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Mepolizumab induced palmoplantar psoriasis:A case report

世界临床病例杂志 2023年第26期11卷 6154-6158页

作者： Fabio Artosi Laura Diluvio martina vultaggio Elena Campione Luca Bianchi Department of Systems Medicine University of Rome“Tor Vergata”Rome 00133Italy Department of Dermatology Dermatology UnitPoliclinico Tor VergataRome 00133Italy Department of Dermatology University Roma Tor VergataRome 00133Italy

BACKGROUND Atopic dermatitis and asthma are two diseases whose pathogenesis is largely attributable to the activation,at least in the initial stages,of T helper(Th)-2 Lymphocytes,the related cytokine axis,and B lymphocytes with antibody *** is conversely a pathology resulting from a recruitment of Th-17 and Th-1 lymphocytes,after an initial role of innate *** is a humanized monoclonal antibody directed against interleukin(IL)-5,a central cytokine in the Th-2 axis,therefore involved in the pathogenesis of *** authors have described the appearance of psoriatic lesions in patients with asthma or atopic dermatitis following the therapy with dupilumab,a monoclonal antibody that blocks the interleukin(IL)-4,another Th-2 *** SUMMARY We present the case of a 59-year-old patient who developed psoriasiform lesions on the palms after mepolizumab therapy for asthma,for the activation of the parallel cytokine cascade after the blockade of *** successfully treated the patient with a topical calcipotriol and betamethasone *** We should investigate with further attention the possible impact on the human immunological ecosystem put in place by the inhibition of the activity of individual inflammatory mediators,so as to be able to recognize the initial adverse effects early.

关键词： Psoriasis Interleukin-5 Mepolizumab Asthma Immunology Case report

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