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模型世界 2019年第6期 76-79+5页

作者： francisco j.Martínez

最后,francisco j.martinez制作的英国皇家空军"TILLY"小卡车闪亮登场,主角为田宫(TAMIYA)的1/35套件。虽说只是一台小车,但经过精心旧化,就可以和不列颠之战的英军地勤场景增添亮色。

关键词：油画颜料 Tilly

Preoperative calculation of angles of vision and working area in laparoscopic surgery to treat a giant hiatal hernia

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World j.urnal of Gastrointestinal Surgery 2021年第12期13卷 1638-1650页

作者： francisco j.vier Perez Lara Rogelio Zubizarreta j.menez francisco j.vier Moya Donoso j.se Manuel Hernández Gonzalez Tatiana Prieto-Puga Arj.na Arturo del Rey Moreno Maria Pitarch martinez Surgery Service Antequera HospitalRincón de la Victoria 29730MálagaSpain DOXA Microfluidics Rincon de la Victoria 29738MálagaSpain

BACKGROUND Giant hiatal hernias still pose a maj.r challenge to digestive surgeons,and their repair is sometimes a highly complex task.This is usually performed by laparoscopy,while the role of the thoracoscopic approach has yet to be clearly defined.AIM To preoperatively detect patients with a giant hiatal hernia in whom it would not be safe to perform laparoscopic surgery and who,therefore,would be candidates for a thoracoscopic approach.METHODS In the present study,using imaging test we preoperatively simulate the field of vision of the camera and the working area(instrumental access)that can be obtained in each patient when the laparoscopic approach is used.RESULTS From data obtained,we can calculate the access angles that will be obtained in a preoperative computerised axial tomography coronal section,according to the location of the trocar.We also provide the formula for performing the angle calculations If the trocars are placed in loss common situations,thus enabling us to determine the visibility and manoeuvrability for any position of the trocars.CONCLUSION The working area determines the cases in which we can operate safely and those in which certain areas of the hernia cannot be accessed,which is when the thoracoscopic approach would be safer.

关键词： Hiatal hernia Angles Approach Laparoscopy Thoracoscopy

基于平行共聚焦激光技术并考虑操作者经验和种植角度及深度的种植数字化印模系统的精度分析

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中国口腔医学继续教育杂志 2016年第2期19卷 77-84页

作者： Beatriz Gimenez Mutlu Ozcan francisco martinez-Rus Guillermo Pradies 周文娟柳忠豪不详滨州医学院附属烟台市口腔医院山东省烟台市芝罘区北大街142号264008

目的：对一种基于平行共聚焦激光技术的种植数字化印模系统的精度进行评价，将诸如操作者经验和种植体角度及长度等方面的临床参数考虑在内。材料和方法：在含6颗种植体（位置为双侧第二磨牙，第二前磨牙及侧切牙）的上颔主模型上安装6... 详细信息

目的：对一种基于平行共聚焦激光技术的种植数字化印模系统的精度进行评价，将诸如操作者经验和种植体角度及长度等方面的临床参数考虑在内。材料和方法：在含6颗种植体（位置为双侧第二磨牙，第二前磨牙及侧切牙）的上颔主模型上安装6个聚醚醚酮扫描体。其中一个第二前磨牙植体近中倾斜30°;对侧种植体远中倾斜30°；侧切牙植入龈下2mm或4mm。由两名有经验的医师和两名没有经验的操作者进行口内扫描．测量5个不同的种植体间距,扫描所得到的数据输入逆向工程软件。使用一个坐标测量机进行测量，从主模型上得到的数据作为参考值，计算实际值的误差。统计分析有经验的医师与没有经验的医师以及不同的种植体角度和深度之间的差异。结果：总体上,操作者3得到了明显低精度的结果。与平行植入的植体相比，倾斜植入的植体对于精度没有显著影响。不同象限的误差量存在差异，第二扫描象限的结果比第一象限结果差。种植体植入水平位于软组织的．其精度低于植入龈下2mm及4mm的种植体。结论：操作者影响测量的精度，但是并不一定依赖经验。倾斜种植体不会降低数字化印模系统的精度。扫描距离影响扫描仪精度的可预测性，扫描区长度的增加会导致误差增加。

关键词：精度牙种植数字印模种植体角度种植体深度口内扫描

COVID-19 pandemic,as experienced in the surgical service of a district hospital in Spain

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World j.urnal of Clinical Cases 2021年第23期9卷 6582-6590页

作者： francisco j.vier Pérez Lara Maria Belen j.menez martinez francisco Pozo Muñoz Andres Fontalba Navas Rogelio Garcia Cisneros Maria j.se Garcia Larrosa Ignacio Garcia Delgado Maria del Mar Callej.n Gil Department of Surgery Hopital de AntequeraAntequera 29200MálagaSpain North Malaga Healthcare District Hopital de AntequeraAntequera 29200MálagaSpain

The coronavirus disease 2019,which is caused by severe acute respiratory syndrome coronavirus 2,was first identified in December 2019 in Wuhan,China,and has since spread rapidly,evolving into a full-blown pandemic.We would like to report our experience after 1 year of this pandemic in the surgical service of a district hospital in Spain.There have been many changes(including new protocols)that our service and the hospital have undergone,to adapt to the new situation.We believe that this experience can be useful for other professionals who have lived and are living a similar situation.

关键词： COVID-19 Hospital Experience Surgery Service Treatment

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“黑钢”95式乘用车

模型世界 2018年第9期 68-69+5页

作者： francisco j.Martínez

市面上可以供选择的二战日军车辆模型并不是太多,所以由田宫出品的1/48比例95式乘用车无疑是其中质量最为上乘的之一,并且非常适合搭配机场场景。francisco j.vier martinez Rodriguez将会向我们展示如何仅用简单几步就制作出一个十分... 详细信息

市面上可以供选择的二战日军车辆模型并不是太多,所以由田宫出品的1/48比例95式乘用车无疑是其中质量最为上乘的之一,并且非常适合搭配机场场景。francisco j.vier martinez Rodriguez将会向我们展示如何仅用简单几步就制作出一个十分精良的车辆模型。

关键词：车辆模型乘用车天然土 AK

Novel suturing technique,based on physical principles,achieves a breaking point double that obtained by conventional techniques

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World j.urnal of Gastrointestinal Surgery 2021年第9期13卷 1039-1049页

作者： francisco j.vier Pérez Lara Rogelio Zubizarreta j.menez francisco j.vier Moya Donoso j.se Manuel Hernández Gonzalez Tatiana Prieto-Puga Arj.na Ricardo Marín Moya Maria Pitarch martinez Department of Surgery Hopital de AntequeraMalaga 29200Spain DOXA Malaga 29730Spain

BACKGROUND Sutures have been used to repair wounds since ancient times.However,the basic suture technique has not significantly changed.In Phase I of our proj.ct,we proposed a“double diabolo”suture design,using a theoretical physical study to show that this suture receives 50%less tension than conventional sutures,and so a correspondingly greater force must be applied to break it.AIM To determine whether these theoretical levels of resistance were met by the new type of suture.METHODS An observational study was performed to compare three types of sutures,using a device that exerted force on the suture until the breaking point was reached.The tension produced by this traction was measured.The following variables were considered:Tearing stress on entry/exit points,edge separation stress,and suture break stress.The study sample consisted of 30 sutures with simple interrupted stitches(Group 1),30 with continuous stitches(Group 2),and 30 with the“double diabolo”design(Group 3).RESULTS The mean degree of force required to reach the breaking point for each of these variables(tearing,separation,and final breaking)was highest in Group 3(14.56,18.28,and 21.39 kg),followed by Group 1(7.36,10.38,and 12.81 kg)and Group 2(5.77,7.7,and 8.71 kg).These differences were statistically significant(P<0.001)in all cases.CONCLUSION The experimental results show that with the“double diabolo”suture,compared with conventional sutures,greater force must be applied to reach the breaking point(almost twice as much as in the simple interrupted suture and more than double that required for the continuous suture).If these results are confirmed in Phase III(the clinical phase)of our study,we believe the double diabolo technique should be adopted as the standard approach,especially when the suture must withstand significant tension(e.g.,laparotomy closure,thoracotomy closure,diaphragm suture,or hernial orifice closure).

关键词： Suture Technique Physical principles Tension

Dissecting the molecular pathophysiology of drug-induced liver inj.ry

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World j.urnal of Gastroenterology 2018年第13期24卷 1373-1385页

作者： Hui Ye Leonard j.Nelson Manuel Gómez del Moral Eduardo Martínez-Naves francisco j.vier Cubero Department of Immunology Ophtalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for BioEngineering(Human Liver Tissue Engineering Faraday BuildingThe University of EdinburghThe King BuildingsMayfield RoadEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain

Drug-induced liver inj.ry(DILI) has become a maj.r topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways.

关键词： signaling pathways acetaminophen Drug-induced liver inj.ry cell death reactive oxygen species

Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

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Oncology Research 2023年第3期31卷 361-374页

作者： francisco RAÚL BORZONE MARÍA BELÉN GIORELLO LEANDRO MARCELO martinez MARÍA CECILIA SANMARTIN LEONARDO FELDMAN FEDERICO DIMASE EMILIO BATAGELj.GUSTAVO YANNARELLI NORMA ALEj.NDRA CHASSEING Laboratorio de Inmunohematología Instituto de Biología y Medicina Experimental(IBYME)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos AiresArgentina Division of Hematology and Medical Oncology Department of MedicineWeill Cornell Medical CollegeNew YorkUSA Laboratorio de Regulación Génica y Células Madre Instituto de Medicina TraslacionalTrasplante y Bioingeniería(IMeTTyB)Universidad Favaloro-CONICETBuenos AiresArgentina Facultad de Ciencias de la Salud Universidad Nacional del Centro de la Provincia de Buenos Aires(UNCPB)TandilBuenos AiresArgentina Servicio de Hematología Hospital Militar CentralBuenos AiresArgentina Servicio de Oncología Hospital Militar CentralBuenos AiresArgentina

Breast cancer is the predominant form of carcinoma among women worldwide,with 70%of advanced patients developing bone metastases,with a high mortality rate.In this sense,the bone marrow(BM)mesenchymal stem/stromal cells(MSCs)are critical for BM/bone homeostasis,and failures in their functionality,transform the BM into a premetastatic niche(PMN).We previously found that BM-MSCs from advanced breast cancer patients(BCPs,infiltrative ductal carcinoma,stage III-B)have an abnormal profile.This work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile in this group of patients.A comparative analysis was undertaken,which included self-renewal capacity,morphology,proliferation capacity,cell cycle,reactive oxygen species(ROS)levels,and senescence-associatedβ‑galactosidase(SA‑β‑gal)staining of BMderived MSCs isolated from 14 BCPs and 9 healthy volunteers(HVs).Additionally,the expression and activity of the telomerase subunit TERT,as well as telomere length,were measured.Expression levels of pluripotency,osteogenic,and osteoclastogenic genes(OCT-4,SOX-2,M-CAM,RUNX-2,BMP-2,CCL-2,M-CSF,and IL-6)were also determined.The results showed that MSCs from BCPs had reduced,self-renewal and proliferation capacity.These cells also exhibited inhibited cell cycle progression and phenotypic changes,such as an enlarged and flattened appearance.Additionally,there was an increase in ROS and senescence levels and a decrease in the functional capacity of TERT to preserve telomere length.We also found an increase in pro-inflammatory/pro-osteoclastogenic gene expression and a decrease in pluripotency gene expression.We conclude that these changes could be responsible for the abnormal functional profile that MSCs show in this group of patients.

关键词： Mesenchymal stem/stromal cells Senescence Breast cancer Bone marrow Pre-metastatic niche Bone metastasis

Determining the need for a thoracoscopic approach to treat a giant hiatal hernia when abdominal access is poor

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World j.urnal of Gastrointestinal Surgery 2023年第12期15卷 2739-2746页

作者： francisco j.vier Pérez Lara Rogelio Zubizarreta j.menez Tatiana Prieto-Puga Arj.na Pilar Gutierrez Delgado j.an Manuel Hernández Carmona j.se Manuel Hernández Gonzalez Maria Pitarch martinez Department of Surgery Hopital de AntequeraAntequera 29200Spain DOXA MicrofluidicsRincon de la Victoria 29730Spain Department of Surgery HRU Carlos HayaUnidad Cirugia Hepatobiliopancreat&TrasplantesMalaga 29200Spain

BACKGROUND Giant hernias present a significant challenge for digestive surgeons.The approach taken(laparoscopic vs thoracoscopic)depends largely on the preferences and skills of each surgeon,although in most cases today the laparoscopic approach is preferred.AIM To determine whether patients presenting inadequate laparoscopic access to the intrathoracic hernial sac obtain poorer postoperative results than those with no such problem,in order to assess the need for a thoracoscopic approach.METHODS For the retrospective series of patients treated in our hospital for hiatal hernia(n=112),we calculated the laparoscopic field of view and the working area accessible to surgical instruments,by means of preoperative imaging tests,to assess the likely outcome for cases inaccessible to laparoscopy.RESULTS Patients with giant hiatal hernias for whom a preoperative calculation suggested that the laparoscopic route would not access all areas of the intrathoracic sac presented higher rates of perioperative complications and recurrence during follow-up than those for whom laparoscopy was unimpeded.The difference was statistically significant.Moreover,the insertion of mesh did not improve results for the non-accessible group.CONCLUSION For patients with giant hiatal hernias,it is essential to conduct a preoperative evaluation of the angle of vision and the working area for surgery.When parts of the intrathoracic sac are inaccessible laparoscopically,the thoracoscopic approach should be considered.

关键词： Hiatal hernia Abdominal surgery Laparoscopy Thoracoscopy surgery

Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy

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World j.urnal of Gastroenterology 2018年第19期24卷 2095-2107页

作者： Carolina González David Tabernero Maria Francesca Cortese j.sep Gregori Rosario Casillas Mar Riveiro-Barciela Cristina Godoy Sara Sopena Ariadna Rando Marcal Yll Rosa Lopez-martinez j.sep Quer Rafael Esteban Maria Buti francisco Rodríguez-Frías Liver Pathology Unit Departments of Biochemistry and MicrobiologyHospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Liver Unit Liver Disease Laboratory-Viral HepatitisVall d’Hebron Institut Recerca-Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas(CIBERehd) Instituto de Salud Carlos IIIMadrid 28029Spain Roche Diagnostics SL Sant Cugat del Vallès 08174Spain Liver Unit Department of Internal MedicineHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035Spain

AIM To detect hyper-conserved regions in the hepatitis B virus(HBV) X gene(HBX) 5' region that could be candidates for gene therapy.METHODS The study included 27 chronic hepatitis B treatmentnaive patients in various clinical stages(from chronic infection to cirrhosis and hepatocellular carcinoma, both HBeA g-negative and HBeA g-positive), and infected with HBV genotypes A-F and H. In a serum sample from each patient with viremia > 3.5 log IU/m L, the HBX 5' end region [nucleotide(nt) 1255-1611] was PCRamplified and submitted to next-generation sequencing(NGS). We assessed genotype variants by phylogenetic analysis, and evaluated conservation of this region by calculating the information content of each nucleotide position in a multiple alignment of all unique sequences(haplotypes) obtained by NGS. Conservation at the HBx protein amino acid(aa) level was also analyzed.RESULTS NGS yielded 1333069 sequences from the 27 samples, with a median of 4578 sequences/sample(2487-9279, IQR 2817). In 14/27 patients(51.8%), phylogenetic analysis of viral nucleotide haplotypes showed a complex mixture of genotypic variants. Analysis of the information content in the haplotype multiple alignments detected 2 hyper-conserved nucleotide regions, one in the HBX upstream non-coding region(nt 1255-1286) and the other in the 5' end coding region(nt 1519-1603). This last region coded for a conserved amino acid region(aa 63-76) that partially overlaps a Kunitz-like domain.CONCLUSION Two hyper-conserved regions detected in the HBX 5' end may be of value for targeted gene therapy, regardless of the patients' clinical stage or HBV genotype.

关键词： Hepatitis B virus Hepatitis B X gene Hepatitis B X protein Gene therapy Next-generation sequencing HBV conserved regions Small interference RNA