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成功还是失败？荷兰50年城镇化政策回顾

国际城市规划 2018年第1期33卷 60-67页

作者：瑞斯·范德尔沃登赵鹏军白羽安妮·特·维尔德荷兰环境评估机构空间规划与地方环境部北京大学城市与环境学院荷兰王国驻北京大使馆

荷兰城镇化政策始于50年前。起初,它是基于集中化分散概念和增长中心政策;1988年以后,则是基于紧凑城市和开发区位管理政策。本文基于已有的评价性研究和地图分析,评估了荷兰50年来的城镇化政策。虽然这些政策在强大的城镇化压力之下无... 详细信息

荷兰城镇化政策始于50年前。起初,它是基于集中化分散概念和增长中心政策;1988年以后,则是基于紧凑城市和开发区位管理政策。本文基于已有的评价性研究和地图分析,评估了荷兰50年来的城镇化政策。虽然这些政策在强大的城镇化压力之下无法完全阻止城市蔓延,但的确产生了一些积极的效果。

关键词：荷兰空间规划城镇化政策制度变迁政策评估

Molecular mechanism and functional consequences of lansoprazole-mediated heme oxygenase-1 induction

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World Journal of Gastroenterology 2009年第35期15卷 4392-4401页

作者： Stephanie Schulz-Geske Kati Erdmann Ronald J Wong David K Stevenson Henning Schrder Nina Grosser Department of Pharmacology and Toxicology School of PharmacyMartin Luther University Halle-Wittenberg06099 HalleGermany Department of Pediatrics Stanford University School of MedicineStanfordCA 94305 United States Department of Pharmaceutics College of PharmacyUniversity of MinnesotaMinneapolisMN 55455 United States

AIM： To investigate the molecular mechanism and functional consequences of heme oxygenase-1 （HO-1） activation by lansoprazole in endothelial cells and macrophages. METHODS： Expression of HO-1 mRNA was analyzed by Northern blotting. Western blotting was used to determine the HO-1 and ferritin protein levels. NADPH-dependent reactive oxygen species （ROS） formation was measured with lucigenin-enhanced chemiluminescence. HO-1 promoter activity in mouse fibroblasts, stably transfected with a 15-kb HO-1 gene that drives expression of the reporter gene luciferase, was assessed usingin vivo bioluminescence imaging. RESULTS： Lansoprazole levels in endothelial cells increased HO-1 mRNA and HO-1 protein levels in macrophages. In addition, lansoprazole-induced ferritin protein levels in both cell systems. Moreover, induction of the antioxidant proteins HO-1 and ferritin by lansoprazole was followed by a decrease in NADPH- mediated ROS formation. The radical scavenging properties of lansoprazole were diminished in the presence of the HO inhibitor, chromium mesoporphyrin IX. Induction of HO-1 gene expression by lansoprazole was not related to oxidative stress or to the activation of the mitogen-activated protein kinase pathway. However, the phosphatidylinositol 3-kinase inhibitor LY294002 showed a concentration-dependent inhibition of HO-1 mRNA and promoter ***： Activation of HO-1 and ferritin may account for the gastric protection of lansoprazole and is dependent on a pathway blocked by LY294002.

关键词： Antioxidants Ferritin Heme oxygenase-1 Lansoprazole Reactive oxygen species

A SYNDROME OF SEVERE HYPOGLYCEMIA AND ACIDOSIS IN YOUNG IMMUNOSUPPRESSED DIABETIC MONKEYS - ASSOCIATION WITH SEPSIS

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A SYNDROME OF SEVERE HYPOGLYCEMIA AND ACIDOSIS IN YOUNG IMMU...

2012中国器官移植大会

作者： Dirk J.van der Windt Eefje M.Dons Gabriel J. Echeverri Noriko Murase Rita Bottino martin Wijkstrom Robert Wagner David K.C.Cooper Thomas E.Starzl Transplantation Institute Department of SurgeryUniversity of Pittsburgh Medical CenterPittsburghPAUSA Division of Immunogenetics Department of PediatricsChildren's Hospital of PittsburghPittsburghPAUSA

Large animals treated with immunosuppressive drug regimens for preclinical experiments of transplantation have increased risks of infection,as do individuals with *** we report our experience with severe sepsis in two young cynomolgus monkeys that were subjected to diabetes induction +/- islet *** both monkeys,infection was associated with a syndrome of profound hypoglycemia accompanied by severe *** the discussion of these cases we include information on five immunosuppressed pigs that also experienced severe hypoglycemic episodes after diabetes induction and islet

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营养对动物健康和粮食安全保障的影响

饲料与畜牧（新饲料） 2008年第2期 14-16页

作者： martin W.A.Verstegen Jan Dirk van der Klis 李博(译) 齐广海(审校) 李海涛(审校) 不详中国农业科学院饲料研究所博士建明工业(珠海)有限公司博士

Lan（2004）发现一些大豆中碳水化合物可以增加雏鸡盲肠中乳酸菌的数量，并减少艾美耳球虫感染后的卵囊数。与此类似，Guo（2003）发现蘑菇中的碳水化合物也可以使微生物活性发生有益变化。

关键词：安全保障动物健康碳水化合物粮食营养微生物活性球虫感染乳酸菌

Techno-economic analysis of sidestream ammonia removal technologies:Biological options versus thermal stripping

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Environmental Science and Ecotechnology 2023年第1期13卷 107-114页

作者： Pascal Ochs Ben martin Eve Germain-Cripps Tom Stephenson Mark van Loosdrecht Ana Soares Cranfield University College RoadCranfieldBedfordMK430ALUnited Kingdom Thames Water Reading STWIsland RoadRG20RPReadingUnited Kingdom Delft University of Technology Building 58Van der Maasweg 92629DelftNetherlands

Over the past twenty years,various commercial technologies have been deployed to remove ammonia(NH4eN)from anaerobic digestion(AD)*** recent years many anaerobic digesters have been upgraded to include a pre-treatment,such as the thermal hydrolysis process(THP),to produce more biogas,increasing NH4eN concentrations in the liquors are costly to *** study provides a comparative techno-economic assessment of sidestream technologies to remove NH4eN from conventional AD and THP/AD dewatering liquors:a deammonification continuous stirred tank reactor(PNA),a nitrification/denitrification sequencing batch reactor(SBR)and thermal ammonia stripping process with an ammonia scrubber(STRIP).The SBR and PNA were based on full-scale data,whereas the STRIP was designed using a computational approach to achieve NH4eN removals of 90e95%.The PNA presented the lowest whole-life cost(WLC)over 40 years,with£7.7 M,while the STRIP had a WLC of£43.9 *** study identified that THP dewatering liquors,and thus a higher ammonia load,can lead to a 1.5e3.0 times increase in operational expenditure with the PNA and the ***,this study highlighted that deammonification is a capable and cost-effective nitrogen removal *** like the STRIP respond to current pressures faced by the water industry on ammonia recovery together with targets to reduce nitrous oxide ***,ammonia striping-based processes must further be demonstrated in WWTPs and WLC reduced to grant their wide implementation and replace existing technologies.

关键词： Deammonification Nitrification Denitrification Wastewater Sludge dewatering liquors

<i>STAT</i>1 gene mutation is not implicated in upper aerodigestive cancers

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Open Journal of Gastroenterology 2012年第2期2卷 68-71页

作者： Polat Dura Rene H. M. te Morsche martin Lacko Mihai G. Netea Jos W. M. van der Meer Joost P. H. Drenth Wilbert H. M. Peters Department of Otorhinolaryngology Maastricht University Medical Center Maastricht the Netherlands Departments of Gastroenterology and Internal Medicine Radboud University Nijmegen Medical Center Nijmegen the Netherlands

Autosomal Dominant Chronic Mucocutaneous Candidiasis (AD-CMC) is characterized by defective T cell immunity, leading to fungal infections limited to mucosal surfaces. Recently it was discovered that mutations in the coiled-coil (CC) domain of STAT1 are the cause of AD-CMC. STAT1 deficiency has been implicated in experimental models of oesophageal cancer (EC) and head and neck carcinoma (HNC). Both carcinoma types are prevalent among CMC patients. Consequently, we postulated that the same mutation in the STAT1 gene triggering AD-CMC, could also be involved in oesophageal- or head and neck carcinogenesis. However we failed to identify the c.820C>T mutation in the STAT1 CC domain in 3 cohorts of Dutch Caucasian origin: being 351 EC patients, 325 HNC patients and 309 controls. Although it seems valuable to investigate the relationship between AD-CMC and upper aerodigestive neo- plasms, the c.820C>T mutation in the STAT1 gene does not seem implicated in EC and HNC aetiology.

关键词： STAT1 Signal Transducers and Activators of Transcription Chronic Mucocutaneous Candidiasis Genetic Mutation Esophageal Carcinoma Head and Neck Carcinoma

Chapter model systems in heterogeneous catalysis at the atomic level: a personal view

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Science China Chemistry 2020年第4期63卷 426-447页

作者： Hans-Joachim Freund Markus Heyde Helmut Kuhlenbeck Niklas Nilius Thomas Risse Thomas Schmidt Shamil Shaikhutdinov martin Sterrer Fritz Haber Institute of the Max Planck Society Faradayweg 4-6Berlin D-14195Germany Fakultat V-Mathematik und Naturwissenschaften Carl von Ossietzky Universitat OldenburgGermany Institut fur Chemie und Biochemie Freie UniversitatBerlinGermany Institute of Physics University of GrazGrazAustria

The review presents an overview of studies in the surface science of oxide and related surfaces with an emphasis of the studies performed in the authors’ group. Novel instruments and technique developments, as well as their applications are reported, in an attempt to cover studies on model systems of increasing complexity, including some of the key ingredients of an industrially applied heterogeneous catalyst and its fabrication. The review is intended to demonstrate the power of model studies in understanding heterogeneous catalysis at the atomic level. The studies include those on supported nano-particles, both, prepared in vacuum and from solution, interaction of surfaces and the underlying bulk with molecules from the gas phase, strong metal support interaction, as well as the first attempt to include studies on reactions in confined spaces.

关键词： model catalysts oxide surfaces structure and spectroscopy supported nanoparticles reactions in the confined space

Multi-photon quantum cutting in Gd_(2)O_(2)S:Tm^(3+) to enhance the photo-response of solar cells

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Light(Science & Applications) 2015年第1期4卷 144-151页

作者： De-Chao Yu Rosa martin-Rodriguez Qin-Yuan Zhang Andries Meijerink Freddy T Rabouw State Key Laboratory of Luminescence Materials and Devices and Institute of Optical Communication Materials South China University of TechnologyGuangzhou 510641China Debye Institute for Nanomaterials Science Utrecht UniversityP.O.Box 800003508 TA Utrechtthe Netherlands

Conventional photoluminescence(PL)yields at most one emitted photon for each absorption ***(or quantum cutting)materials can yield more than one photon by virtue of energy transfer processes between luminescent *** this work,we introduce Gd2O2S:Tm^(3+) as a multi-photon quantum *** can convert near-infrared,visible,or ultraviolet photons into two,three,or four infrared photons of,1800 nm,*** cross-relaxation steps between Tm^(3+) ions that lead to quantum cutting are identified from(time-resolved)PL as a function of the Tm^(3+) concentration in the crystal.A model is presented that reproduces the way in which the Tm^(3+) concentration affects both the relative intensities of the various emission lines and the excited state dynamics and providing insight in the quantum cutting ***,we discuss the potential application of Gd2O2S:Tm^(3+) for spectral conversion to improve the efficiency of next-generation photovoltaics.

关键词： downconversion infrared emission quantum cutting solar cells spectral conversions

Cenozoic diatreme field in Chubut （Argentina） as evidence of phreatomagmatic volcanism accompanied with extensive Patagonian plateau basalt volcanism？

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Episodes 2007年第3期30卷 217-223页

作者： Karoly Nemeth Ulrike martin Miguel J. Haller Viviana I. Alric Institute of Natural Resources Volcanic Risk Solutions M_asse_y Uniyer_sity Palmerston North New Zealand. Department of Mapping Geological Institute of Hungary Stefainia 14 Budapest H- 1143 Hungary. Geo-Zentrum an der KTB Am Bohrturm 2 92670 Windischeschenbach Germany. Universidad Nacional de la Patagonea San Juan Bosco Bvard Brown 3700 （9120） Puerto Ma.dryn Argentina. Centro Nacional Patagenico-CONICET Bvard. Brown 3500 （9120） Puerto Madryn Argentina.

In Patagonia, Argentina, at the northern border of the Patagonian Cenozoic mafic plateau lava fields, newly discovered diatremes stand about I00 m above the sur- rounding plain. These diatremes document phreato- magmatic episodes associated with the formation of the volcanic fields. The identified pyroclastic and intrusive rocks are exposed lower diatremes of former phreato- magmatic volcanoes and their feeding dyke systems. These remotely located erosional remnants cut through Paleozoic granitoids and Jurassic/Cretaceous alternating siliciclastic continental successions that are rela-

关键词：新生界火山地下水湿生植物玄武岩