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Importance of clinical suspicion and multidisciplinary management for early diagnosis of a cardiac laminopathy patient:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7472-7477页

作者： Vincenzo Ezio Santobuono Andrea Igoren Guaricci Eugenio Carulli Nicola Bozza martino pepe Alfredo Ranauro Carlotta Ranieri Maria Cristina Carella Francesco Loizzi Nicoletta Resta Stefano Favale Cinzia Forleo Department of Emergency and Organ Transplantation Cardiology Unit of Policlinic University of BariBari 70124BAItaly Division of Medical Genetics Department of Biomedical Sciences and Human OncologyPoliclinic University of BariBari 70124BAItaly

BACKGROUND Laminopathies are rare diseases,whose cardiac manifestations are heterogeneous and,especially in their initial stage,similar to those of more common conditions,such as ischemic heart *** diagnosis is essential,as these conditions can first manifest themselves with sudden cardiac *** complications usually appear before structural complications;therefore,it is important to take into consideration these rare genetic disorders for the differential diagnosis of brady and tachyarrhythmias,even when left ventricle systolic function is still *** SUMMARY A 60-year-old man,without history of previous disorders,presented in September 2019 to the emergency department because of the onset of syncope associated with *** patient was diagnosed with a high-grade atrioventricular block.A dual chamber pacemaker was implanted,but after the onset of a sustained ventricular tachycardia during physical exertion,a drug eluting stent was implanted on an intermediate stenosis on the left anterior descending artery,which had previously been considered non-haemodynamically *** the follow-up,the treating cardiologist,suspicious of the overall clinical picture,recommended a genetic test for the diagnosis of cardiomyopathies,which tested positive for a pathogenetic mutation of the lamin A/C *** awaiting the result of the genetic test and,later,the pacemaker to be upgraded to a biventricular defibrillator,a remote monitoring device was given to the patient in 2019-related *** case aims to raise awareness of the cardiological manifestations of laminopathies,which can be dangerously misdiagnosed as other, more common conditions.

关键词： Lamin A/C-mutation Cardiolaminopathy Ventricular tachyarrhythmias Remote-monitoring COVID-19 Case report

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Supnorm Estimates for ā on Product Domains in C^(n)

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Acta Mathematica Sinica,English Series 2024年第10期40卷 2307-2323页

作者： martino FASSINA Yi Fei PAN Department of Mathematics University of Illinois at Urbana-Champaign1409 West Green StreetUrbanaIL 61801USA Department of Mathematical Sciences Purdue University Fort Wayne2101 East Coliseum BoulevardFort WayneIN 46805USA

Using methods from complex analysis in one variable,we define an integral operator that solves ā with supnorm estimates on product domains in C^(n).

关键词： Supnorm estimates product domains Cauchy Riemann equation

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Genome-wide investigation to assess copy number variants in the Italian local chicken population

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Journal of Animal Science and Biotechnology 2024年第2期15卷 563-577页

作者： Filippo Cendron martino Cassandro Mauro Penasa Department of Agronomy FoodNatural ResourcesAnimals and Environment(DAFNAE)University of PadovaViale Dell’Universita 1635020 LegnaroPDItaly Federazione Delle Associazioni Nazionali Di Razza E Specie Via XXIV Maggio 4300187 RomeItaly

Background Copy number variants(CNV)hold significant functional and evolutionary *** ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure of ***-density chips have enabled the detection of CNV with increased resolution,leading to the identification of even small *** study aimed to identify CNV in local Italian chicken breeds and investigate their distribution across the *** Copy number variants were mainly distributed across the first six chromosomes and primarily associated with loss type *** majority of CNV in the investigated breeds were of types 0 and 1,and the minimum length of CNV was significantly larger than that reported in previous ***,a high proportion of the length of chromosome 16 was covered by copy number variation regions(CNVR),with the major histocompatibility complex being the likely *** the genes identified within CNVR,only those present in at least five animals across breeds(n=95)were discussed to reduce the focus on redundant *** of these genes have been associated to functional traits in ***,several CNVR on different chromosomes harbor genes related to muscle development,tissue-specific biological processes,heat stress resistance,and immune *** trait loci(QTL)were also analyzed to investigate potential overlapping with the identified CNVR:54 out of the 95 gene-containing regions overlapped with 428 QTL associated to body weight and size,carcass characteristics,egg production,egg components,fat deposition,and feed *** The genomic phenomena reported in this study that can cause changes in the distribution of CNV within the genome over time and the comparison of these differences in CNVR of the local chicken breeds could help in preserving these genetic resources.

关键词： Chicken Copy number variant Conservation Local breed SNP

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The phenotypic convergence between microglia and peripheral macrophages during development and neuroinflammation paves the way for new therapeutic perspectives

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Neural Regeneration Research 2021年第4期16卷 635-637页

作者： Francesca Grassivaro Gianvito martino Cinthia Farina Institute of Experimental Neurology Division of NeuroscienceSan Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly

Microglia,the tissue resident macrophages of the brain,are increasingly recognized as key players for central nervous system development and *** are long-lived cells deriving from a transient wave of yolk-sac derived erythro-myeloid progenitors early in *** unique ontology has prompted the search for specific markers to be used for their selective investigation and *** first generation of genomewide expression studies has provided a bundle of transcripts(such as Olfml3,Fcrls,Tmem119,P2ry12,Gpr34,and Siglech)useful to distinguish microglia from peripheral ***,more recent reports have revealed that microglial phenotype is constantly shaped by the microenvironment in a time-,and context-dependent *** this article,we review data that provide additional pieces to this complex scenario and show the existence of unexpected phenotypic convergence between microglia and peripheral macrophages at certain developmental stages and under pathological *** observations suggest that the two cell types act synergically boosting their mutual activities depending on the *** novel information about the biology of microglia and peripheral macrophages sheds new light about their therapeutic potential for neuroinflammatory and neurodegenerative diseases.

关键词： cell reprogramming cell therapy macrophages microglia neuroinflammation plasticity

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Biomechanical modeling of metal screw loadings on the human vertebra

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Acta Mechanica Sinica 2021年第2期37卷 307-320页

作者： Leonardo Molinari Cristina Falcinelli Alessio Gizzi Alberto Di martino Department of Engineering Campus Bio-Medico University of RomeVia A.del Portillo 21Rome 00128Italy Department of Biomedical and Neuromotor Science DIBINEM University of BolognaBolognaItaly 1st Orthopaedic and Traumatologic Clinic IRCCS Istituto Ortopedico RizzoliBolognaItaly

During spinal fusion surgery,angled screw insertion can provide a more favorable stress distribution reducing failure events(screw breakage and loosening).Finite element(FE)analysis can be employed for identifying the optimal insertion path,preventing stress concentrations,and ensuring a lower failure *** this work,a patient-specific FE model of L4 vertebra,virtually implanted with two pedicle screws,was obtained from diagnostic images and numerically *** elastic,inhomogeneous,and isotropic material properties were assigned to bone based on density distributions reconstructed from the medical *** mechanical response of the screws-vertebra system was analyzed through a progressive damage procedure,considering a stress-based *** screws insertion angles were simulated,as well as physiological loading *** each loading case,screw orientation influences the fracture mechanism(i.e.,brittle or ductile one),as well as the fracture pattern and ***,stresses in trabecular bone and pedicle screws are significantly affected by the screw *** caudomedial trajectory indicates the most safe case,significantly reducing the stress concentrations in both trabecular bone and *** findings aim to furnish a useful indication to surgeons regarding the screws insertion angle,further reducing the failure risk and improving the clinical outcome of the fixation procedure.

关键词： Fracture mechanics Patient-specific FE modeling Vertebra mechanics Screw orientation Stress analysis

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Long-term experience with debulking surgery in extensive hepatic alveolar echinococcosis:A case series and literature review

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Asian Pacific Journal of Tropical Medicine 2022年第10期15卷 468-473页

作者： Mohsen Aliakbarian Marcello Di martino Sara Saeidi Department of General Surgery Surgical Oncology Research CenterMashhad University of Medical SciencesMashhadIran Division of Hepatobiliary and Liver Transplantation Surgery.A.O.R.N.Cardarelli NapoliItaly

Objective:To assess the role of debulking surgery in extensive hepatic alveolar echinococcosis(HAE).Methods:Five cases of extensive HAE undergoing debulking surgery with their long-term follow-ups were ***,a systematic review was carried ***:The average age of patients in the study was(50.8±17.1)years(range 36 to 77 years).Three cases were *** median follow-up period was 61 months(range 12 to 84 months).Left liver resections were performed in 2 cases and right hemihepatectomies were undertaken in 2 *** patients(cases 2 and 4)developed early surgical complications,while one of them(case 4)who suffered from the recurrent sub-hepatic abscess died at 12 months ***:This study highlights the importance of debulking surgery for the management of complex symptomatic HAE lesions in patients with no curative option available.

关键词： Alveolar echinococcosis Debulking surgery Reduction Palliative Echinoccocosis multilocularis Case series

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Ultrathin Wood Laminae–Thermoplastic Starch Biodegradable Composites

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Journal of Renewable Materials 2018年第5期6卷 493-503页

作者： Andrea Dorigato martino Negri Alessandro Pegoretti University of Trento Department of Industrial Engineering and INSTM Research UnitVia Sommarive 938123 TrentoItaly Trees&Timber Institute CNR IVALSAI-38010 San Michele all’AdigeTrentoItaly

Novel fully biodegradable thermoplastic composite laminates reinforced with ultrathin wood laminae were prepared through a hot-pressing process by using two different thermoplastic starch(TPS)*** microstructure and physical properties of the resulting unidirectional and bidirectional laminates were *** investigated materials presented a complex microstructure,in which the porosity of the wood laminae was almost entirely occluded by the polymer *** mechanical behavior of the laminates was strongly affected by the obtained microstructure,and matrix penetration in wood pores led to biodegradable composites with elastic modulus and tensile strength higher than those of their ***,thermal welding and thermoformability tests proved how these materials possess features typical of thermoplastic materials.

关键词： Starch ultrathin wood laminae composites mechanical properties

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An Analysis of Overseas’ Chinese Enterprises’ Cause-Related Marketing Fit and Their Impact on the Brand Image in Indonesia

An Analysis of Overseas’ Chinese Enterprises’ Cause-Relate...

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作者： Kevin martino 浙江工商大学

学位级别：硕士

Cause-related marketing fit and its impact on organizational brand image has dominated fields of organizational studies in the recent *** study sought to find out how cause-related marketing fit influence customer trust and brand image of Chinese telecommunication products in *** objectives guided the study: To assess the influence of cause-related marketing fit on customer trust in Chinese multinationals in Indonesia;To find out the influence of customer trust on brand image in Chinese multinationals in Indonesia;To assess the mediation effect of customer trust in the relationship between cause-related marketing fit and brand image in Chinese multinationals in *** study utilized survey research design to sample of 225 consumers sampled from three municipalities through proportionate ***,the study found out that cause-related marketing fit,high customer trust were positively associated to organizational brand ***,customer trust mediating the relationship between cause-related marketing fit and brand image such that the effect of cause-related marketing strategies’ effect on brand image is high with high customer trust on the Chinese product than when the trust is *** study recommends a more versatile marketing strategy of the Chinese products in the language familiar with consumers in Indonesia so as to increase their trust on the product and brand image.

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Locoregional therapy response in patients with hepatocellular cancer waiting for liver transplantation:Only selection or biological effect?

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World Journal of Gastroenterology 2018年第31期24卷 3469-3471页

作者： Quirino Lai Michele Di martino Pierleone Lucatelli Gianluca Mennini Department of General Surgery and Organ Transplantation Sapienza University of Rome Department of Radiology Sapienza University of Rome

Locoregional treatments(LRT) represent a broad strategy used for reducing the risk of drop-off and contextually improving the survivals in patients with hepatocellular cancer receiving a liver transplantation(LT). However, it is not sufficiently clear if LRT are only a surrogate of tumor aggressiveness or if they consent a real benefit in terms of tumor stabilization. A recent study by Pommergaard et al reported the results from the European Liver Transplant Registry. Patients receiving LRT before LT had better 5-year survival rates respect to no-LRT cases(69.7% vs 65.8%; P < 0.001). When the number of LRT was tested, one-to-two treatments were connected with improved survivals respect to no treatment [hazard ratio(HR) = 0.85 and 0.71, respectively]. The efficacy of LRT was also reported in the presence of larger tumors(HR = 0.78) and micro-macrovascular invasion(HR = 0.71). The results observed in the present study are partially in discordance with other analyses showing a detrimental effect of LRT. The main problem in the interpretation of these results is connected with the possible initial selection biases present in the studies. The most recent guidelines suggest to perform LRT before the transplant, but the level of evidence is typically low due to the absence of prospectively designed studies.

关键词： Allocation Recurrence Trans-arterial chemo-embolization Radiofrequency ablation Model for end-stage liver disease

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Multiplexed laser particles for spatially resolved single-cell analysis

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Light(Science & Applications) 2019年第1期8卷 526-530页

作者： Sheldon J.J.Kwok Nicola martino Paul H.Dannenberg Seok-Hyun Yun Harvard Medical School and Wellman Center for Photomedicine Massachusetts General Hospital50 Blossom StreetBostonMA 02114USA Harvard-MIT Health Sciences and Technology Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA LASE Innovation Inc. 650 E.Kendall Street2nd FLCambridgeMA 02142USA

Biomolecular analysis at the single-cell level is increasingly important in the study of cellular heterogeneity and its consequences,particularly in organismic development and complex diseases such as ***-cell molecular analyses have led to the identification of new cell types1 and the discovery of novel targets for diagnosis and *** these analyses are performed predominantly on dissociated single cells,emerging techniques seek understanding of cellular state,cellular function and cell–cell interactions within the native tissue environment by combining optical microscopy and single-cell molecular *** techniques include in situ multiplexed imaging of fluorescently labeled proteins and nucleotides,as well as low-throughput ex vivo methods in which specific cells are isolated for downstream molecular ***,these methods are limited in either the number and type of molecular species they can identify or the number of cells that can be ***-throughput methods are needed for comprehensive profiling of many cells(>1000)to detect rare cell types,discriminate relevant biomarkers from intrinsic population noise,and reduce the time and cost of *** established,highthroughput single-cell analyses are not directly applicable because they require tissue dissociation,leading to a loss of spatial *** current methods exist that can seamlessly connect spatial mapping to single-cell *** this Perspective,we review current methods for spatially resolved single-cell analysis and discuss the prospect of novel multiplexed imaging probes,called laser particles,which allow individual cells to be tagged in tissue and analyzed subsequently using high-throughput,comprehensive single-cell techniques.

关键词： diagnosis spatially resolved

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