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Current Medical Science 2023年第3期43卷 423-433页

作者： joyce Peper Michiel L.Bots Tim Leiner martin j.swaans Department of Cardiology St.Antonius HospitalNieuwegein 3435 CMThe Netherlands Department of Radiology University Medical Center UtrechtUtrecht 3508 GAThe Netherlands julius Center for Health Sciences and Primary Care University Medical Center UtrechtUtrecht 3584 CGThe Netherlands

New non-and less-invasive techniques have been developed to overcome the procedural and operator related burden of the fractional flow reserve(FFR)for the assessment of potentially significant stenosis in the coronary *** FFR-techniques can obviate the need for the additional flow or pressure wires as used for FFR *** review provides an overview of the developments and validation of the virtual FFR-algorithms,states the challenges,discusses the upcoming clinical trials,and postulates the future role of virtual FFR in the clinical practice.

关键词： coronary artery disease quantitative flow ratio fractional flow reserve diagnostic accuracy physiology guided percutaneous coronary intervention

Adaptive optical microscopy: the ongoing quest for a perfect image

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Light(Science & Applications) 2014年第1期3卷 243-249页

作者： martin j Booth Department of Engineering Science University of OxfordOxford OX13PJUK Centre for Neural Circuits and Behaviour University of OxfordOxford OX13SRUnited Kingdom School in Advanced Optical Technologies Friedrich-Alexander Universita¨t Erlangen-Nu¨rnberg91052 ErlangenGermany

Adaptive optics is becoming a valuable tool for high resolution microscopy,providing correction for aberrations introduced by the refractive index structure of *** is proving particularly promising for applications that require images from deep within biological tissue *** review recent developments in adaptive microscopy,including methods and applications.A range of advances in different microscope modalities is covered and prospects for the future are discussed.

关键词： aberrations adaptive optics microscopy

An Integrated Approach to Crop Genetic Improvement

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journal of Integrative Plant Biology 2012年第4期54卷 250-259页

作者： martin A.j.Parry Malcolm j.Hawkesford Rothamsted Research Plant Science Department

The balance between the supply and demand of the major food crops is fragile, fueling concerns for long-term global food security. The rising population, increasing wealth and a proliferation of non- food uses （e.g. bioenergy） has led to growing demands on agricul- ture, while increased production is limited by greater urbanization, and the degradation of land. Furthermore, global climate change with increasing temperatures and lower, more erratic rainfall is projected to decrease agricultural yields. There is a predicted need to increase food production by at least 70% by 2050 and there- fore an urgent need to develop novel and integrated approaches, incorporating high-throughput phenotyping that will both increaseproduction per unit area and simultaneously improve the resource use efficiency of crops. Yield potential, yield stability, nutrient and water use are all complex multigenic traits and while there is genetic variability, their complexity makes such traits difficult to breed for directly. Nevertheless molecular plant breeding has the potential to deliver substantial improvements, once the component traits and the genes underlying these traits have been identified. In addition, interactions between the individual traits must also be taken into account, a demand that is difficult to fulfill with traditional screening approaches. Identified traits will be incorporated into new cultivars using conventional or biotechnological tools. In order to better understand the relationship between genotype, component traits, and environment over time, a multidisciplinary approach must be adopted to both understand the underlying processes and identify candidate genes, QTLs and traits that can be used to develop improved crops.

关键词： Germpiasm variation nitrogen TILLING transformation trait water wheat yield.

Evolving landscape and novel treatments in, metastatic castrate-resistant prostate cancer

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Asian journal of Andrology 2013年第3期15卷 342-349页

作者： Paul j Toren martin E Gleave Department of Urologic Sciences Faculty of Medicine University of British Columbia Vancouver BC V5Z 1M9 Canada

Treatment options for castrate-resistant prostate cancer （CRPC） have advanced in recent years and significantly improved the Outlook for patients with this aggressive and lethal disease. Further understanding of the biology＇of CRPC has led to several new targeted therapies and continues to emphasize the importance of androgen receptor （AR） directed therapy. The treatment landscape is rapidly changing and further biologically rationale, biomarker-based ongoing clinical trials are needed. We review the recent results of major clinical trials in CRPC. New and investigational agents now in clinical evaluation are reviewed including inhibitors of angiogenesis, microtubules, chaperones, AR and intracellular kinases, as well as immunotherapy, radiopharmaceuticals and bone-targeted agents. The recent improvement in prognosis for CRPC brings continued optimism for further improvements. Thoughtful planning of clinical trials and further understanding of the mechanisms of resistance to therapies will allow for continued progress in patient care.

关键词： prostate cancer treatment resistance androgen receptor antagonists molecular targets

Adaptive optics in laser processing

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Light(Science & Applications) 2019年第1期8卷 140-155页

作者： Patrick S.Salter martin j.Booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK

Adaptive optics are becoming a valuable tool for laser processing,providing enhanced functionality and flexibility for a range of *** a single adaptive element,it is possible to correct for aberrations introduced when focusing inside the workpiece,tailor the focal intensity distribution for the particular fabrication task and/or provide parallelisation to reduce processing *** is particularly promising for applications using ultrafast lasers for threedimensional *** review recent developments in adaptive laser processing,including methods and applications,before discussing prospects for the future.

关键词： laser optics workpiece

Mending the broken in amyotrophic lateral sclerosis: DNA damage and repair in motor neuron degeneration

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Neural Regeneration Research 2021年第1期16卷 104-105页

作者： Byung Woo Kim Lee j.martin Department of Pathology Division of Neuropathologythe Pathobiology Graduate Training ProgramJohns Hopkins University School of MedicineBaltimoreMDUSA Department of Neuroscience Johns Hopkins University School of MedicineBaltimoreMDUSA

Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease that causes paralysis and respiratory failure(Petrov et al.,2017).The driving mechanisms are unknown,and there are no effective treatments(Petrov et al.,2017).Aging and a few gene mutations,a common one being missense mutations in superoxide dismutase-1(SOD1),are risk factors for ALS(Figure 1).The recent Food and Drug Administration approval of edaravone for the treatment of ALS putatively supports a role for oxidative and nitrative stresses in the disease processes(Figure 1A).DNA damage,abnormalities in DNA repair,and other nuclear abnormalities are implicated also in the pathogenesis of human ALS(Bradley and Krasin,1982;Kim et al.,2020).

关键词： al. damage degeneration

Flow in Porous Media in the Energy Transition

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Engineering 2022年第7期8卷 10-14页

作者： martin j.Blunt Qingyang Lin Department of Earth Science and Engineering Imperial College LondonLondon SW72BPUK State Key Laboratory of Clean Energy Utilization State Environmental ProtectionEngineering Center for Coal-Fired Air Pollution ControlZhejiang UniversityHangzhou 310027China

*** context Flow in porous media is encountered in a wide variety of natural and engineered settings,including gas exchange in lungs and blood vessels,water extraction from underground aquifers,hydrocarbon production,and microfluidics in drug delivery and food *** rock is a porous medium that holds water and hydrocarbons,and is a potential storage site for carbon dioxide(CO_(2))and *** manufactured devices also contain porous media to allow the transport of gases and water,including fuel cells,electrolyzers,and electrocatalysts for CO_(2) *** performance is limited by how rapidly two fluid phases can flow through a porous layer.

关键词： underground rock setting

A Tutorial Review of the Solar Power Curve: Regressions, Model Chains, and Their Hybridization and Probabilistic Extensions

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Advances in Atmospheric Sciences 2024年第6期41卷 1023-1067页

作者： Dazhi YANG Xiang’ao XIA martin jános MAYER School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Key Laboratory for Middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3Budapest H-1111Hungary

Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly *** numerous trending topics,energy meteorology has been attracting the most attention *** essential skill of solar energy meteorologists is solar power curve modeling,which seeks to map irradiance and auxiliary weather variables to solar power,by statistical and/or physical *** this regard,this tutorial review aims to deliver a complete overview of those fundamental scientific and engineering principles pertaining to the solar power *** power curves can be modeled in two primary ways,one of regression and the other of model *** classes of modeling approaches,alongside their hybridization and probabilistic extensions,which allow accuracy improvement and uncertainty quantification,are scrutinized and contrasted thoroughly in this review.

关键词： review energy meteorology solar power curve model chain solar power prediction

Absolute characterization of high numerical aperture microscope objectives utilizing a dipole scatterer

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Light(Science & Applications) 2021年第12期10卷 2342-2348页

作者： jörg S.Eismann martin Neugebauer Klaus Mantel Peter Banzer Institute of Physics University of GrazNAWI GrazUniversitätsplatz 58010 GrazAustria Max Planck Institute for the Science of Light Staudtstr.291058 ErlangenGermany Institute of Optics Information and PhotonicsUniversity Erlangen-NurembergStaudtstr.7/B291058 ErlangenGermany

Measuring the aberrations of optical systems is an essential step in the fabrication of high precision optical *** a characterization is usually based on comparing the device under investigation with a calibrated reference ***,when working at the cutting-edge of technology,it is increasingly difficult to provide an even better or well-known reference *** this manuscript we present a method for the characterization of high numerical aperture microscope objectives,functioning without the need of calibrated reference *** technique constitutes a nanoparticle,acting as a dipole-like scatterer,that is placed in the focal volume of the microscope *** light that is scattered by the particle can be measured individually and serves as the reference wave in our *** the well-characterized scattered light as nearly perfect reference wave is the main idea behind this manuscript.

关键词： characterization scatter scattered

Characterization of particle deposition during crossflow filtration as influenced by permeate flux and crossflow velocity using a microfluidic filtration system

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Frontiers of Chemical Science and Engineering 2021年第3期15卷 552-561页

作者： Hongzhan Di Gregory j.O.martin Dave E.Dunstan Department of Chemical and Biomolecular Engineering University of MelbourneParkvilleVictoria 3010Australia

Particle deposition during crossflow filtration is significantly influenced by the operating conditions,in particular the permeate flux and crossflow ***,there is a lack of detailed knowledge about how deposit layer structures and distributions depend on operating *** study uses a microfluidic visualisation filtration system to examine the influence of operating conditions on the deposition process during crossflow ultrafiltration from a microscopic *** the permeate flux caused an increasing amount of deposition and a thicker deposit *** crossflow velocities reduced the extent of *** degree of deposition varied over a range of operating conditions due to the altered hydrodynamic forces exerted on the particles,which can be examined by the deposition probability according to an existing *** on this,an empirical correlation between the deposition probability and volume of deposition as a function of filtration time was developed,which gave good agreement with experimental *** effect of solution conditions was also involved in this correlation as a interaction *** could be useful for predicting the dynamic deposition process during crossflow filtration over a range of operating and solution conditions.

关键词： particle deposition crossflow filtration microfluidics confocal microscopy