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Activin Gene in Avian Species: A Case Study

Open Journal of Animal Sciences 2023年第4期13卷 513-528页

作者： Chinyere Mary-Cynthia Ikele Ifeanyi Solomon Ahamba marvin Egom Christian Uchechukwu Ekugba Chukwuebuka Edwin Awaogu Integrated Germline Biology Group Laboratory Osaka University Osaka Japan Department of Animal Science and Technology Federal University of Technology Owerri Nigeria Department of Animal Science Faculty of Agriculture University of Nigeria Nsukka Nigeria Department of Animal Science Nnamdi Azikiwe University Awka Nigeria Department of Soil Science Faculty of Agriculture University of Nigeria Nsukka Nigeria

Among the avian species, understanding the roles of activin happen to be a dominant challenge in genetic evolution due to its complexity in nature. A case study of the activin gene in avian species was carried out using bioinformatics. As a sedentary bird, guinea fowl is more susceptible to local selection processes and needs a proper genetic study for conservation. The present study provides the basis for the use of activin or its target genes for the improvement of impaired wound healing, and activin antagonists for the prevention and treatment of fibrosis and the end of malignant tumors that over-express activin. The information provided will serve as a basic tool for broader genetic diversity studies to identify valuable poultry genetic resources and major genes for the development of breeding programs. This study was done by retrieving hundred (100) nucleotides and amino acid sequences of the activin gene belonging to guinea fowl and other avians from the GeneBank, aligning the sequences using BlastP determined the percent identity and phylogenetic relationship of the activin gene of guinea fowl and other avians. The shortest activin nucleotide sequence (467 bp) was observed in chicken and the longest (39896445 bp) in duck. Using the comparative sequence analysis, it was observed that the activin gene of chickens, turkeys and guinea fowl shared percent identity ranging from 91% to 95%. The percent identity reflects the degree of relatedness of species. Although closely related (90%) in ancestral line, the activin gene of guinea fowl and quail cannot be compared with guinea fowl-turkey (95%) nor guinea fowl-chicken (90%), in both biological functions and evolutionary relationship. Finally, the percent identity and similarity in function of the activin gene of guinea fowl, turkey, and chicken were in the range of 93% - 100%, indicating that the activin gene of avians possesses similar functions, well conserved and is very effective in performing functions like in

关键词： Activin Avians Phylogenetics Bioinformatics

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Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer

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Bioactive Materials 2023年第7期25卷 360-373页

作者： Menekse Ermis Natashya Falcone Natan Roberto de Barros marvin Mecwan Reihaneh Haghniaz Auveen Choroomi Mahsa Monirizad Yeji Lee Jihyeon Song Hyun-Jong Cho Yangzhi Zhu Heemin Kang Mehmet R.Dokmeci Ali Khademhosseini Junmin Lee Han-Jun Kim Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCA90024USA Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangGyeongbuk37673Republic of Korea College of Pharmacy Kangwon National UniversityChuncheonGangwon24341Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheon 21983Republic of Korea College of Pharmacy Korea UniversitySejong30019Republic of Korea

The tumor microenvironment consists of diverse,complex etiological *** matrix component of pancreatic ductal adenocarcinoma(PDAC)plays an important role not only in physical properties such as tissue rigidity but also in cancer progression and therapeutic *** significant efforts have been made to model desmoplastic PDAC,existing models could not fully recapitulate the etiology to mimic and understand the progression of ***,two major components in desmoplastic pancreatic matrices,hyaluronic acid-and gelatin-based hydrogels,are engineered to provide matrices for tumor spheroids composed of PDAC and cancer-associated fibroblasts(CAF).Shape analysis profiles reveals that incorporating CAF contributes to a more compact tissue *** expression levels of markers associated with proliferation,epithelial to mesenchymal transition,mechanotransduction,and progression are observed for cancer-CAF spheroids cultured in hyper desmoplastic matrix-mimicking hydrogels,while the trend can be observed when those are cultured in desmoplastic matrix-mimicking hydrogels with the presence of transforming growth factor-β1(TGF-β1).The proposed multicellular pancreatic tumor model,in combination with proper mechanical properties and TGF-β1 supplement,makes strides in developing advanced pancreatic models for resembling and monitoring the progression of pancreatic tumors,which could be potentially applicable for realizing personalized medicine and drug testing applications.

关键词： Pancreatic cancer Desmoplasia Fibrosis Extracellular matrix Tumor microenvironment

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Associations with Organ Involvement and Autoantibodies in Systemic Sclerosis: Results from the Canadian Scleroderma Research Group (CSRG)

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第2期3卷 113-118页

作者： Vikram Tangri Carly Hewson Murray Baron A. Bonner marvin Fritzler Janet E. Pope McGill University Montreal Canada McMaster University Hamilton Canada University of Calgary Calgary Canada University of Western Ontario London Canada

Objective: Serum from SSc patients was analyzed centrally to determine ANA patterns and extractable nuclear antigens (ENAs) between lcSSc and dcSSc and associations with organ involvement. Methods: 1145 SSc patients had ANA and ENA analyzed by indirect immunofluorescence on HEp-2 substrate at a screening serum dilution of 1/160. Most ENA antibodies [Sm. U1-RNP, Ro52, SS-A/Ro60, topoisomeraseI (Topo1), SS-B/La, chromatin, ribosomal P and Jo1] were measured by laser bead immunoassay;and RNA polymerase III (RNAP) by ELISA. Results: ANA was positive in 95% (same in lcSSc, and dcSSc). Centromere pattern was present in 34%, speckled 22%, nucleolar 18%, homogeneous and speckled (H&S) 16%, multiple nuclear dots 6%. Anti-centromere Ab (ACA) occurred in 46% of lcSSc and 11% of dcSSc (P = 0.0001). ENAs that differed between lcSSc and dcSSc subsets were Topo1 (OR 2.4, P = 0.0001) and RNAP (OR 5.6, P 0.0001) more common in dcSSc. Overall, 15% had positive Topo1;usually with a H&S pattern (67%);Topo1 was associated with ILD on CXR (OR 2.3;95% CI 1.5 - 3.5) and HRCT (OR 3.8;95% CI 1.8 - 8.2). RNAP occurred in 18.5% (35.4% in dcSSc vs. 8.9% in lcSSc). Scleroderma renal crisis (SRC) was 13 times more likely if RNAP positive;P = 0.0001. ACA was only weakly associated with sPAP > 50 mmHg (OR 1.8;95%CI 1.1 - 3.0). Conclusion: ANA homogeneous pattern alone is rare in SSc;ACA was significantly more common in lcSSc. Many ENAs are equal in lcSSc and dcSSc except RNAP and Topo1. RNAP has the highest OR of SRC. Topo1 is less strongly associated with ILD. Abstract word count: 249, Body word count 1246, Figures 2, Tables 2. Key Messages: 1) 95% of SSc has a positive ANA and ANA patterns in SSc include centromere, nucleolar, and homogeneous and speckled together;2) Most ENAs are equal in both dcSSc and lcSSc except anti RNA polymerase III and topoisomerase I;3) RNA polymerase III has the highest association (odds ratio) with scleroderma renal crisis, topoisomerase I is associated with interstit

关键词： Scleroderma SSc Systemic Sclerosis Antibodies Anticentromere Topoisomerase I RNA Polymerase III Organ Involvement Scleroderma Renal Crisis Pulmonary Fibrosis ILD ANA Pulmonary Hypertension

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低成本集成电路式的A/D-D/A转换

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电子计算机参考资料 1970年第5期 36-42页

作者： marvin B.Rudin

目前最复杂的双极綫性集成电路的移交生产,可能使数字——模拟转换设备的成本降低到仅为以前同类设备的十分之一。仙童(Fairchild)半导体公司的工程师们看到自动数字数据处理设备的迅速发展,感到廉价的转换设备将会满足现实的要求。他... 详细信息

目前最复杂的双极綫性集成电路的移交生产,可能使数字——模拟转换设备的成本降低到仅为以前同类设备的十分之一。仙童(Fairchild)半导体公司的工程师们看到自动数字数据处理设备的迅速发展,感到廉价的转换设备将会满足现实的要求。他们就开始对众所周知的转换技术及其优缺点进行通盘

关键词：精度放大器电阻电子设备电阻抗分解度 A/D-D/A

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若美联储利率见顶A股会怎么走?

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商业周刊（中文版） 2023年第22期 44-45页

作者： marvin M Chen 不详

如果美联储释放利率见顶信号,因收益率上升和美元走强导致的资金流出将有所放缓,2023年结束时A股的资金流人可能会更加强劲。8-10月,北向资金流出A股的规模超过1700亿元人民币。

关键词：资金流出 A股美联储收益率美元人民币

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高压电机的表面电晕

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绝缘材料简讯 1971年第5期 52-59页

作者： marvin M·Fromm 国家电气线啳公司

高压旋转电机的表面电晕放电发生在二种情况下,一种是在铁心迭片和紧挨线啳边之间空气隙击穿时,另一种是地电位和在线啳表面电容性的感应高电位之间在交界面处的刷形放电,二种形式放电对绝缘的损坏已有一段很长的历史。这些放电形式的... 详细信息

高压旋转电机的表面电晕放电发生在二种情况下,一种是在铁心迭片和紧挨线啳边之间空气隙击穿时,另一种是地电位和在线啳表面电容性的感应高电位之间在交界面处的刷形放电,二种形式放电对绝缘的损坏已有一段很长的历史。这些放电形式的存在以及它们的防止措施也早已知道,但近来的一些经验引起我们重新

关键词：表面电阻系数石棉带玻璃布气隙交界面表面电阻率玻璃纤维纺织品电晕电晕放电涂层表面

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甜菜夜蛾体内酶活性对三种棉酚含量棉花的响应

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中国科学（C辑） 2009年第11期39卷 1049-1056页

作者：吴刚 marvin K.Harris 郭建英万方浩中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室北京100081 华中农业大学植物科技学院武汉430070 Department of Entomology Texas A&M University of USATXUSA 中国农业部外来入侵生物预防与控制研究中心北京100081

在室内用3种不同棉酚含量的棉花饲养甜菜夜蛾幼虫,并在不同取食时间测定了甜菜夜蛾幼虫的营养物质、消化酶、保护酶和解毒酶活性的变化.实验结果表明,甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种6h后,体内的游离脂肪酸较取食其他两种低... 详细信息

在室内用3种不同棉酚含量的棉花饲养甜菜夜蛾幼虫,并在不同取食时间测定了甜菜夜蛾幼虫的营养物质、消化酶、保护酶和解毒酶活性的变化.实验结果表明,甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种6h后,体内的游离脂肪酸较取食其他两种低酚含量棉花出现了显著性的降低.甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种24h后,体内的胰蛋白酶较取食1,4,6h后出现了显著性的增加.甜菜夜蛾幼虫取食高棉酚含量的棉花M9101品种1,4,6,24h后,体内的过氧化氢酶和总超氧化物歧化酶显著高于取食低酚棉花品种ZMS13和HZ401,但体内显著较低的羧酸酯酶和乙酰胆碱酯酶酶活性显著低于取食低酚棉花品种ZMS13和HZ401.多因素方差分析表明,不同棉酚含量棉花品种除对甜菜夜蛾幼虫体内淀粉酶活性无影响外,对其他消化酶、保护酶和解毒酶活性均有显著性的影响.棉花品种和甜菜夜蛾不同为害时间的交互作用可显著影响甜菜夜蛾幼虫体内的羧酸酯酶和过氧化氢酶活性.测定对甜菜夜蛾不同为害时间体内酶活性对不同棉酚含量的棉花的响应,可有效评估植食性昆虫在植物次生代谢物质压力下的生理反应和抗性变化.

关键词：甜菜夜蛾棉酚游离脂肪酸解毒酶乙酰胆碱酯酶总过氧化物歧化酶

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告诉孩子你最好美国孩子的激励教育法

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2004年

作者：（美）马文·马歇尔（marvin Marshall）张喻译

科文图书:美国教育研究学会(AREA)推荐父母和教师用书:本书涉及了三个教育，养育和个人成长三个领域。内容充满远见卓识，讲的不仅是技巧，而且对大部分家长和教育者所面临的100多个常见问题给出了很实用的建议。

ISBN: (纸本)7801652029

关键词：家庭教育学科:方法

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Novel anti-AD dimeric leads:from relieving symptoms to modifying diseases via multi-targets

Novel anti-AD dimeric leads:from relieving symptoms to modif...

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2019全国老年痴呆与认知障碍相关疾病学术大会

作者： HAN Yi-fan HU Sheng-quan marvin MAK WANG Jia-jun State Key Laboratory of Chinese Medicine and Molecular Pharmacology (Incubation) The Hong Kong Polytechnic University Shenzhen Research Institute Department of Applied Biology and Chemical Technology Institute of Modern Chinese MedicineThe Hong Kong Polytechnic University

Alzheimer disease(AD) has now become the most common brain disorder among the older *** addition,the currently existing therapeutics only offer temporary symptomatic ***,further research and development of more efficacious and disease-modifying agents for the prevention,treatment and restoration of AD will have tremendous value from both scientific,and economic *** the past few years,our series of studies have identified several highly promising anti-AD dimeric leads,with disease-modifying *** this presentation,the latest progress on the neuroprotective and disease modifying effects and the underlying mechanisms of those candidates will be comprehensively illustrated and discussed.

关键词： Alzheimer disease dimeric leads multi-targets relieving symptoms modifying diseases

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种子小蜂和空壳果实对生物能源树种黄连木果实和油产量的影响(英文)

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昆虫学报 2011年第10期54卷 1133-1139页

作者：刘琼霞文礼章周华建吴倩 marvin K.HARRIS 肖治术湖南农业大学生物科学与生物技术学院长沙410128 中国科学院动物研究所农业虫鼠害综合治理研究国家重点实验室北京100101 郑州大学生物工程系郑州450001 College Station Texas A&M UniversityTexas 77843USA

黄连木Pistacia chinensis Bunge因果实含油量高,被作为生物能源树种在我国进行大面积栽培推广和能源开发利用。然而,专性寄生害虫(主要为黄连木广肩小蜂Eurytoma plotnikovi Nikolskaya)的危害及由单性结实和败育所造成的空壳果实可能... 详细信息

黄连木Pistacia chinensis Bunge因果实含油量高,被作为生物能源树种在我国进行大面积栽培推广和能源开发利用。然而,专性寄生害虫(主要为黄连木广肩小蜂Eurytoma plotnikovi Nikolskaya)的危害及由单性结实和败育所造成的空壳果实可能影响黄连木的果实产量和质量。为了评价种子害虫和空壳果实对黄连木果实产量和质量的影响,我们测定了河南省济源市3个黄连木种群40株结果雌树的果实产量和油产量,同时测定了完好果实、空壳果实和虫蛀果实等3类果实的干重和含油量。结果表明:(1)虫害率和空壳率分别达22.6%和53.0%,且不同个体和种群间均存在显著差异(P<0.05)。(2)空壳果实(30.7mg/果)和虫蛀果实(33.1mg/果)的干重均不到完好果实(67.4mg/果)的一半;空壳果实(3.9%)和虫蛀果实(3.8%)的含油量均显著低于完好果实(39.9%)。(3)实测的果实产量(2.9kg/树)和油产量(0.6kg/树)分别仅为期望产量的50%(4.7kg/树)和33%(1.9kg/树),但在3个种群之间无显著差异。本研究显示小蜂危害和空壳果实对黄连木果实产量和质量能造成严重影响,在将其作为生物能源树种利用时对此应加以克服。

关键词：黄连木生物能源生物能源树种种子小蜂黄连木广肩小蜂空壳果实果实产量油产量

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