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Supercritical carbon dioxide extraction of Triognella foenum graecum Linn seeds:Determination of bioactive compounds and pharmacological analysis

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1085-1091页

作者： Ola Basa’ar Samreen Fatema Ali Alrabie Mohammed Mohsin Mazahar Farooqui Department of Chemistry Hodeidah University Post Graduate & Research Center Maulana Azad College Dr.Rafiq Zakaria College for women

Objective: To investigate the effect of temperature and pressure on supercritical CO_2 extraction of Triognella foenum graecum Linn seeds, to determine the optimal condition which leads to highest percentage of the accumulative yield and revealing the chemical composition of supercritical CO_2 ***: Temperatures in the range of 40–60C and pressures in the range of 10–25 MPa were used. FTIR and GC–MS analysis were used to detect the bioactive compounds present in the extract. The broth dilution method and slope method were used to evaluate the anti-microbial and anti-tuberculosis activities and the in vitro anti-malarial assay was carried out according to the micro assay protocol of Rieckmann and his ***: The temperature was more affected than the pressure on the extraction performance and the highest yield of the extract(3.111%) was attained at 60C and 10 *** and GC–MS showed that the chemical composition of the extract included conjugated linoleic acid methyl ester as the major active principle(with concentration of72.28%), followed by saturated fatty acid methyl esters(16.03%), steroids(8.09%) and organic siloxane compound(3.61%). The extract showed moderate anti-bacterial activity with MIC values 100, 250, 125 mg/m L towards Escherichia coli, Staphylococcus aureus and Streptococcus pyogenus respectively. It exhibited high inhibition effect towards the fungi Candida albican with MFC value(250 mg/m L). The extract had low antituberculosis activity with MIC value(100 mg/m L) and comparable MIC value(0.29 mg/m L) towards Plasmodium ***: Supercritical CO_2 extraction as alternate and green technology is performed successfully to extract the bioactive compounds from the seeds of T. foenum graecum Linn and it is concluded that this extract can be used as an alternate source of synthetic anti-biotic drugs.

关键词： Anti-bacterial Anti-fungal Anti-malarial Anti-tuberculosis Sc–CO2 extraction Triognella foenum graecum Linn

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中美互换摘要

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中华高血压杂志（中英文） 2024年第2期32卷 200-200页

作者： Heckel ar arcidiacono DM Coonan KA Glasgow AC DeBlois JP Gump BB Kim JY Heffernan KS 刘青练桂丽

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour am... 详细信息

曾患与未患新型冠状病毒成年人的24h中心血流动力学负荷。高血压虽是新型冠状病毒(corona virus disease2019,COVID-19)重症的危险因素,但COVID-19对血压的影响尚不明确。相比于与单一时间点测量肱动脉血压,24 h动态血压监测(24 hour ambulatory blood pressure monitoring,ABPM)测量的中心血压对评估心血管疾病(cardiovascular disease,CVD)风险更有预测价值。本研究采用ABPM测量24 h中心血流动力学负荷,评估曾患与未患COVID-19成年人的CVD风险。

关键词：肱动脉血压新型冠状病毒心血管疾病 ABPM 点测量危险因素

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A Crystallization Study of Nanocrystalline PZT 53/47 Granular arrays Using a Sol-Gel Based Precursor

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Journal of Materials Science & Technology 2011年第6期27卷 489-496页

作者： A.Surez-Gómez J.M.Saniger-Blesa F.Calderón-Pinar CCADET-Universidad Nacional Autónoma de México Cd.UniversitariaCirc.Exterior s/nA.P.70-186Coyoacn 04510México D.F.México Laboratorio de Ingeniería Electroquímica Facultad de QuímicaUniversidad Nacional Autónoma de MéxicoCd.UniversitariaCoyoacn 04510México D.F.México Facultad de Física/IMRE San Lzaro y LUniversidad de la Habana

In this work,we intend to perform a detailed study on the crystallization process of PZT 53/47 nanostructured powders by starting out with an amorphous precursor synthesized by a sol-gel based *** interests also lie in the feasibility for controlling the average grain size of the final structure in the submicron range on an ab initio ***,Fourier transform infrared spectroscopy（FT-IR）,Raman（Stokes and Anti-Stokes）,X-ray diffraction（XRD） and scanning electron microscopy（SEM） are used to examine the microstructural characteristics based on previously reported differential thermal analysis/thermal gravimetric analysis（DTA/TGA） *** results show a crystallization temperature of 800℃ to attain pure perovskite phase with excellent morphological quality,average grain size 〈DG〉〈 300 nm and with average crystallite size 〈DC〉〈15 nm.

关键词： Powders-chemical preparation PZT synthesis Sol-gel precursors Microstructure- final Vibrational spectroscopies X-ray diffraction

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Computational Prediction of Micro RNAs from Toxoplasma gondii Potentially Regulating the Hosts' Gene Expression

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Genomics, Proteomics & Bioinformatics 2014年第5期12卷 228-238页

作者： Müs?erref Duygu Saar Caner Bagc? Jens Allmer Molecular Biology and Genetics Izmir Institute of Technology Urla Izmir 35430 Turkey Biotechnology Izmir Institute of Technology Urla Izmir 35430 Turkey Bionia Incorporated IZTEKGEB A8 Urla Izmir 35430 Turkey

MicroRNAs （miRNAs） were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene reg- ulation. It may also regulate its hosts＇ gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.

关键词： Toxoplasma gondii MicroRNA Regulation Host interaction Parasite

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Geometric Properties of ar(q) Nonlinear Regression Models

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Chinese Quarterly Journal of Mathematics 2004年第2期19卷 146-154页

作者： LIUYing-ar WEIBo-cheng DepartmentofMathematics SoutheastUniversityNanjing210096China

This paper is devoted to a study of geometric properties of ar(q) nonlinear regression models. We present geometric frameworks for regression parameter space and autoregression parameter space respectively based on the weighted inner product by fisher information matrix. Several geometric properties related to statistical curvatures are given for the models. The results of this paper extended the work of Bates & Watts(1980,1988)[1.2] and Seber & Wild (1989)[3].

关键词： nonlinear regression model ar(q) errors geometric framework statistical curvature Fisher information matrix

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Alluvial sedimentation and tectonostratigraphic evolution in a narrow extensional zigzag basin margin (northern Teruel Basin, Spain)

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Journal of Palaeogeography 2019年第4期8卷 368-392页

作者： Lope Ezquerro aránzazu Luzón José L.Simón Carlos L.Liesa Departamento de Ciencias de la Tierra Facultad de Ciencias Geotransfer Research Group and Instituto de Investigación en Ciencias Ambientales (IUCA) Universidad de Zaragoza

The northern part of the eastern margin of the extensional Neogene Teruel Basin(central-eastern Spain)consists of a non-linear,zigzag fault zone made of alternating ca.2 km long,NNW-SSE trending segments and shorter NNESSW *** outcrop conditions made possible a comprehensive integrated stratigraphic and structural study,especially focused on coarse clastic sediments deposited along the basin ***-exposed stratal relationships with boundary faults,allowed the analysis of tectonic influence on *** deformation includes growth faulting,rollover anticlines,and monoclines and associated onlap stratal terminations,angular unconformities,and other complex growth strata *** of them is the onlap-over-rollover bed arrangement described here for the first time,which reveals the competition between tectonic subsidence and sedimentary ***,the structural inheritance(dense Mesozoic fracture grid)and the dominant,nearly‘multidirectional’(σ1 vertical,σ2≈σ3),Pliocene extensional regime withσ3 close to E-W,are considered to have controlled the margin structure and ***-stratigraphic evolution includes:(i)reactivation of inherited NNW-SSE faults and development of W-SW-directed small alluvial fans(SAF)while NNE-SSW segments acted as gentle relay ramp zones;(ii)progressive activation of NNE-SSW faults and development of NW-directed very small alluvial fans(VSAF);during stages i and ii sediments were trapped close to the margin,avoiding widespread progradation;(iii)linking of NNW-SSE and NNE-SSW structural segments,overall basin sinking and widespread alluvial progradation;(iv)fault activity attenuation and alluvial *** particular structure and kinematic evolution of this margin controlled alluvial system *** of alluvial fans,directly set up at the border faults,was conditioned by the narrowness of the margin,small catchment areas,and proximity between faults,which prevented the development of l

关键词： Extensional basin Alluvial fan Stratal stacking pattern Structural inheritance Fault linkage

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BANACH SPACES AND INEQUALITIES ASSOCIATED WITH NEW GENERALIZATION OF CESàRO MATRIX

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Acta Mathematica Scientia 2023年第4期43卷 1518-1536页

作者： Feyzi BASar Hadi ROOPAEI Department of Primary Mathematics Teacher Education Inonu University44280–MalatyaTurkiye Department of Mathematics and Statistics University of VictoriaVictoriaCanada

Let the triangle matrix A^(ru)be a generalization of the Cesàro matrix and U∈{c_(0),c,l_(∞)}.In this study,we essentially deal with the space U(A^(ru))defined by the domain of A^(ru)in the space U and give the bases,and determine the Kothe-Toeplitz,generalized K?theToeplitz and bounded-duals of the space U(A^(ru)).We characterize the classes(l_(∞)(A^(ru)):l_(∞)),(l_(∞)(A^(ru)):c),(c(A^(ru)):c),and(U:V(A^(ru)))of infinite matrices,where V denotes any given sequence ***,we also present a Steinhaus type *** an another result of this study,we investigate the l_(p)-norm of the matrix A^(ru)and as a result obtaining a generalized version of Hardy's inequality,and some inclusion ***,we compute the norm of well-known operators on the matrix domain l_(p)(A^(ru)).

关键词： matrix domain normed sequence space duals and matrix transformations

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Optimal culture conditions and toxicity assessment of Fomitopsis feei(Fr.):a newly documented macro fungus from Philippines

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Studies in Fungi 2020年第1期5卷 491-507页

作者： De Leon AM Dulay ar Villanueva AL Kalaw SP Department of Biological Sciences College of ScienceCentral Luzon State UniversityScience City of MuñozNueva EcijaPhilippines Center for Tropical Mushroom Research and Development Central Luzon State UniversityScience City of MuñozNueva EcijaPhilippines

Mushrooms are known to be utilized by ethnic communities and Paracelis,Mountain Province is one of the places in Philippines inhabited by several of these native *** studies have been conducted on various macrofungi,however no studies have been reported about Fomitopsis feei in the Philippines particularly in Paracelis,Mountain *** is a brown-rot bracket fungus,belonging to the family Fomitopsidaceae,characterized by a sessile effuse-reflexed basidiomata,with its color ranging from white to pinkish or *** mushroom has been reported to have antimicrobial properties,hence optimization of its culture condition could lead to its mass production for its biopharmaceutical *** order to develop a mass cultivation protocol of this mushroom,this study was conducted to determine the optimum conditions for its mycelial *** effect of different culture media using local substrates and evaluating environmental factors such as pH,aeration,illumination,and temperature were *** conditions for the secondary mycelial growth of *** produced very thick and largest radial growth on coconut water gelatin(CWG)medium(83.57 mm)at pH 6.5(83.13 mm),in sealed(85 mm),dark conditions(85.00 mm)at room temperature(28-32℃)(81.96 mm).The most abundant mycelial growth was found in cracked corn as grain spawning *** study also determined the teratogenic and cytotoxic activity of the ethanol extract of *** against the zebra fish(Danio rerio)embryos and brine shrimp(artemia salina)*** feei exhibited teratogenic effects against the developing *** embryos wherein growth retardation,malformation of tail,yolk deformity,pericardial edema,curved body,scoliosis and little pigmentation were the notable teratogenic effects of the ethanol extract to the developing *** treated with≥1000 ppm recorded high mortality *** was most evident at lower concentrations≤750 *** terms of heartbeat,as the concentrat

关键词： cultivation cytotoxicity grain spawn local substrate media teratogenicity

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Decentralized multi-agent reinforcement learning with networked agents: recent advances

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Frontiers of Information Technology & Electronic Engineering 2021年第6期22卷 802-814页

作者： Kaiqing ZHANG Zhuoran YANG Tamer BAŞar Coordinated Science Laboratory University of Illinois at Urbana-ChampaignIL 61801USA Department of Operations Research and Financial Engineering Princeton UniversityNJ 08544USA

Multi-agent reinforcement learning(MarL) has long been a significant research topic in both machine learning and control systems. Recent development of(single-agent) deep reinforcement learning has created a resurgence of interest in developing new MarL algorithms, especially those founded on theoretical analysis. In this paper, we review recent advances on a sub-area of this topic: decentralized MarL with networked *** this scenario, multiple agents perform sequential decision-making in a common environment, and without the coordination of any central controller, while being allowed to exchange information with their neighbors over a communication network. Such a setting finds broad applications in the control and operation of robots, unmanned vehicles, mobile sensor networks, and the smart grid. This review covers several of our research endeavors in this direction, as well as progress made by other researchers along the line. We hope that this review promotes additional research efforts in this exciting yet challenging area.

关键词： Reinforcement learning Multi-agent systems Networked systems Consensus optimization Distributed optimization Game theory

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Evolving landscape and novel treatments in, metastatic castrate-resistant prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 342-349页

作者： Paul J Toren martin E Gleave Department of Urologic Sciences Faculty of Medicine University of British Columbia Vancouver BC V5Z 1M9 Canada

Treatment options for castrate-resistant prostate cancer （CRPC） have advanced in recent years and significantly improved the Outlook for patients with this aggressive and lethal disease. Further understanding of the biology＇of CRPC has led to several new targeted therapies and continues to emphasize the importance of androgen receptor （ar） directed therapy. The treatment landscape is rapidly changing and further biologically rationale, biomarker-based ongoing clinical trials are needed. We review the recent results of major clinical trials in CRPC. New and investigational agents now in clinical evaluation are reviewed including inhibitors of angiogenesis, microtubules, chaperones, ar and intracellular kinases, as well as immunotherapy, radiopharmaceuticals and bone-targeted agents. The recent improvement in prognosis for CRPC brings continued optimism for further improvements. Thoughtful planning of clinical trials and further understanding of the mechanisms of resistance to therapies will allow for continued progress in patient care.

关键词： prostate cancer treatment resistance androgen receptor antagonists molecular targets

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