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Journal of Marine Science and Application 2021年第2期20卷 229-247页

作者： Domenico Flagiello martina esposito Francesco Di Natale Kent Salo The Sustainable Technologies for Pollution ControlLaboratory Department of ChemicalMaterials and Industrial Production EngineeringUniversity of Naples Federico IIP.le V.Tecchio8080125 NaplesItaly Department of Mechanics and Maritime Science Chalmers University of TechnologyLindholmen Horselgangen441296 GothenburgSweden

Maritime shipping is a strategic sector with a strong international vocation and *** need to define regulations valid for many different countries without generating disparities of treatment slowed down the formulation of environmental regulations,especially for atmospheric *** particular,regulations pertaining to the reduction of sulphur compounds allowed two distinct approaches:the use of low-sulphur fuels or exhaust gas cleaning systems,the so-called *** actual implementation of these solutions presents specific concerns either related to the toxicity of atmospheric by-products and to the fuel cost or to the generation of polluting washwaters that may need treatment before *** this paper we analyzed the potential environmental benefit deriving from the use of a distillate fuel,not compliant with current IMO Sulphur Regulations,together with a *** pilot-scale experimental results indicated that a limited amount of water and/or scrubber volume is needed to reduce sulphur emissions below regulations on maritime shipping,especially with the addition of NaOH reaching a water-saving between 25%-33%compared to the use of pure *** indicated that scrubber washwater PAHs emissions are within the available water quality standards indicated by EU and USA guidelines.A bottom-up analysis on heavy metals concentration shed light on the prominent role of metal-parts corrosion on the washwater *** into account for corrosion phenomena,the actual heavy metals concentration in the washwater deriving from scrubbing was normally below the water quality standards.

关键词： Ships environmental footprint Exhaust gas cleaning system Washwater emissions Marine distillate fuels Marine seawater scrubber Persistent pollutants

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Vulvar Swelling in a 12-Year-Old Girl: An Early Manifestation of Crohn’s Disease

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Case Reports in Clinical Medicine 2024年第7期13卷 219-226页

作者： Stefania Rendina Dolores Ferrara Rosanna Mamone Sara Isoldi Massimo Zeccolini Francesco esposito Department of Radiology Universit degli studi di Napoli Luigi Vanvitelli Naples Italy Department of Radiology A.O.R.N. Santobono-Pausilipon Children Hospital Naples Italy Pediatric Gastroenterology and Hepatology Unit Santobono-Pausilipon Childrens Hospital Naples Italy

Vulvar Crohn’s disease (VCD) is a rare complication of Crohn’s disease, especially in pediatric population. An early diagnosis can result difficult if the complication does not present in conjunction with the classic gastrointestinal symptoms that characterize this disease. In this study we present the case of a 12-year-old girl whose initial symptom of Crohn’s disease was a symptomatic vulvar swelling promoted by a rectovaginal fistula. We also provide an overview of Crohn’s disease and the vulvar changes found in the course of this disease.

关键词： Recto-Vaginal Fistula Vulvar Swelling Metastatic Crohn’s Disease

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Pseudo-orthogonality for graph 1-Laplacian eigenvectors and applications to higher Cheeger constants and data clustering

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Frontiers of Mathematics in China 2022年第4期17卷 591-623页

作者： Antonio Corbo esposito Gianpaolo PISCITELLI Dipartimento di Ingegneria Elettrica e dell’Informazione“M.Scarano” Universitàdegli Studi di Cassino e del Lazio MeridionaleVia G.Di Biasio n.4303043Cassino(FR)Italy

The data clustering problem consists in dividing a data set into prescribed groups of homogeneous *** is an NP-hard problem that can be relaxed in the spectral graph theory,where the optimal cuts of a graph are related to the eigenvalues of graph *** this paper,we first give new notations to describe the paths,among critical eigenvectors of the graph 1-Laplacian,realizing sets with prescribed *** introduce the pseudo-orthogonality to characterize m_(3)(G),a special eigenvalue for the graph ***,we use it to give an upper bound for the third graph Cheeger constant h_(3)(G),that is,h_(3)(G)≤m_(3)(G).This is a first step for proving that the k-th Cheeger constant is the minimum of the 1-Laplacian Raylegh quotient among vectors that are pseudo-orthogonal to the vectors realizing the previous k−1 Cheeger ***,we apply these results to give a method and a numerical algorithm to compute m3(G),based on a generalized inverse power method.

关键词： Graph 1-Laplacian graph Cheeger constants pseudo-orthogonality critical values data clustering

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A Mixed Radiative-Convective Technique for the Calibration of Heat Flux Sensors in Hypersonic Flow

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Fluid Dynamics & Materials Processing 2022年第2期18卷 189-203页

作者： Antonio esposito Marcello Lappa Rocco Pagliara Gennaro Spada Department of Industrial Engineering University of NaplesNaples80125Italy Department of Mechanical and Aerospace Engineering University of StrathclydeGlasgowG11XJUK Cheminox srl San Vito dei Normanni(BR)72019Italy

The ability to measure the very high heat fluxes that typically occur during the hypersonic re-entry phase of space vehicles is generally considered a subject of great importance in the aerospace *** of the sensors used for these measurements need to be checked periodically and re-calibrated *** bottleneck relates to the need to procure thermal sources that are able to generate reliable reference heat fluxes in the range between 100 and 1000 kW/m^(2)(as order of magnitude).In the present study,a method is presented by which,starting from a calibration system with a capacity of approximately 500 kW/m^(2) only,heat fluxes in the range of interest for hypersonic applications are *** related procedure takes advantage of established standards for the characterization of a radiative heat *** also builds on the hybrid radiative-convective nature of typical hypersonic heat fluxes and the yet poorly explored possibility to use convective sources of heat to produce high-intensity *** reliability of such a strategy has been tested using a high enthalpy supersonic flow facility relying on an electric arc-heater and pure Nitrogen as work ***-point heat fluxes have been successfully measured(with reasonable accuracy)in the range between 600 and 1500 kW/m^(2) for values of the centerline enthalpy spanning the interval from to 6 to 24 MJ/kg.

关键词： Photometry heat flux sensor calibration facility radiative source convective source

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Thrombocytopenia in chronic liver disease:Physiopathology and new therapeutic strategies before invasive procedures

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World Journal of Gastroenterology 2022年第30期28卷 4061-4074页

作者： Paolo Gallo Francesca Terracciani Giulia Di Pasquale Matteo esposito Antonio Picardi Umberto Vespasiani-Gentilucci Clinical Medicine and Hepatology Unit Campus Bio-Medico UniversityRoma 00128Italy

Chronic liver disease is characterized by several hematological derangements resulting in a complex and barely rebalanced haemostatic *** is the most common abnormality observed in these patients and recent advances have led to researchers focus the attention on the multifactorial origin of thrombocytopenia and on the key role of thrombopoietin(TPO)in its *** thrombocytopenia(platelet count<50000/μL)complicates the management of patients with chronic liver disease by increasing the potential risk of bleeding for invasive procedures,which may be therefore delayed or canceled even if *** the very last years,the development of new drugs which exceed the limits of the current standard of care(platelet transfusions,either immediately before or during the procedure)paves the way to a new scenario in the management of this population of *** agents,such as the TPOreceptor agonists avatrombopag and lusutrombopag,have been developed in order to increase platelet production as an alternative to platelet *** agents have demonstrated a good profile in terms of efficacy and safety and will hopefully allow reducing limitations and risks associated with platelet transfusion,without any delay in scheduled ***,it is expected that patients with chronic liver disease will be able to face invasive procedures with one more string in their bow.

关键词： Thrombocytopenia Chronic liver disease Thrombopoietin agonists Platelet transfusions Avatrombopag Lusutrombopag

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Robot-assisted extravesical ureteral reimplantation with ureteral tailoring and dismembering for complex obstructed megaureter

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Asian Journal of Urology 2023年第1期10卷 101-102页

作者： Ciro esposito Lorenzo Masieri Giuseppe Autorino Maria Escolino Division of Pediatric Surgery Federico II University of NaplesNaplesItaly Division of Pediatric Urology Meyer Children HospitalFlorenceItaly

Dear Editor,The advantages of robotic technology including improved dexterity and visualization are particularly evident in challenging reconstructive procedures of the lower urinary tract[1,2].A recent literature review confirmed the feasibility and efficacy of robot-assisted ureteral reimplantation in case of complex anatomy or prior surgery[3].Intra-corporeal ureteral tapering and dismembering are also feasible options using robot-assisted surgery[4].

关键词： ureteral anatomy surgery

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Multifaceted relationship between diabetes and kidney diseases:Beyond diabete

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World Journal of Diabetes 2023年第10期14卷 1450-1462页

作者： Pasquale esposito Daniela Picciotto Francesca Cappadona Francesca Costigliolo Elisa Russo Lucia Macciò Francesca Viazzi Department of Internal Medicine and Medical Specialties(DiMI) University of GenoaGenoa 16132Italy Unit of Nephrology Dialysis and TransplantationIRCCS Ospedale Policlinico San MartinoGenoa 16132Italy

Diabetes mellitus is one of the most common causes of chronic kidney *** involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney *** development of kidney disease in diabetes is associated with structural changes in multiple kidney compartments,such as the vascular system and *** alterations include thickening of the glomerular basement membrane,loss of podocytes,and segmental mesangiolysis,which may lead to microaneurysms and the development of pathognomonic Kimmelstiel-Wilson *** lesions directly related to diabetes,awareness of the possible coexistence of nondiabetic kidney disease in patients with diabetes is *** nondiabetic lesions include focal segmental glomerulosclerosis,IgA nephropathy,and other primary or secondary renal *** diagnosis of these conditions is crucial in guiding clinical management and therapeutic ***,the relationship between diabetes and the kidney is bidirectional;thus,new-onset diabetes may also occur as a complication of the treatment in patients with renal ***,we review the complex and multifaceted correlation between diabetes and kidney diseases and discuss clinical presentation and course,differential diagnosis,and therapeutic opportunities offered by novel drugs.

关键词： Diabetes Diabetic kidney disease Nondiabetic kidney disease Biomarkers Glomerular disease Kidney biopsy Sodium-glucose cotransporter-2 inhibitors

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Leaky gut, dysbiosis, and enteric glia activation: the trilogy behind the intestinal origin of Parkinson’s disease

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Neural Regeneration Research 2020年第6期15卷 1037-1038页

作者： Luisa Seguella Giovanni Sarnelli Giuseppe esposito Department of Physiology and Pharmacology“V.Erspamer”-Sapienza University RomeItaly(Seguella LEsposito G)Department of Clinical Medicine and SurgeryUniversity of Naples“Federico II”NaplesItaly(Sarnelli G)

Early diagnosis of Parkinson’s disease(PD):how we can improve the therapeutic approach:PD is a neurodegenerative disease characterized by motor dysfunctions(tremor,rigidity,bradykinesia and impaired posture/balance)elicited by selective depletion of dopaminergic(DA)neurons in substantia nigra pars *** neuron loss is associated with neuronal inclusions of the phosphorylatedα-synuclein protein called Lewy body(Shults,2006).Although the underlying neurodegenerative process is not affected,the management of PD patients has been revolutionized with the introduction of levodopa and DA drugs in the routine therapy,which ensures initial symptomatic relief of motor functions through the DA supply in the nigrostriatal *** drugs are currently the best option for treating PD,although their chronic use is associated with progressive dopamine resistance and loss of effectiveness in the recovery of motor *** therapeutic strategies,including agonists of DA receptors,monoamine oxide B inhibitors,and even deep brain stimulation techniques have been developed to overcome these clinical ***,these therapeutic approaches cannot restore PD-compromised functions,as irreversible DA neurodegeneration has occurred in substantia nigra pars compacta when first motor symptoms *** nigrostriatal system is traditionally considered as the first region affected by neuronal impairment in Parkinsonisms;however,α-synuclein aggregation appears in a pre-motor stage of the disease in the enteric nervous system(ENS).

关键词： impaired routine overcome

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Experience with intraoperative radiotherapy for breast cancer: the Geneva University Hospital's experience

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Chinese Journal of Cancer Research 2016年第4期28卷 463-466页

作者： Emanuela esposito Michael Douek Division of Cancer Studies King's College London Department of Breast Surgery Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale"–IRCCS

Background Breast conserving surgery along with adjuvant radiotherapy is effective in terms of local control and survival for early- stage breast cancer （1）. External beam radiotherapy （EBRT） following breast conserving surgery has been shown to improve survival by preventing local recurrence, in the Early Breast Cancer Trialists＇ Collaborative Group meta-analysis （2）. Standard radiotherapy typically requires numerous fractions over a 3-5 week period and is performed weeks or months after surgery or chemotherapy.

关键词： IORT Experience with intraoperative radiotherapy for breast cancer the Geneva University Hospital’s experience

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Gut microbiota and COVID-19: An intriguing pediatric perspective

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World Journal of Clinical Cases 2022年第23期10卷 8076-8087页

作者： Maria Sole Valentino Claudia esposito Simone Colosimo Angela Maria Caprio Simona Puzone StefanoGuarino Pierluigi Marzuillo Emanuele Miraglia del Giudice Anna Di Sessa Department of Woman Childand General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaples 80138Italy

Gastrointestinal(GI)involvement has been reported in approximately 50%of patients with coronavirus disease 2019(COVID-19),which is due to the pathogenic role of inflammation and the intestinal function of the angiotensinconverting enzyme 2 and its *** adult data has pointed out that gut dysbiosis might occur in these patients with a potential impact on the severity of the disease,however the role of gut microbiota in susceptibility and severity of COVID-19 disease in children is still poorly *** the last decades,the crosstalk between gut and lung has been largely recognized resulting in the concept of“gut-lung axis”as a central player in modulating the development of several *** organs are involved in the common mucosal immune system(including bronchus-associated and gut-associated lymphoid tissues)and their homeostasis is crucial for human *** this framework,it has been found that the role of GI dysbiosis is affecting the homeostasis of the gutliver *** note,a gut microbiome imbalance has been linked to COVID-19 severity in adult subjects,but it remains to be *** on the increased risk of inflammatory diseases in children with COVID-19,the potential correlation between gut microbiota dysfunction and COVID-19 needs to be studied in this *** aimed to summarize the most recent evidence on this striking aspect of COVID-19 in childhood.

关键词： Gut Microbiota Dysbiosis Microbiome COVID-19 Children

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