture and Natural Resources Aswan University Aswan Egypt

The accurate assessment of soil properties is a crucial factor for composing and implementing reclamation plans. The main objective of this study was to evaluate soil chemical and physical properties and calculate the chemical and fertility index for assisting land reclamation in Toshka area. The Toshka area is located between latitudes 31°32'N and 31°36'N and longitudes 32°40'E and 32°60'E. GIS was used to select 16 sites. The results revealed the soil has undesirable characteristics. The soil pH ranged from slightly alkaline to moderately alkaline. Furthermore, it was characterized as saline (with a ECe of 4.65 - 11.45 dS⋅m−1) and moderately calcareous soil (with CaCO3 at 11.85% - 17.20%). The soil had a low soil organic matter content which did not exceed 0.18%. The soil was dominated by a sandy loam texture (62.50%) followed by a sandy clay loam texture (18.75%). The bulk density, total soil porosity and saturated hydraulic conductivity values varied with 1.38 - 1.55 Mg⋅cm−3, 41.85% - 48.45% and 1.20 - 3.34 cm⋅h−1, respectively. The chemical index ranged from low to moderate quality. The correlations between the parameters osculated between negative and positive. Therefore, the soil may be reclaimed if the soil properties are improved and crop selection is optimized for this soil.

关键词： Land Reclamation Soil Chemical and Physical Properties Chemical Quality Index Fertility Quality Index

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Non-pulmonary involvement in COVID-19:A systemic disease rather than a pure respiratory infection

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World Journal of Clinical Cases 2023年第3期11卷 493-505页

作者： Mohamed El-Kassas Mohamed Alboraie Mohamed Elbadry Reem El Sheemy Mohamed Abdellah Shimaa Afify Ahmad Madkour Mariam Zaghloul Abeer awad Mohamed-Naguib Wifi Amira Al Balakosy Mohamed Eltabbakh Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11731Egypt Department of Internal Medicine Al-Azhar UniversityCairo 11884Egypt Department of Tropical Medicine Minia Faculty of MedicineMinia UniversityMinia 61511Egypt Department of Gastroenterology National Hepatology and Tropical Medicine Research InstituteCairo 11451Egypt Department of Hepatology Gastroenterology and Infectious DiseasesFaculty of MedicineKafrelsheikh UniversityKafrelsheikh 33511Egypt Department of Internal Medicine Hepatogastroenterology UnitKasr Al-Ainy School of MedicineCairo 11451Egypt Department of Tropical Medicine Ain Shams UniversityCairo 11451Egypt

During the early phase of the coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),diagnosis was difficult due to the diversity in symptoms and imaging findings and the variability of disease *** manifestations are reportedly the main clinical presentations of COVID-19 *** are working hard on a myriad of clinical,epidemiological,and biological aspects to better understand SARS-CoV-2 infection,aiming to mitigate the ongoing *** reports have documented the involvement of various body systems and organs apart from the respiratory tract including the gastrointestinal,liver,immune system,renal,and neurological *** involvement will result in diverse presentations related to effects on these *** presentations such as coagulation defects and cutaneous manifestation may also *** with specific comorbidities including obesity,diabetes,and hypertension have increased morbidity and mortality risks with COVID-19.

关键词： COVID-19 Non-pulmonary Extrapulmonary Clinical manifestations Systemic disease

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Antioxidant Properties of Fermented Camel Milk Prepared Using Different Microbial Cultures

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Food and Nutrition Sciences 2022年第11期13卷 861-877页

作者： Nagwa Hussein Ismail Abou-Soliman Mahmoud Ibrahim El-Sayed Sameh awad Department of Animal Breeding Animal and Poultry Production Division Desert Research Centre Cairo Egypt Department of Dairy Technology Research Food Technology Research Institute Agricultural Research Center Giza Egypt Department of Dairy Science and Technology Faculty of Agriculture Alexandria University Alexandria Egypt

This study investigated the effect of using different combinations of commercial starter culture and lactobacilli strains on the antioxidant properties of fermented camel milk for 14 days. The bacterial strains included Lb. casei subsp. casei B-1922, Lb. paracasei subsp. paracasei B-4560, Lb. rhamnosus B-442 and Lb. rhamnosus B-1445. The antioxidant activity of fermented milk was estimated using DPPH radical scavenging activity, ferrous ion chelating activity (FCA) and ferric reducing power assays. The total phenolic content (TPC), titratable acidity, proteolysis degree and sensory acceptability of samples were also evaluated. The results showed that all the studied parameters were affected by both the type of starter culture and storage. Samples containing the commercial starter and Lb. rhamnosus B-1445 had the highest DPPH radical scavenging activity and TPC throughout storage. Fermented milks prepared using the commercial starter and Lb. rhamnosus B-442 or Lb. paracasei retained their high FCA and reducing power throughout storage compared to the other samples. Fermented milk containing the commercial starter and Lb. casei showed the lowest antioxidant activity. The DPPH scavenging activity for all fermented milks decreased sharply during storage, while the change in FCA, reducing power and TPC differed among the samples during storage. The highest acidity was observed in the samples containing the commercial starter and Lb. paracasei, while fermented milk prepared using commercial starter and Lb. rhamnosus B-1445 had the lowest acidity. Samples containing the commercial starter and Lb. casei had the greatest proteolysis during the first week of storage, while samples containing the commercial starter and Lb. rhamnosus B-1445 had the highest proteolysis on day 14. Fermented milks with commercial starter and Lb. rhamnosus B-1445 or Lb. paracasei were the most acceptable products, while samples containing the commercial starter and Lb. casei were less acceptable.

关键词： Antioxidant Activity Fermented Camel Milk Lactobacilli

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Flexural and Dynamic Mechanical Properties of Alkali-Treated Coir/Pineapple Leaf Fibres Reinforced Polylactic Acid Hybrid Biocomposites

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Journal of Bionic Engineering 2021年第6期18卷 1430-1438页

作者： Ramengmawii Siakeng Mohammad Jawaid Mohammad Asim Hassan Fouad Sameer awad Naheed Saba Suchart Siengchin Department of Mechanical and Process Engineering The Sirindhorn International Thai-GermanGraduate School of Engineering(TGGS)King Mongkut’s University of Technology North BangkokBangkok10800Thailand Laboratory of Biocomposite Technology Institute of Tropical Forestry and Forest Products(INTROP)Universiti Putra Malaysia43400 UPMSerdangSelangorMalaysia Applied Medical Science Department Community CollegeKing Saud UniversityP.O.Box 10219Riyadh11433Saudi Arabia Chemistry School of Science and TechnologyUniversity of New EnglandArmidaleNSW2351Australia

Polylactic acid(PLA)possesses good mechanical and biodegradability properties which make it a suitable material for polymer composites whereas brittleness and high costs limit its utilization in various *** reinforcement of natural fibres with biopolymers has been formed to be an efficient technique to develop composites having the ability to be fully *** study concerns with the incorporation of various percentages of untreated and alkali-treated Coir Fibres(CF)and pineapple leaf fibres(PALF)in PLA biocomposites and characterizations of flexural,morphological and dynamic mechanical *** properties showed that the treated C1P1 hybrid composites(C1P1A)displayed highest flexural strength(35.81 MPa)and modulus(5.28 GPa)among all hybrid *** Electron Microscopy(SEM)revealed a behaviour of fibre-matrix adhesion in untreated treated *** observation revealed good dispersion of the fillers in *** mechanical analysis revealed that C1P1A showed highest glass transition temperature(Tg)and storage modulus(E')while untreated C3P7 displayed the least Tg and E'.Overall findings showed that alkali-treated hybrid biocomposites(CF/PALF/PLA)especially C1P1A have improved flexural properties,dynamic and morphological properties over untreated *** of these findings will provide attracting consideration of these hybrid biocomposites for various lightweight uses in a broad selection of industrial applications such as biomedical sectors,automobile,construction,electronics equipment,and hardware tools.

关键词： Coir fibres Pineapple leaf fibres Biocomposites Polylactic acid Mechanical properties Dynamic mechanical properties

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An Investigation of ~4He+^(12)C and ~4He+^(16)O Reactions Using the Cluster Model

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Communications in Theoretical Physics 2012年第7期58卷 135-140页

作者： A.H.Al-Ghamdi awad A.Ibraheem M.El-Azab Farid Physics Department Faculty of ScienceKing Abdul Aziz UniversityJeddahSaudi Arabia Physics Department Al-Azhar UniversityAssiut BranchAssiut 71524Egypt Physics Department King Khalid UniversityAbhaSaudia Arabia Physics Department Assiut UniversityAssiut 71516Egypt

The α-target semimicroscopic single folding potentials have been derived by folding a composite (repul-sive and attractive) effective α-α interaction with the α-cluster distribution density in the target nuclei. The obtained potentials are considered as the real part of the nuclear optical model potentials, while the imaginary parts are phe-nomenologicaly expressed using the Woods-Saxon form. Nine sets of measured experimental data of the 4He+12C and 4 He+16O elastic rainbow scattering over the energy range 80-240 MeV are analyzed using the obtained potentials. The data are successfully reproduced using the extracted potentials. The resulted reaction cross sections are also investigated and compared with the available corresponding data.

关键词：光学模型势反应截面比值群集相互作用分布密度苯丙氨酸实验数据

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Grapevine Phenological Quantitative Trait SSR Genotyping Using High-Throughput HRM-PCR Analysis

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 905-923页

作者： Murad awad Photini V.Mylona Alexios N.Polidoros Laboratory of Genetics and Plant Breeding Faculty of AgricultureForestry and Natural EnvironmentAristotle University of ThessalonikiThessaloniki54124Greece Institute of Plant Breeding&Genetic Resources HAO-DEMETERThermi57001Greece

Discrimination among grapevine varieties based on quantitative traits,such as flowering,veraison and ripening dates is crucial for variety selection in the context of climate change and in breeding *** traits are under complex genetic control for which 6 linked SSR loci(VVS2,VVIn16,VMC7G3,VrZAG29,VMC5G7,and VVIB23)have been *** these markers in HRM-PCR analysis,we assessed genetic diversity among a large collection of 192 grapevine *** grapevine germplasm used encompasses the majority of Greek vineyard with 181 varieties,3 prominent foreign varieties and 11 varieties of Palestinian *** SSR markers used were highly polymorphic,displaying unique melting curves for unusually higher number of samples than generally observed in SSR *** prompted us to examine sequence composition for selected samples and found that variation present as SNPs in the flanking sequences of SSR motifs was responsible for the observed ***,HRM-PCR proved to be a tool of higher analytical power to distinguish genotypes surpassing the discrimination power of conventional gel-based SSR *** study provides a better understanding of genetic variation of SSR marker loci associated to phenological traits in grapevine varieties,signifying an analytical methodology that may be of higher discrimination power in detection of polymorphism for utilization in breeding programs.

关键词： Vitis vinifera L phenological QTLs microsatellites genotyping High-resolution melting

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Application of Plant Growth-Promoting Bacteria as an Eco-Friendly Strategy for Mitigating the Harmful Effects of Abiotic Stress on Plants

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Phyton-International Journal of Experimental Botany 2023年第12期92卷 3305-3321页

作者： Ahmed Hassan Abdou Omar Abdullah Alkhateeb Hossam Eldin Hamed Mansour Hesham S.Ghazzawy Muayad Saud Albadrani Nadi awad Al-harbi Wasimah B.Al-Shammari Khaled Abdelaal Social Studies Department College of ArtsKing Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Agribusiness and Consumer Sciences College of Agriculture&Food SciencesKing Faisal UniversityAl-Ahsa31982Saudi Arabia Agribusiness and Consumer Sciences Department College of Agricultural and Food SciencesKing Faisal UniversityAl-Ahsa31982Saudi Arabia Date Palm Research Center of Excellence King Faisal UniversityAl-Ahsa31982Saudi Arabia Department of Family and Community Medicine College of MedicineTaibah UniversityAl-Madinah Al-Munawara42353Saudi Arabia Biology Department University College of TaymaUniversity of TabukTabukSaudi Arabia Department of Biology College of ScienceUniversity of HailP.O.Box 2440Hail55476Saudi Arabia EPCRS Excellence Center Plant Pathology and Biotechnology LaboratoryAgricultural Botany DepartmentFaculty of AgricultureKafrelsheikh University33516Egypt

Plant growth-promoting bacteria(PGPB)play an important role in improving agricultural production under several abiotic stress *** can be used to increase crop growth and development through hormonal balance and increase nutrient *** positive effect of PGPB may be due to its pivotal role in morphophysiological and biochemical characteristics like leaf number,leaf area,and stem ***,relative water content,chlorophyll content,carotenoids,antioxidant enzymes,and plant hormones were improved with PGPB *** yield and yield components were also increased with PGPB treatment in numerous *** anatomical structure of plant organs was increased such as lamina thickness,stem diameter,xylem vessel diameter,and number of xylem vessels as well as phloem thickness under treatment with ***,PGPB can alleviate the negative effects of several abiotic stresses by regulating the antioxidant defense system to scavenge the reactive oxygen species resulting in an improvement of yield production in the stressed ***,gene expressions were controlled by calcium ion modulation during secondary messengers that act upon calcium-dependent protein kinase and protein *** includes many transcription factors such as MYB,AP2/ERF,bZIP,and NAC which regulate genes related to salinity stress *** can demonstrate induction genes of signaling under abiotic stress *** review gives an outline of the PGPB role in alleviating the harmful effects of abiotic factors such as salinity,drought,and heat associated with the improvement of the morpho-physiological and biochemical features especially,leaves and branches number,leaf area,antioxidant compounds,plant hormones,and relative water content.

关键词： PGPB salinity drought heat reactive oxygen species antioxidants gene expressions

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Magnetic force microscopy of an operational spin nano-oscillator

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Microsystems & Nanoengineering 2022年第3期8卷 247-252页

作者： Seyed Amir Hossein Banuazizi Afshin Houshang Ahmad A awad Javad Mohammadi Johan Akerman Liubov M.Belova Faculty of New Sciences and Technologies University of TehranTehranIran Materials and Nanophysics Department of Applied PhysicsSchool ofEngineering SciencesKTH Royal Institute of Technology11419 StockholmSweden Department of Physics University of Gothenburg41296 GothenburgSweden Department of Materials Science and Engineering KTHRoyal Institute of Technology10044 StockholmSweden

Magnetic force microscopy(MFM)is a powerful technique for studying magnetic microstructures and nanostructures that relies on force detection by a cantilever with a magnetic *** detected magnetic tip interactions are used to reconstruct the magnetic structure of the sample ***,we demonstrate a new method using MFM for probing the spatial profle of an operational nanoscale spintronic device,the spin Hall nano-osillator(SHNO),which generates high-intensity spin wave auto-osillations enabling novel microwave applications in magnonics and neuromorphic *** developed an MFM system by adding a microwave probe station to allow electrical and microwave characterization up to 40 GHz during the MFM ***-based on NiFe/Pt bilayers with a specific design compatible with the developed system-were fabricated and scanned using a Co magnetic force microscopy tip with 10 nm spatial MFM resolution,while a DC current sufficient to induce auto-oscillation *** results show that this developed method provides a promising path for the characterization and nanoscale magnetic field imaging of operational nano-osilators.

关键词： microwave characterization system

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