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Multimodal imaging of experimental choroidal neovascularization

International Journal of Ophthalmology(English edition) 2022年第6期15卷 886-893页

作者： Ioanna Tsioti Xuan Liu Petra schwarzer martin s.zinkernagel Despina Kokona Department of Ophthalmology InselspitalBern University Hospitaland Department of BioMedical ResearchUniversity of BernBern 3010Switzerland Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To compare choroidal neovascularization(CNV)lesion measurements obtained by in vivo imaging modalities,with whole mount histological preparations stained with isolectin Gs-IB4,using a murine laser-induced CNV ***:B6 ***-Tg(Csf1 r-EGFP)1 Hume/J heterozygous adult mice were subjected to laser-induced CNV and were monitored by fluorescein angiography(FA),multicolor(MC)fundus imaging and optical coherence tomography angiography(OCTA)at day 14 after CNV *** pigment epithelium(RPE)whole mounts were prepared at the end of the experiment and were stained with isolectin *** areas were measured in all different imaging modalities at day 14 after CNV from three independent raters and were compared to choroidal-RPE whole *** correlation coefficient(ICC)type 2(2-way random model)and its 95%confidence intervals(CI)were calculated to measure the correlation between different raters’***’s rank correlation coefficient(spearman’s r)was calculated for the comparison between FA,MC and OCTA data and histology ***:FA(early and late)and MC correlates well with the CNV measurements ex vivo with FA having slightly better correlation than MC(FA early spearman’s r=0.7642,FA late spearman’s r=0.7097,and MC spearman’s r=0.7418),while the interobser ver reliability was good for both techniques(FA early ICC=0.976,FA late ICC=0.964,and MC ICC=0.846).In contrast,OCTA showed a poor correlation with ex vivo measurements(spearman’s r=0.05716)and high variability between different raters(ICC=0.603).CONCLUsION:This study suggests that FA and MC imaging could be used for the evaluation of CNV areas in vivo while caution must be taken and comparison studies should be performed when OCTA is employed as a CNV monitoring tool in small rodents.

关键词： choroidal neovascularization in vivo imaging fluorescein angiography multicolor fundus imaging optical coherence tomography angiography

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Porphyrinic Acceptors forFullerene-Free MolecularPhotovoltaics

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CCs Chemistry 2024年第2期6卷 276-296页

作者： Jorge Labella Juan Laforga-martin Tomás Torres Department of Organic Chemistry Universidad Aut´onoma de Madrid28049 Madrid Institute for Advanced Research in Chemical sciences Universidad Aut´onoma de MadridMadrid IMDEA—Nanociencia 28049 Madrid

Over the past few years,the development of nonfullerene acceptors(NFAs)has become a prominent focus in both organic and perovskite solar cell(OsCs and PsCs,respectively)research *** this context,porphyrinoids,compounds structurally related to porphyrins,have emerged as promising solar cell *** contrast to the widely used fullerene acceptors,porphyrinoids exhibit strong,broad absorption properties across the UV–vis/NIR spectrum,which can be easily tuned through chemical ***,they can be prepared and derivatized using cost-effective and straightforward methodologies,allowing for convenient adjustments in thin-film morphology,processability,supramolecular organization,and energy ***,these compounds offer higher thermal and photochemical stability,resulting in longer device lifetimes compared to their fullerene-based *** this review,we outline the utilization of porphyrinoids as NFAs in OsCs and PsCs,discussing essential aspects such as design guidelines,molecular properties,and device *** goal is to inspire and further promote the development of n-type porphyrinoids,which have not yet fully unleashed their potential.

关键词： fullerene-free molecular photovoltaics nonfullerene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovskite solar cells

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Assistive technologies and habit development:a semiotic Model of Technological Mediation

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Language and semiotic studies 2024年第1期10卷 43-64页

作者： Bent sørensen martin Thellefsen Torkild Thellefsen Independent scholar AalborgDenmark Department of Communication Copenhagen UniversityCopenhagenDenmark Independent scholar Nr.SundbyDenmark

In the field of philosophy of technology,the concept of mediation is central to understanding how technology shapes human experience and *** aim in this paper is to contribute to the understanding of technological mediation,in particular how and why it is *** mediation occurs within a mediation space between the technological realm and the user *** the technological realm,technology regularizes events and actions,while in the user realm,the user interprets the significative potential of the *** interpretation process is identical with use and involves the formation of user habits,which are constrained by technological,cognitive,and sociocultural *** provide a theoretical framework for our analysis,we propose the semiotic Model of Technological Mediation(sMTM),which draws on Charles Peirceʼs *** illustrate our argument,we focus on assistive technology and provide a recurring example of the Medimi®smart,a digital,comprehensive system for medication handling.

关键词： philosophy of technological mediation assistive technology Charles Peirceʼs semiotics habit formation and user technology relation semiotic Model of Technological Mediation

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The energetics of cellular life transitions

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Life Metabolism 2024年第3期3卷 12-20页

作者： Anna s.Monzel Michael Levin martin Picard Department of Psychiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Discovery Center at Tufts University MedfordMA 02155United States Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York state Psychiatric Institute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life transitions are always difficult because change costs *** findings have demonstrated how mitochondrial oxidative phosphorylation(OxPhos)defects increase the energetic cost of living and that excessive integrated stress response(IsR)signaling may prevent cellular identity transitions during *** this perspective,we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift *** energetic cost of cellular differentiation has not been directly quantified,representing a gap in *** propose that the IsR is an energetic checkpoint evolved to(i)prevent OxPhos-deficient cells from engaging in excessively costly transitions and(ii)allow IsR-positive cells to recruit systemic energetic resources by signaling via GDF15 and the brain.

关键词： energy mitochondria signaling pathway growth differentiation factor 15 energy balance development

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Kentish Plover(Charadrius alexandrinus) and Little Tern(sternula albifrons) prefer shells for nesting:A field experiment

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Avian Research 2024年第1期15卷 55-59页

作者： Macarena Castro Andrés De la Cruz Nuria martin-sanjuan Alejandro Pérez-Hurtado Instituto Universitario de Investigacion Marina(INMAR) Campus de Excelencia Internacional del Mar(CEIMAR)Departamento de BiologíaUniversidad de CadizPuerto RealSpain servicios centrales de Investigacion salinas de la Esperanza Universidad de CadizPuerto RealSpain

shorebird populations are declining worldwide,mainly due to human disturbances and loss of coastal ***,supratidal habitats as saltpans could play a role in buffering human *** have shown to be important as feeding or breeding sites of some shorebird species.A potential conservation strategy to increase shorebird populations in saltpans is to manipulate the cues that birds use to select optimal breeding *** it is hypothesized that shorebirds are attracted to bivalve shells due to the advantages they *** this hypothesis,we supplemented a restored saltpan in 2019 and 2021 with bivalve shells,expecting an increase in the number of breeding birds’ *** than 75% of Kentish Plover(Charadrius alexandrinus) and Little Tern(sternula albifrons) nests were found in patches with shells in both *** best model for both species indicates that the presence of shells is the factor that most correlates with the location of *** probability of choosing one place over another to settle their nest increases in areas with an abundance of shells,double in the case of the Kentish Plover and triple in the case of the Little *** result of this study may constitute a valuable tool for attracting birds to restored saltpans and could contribute to the success of expensive restoration projects where time is usually a constraint.

关键词： Habitat management Nest site selection saltpan restoration shell supplementation shorebirds

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Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?

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Neural Regeneration Research 2024年第1期19卷 29-34页

作者： Marta Zagrebelsky martin Korte Division of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz Centre for Infection Research AG NINDBraunschweigGermany

Brain-derived neurotrophic factor signaling via its receptor tro pomyosin receptor kinase B regulates several crucial physiological *** has been shown to act in the brain,promoting neuronal survival,growth,and plasticity as well as in the rest of the body where it is involved in regulating for instance aspects of the *** to its crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels and alterations in the brain-derived neurotrophic factor/tropomyosin receptor kinase B signaling have been found to be associated with a wide spectrum of neurological *** r,because of its poor bioavailability and pharmacological properties,brain-derived neurotrophic factor itself has a very low therapeutic ***,the concomitant binding of exogenous brain-derived neurotrophic factor to the p75 neurotrophin receptor has the potential to elicit several unwanted and deleterious side *** re,developing tools and approaches to specifically promote tropomyosin receptor kinase B signaling has become an important goal of translational *** the newly developed tools are different categories of tropomyosin receptor kinase B receptor agonist *** this review,we give a comprehensive description of the diffe rent tro pomyosin receptor kinase B receptor agonist drugs developed so far and of the res ults of their application in animal models of several neurological ***,we discuss the main benefits of tropomyosin receptor kinase B receptor agonists,concentrating especially on the new tropomyosin receptor kinase B agonist *** benefits observed both in vitro and in vivo upon application of tropomyosin receptor kinase B receptor agonist drugs seem to predominantly depend on their general neuroprotective activity and their ability to promote neuronal ***,tro pomyosin receptor kinase B agonist antibodies have been shown to specifically bind the tropomyosin recepto

关键词： Alzheimer's disease brain-derived neurotrophic factor depression Parkinson's disease tropomyosin receptor kinase B receptor

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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan Cuccia Rachael Coates Blake Nassar Ethan Littlefield Elizabeth C.martin Adam T.Melvin Cain Department of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(Fss)found in human vasculature was designed and *** device provides a platform to evaluate the effects of Fss on MCF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of Fss on MCF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an Fss magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the MCF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKT,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKT,p-mTOR,and p-sTAT3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that Fss can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-martin Jose Guadix Jesus Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

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Particle size Optimization of Thermochemical salt Hydrates for High Energy Density Thermal storage

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Energy & Environmental Materials 2024年第2期7卷 326-333页

作者： Andrew martin Drew Lilley Raνi Prasher sumanjeet Kaur Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Mechanical Engineering UC BerkeleyBerkeleyCA 94720USA

Thermal energy storage(TEs)solutions offer opportunities to reduce energy consumption,greenhouse gas emissions,and ***,they can help reduce the peak load and address the intermittency of renewable energy sources by time shifting the load,which are critical toward zero energy *** materials(TCMs)as a class of TEs undergo a solid-gas reversible chemical reaction with water vapor to store and release energy with high storage capacities(600 kWh m^(-3))and negligible self-discharge that makes them uniquely suited as compact,stand-alone units for daily or seasonal ***,TCMs suffer from instabilities at the material(salt particles)and reactor level(packed beds of salt),resulting in poor multi-cycle efficiency and high-levelized cost of *** this study,a model is developed to predict the pulverization limit or Rcrit of various salt hydrates during thermal *** is critical as it provides design rules to make mechanically stable TCM composites as well as enables the use of more energy-efficient manufacturing process(solid-state mixing)to make the *** model is experimentally validated on multiple TCM salt hydrates with different water content,and effect of Rcrit on hydration and dehydration kinetics is also investigated.

关键词： high energy density hydration kinetics long-term cycling thermal energy storage thermochemical materials

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Arabidopsis photoperiodic regulator CONsTANs feeds back to control the circadian clock

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Molecular Plant 2024年第9期17卷 1338-1340页

作者： Abril san martin Marcelo Javier Yanovsky Instituto de Investigaciones Bioquimicas de Buenos Aires(Fundacion Instituto Leloir-CONICET) Av.Patricias Argentinas 435Buenos AiresC1405BWE

Human beings live in a world defined by daily cycles of light and darkness caused by the Earth's rotation around its ***,like most living organisms,have evolved internal circadian clocks that time biological processes in anticipation of these daily environmental changes(Young and Kay,2001).The plant clock relies on core genes encoding transcription factors(TFs),which regulate each other's expression through intricate networks of interlocking transcriptional-translational feedback loops(Nohales and Kay,2016).These loops ultimately control the expression of thousands of genes,allowing plants to adapt to daily fluctuations in light,temperature,and humidity(Covington et al.,2008).In addition to daily rhythms,the Earth experiences yearly seasonal cycles marked by longer,warmer days in spring and summer,followed by shorter,cooler days in autumn and *** changes in day length and temperature intensify with distance from the ***,the ability of plants to adjust their growth and development in anticipation of seasonal changes determines their latitudinal distribution(McMillan,1960).

关键词： circadian seasonal Arabidopsis

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