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流程工业 2010年第15期 34-34,36页

作者： martina vaupel 德国Weil市Endress+Hauser公司

为了能够对产品的特性和质量进行比较，常常在相对温度条件下对液体介质的粘度进行检测。在石油精炼企业提供的采暖重油或者柴油产品中，粘度往往是一个重要的质量指标。

关键词：粘度检测液体介质温度条件在线检测油品粘度质量指标石油精炼产品

Role of copper in central nervous system physiology and pathology

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Neural Regeneration Research 2025年第4期20卷 1058-1068页

作者： martina Locatelli Cinthia Farina Institute of Experimental Neurology Division of NeuroscienceIstituto di Ricovero e Cura a Carattere Scientifico(IRCCS)San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly

Copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous *** copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple *** review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper ***,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.

关键词： astrocytes central nervous system copper cuprizone multiple sclerosis myelin neurodegenerative disorders

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： Tong Zhang martina Schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of Pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(Zhang et al.,2023b).

关键词： Alzheimer impaired Aβ

Wilson's disease in two siblings from Ecuador:Two case reports

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World Journal of Clinical Cases 2025年第3期13卷 50-60页

作者： Enrique Carrera Jonathan Alvarado martina Astudillo Galo Pillajo Department of Gastroenterology and Hepatology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador Faculty of Medicine Pontificia Universidad Catolica del EcuadorQuito 170143PichinchaEcuador Department of Radiology Hospital de Especialidades Eugenio EspejoQuito 170136PichinchaEcuador

BACKGROUND Wilson's disease(WD)is a rare metabolic disorder of copper accumulation in organs such as liver,brain,and *** and treatments are challenging in settings,where advanced diagnostic tests are unavailable,copper chelating agents are frequently scarce,healthcare professionals lack disease awareness,and medical follow-ups are *** diagnoses and treatments help prevent complications,improve patients’quality of life,and ensure a normal life *** clinical presentations and outcomes of WD can vary within a single *** SUMMARY We present the cases of two siblings(19 and 27 years)from a consanguineous family in rural Ecuador,diagnosed as having WD during a family *** male patient,diagnosed at age 19 after his brother’s death from acute liver failure,presented with compensated cirrhosis,neurological symptoms,and bilateral Kayser-Fleischer *** developed progressive neurological deterioration during an irregular treatment with D-penicillamine due to medication *** condition improved upon switching to trientine tetrahydrochloride,and his neurological symptoms improved over an 8-year period of *** female patient,diagnosed at age 10,exhibited only biochemical *** treatment history was similar;however,she remained asymptomatic without disease progression over the same follow-up *** discuss the potential influence of epigenetic mechanisms and modifier genes on the various phenotypes,emphasizing the need for research in these areas to optimize therapeutic *** Our patients’medical histories show how early diagnosis and treatment can prevent disease progression;and,how suboptimal treatments impact disease outcomes.

关键词： Wilson disease Kayser-Fleischer rings Copper chelator D-penicillamine Trientine tetrahydrochloride Case report

Lactate-avid regulatory T cells:metabolic plasticity controls immunosuppression in tumour microenvironment

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1418-1419页

作者： Gabriele Multhoff Peter vaupel Radiation Immuno-Oncology Project Group TranslaTUM–Central Institute for Translational Cancer ResearchKlinikum rechts der IsarTU MünchenMunichGermany Department of Radiation Oncology Klinikum rechts der IsarTU MünchenMunichGermany Department of Radiooncology and Radiotherapy Tumour Pathophysiology GroupUniversity Medical Centre MainzMainzGermany

The excellent article by Watson et al.1 points the way ahead to the important role of lactic acid/lactate-anion and glucose on the immunosuppressive activity of lactate-and glucose-affine metabolically distinct subset... 详细信息

关键词： tumour al. microenvironment

Imaging tumor hypoxia:Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 12-17页

作者： Peter vaupel Armulf Mayer Department of Radioncology and Radiotherapy University Medical Center 55131 MainzGermany

Dedicated to the memory of Professor Briton Chance on the ccasion of his 100th birthday(July24 th,2013),and remembering mary erciting discussions on the orygenation of breast cancer,ontumor hyporia in general and imaging of the orygenation status of malignant *** tissue subvolumes are a hallmark feat ure of solid malignant tumors,relevant for cancertherapy and patient outcome because they increase both the intrinsic aggressiveness of tumor cells and their resist ance to several commonly used anticancer *** mech-anisms leading to hypoxia are diverse,may coexist within the same tumor and are commonlygrouped according to the duration of their *** hypoxia is mainly caused by difusionlimitations resulting from enlarged intercapilary distances and adverse difusion geometriesand--to a lsser extent--by hypoxemia,compromised perfusion or long-lasting microregionalfow ***,acute hypoxia preferentilly results from transient disruptions in *** each of these features of the tumor microenvironment can contribute to a criticalreduction of oxy gen availability,the delivery of imaging agents(as well as nutrients and anti-cancer agents)may be compromised or remain unaffected,Thus,a critial appraisal of the ffectsof the various mechanisms leading to hypoxia with regard to the blood-bome delivery of imagingagents is necessary to judge their ability to correctly represent the hypoxic phenotype of solidmalignancies.

关键词： Delivery of imaging agents tumor hypoxia hypoxia subty pes,chronic hypoxia acutehypoxia.

Promising new treatment targets in patients with fibrosing lung disorders

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World Journal of Clinical Cases 2014年第11期2卷 668-675页

作者： martina Sterclova martina Vasakova Department of Respiratory Medicine Thomayer Hospital and 1st Medical Faculty of Charles University Prague 14000 Czech Republic

The processes of lung fibrogenesis and fibrotic healing are common to a number of conditions with different etiologies. The lungs are the only affected organ in some cases, whereas in others, several organ systems are involved. Therapeutic options can be discussed from various perspectives. In this review, we address the localization of therapeutic targets with regard to cell compartments, including secreted ligands, cell surface, plasma membrane-cytosol interplay, cytosol and nucleus. Complex approach using stem cell therapy is also discussed. As the prognosis of patients with these disorders remains grim, treatment combinations targeting different molecules within the cell should sometimes be considered. It is reasonable to assume that blocking specific pathways will more likely lead to disease stabilization, while stem cell-based treatments could potentially restore lung architecture. Gene therapy could be a candidate for preventive care in families with proven specific gene polymorphisms and documented familial lung fibrosis. Chronobiology, that takes into account effect of circadian rhythm on cell biology, has demonstrated that timed drug administration can improve treatment outcomes. However, the specificrecommendations for optimal approaches are still under debate. A multifaceted approach to interstitial lung disorders, including cooperation between those doing basic research and clinical doctors as well as tailoring research and treatment strategies toward(until now) unmet medical needs, could improve our understanding of the diseases and, above all, provide benefits for our patients.

关键词： Interstitial lung disease Treatment Idiopathic pulmonary fibrosis Connective tissue disease Cell compartments Signaling molecules Signal transducers Transcription factors

Rheology of Poly(vinyl butyral)Solution Containing Fumed Silica in Correlation with Electrospinning

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Chinese Journal of Polymer Science 2018年第6期36卷 742-748页

作者： Petra Peer martina Polaskova Pavol Suly Institute of Hydrodynamics of the Czech Academy of Sciences Pod Patankou 5166 12 Prague 6Czech Republic Centre of Polymer Systems Tomas Bata University in Zlintrida Tomase Bati 5678760 O1 ZlinCzech Republic Department of Polymer Engineering Faculty of TechnologyTomas Bata University in ZlinVavreckova 27576001 ZlinCzech Republic

The rheological properties in question are influenced by many factors, ranging from the characteristics of the given polymer or solvent to the flowing conditions. The primary focus of this study is to analyse the rheological behaviour of poly（vinyl butyral）—Mowital B 60 H—（PVB） solutions dissolved in methanol and a blend of these with fumed silica nanoparticles. The preparation of the nanofibrous web and the quality of nanofibres were correlated with the rheology of the polymer solution. It was discerned that drastically intensifying shear viscosity and the elasticity of the solution exerted a negligible effect on the formation of fibres, a finding which has rarely been discussed in the literature. The morphologies and structures of the PVB/silica nanofibrous membranes were investigated by scanning electron microscopy, thermogravimetric analysis and Fourier transform infrared spectroscopy.

关键词： Electrospinning Nanofibres Poly(vinyl butyral) Fumed silica Rheology

The combined influence of grain size distribution and dislocation density on hardness of interstitial free steel

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Journal of Materials Science & Technology 2020年第10期42卷 35-43页

作者： Wei Li martina Vittorietti Geurt Jongbloed Jilt Sietsma Department of Materials Science and Engineering Delft University of TechnologyMekelweg 22628 CDDelftthe Netherlands Department of Applied Mathematics Delft University of TechnologyVan Mourik Broekmanweg 62628 XEDelftthe Netherlands Materials Innovation Institute(M2i) Van der Burghweg 1.2628 CSDelftthe Netherlands

Understanding the relationship between microstructure features and mechanical properties is of great significance for the improvement and specific adjustment of steel *** relationship between mean grain size and yield strength is established by the well-known Hall-Petch *** due to the complexity of the grain configuration within materials,considering only the mean value is unlikely to give a complete representation of the mechanical *** classical Taylor equation is often used to account for the effect of dislocation density,but not thoroughly tested in combination with grain size *** the present study,systematic heat treatment routes and cold rolling followed by annealing are designed for interstitial free(IF)steel to achieve ferritic microstructures that not only vary in mean grain size,but also in grain size distribution and in dislocation density,a combination that is rarely studied in the *** microscopy is applied to determine the grain size *** dislocation density is determined through XRD *** hardness is analyzed on its relation with the mean grain size,as well as with the grain size distribution and the dislocation *** the help of the variable selection tool LASSO,it is shown that dislocation density,mean grain size and kurtosis of grain size distribution are the three features which most strongly affect hardness of IF steel.

关键词： Interstitial free steel Hardness Grain size distribution Dislocation density

A strategy for uncovering germline variants altering anti-tumor CD8 T cell response

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Journal of Genetics and Genomics 2023年第5期50卷 353-361页

作者： Vijay Kumar Ulaganathan martina H.Vasileva Klinik fur Dermatologie&Allergology Universitatsmedizin GottingenGottingen 37075Germany Institut fuir Multiple Sklerose Forschung NeuroimmunologieUniversitatsmedizin GottingenGottingen 37075Germany University of Lorraine NGERE UnitFaculte de Medecine9 Avenue de La Foret de HayeVandoeuvre-les-Nancy 54505France

Among many factors known to alter the outcomes of T cell receptor(TCR)-induced proximal signaling,the role of human germline variants in dictating the individuality of the anti-tumor CD8 T cell response has remained challenging to ***,we describe a convenient strategy for molecular and functional characterization of phosphotyrosine-altering non-synonymous single nucleotide variations(pTyr-SNVs)that directly impact TCR-induced proximal phosphotyrosine motif-based signaling *** devise an experimental co-cultivation set-up comprising a C57BL/6 mouse-derived metastatic melanoma cell line engineered to constitutively present ovalbumin(OVA)antigens and retrovirally engineered syngeneic major histocompatibility complex(MHC)Class I restricted OVA TCR-transgenic CD8 T cells(OT-I).Using the synthetic version of pTyr-SNV rs1178800678-G/T-encoding integrin alpha 4(ITGA4)p.S1027I variant as a prototype,we show that under identical TCR stimulation conditions,genetically determined membrane-proximal immunoreceptor tyrosin activation motif(ITAM)results in increased tyrosine phosphorylation of 70 kDa zeta-chain-associated protein(ZAP70)and the levels of cytotoxic effector molecule granzyme B(GZMB),which in turn result in enhanced cytotoxic activity against metastatic melanoma cell *** strategy paves the way for rapid molecular and functional characterization of anti-tumor immune response-linked germline pTyr-SNVs so as to improve our understanding of the genetic basis of individual-to-individual differences in anti-tumor CD8 T cell response.

关键词： Non-synonymous single nucleotide variants(nsSNVs) Membrane-proximal phosphotyrosine signalling motifs Phosphotyrosine-altering non-synonymous single nucleotide variants(pTyr-SNVs) Immunoreceptor tyrosine activation motif(ITAM) CD8 T cells Melanoma B16-F10