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rosuvastatin‑Eluting Gold‑Nanoparticle‑Loaded Perivascular Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model

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Advanced Fiber Materials 2023年第6期5卷 1986-2001页

作者： Carleigh Klusman Benjamin Martin Joy Vanessa D.Perez Allan John r.Barcena marvin r.bernardino Erin Marie D.San Valentin Jossana A.Damasco Huckie C.Del Mundo Karem A.Court Biana Godin Gino Martin Canlas Natalie Fowlkes richard Bouchard Jizhong Cheng Steven Y.Huang Marites P.Melancon Department of Interventional radiology The University of Texas MD Anderson Cancer CenterHouston 77030USA Baylor College of Medicine Houston 77030USA College of Medicine University of the Philippines Manila1000 ManilaPhilippines Department of Nanomedicine Houston Methodist Research InstituteHouston 77030USA Department of Chemistry Lamar UniversityBeaumont 77710USA Department of Veterinary Medicine and Surgery The University of Texas MD Anderson Cancer CenterHouston 77030USA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHouston 77030USA Section of Nephrology Department of MedicineSelzman Institute for Kidney HealthBaylor College of MedicineHouston 77030USA The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences Houston 77030USA

Arteriovenous fistulas(AVFs)are a vital form of AV access for patients requiring hemodialysis,but they link to overall morbidity and mortality when they fail to *** most common cause of AVF non-maturation is neointimal hyperplasia(NIH).To minimize the deleterious effects of NIH,a perivascular wrap composed of polycaprolactone(PCL),rosuvastatin(rOSU),and gold nanoparticles(AUNPs)was *** study assessed the impact of rOSU-eluting,radiopaque resorbable perivascular wraps on pathologic NIH in a chronic kidney disease(CKD)rodent model of *** PCL wraps containing AuNPs and/or rOSU were monitored for in vitro tensile strength,AuNP release,rOSU elution,and effect on cellular *** wraps were then implanted around an AVF in a CKD rodent model for in vivo ultrasound(US)and micro-computed tomography(mCT)*** specimens were collected for histological *** viability was preserved in the presence of both AuNP-and rOSU-containing *** vitro release of rOSU and AuNPs correlated with in vivo findings of decreasing radiopacity on mCT over ***-loaded wraps had higher radiopacity(1270.0-1412.0 HU at week 2)compared with other wraps(103.5-456.0 HU),which decreased over *** addition of rOSU decreased US and histologic measurements of *** reduced NIH seen with rOSU-loaded perivascular wraps suggests a synergistic effect between mechanical support and anti-hyperplasia ***,AuNP loading increased wrap ***,our results show that AuNP-and rOSU-loaded PCL wraps induce AVF maturation and suppress NIH while facilitating optimal implanted device visualization.

关键词： Arteriovenous fistula Chronic kidney disease Nanoparticles Polycaprolactone radiopacity rosuvastatin

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