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Pedigree analysis of 220 almond genotypes reveals two world mainstream breeding lines based on only three different cultivars

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Horticulture Research 2021年第1期8卷 72-82页

作者： Felipe Perez de los Cobos Pedro j.martinez-Garcia Agusti Romero Xavier Miarnau Iban Eduardo Werner Howad Mourad Mnej.a Federico Dicenta Rafel Socias i Company Maria j.Rubio-Cabetas Thomas M.Gradziel Michelle Wirthensohn Henri Duval Doron Holland Pere Arus francisco j.Vargas Ignasi Batlle Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Mas BoveCtra.Reus-El Morell Km 3843120 ConstantiTarragonaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) Centre de Recerca en Agrigenomica(CRAG)CSIC-IRTA-UAB-UB.Cerdanyola del Valles(Bellaterra)08193 BarcelonaSpain Centro de Edafologia y Biologia Aplicada del Segura Consejo Superior de Investigaciones Cientificas(CEBAS-CSIC)P.O.Box 16430100 EspinardoMurciaSpain Institut de Recerca i Tecnologia Agroalimentaries(IRTA) FruitcentrePCiTALGardeny ParkFruitcentre Building25003 LleidaSpain Centro de Investigacion y Tecnologia Agroalimentaria de Aragon(CITA) Avda.Montanana 93050059ZaragozaInstituto Agroalimentario de Aragon IA2(CITA-Universidad de Zaragoza)ZaragozaSpain University of California 1 Shields AvenueDavisCA 95616USA University of Adelaide Waite ResearchSchool of AgricultureFood and WinePMB 1Glen OsmondAdelaideSA 5064Australia Institut National de la Recherche Agronomique(INRA) Domain St.Maurice CS 6009484143 Montfavet CedexFrance Agricultural Research Organization Newe-Ya’ar Research CenterP.O.Box 1021Ramat Yishad 30095Israel

Loss of genetic variability is an increasing challenge in tree breeding programs due to the repeated use of a reduced number of founder genotypes.However,in almond,little is known about the genetic variability in current breeding stocks,although several cases of inbreeding depression have been reported.To gain insights into the genetic structure in modern breeding programs worldwide,marker-verified pedigree data of 220 almond cultivars and breeding selections were analyzed.Inbreeding coefficients,pairwise relatedness,and genetic contribution were calculated for these genotypes.The results reveal two mainstream breeding lines based on three cultivars:“Tuono”,“Cristomorto”,and“Nonpareil”.Descendants from“Tuono”or“Cristomorto”number 76(sharing 34 descendants),while“Nonpareil”has 71 descendants.The mean inbreeding coefficient of the analyzed genotypes was 0.041,with 14 genotypes presenting a high inbreeding coefficient,over 0.250.Breeding programs from France,the USA,and Spain showed inbreeding coefficients of 0.075,0.070,and 0.037,respectively.According to their genetic contribution,modern cultivars from Israel,France,the USA,Spain,and Australia trace back to a maximum of six main founding genotypes.Among the group of 65 genotypes carrying the S f allele for self-compatibility,the mean relatedness coefficient was 0.125,with“Tuono”as the main founding genotype(24.7%of total genetic contribution).The results broaden our understanding about the tendencies followed in almond breeding over the last 50 years and will have a large impact into breeding decision-making process worldwide.Increasing current genetic variability is required in almond breeding programs to assure genetic gain and continuing breeding progress.

关键词： breeding cultivar founding

The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

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Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： j.se AG Agundez Elena Garcia-Martin Carmen martinez j.lian Benito-Leon j.lian Benito-Leon j.rge Millan-PascualMaria Diaz-Sanchez Patricia Callej. Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro Lucia Ayuso-Peralta Dolores Torrecillas Esteban Garcla-Albea j.se francisco Plaza-Nieto Felix j.vier j.menez-j.menez Department of Pharmacology University of Extremadura CAceres Spain Department of Biochemistry and Molecular Biology University of Extremadura Caceres Spain CiBERNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de Biologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词：多发性硬化多态性单核苷酸发病年龄谷胱甘肽基因性别特性一氧化氮胰岛素

Synthesis of Tenoltrifluoroacetone Composite Doped with Terbium, Dysprosium and Europium Encapsulated in Silica Oxide Matrix

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j.urnal of Surface Engineered Materials and Advanced Technology 2020年第4期10卷 63-74页

作者： Yazmin francisco Dulce Medina Miguel Barron j.an Reyes Pedro Adrian martinez Angel de j.sus Morales Elizabeth Garfias Universidad Autónoma Metropolitana Departamento de Materiales Ciencias Básicas e Ingeniería Reynosa Tamaulipas México Instituto Politécnico Nacional ESIQIE UPALM S/N Mexico City México

The synthesis of the thenoyltrifluoroacetone compound doped with terbium, dysprosium and europium encapsulated in a silica matrix (TTA:Tb:Dy:Eu@SiO2) were performed by the sol-gel method. The precursors to obtain the vitreous phase (SiO2) were: Tetraethylorthosilicate (TEOS, C8H2O4Si, 98%, Aldrich), and ethyl alcohol (CH3CH2OH, 99.5%, Meyer), distilled water and 0.05 ml of hydrochloric acid (HCl, Meyer). The sample with molar ratio 20:80 TTA:Tb:Dy:Eu@SiO2 has the best emission intensity. Thermogravimetric analysis (TGA) shown that silica encapsulated samples decompose at lower temperatures than pure TTA:Tb:Dy:Eu luminescent material. Fourier Transform Infrared (IR-TF) shown the characteristic Si-O-Si bands that are presented at a wavelength of 1049, 853 and 440 cmǃ confirming that the luminescent material is encapsulated in a silica matrix, finally X-ray diffraction (XRD) shown that TTA:Tb:Dy:Eu@SiO2 composite is amorphous.

关键词： Synthesis Luminescence Composite Sol-Gel Terbium Dysprosium and Europium

The Institutionalization of Life Cycle Assessment in Mexico

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j.urnal of Environmental Protection 2015年第8期6卷 804-812页

作者： Nora Munguia Clara Rosalia Alvarez Rafael Perez Alma Flores francisco martinez Luis Velazquez Sustainability Graduate Program University of Sonora Hermosillo Mexico Institute of Agro-Livestock Sciences Autonomous University of Mexico State Toluca Mexico

This article presents a study of Life Cycle Assessment (LCA) at a slaughterhouse located in north-western Mexico with the purpose of testing the premise of a low degree of institutionalization of Industrial Ecology in Mexico. The article aims at analyzing the current role played by the Mexican academia in increasing the degree of institutionalization of the concept of LCA in northwestern Mexico. There was conducted a life cycle analysis study according to the standards ISO 14040: 2006, NMX-SAA-14040-IMNC-2008NOM in a Federally Inspected Type (TIF by Spanish acronym) Slaughterhouse in the state of Sonora in Northwest Mexico. The slaughter process was characterized by observing the production tasks during several walkthroughs the production lines and by having short interviews with workers, supervisors, and the manager. The CH4 emissions were calculated using the guidelines suggested by the Intergovernmental Panel on Climate Change (IPCC 2006). The present LCA case study revealed opportunities for improving the environmental performance of the slaughterhouse by taking measures such as the reduction of CH4 from enteric fermentation since methane was one of the main greenhouse gases responsible for climate change. Although, the LCA generated reliable information in terms of climate change or water eutrophication, the chances of implementing sustainable initiatives were unlikely because the benefits to reduce the impacts to climate change or to reduce the water crisis would be unnoticeable and unaffordable for companies. Findings in this study also confirmed the importance of Mexican universities for promoting and conducting more LCA studies among private and public organizations in order to guide firms towards this tool. The case study here presented gives insights to LCA stakeholders in Mexico to implement or improve the effectiveness of their potential LCA initiatives through the identification of strategies, opportunities, and barriers.

关键词： Institutionalization Academia LCA Sustainability Slaughterhouse Mexico

Refractive errors among children, adolescents and adults attending eye clinics in Mexico

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International j.urnal of Ophthalmology(English edition) 2017年第5期10卷 796-802页

作者： francisco Gomez-Salazar Abraham Campos-Romero Humberto Gomez-Campana Cinthia Cruz-Zamudio Mariano Chaidez-Felix Nidia Leon-Sicairos j.rge Velazquez-Roman Hector Flores-Villasenor Secundino Muro-Amador Alma Marlene Guadron-Llanos j.vier j.martinez-Garcia j.el Murillo-Llanes j.ime Sanchez-Cuen Alej.ndo Llausas-Vargas Gerardo Alapizco-Castro Ana Irineo-Cabrales Enrique Graue-Hernandez Tito Ramirez-Luquin Adrian Canizalez-Roman Salud Digna Para Todos I.A.P Culiacan Sinaloa 80000Mexico CIASaP School of Medicine Autonomous University of Sinaloa Culiacan Sinaloa 80246 Mexico Pediatric Hospital of Sinaloa Culiacan Sinaloa 80200Mexico The Women's Hospital Secretariat of Health Culiacan Sinaloa 80127 Mexico Department of Gastroenterology Regional Hospital ISSSTECuliacan 80230 Sinaloa Mexico Education and Research Department Regional general Hospital No. 1 IMSS Culiacan Sinaloa 80220 Mexico Department of Cornea and Refractive Surgery Institute of Ophthalmology 'Conde de Valenciana' Mexico City 06800Mexico

AIM：To assess the proportion of refractive errors in the Mexican population that visited primary care optometry clinics in fourteen states of Mexico. METHODS：Refractive data from 676 856 patients aged 6 to 90 y were collected from optometry clinics in fourteen states of Mexico between 2014 and 2015. The refractive errors were classified by the spherical equivalent（SE）, as follows：sphere＋？ cylinder. Myopia（SE〉-0.50 D）, hyperopia（SE〉＋0.50 D）, emmetropia（-0.50≤SE≤＋0.50）, and astigmatism alone（cylinder≥-0.25 D）. A negative cylinder was selected as a notation.RESULTS：The proportion（95% confidence interval） among all of the subj.cts was hyperopia 21.0%（20.9-21.0）, emmetropia 40.7%（40.5-40.8）, myopia 24.8%（24.7-24.9） and astigmatism alone 13.5%（13.4-13.5）. Myopia was the most common refractive error and frequency seemed to increase among the young population（10 to 29 years old）, however, hyperopia increased among the aging population（40 to 79 years old）, and astigmatism alone showed a decreasing trend with age（6 to 90y; from 19.7% to 10.8%）. There was a relationship between age and all refractive errors（approximately 60%, aged 50 and older）. The proportion of any clinically important refractive error was higher in males（61.2%） than in females（58.3%; P〈0.0001）. From fourteen states that collected information, the proportion of refractive error showed variability in different geographical areas of Mexico.CONCLUSION：Myopia is the most common refractive error in the population studied. This study provides the first data on refractive error in Mexico. Further programs and studies must be developed to address the refractive errors needs of the Mexican population.

关键词： refractive errors hyperopia myopia astigmatism

Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation

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j.urnal of Geriatric Cardiology 2020年第3期17卷 141-148,I0005-I0007页

作者： Gines Elvira-Ruiz Cesar Caro-martinez Pedro j.seFlores-Blanco j.an j.seCerezo-Manchado Helena Albendin-Iglesias Alej.ndro Lova-Navarro francisco Arregui-Montoya Francisca Maria Munoz-Franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola j.seLuis Bailen-Lorenzo Domingo Andres Pascual-Figal Sergio Manzano-Fernández Department of Cardiology University Hospital Virgen de la ArrixacaMurciaSpain Instituto Murciano de Investigación en Biomedicina(IMIB) MurciaSpain Department of Cardiology University Hospital Morales MeseguerMurciaSpain Department of Hematology University Hospital Virgen de la ArrixacaMurciaSpain Department of Internal Medicine University Hospital Virgen de la ArrixacaMurciaSpain School of Medicine University of MurciaMurciaSpain Department of Cardiology Hospital Vega BajaAlicanteSpain

Background The identification of modifiable bleeding risk factors may be of relevance.The aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting maj.r bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between j.nuary 2013 and December 2016.AS was defined as moderate or severe according to European echocardiography guidelines criteria.HASBLED,ATRIA and ORBIT scores were used to evaluate the bleeding risk.MB was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of follow-up.Results 168(5.8%)patients had AS.Patients with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest one.Discrimination and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of follow-up.Conclusions In this population,AS was associated with an increased risk for MB at midterm follow-up.The three scoring systems showed a moderate discriminatory ability for MB.Moreover,the addition of AS was associated with a significant improvement in their predictive accuracy.We suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment.

关键词： Anticoagulants Aortic stenosis Atrial fibrillation Maj.r bleeding Valvular disease

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改造工程：圣巴巴拉城堡

中国电梯 2014年第22期25卷 56-57页

作者：弗朗西斯科·乔斯·布莱克·马丁内斯

位于西班牙阿利坎特的圣巴巴拉城堡是该国在9世纪被穆斯林占领期间修建的堡垒。城堡就建在Monte Benacantil山峰上，是该市的象征和重要的旅游景点。为了改善建筑遗址及旅游便利性，为城堡设计了修复工程，包括内壁、准备用作博物馆的... 详细信息

位于西班牙阿利坎特的圣巴巴拉城堡是该国在9世纪被穆斯林占领期间修建的堡垒。城堡就建在Monte Benacantil山峰上，是该市的象征和重要的旅游景点。为了改善建筑遗址及旅游便利性，为城堡设计了修复工程，包括内壁、准备用作博物馆的区域、展览室以及从Postiguet海滩到城堡的入口区的改造。

关键词：修复工程城堡改造旅游景点建筑遗址穆斯林西班牙便利性

Biodrying under Greenhouse Conditions as Pretreatment for Horticultural Waste

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j.urnal of Environmental Protection 2012年第4期3卷 298-303页

作者： Fabian Robles-martinez Elizabeth M.Silva-Rodriguez Teodoro Espinosa-Solares Belem Pina-Guzman Carmen Calixto-Mosqueda francisco j.Colomer-Mendoza Enrique Duran-Paramo Unidad Profesional Interdisciplinaria de Biotecnología Instituto Politecnico NacionalMexico CityMexico Gus R.Douglass Institute West Virginia State UniversitySouth CharlestonUSA Departamento de Ingenieria Agroindustrial Universidad Autonoma ChapingoTexcocoMexico Departamento de Ingenieria Mecanica y Construccion Universitat Jaume ICastellonSpain

The biodrying process was studied as an alternative technology to reduce the mass and volume of horticultural waste. Four static piles were prepared inside a greenhouse: two containing whole waste and two consisting of shredded waste. All the piles were compared with a test pile containing whole waste and placed outside the greenhouse. In two cases, ventilation ducts were installed to improve aeration. Each greenhouse was 2.0 m wide, 3.5 m long and 1.16 m high. The air temperature and relative humidity were monitored both inside and outside the greenhouse. Mass, humidity, organic matter and total nitrogen in the waste were measured. Piles inside the greenhouse showed decreases of 80% and 75% in weight and volume, respectively, during the first 16 days. The data obtained in this work suggest that biodrying could improve the handling and transport of horticultural waste while also minimizing the impact of pollutants.

关键词： Solid Waste Aerobic Degradation Stabilization Greenhouse

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旧金山市结核病流行病学中的性别差异

国际结核病与肺部疾病杂志 2000年第Z1期 55-59页

作者： A. N. martinez j. T. Rhee P. M. Small M. A. Behr 王延莉 Division of Pulmonary and Critical Care Medicine University of CaliforniaSan Francisco Divisions Division of Pulmonary and Critical Care Medicine University of CaliforniaSan Francisco Divisions Epidemiology Infectious Diseases and Geographic Medicine Stanford University Stanford California USA Division of Infectious Diseases McGill University Health Centre Montreal Quebec Canada

背景:在全球范围内,结核病性别发病率的差异仍无根本性的解释。目的:探究旧金山市1991～1996年有可能解释结核病发病率性别差异的各种因素。设计:对旧金山市1991～1996年结核病特定性别发病率进行回顾性流行病学分析。按诊断时年龄、种... 详细信息

背景:在全球范围内,结核病性别发病率的差异仍无根本性的解释。目的:探究旧金山市1991～1996年有可能解释结核病发病率性别差异的各种因素。设计:对旧金山市1991～1996年结核病特定性别发病率进行回顾性流行病学分析。按诊断时年龄、种族群、人类免疫缺陷病毒(HIV)感染情况以及出生地等进行分层分析。使用带有IS6110数据的分子指纹研究新感染和复燃结核病例发病率的性别差异。结果:研究期内,男性与女性发病率之比为2.1(95%CI 1.9～2.3)。分层分析显示年龄超过14岁可见性别发病率差异,美国出生人群、白种人和黑种人其男性:女性发病率之比最高。具有成簇指纹的病例比值也较高,这与美国出生人群近似。在以结核病复燃病例为主的人群,比值在青春期后高于一般情况,但这种影响报告的较少。结论:结核病在美国出生人口中不断的感染是可解释旧金山市性别发病率不同的原因之一。观察到的两性结核病发病率的差异,可能是由于传播动力学的不同,而不是来自诊断和报告的偏倚。

关键词：结核病性别性流行病学