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A randomized,controlled,open label non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency anemia in China

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Frontiers of Medicine 2024年第1期18卷 98-108页

作者： Jie Jin Zhihua Ran Emanuele Noseda Bernard Roubert Matthieu marty Anna Mezzacasa Udo Michael Göring The First Affiliated Hospital Zhejiang University College of MedicineHangzhou310058China Renji Hospital Shanghai Jiao Tong University School of MedicineShanghai200025China Vifor Pharma Glattbrugg8152Switzerland

Iron deficiency(ID)and ID anemia(IDA)pose significant public health concerns in *** iron sucrose(IS)treatment is well-established in the country,ferric carboxymaltose(FCM)offers the advantage of higher doses and fewer *** open label,randomized,controlled,non-inferiority trial was conducted at multiple sites in China to compare the outcomes of FCM(maximum of 2 doses,500 or 1000 mg iron)and IS(up to 11 infusions,200 mg iron)treatments in subjects with *** primary endpoint was the achievement of hemoglobin(Hb)response(an increase of⩾2 g/dL from baseline)within 8 weeks,whereas secondary endpoints included changes in Hb,transferrin saturation,and serum ferritin *** the 371 randomized subjects,a similar percentage of subjects treated with FCM and IS achieved Hb-response(FCM 99.4%,IS 98.3%),thereby confirming the non-inferiority of FCM compared with IS(difference 1.12(−2.15,4.71;95%confidence interval(CI))).Furthermore,a significantly higher proportion of FCM-treated subjects achieved early Hb-response at Week 2(FCM 85.2%,IS 73.2%;difference 12.1(3.31,20.65;95%CI)).Additionally,the increase in TSAT and serum ferritin levels from baseline was significantly greater at all time points for FCM-treated *** safety profiles of FCM and IS were comparable,with the exception of transient hypophosphatemia and pyrexia,which are consistent with FCM’s known safety *** conclusion,FCM proves to be an efficacious treatment for IDA,providing faster Hb-response and correction of ID with fewer administrations than IS.

关键词： iron deficiency anemia intravenous iron ferric carboxymaltose iron sucrose Hb response early response

Adding Value to Crop Production Systems by Integrating Forage Cover Crop Grazing

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American Journal of Plant Sciences 2024年第3期15卷 180-192页

作者： Robert B. Mitchell Daren D. Redfearn Kenneth P. Vogel Terry J. Klopfenstein Galen Erickson P. Stephen Baenziger Bruce E. Anderson Mary E. Drewnoski Jay Parsons Steven D. Masterson marty R. Schmer Virginia L. Jin USDA-ARS Wheat Sorghum and Forage Research Unit University of Nebraska-Lincoln Lincoln NE USA Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE USA Department of Animal Science University of Nebraska-Lincoln Lincoln NE USA Department of Agricultural Economics University of Nebraska-Lincoln Lincoln NE USA USDA-ARS Agroecosystem Management Research Unit University of Nebraska-Lincoln Lincoln NE USA

In addition to their value as cereal grains, wheat (Triticum aestivum L.) and triticale (× Triticosecale Wittmack) are important cool-season annual forages and cover crops. Yearling steer (Bos taurus) performance was compared in the spring following autumn establishment as for age cover crops after soybean [Glycine max (L.) Merr.] grain harvest. Replicated pastures (0.4 ha) were no-till seeded in three consecutive years into soybean stubble in autumn, fertilized, and grazed the following spring near Ithaca, NE, USA. Each pasture (n = 3) was continuously stocked in spring with four yearling steers (380 ± 38 kg) for 17, 32, and 28 d in 2005, 2006, and 2007, respectively. In 2005, average daily gain (ADG) for steers grazing triticale exceeded the ADG for wheat by 0.31 kghd-1d-1. In 2006, wheat ADG exceeded that for triticale by 0.12 kghd-1d-1. In 2007, steers grazing wheat lost weight, while steers grazing triticale gained 0.20 kghd-1d-1. Based on the 3-year average animal gains valued at $1.32 kg-1, mean net return ($ ha-1 yr-1) was $62.15 for triticale and $22.55 for wheat. Since these grazed cover crops provide ecosystem services in addition to forage, grazing could be viewed as a mechanism for recovering costs and adds additional value to the system. Based on this 3-year grazing trial, triticale was superior to wheat and likely will provide the most stable beef yearling performance across years with variable weather for the western Cornbelt USA.

关键词： Cover crops Soybean Triticale Wheat

Reviewing the Chinese-Specific Reference Amounts Study Conducted by Sun et al.,2022

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China CDC weekly 2023年第34期5卷 763-765页

作者： W.marty Blom Joost Westerhout Geert F.Houben Department RAPID The Netherlands Organisation for Applied Scientific Research(TNO)Utrechtthe Netherlands.

The need for region-specific food intake values to accurately estimate food allergen risk is underscored by the recent Ad Hoc Joint Food and Agriculture Organization/World Health Organization(FAO/WHO)Expert Consultation on Risk Assessment of Food Allergens(1).A recent study published by Sun et *** China CDC Weekly 2022,titled A Chinese-Specific Reference Amounts Study with TNO Food Allergen Risk Assessment Models—China,2022,critically examines and applies a previously established sensitivity analysis aimed at deriving food intake values for food allergen risk assessment(RA)(2–3).In their examination of Chinese food consumption data,the authors find that“the 95th–99th percentiles of the food consumption distribution per eating occasion for condiments and chocolates are the optimal point estimates for use in deterministic allergen RA,aiming to protect 99%of allergic individuals from allergic reactions due to unintended peanut presence.”

关键词： al. intake allergic

A Novel Model for Elementary Particles: Light Charges and Their Motion in 5D Space-Time

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Journal of High Energy Physics, Gravitation and Cosmology 2023年第3期9卷 725-742页

作者： Julie marty Independent Researcher New Hope MN USA

This paper proposes a novel model for elementary particles, introducing the concept of “light charges”, as fundamental entities that exhibit intriguing behavior in 5-dimensional space-time. Light charges are postulated to possess two velocity vectors: one moving at variable velocity, and one moving at the speed of light, that remain fixed relative to each other at perpendicular angles. These light charges interact with each other based on their charges, leading to changes in their motion over time. This paper derives equations based on the proposed model to investigate the behavior of light charges in various scenarios. Remarkably, the model is capable of reproducing known properties of elementary particles, including values for their charge, mass, and spin. This paper further discusses the implications of this model for our understanding of fundamental particles, including the potential connections to quantum mechanics and relativity. The proposed light charge model offers a new perspective on the behavior of elementary particles. While further research and validation are needed, this model may pave the way for a deeper understanding of the fundamental nature of matter and energy in the universe.

关键词： Quantum Gravity Black Holes

Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review

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World Journal of Gastroenterology 2014年第7期20卷 1833-1838页

作者： Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika marty M Meyer Division of Gastroenterology Hepatology and Nutritionthe Ohio State University Wexner Medical CenterColumbusOH 43210United States Division of Human Genetics the Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of Pathology the Ohio State University Wexner Medical CenterColumbusOH 43210United States

AIM: To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten (PTEN) hamartoma tumor syndrome (PHTS) and to perform a systematic literature review rega... 详细信息

关键词： Adenoma Bannayan-Riley-Ruvalcaba syndrome Colon polyps Colorectal cancer Cowden syndrome Endoscopy Ganglioneuroma Hamartoma Hyperplastic Phosphatase and tensin homolog on chromosome ten

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Making Movies

英语沙龙（高中） 2015年第1期 42-43页

作者： marty Kaminsky

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Strategic Tourism

China Textile 2008年第3期 56-60页

作者： Aubry marty

Madonna H&M and the little Chinese girl:the ideal incarnation of"Mass Prestige"in conquering China The term Anglo-Saxon Mass prestige comes from the contraction of mass market(mass market)and *** term first appeared in 2003 in the USA,in the serious Harvard Business Review,under the pen of Michael *** can be defined as an affordable luxury,although this term may

关键词： Strategic Tourism

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Loss of Hox5 function results in myofibroblast mislocalization and distal lung matrix defects during postnatal development

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Science China(Life Sciences) 2018年第9期61卷 1030-1038页

作者： Steven M.Hrycaj Leilani marty-Santos ANDrew J.Rasky Nicholas W.Lukacs Deneen M.Wellik Department of Internal Medicine Division of Molecular Medicine and Genetics University of Michigan Department of Pathology University of Michigan Department of Cell and Developmental Biology University of Michigan

Alveologenesis is the final stage of lung development and is responsible for the formation of the principle gas exchange units called alveoli. The lung mesenchyme, in particular the alveolar myofibroblasts, are drivers of alveolar development, however,few key regulators that govern the proper distribution and behavior of these cells in the distal lung during alveologenesis have been identified. While Hox5 triple mutants(Hox5 aabbcc) exhibit neonatal lethality, four-allele, compound mutant mice(Hox5 AabbCc) are born in Mendelian ratios and are phenotypically normal at birth. However, they exhibit defects in alveologenesis characterized by a BPD-like phenotype by early postnatal stages that becomes more pronounced at adult stages. Invasive pulmonary functional analyses demonstrate significant increases in total lung volume and compliance and a decrease in elastance in Hox5 compound mutants. SMA+ myofibroblasts in the distal lung are distributed abnormally during peak stages of alveologenesis and aggregate, resulting in the formation of a disrupted elastin network. Examination of other key components of the distal lung ECM, as well as other epithelial cells and lipofibroblasts reveal no differences in distribution. Collectively, these data indicate that Hox5 genes play a critical role in alveolar development by governing the proper cellular behavior of myofibroblasts during alveologenesis.

关键词： Hox5 alveologenesis alveolar myofibroblasts lung ECM postnatal lung development

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Images of the Conquest of China

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China Textile 2008年第4期 56-58页

作者： Aubry marty

On October 19,2007,the mark Fendi was set on the Great Wall of *** image,among many others of its kind,has been widely disseminated on the screens around the world (the internet and television).So it is an artistic ev... 详细信息

关键词： very Images of the Conquest of China

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