检索结果-南通市图书馆

A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro

生物活性材料(英文) 2023年第2期20卷 627-637页

作者： Marinus A.Wesdorp Andrea Schwab Ezgi Irem Bektas Roberto Narcisi David Eglin martin j.stoddart Gerjo j.V.M.Van Osch Matteo D’Este AO Research Institute Davos AO FoundationDavos PlatzSwitzerland Department of Orthopaedics and Sports Medicine Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Mines Saint-Étienne Univ LyonUniv Jean MonnetINSERMU1059 SainbioseSaint-ÉtienneFrance Department of Biomaterials Science and Technology University of TwenteEnschedethe Netherlands Department of Otorhinolaryngology Erasmus MCUniversity Medical Center Rotterdamthe Netherlands Department of Biomechanical Engineering Faculty of MechanicalMaritimeand Materials EngineeringDelft University of Technologythe Netherlands Department of Oral and Maxillofacial Surgery Erasmus MCUniversity Medical Center Rotterdamthe Netherlands

Neutrophils play a pivotal role in orchestrating the immune system response to biomaterials,the onset and resolution of chronic inflammation,and macrophage ***,the neutrophil response to biomaterials and the consequent impact on tissue engineering approaches is still scarcely ***,we report an in vitro culture model that comprehensively describes the most important neutrophil functions in the light of tissue *** isolated human primary neutrophils from peripheral blood and exposed them to a panel of hard,soft,naturally-and synthetically-derived *** overall trend showed increased neutrophil survival on naturally derived constructs,together with higher oxidative burst,decreased myeloperoxidase and neutrophil elastase and decreased cytokine secretion compared to neutrophils on synthetic *** culture model is a step to better understand the immune modulation elicited by *** studies are needed to correlate the neutrophil response to tissue healing and to elucidate the mechanism triggering the cell response and their consequences in determining inflammation onset and resolution.

关键词： inflammation healing culture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Functionalized Hydrogels for Articular Cartilage Tissue Engineering

引用

Engineering 2022年第6期8卷 71-90页

作者： Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong jiankun Xu Hao Yao martin j.stoddart Gerjo j.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Innovative Orthopaedic Biomaterials and Drug Translational Research Laboratory Li Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China AO Research Institute Davos DavosCH 7270Switzerland Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518000China Department of Orthopaedics and Sports Medicine&Department of Otorhinolaryngology Erasmus MCUniversity Medical CenterRotterdam 3000 CAthe Netherlands f Department of Biomechanical EngineeringDelft University of TechnologyDelft 2600 AAthe Netherlands Centre for Translational Medicine Research and Development Shenzhen Institute of Advanced TechnologyThe Chinese Academy of SciencesShenzhen 518000China

Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial *** defects are common in the knees of young and physically active *** of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage *** rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating *** can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of *** article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC ***,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation.

关键词： Articular cartilage Functionalized hydrogels Cartilage repair Cartilage tissue engineering Clinical translation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Function-oriented design:A novel strategy for advanced biomedical materials

引用

journal of Materials Science & Technology 2023年第14期145卷 197-209页

作者： Zhiyu Zhou Wentao Wang jianmin Wang Hongshui Wang Yi Xia Wei Zhang Yuxiao Lai Xiao Lin Yongcan Huang Xuenong Zou martin j.stoddart Zhen Li Wei Tian Shaoyu Liu Xinbao Wu Manman Gao junhong Li Lei Yang Dafu Chen Department of Orthopaedic Surgery the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Center for Health Science and Engineering School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Centre for Translational Medicine Research&Development Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518063China Orthopedic Institute and Department of Orthopedics the First Affiliated HospitalSoochow UniversitySuzhou 215000China Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies Department of Spine SurgeryPeking University Shenzhen HospitalShenzhen 518034China AO Research Institute Davos Davos7270Switzerland h Laboratory of Bone Tissue EngineeringBeijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing Jishuitan HospitalBeijing 100035China Department of Sport Medicine Institute of Translational Medicinethe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518025China Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine Department of Medical Cell Biology and GeneticsHealth Sciences CenterShenzhen UniversityShenzhen 518060China The Department of Orthopaedics and Trauma the Affiliated Hospital of Yunnan UniversityYunnan UniversityKunming 650091China

It has always been a dream to construct tissues and even organs for transplantation to replace those with defects caused by diseases or *** engineering is another milestone in the developmental history of life science after cellular and molecular ***,despite decades of rapid de-velopment,tissue-engineered biomaterials have not been widely used *** constructed by physical and chemical methods have lots of difficulty in precisely mimicking the macroscopic and mi-croscopic structures of human *** ultimate way to build organoid tissue for regeneration is to enable the cells to take the initiative and build suitable *** on the thoughts of tissue engi-neering,organoid technology holds great potential as a research tool for a wide range of fields,including developmental biology,disease pathology,cell biology,precision medicine,and drug toxicity and efficacy *** technology also holds tremendous potential for regenerative medicine,as organoids present the possibility for autologous and allogeneic cell therapy through the replacement of damaged or dis-eased tissues with organoid-propagated tissue or stem cell *** this review work,we briefly outlook the development history of organoid technology,summarize the current bottlenecks and the un-derlying reasons,and propose the unified term“function-oriented design in tissue engineering”,a new topic that may provide a solution to overcome these bottlenecks.

关键词： Biomaterial Organoid Tissue engineering Function-oriented design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration

引用

Bioactive Materials 2022年第3期7卷 281-298页

作者： Peng Guo Xizhe Liu Penghui Zhang Zhongyuan He Zhen Li Mauro Alini RGeoff Richards Sibylle Grad martin j.stoddart Guangqian Zhou Xuenong Zou Danny Chan Wei Tian Dafu Chen Manman Gao Zhiyu Zhou Shaoyu Liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhenChina Guangdong Provincial Key Laboratory of Orthopaedics and Traumatology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina AO Research Institute Davos DavosSwitzerland Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine Department of Medical Cell Biology and GeneticsHealth Sciences CenterShenzhen UniversityShenzhenChina School of Biomedical Sciences LKS Faculty of MedicineThe University of Hong KongHong Kong SARChina Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijingChina Department of Sport Medicine Inst Translat MedThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhenChina

The osteogenic microenvironment of bone-repairing materials plays a key role in accelerating bone regeneration but remains incompletely defined,which significantly limits the application of such bioactive ***,the transcriptional landscapes of different osteogenic microenvironments,including three-dimensional(3D)hydroxyapatite(HA)scaffolds and osteogenic medium(OM),for mesenchymal stromal cells(MSCs)in vitro were mapped at single-cell *** findings suggested that an osteogenic process reminiscent of endochondral ossification occurred in HA scaffolds through sequential activation of osteogenic-related signaling pathways,along with inflammation and angiogenesis,but inhibition of adipogenesis and ***,we revealed the mechanism during OM-mediated osteogenesis involves the ZBTB16 and WNT signaling *** of MSCs was also *** vitro ossification of LRRC75A+MSCs was shown to have better utilization of WNT-related ossification process,and PCDH10+MSCs with superiority in hydroxyapatite-related osteogenic *** findings provided further understanding of the cellular activity modulated by OM conditions and HA scaffolds,providing new insights for the improvement of osteogenic *** atlas provides a blueprint for research on MSC heterogeneity and the osteogenic microenvironment of HA scaffolds and a database reference for the application of bioactive materials for bone regeneration.

关键词： inflammation bioactive finding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

引用

Bioactive Materials 2021年第10期6卷 3097-3108页

作者： Penghui Zhang Xizhe Liu Peng Guo Xianlong Li Zhongyuan He Zhen Li martin j.stoddart Sibylle Grad Wei Tian Dafu Chen Xuenong Zou Zhiyu Zhou Shaoyu Liu Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury Department of Orthopaedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen518107China Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Orthopaedic Research Institute/Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China AO Research Institute Davos Clavadelerstrasse 8Davos7270Switzerland Laboratory of Bone Tissue Engineering Beijing Laboratory of Biomedical MaterialsBeijing Research Institute of Orthopaedics and TraumatologyBeijing JiShuiTan HospitalBeijing100035China

It has been proven that the mechanical microenvironment can impact the differentiation of mesenchymal stem cells(MSCs).However,the effect of mechanical stimuli in biofabricating hydroxyapatite scaffolds on the inflammatory response of MSCs remains *** study aimed to investigate the effect of mechanical loading on the inflammatory response of MSCs seeded on *** mechanical loading was applied to biofabricate the cell-scaffold composite for 15 min/day over 7,14,or 21 *** the predetermined time points,culture supernatant was collected for inflammatory mediator detection,and gene expression was analyzed by *** results showed that the expression of inflammatory mediators(IL1B and IL8)was downregulated(p<0.05)and the expression of ALP(p<0.01)and COL1A1(p<0.05)was upregulated under mechanical *** cell-scaffold composites biofabricated with or without mechanical loading were freeze-dried to prepare extracellular matrix-based scaffolds(ECM-based scaffolds).Murine macrophages were seeded on the ECM-based scaffolds to evaluate their *** ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying enhanced the expression of M2 polarization-related biomarkers(Arginase 1 and Mrc1,p<0.05)of macrophages in vitro and increased bone volume/total volume ratio in ***,these findings demonstrated that mechanical loading could dually modulate the inflammatory responses and osteogenic differentiation of ***,the ECM-based scaffolds that were biofabricated with mechanical loading before freeze-drying facilitated the M2 polarization of macrophages in vitro and bone regeneration in *** loading may be a promising biofabrication strategy for bone biomaterials.

关键词： Bioreactor Biofabrication Inflammatory microenvironment Bone biomaterials Macrophage polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Tutorial Review of the Solar Power Curve: Regressions, Model Chains, and Their Hybridization and Probabilistic Extensions

引用

Advances in Atmospheric Sciences 2024年第6期41卷 1023-1067页

作者： Dazhi YANG Xiang’ao XIA martin jános MAYER School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Key Laboratory for Middle Atmosphere and Global Environment Observation(LAGEO) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3Budapest H-1111Hungary

Owing to the persisting hype in pushing toward global carbon neutrality,the study scope of atmospheric science is rapidly *** numerous trending topics,energy meteorology has been attracting the most attention *** essential skill of solar energy meteorologists is solar power curve modeling,which seeks to map irradiance and auxiliary weather variables to solar power,by statistical and/or physical *** this regard,this tutorial review aims to deliver a complete overview of those fundamental scientific and engineering principles pertaining to the solar power *** power curves can be modeled in two primary ways,one of regression and the other of model *** classes of modeling approaches,alongside their hybridization and probabilistic extensions,which allow accuracy improvement and uncertainty quantification,are scrutinized and contrasted thoroughly in this review.

关键词： review energy meteorology solar power curve model chain solar power prediction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

单分子结中的有机自由基

引用

Science China Materials 2024年第3期67卷 709-728页

作者：张雅琦邱仁慧屈恺张成 j.Fraser stoddart 陈洪亮 stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310021China Zhejiang-Israel joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CentreZhejiang UniversityHangzhou 311215China Department of Chemistry and Innovation Center of Pesticide Research China Agricultural UniversityBeijing 100193China Department of Chemistry The University of Hong KongHong Kong SAR 999077China School of Chemistry University of New South WalesSydneyNSW 2052Australia Beijing National Laboratory for Molecular Sciences Beijing 100871China

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可... 详细信息

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可以通过二聚、分子识别和机械互锁等分子间相互作用来构筑超分子器件.本文综述了空气稳定有机自由基在电子学及自旋电子学中的应用,通过详述其卓越的电磁性能来拓展启发分子设计的多样性.本综述还概述了超分子自由基的制备方法和相关性质的研究进展,拓宽了单分子研究的范围.此外,自由基介导的单分子反应是一个新兴的研究方向,本文也对该领域的未来发展方向进行了展望.通过阐明空气稳定有机自由基的应用潜力,本文将有望对分子电子学和自旋电子学的研究产生一定的指导意义.

关键词： air-stable radicals molecular electronics spintronics supramolecular devices

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sustainable plasticulture in Chinese agriculture: a review of challenges and routes to achieving long-term food and ecosecurity

引用

Frontiers of Agricultural Science and Engineering 2024年第1期11卷 155-168页

作者： Samuel j.CUSWORTH William j.DAVIES martin R.MCAINSH Carly j.STEVENS Weilu WANG Lancaster Environment Centre Lancaster UniversityLancasterLA14YQUK The Institutes of Agricultural Science and Technology Development Yangzhou UniversityYangzhou 225009China

Plastic pollution is global concern, affecting most aspects of global food production systems. Plasticulture, a practice used in agriculture to improve crop quality and quantity, among other factors, is a significant source of plastic pollution. This review examines the extent of plasticulture in China, the implications of the practice across decades of use and the legislative instruments used to resolve those issues. It briefly assesses the effectiveness of these policies and proposes possible future innovations to promote increases in long-term food and eco-security, where sustainable plasticulture is a key agent for change. While plasticulture has increased agricultural productivity in growth-limiting conditions, plastic pollution in agricultural soils has become acute in China. Consequently, plastic pollution is having deleterious effects on soil health and in turn, crop productivity in China. Plastic pollution in agriculture is a multifaceted issue and so proposed solutions should be informed by this complexity. Current measures do not reflect a holistic approach to solving this socioecological challenge and adopt a top-down approach, with little or no supportive mechanisms. Future recommendations need to consider the particular set of conditions that influence the production, use and end-of-life management of agriplastics,specific to the environmental, economic and social conditions in each location.

关键词： Circular plastics economy crop production food security plastic pollution sustainable plasticulture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing 3D Reconstruction Accuracy of FIB Tomography Data Using Multi‑voltage Images and Multimodal Machine Learning

引用

Nanomanufacturing and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara Alexander Shkurmanov Yong Li Lukas Riedel Shan Shi Christian j.Cyron Roland C.Aydin martin Ritter Institute for Continuum and Material Mechanics Hamburg University of TechnologyHamburgGermany Electron Microscopy Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physics and Technology Hamburg University of TechnologyHamburgGermany Institute of Materials Mechanics Helmholtz-Zentrum HereonGeesthachtGermany Research Group of Integrated Metallic Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful technique that integrates a focused ion beam(FIB)and a scanning electron microscope(SEM)to capture high-resolution imaging data of *** approach involves collecting in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby producing image ***,theseimage stacks in FIB-SEM tomography are subject to the shine-through effect,which makes structures visible from theposterior regions of the current *** artifact introduces an ambiguity between image intensity and structures in thecurrent plane,making conventional segmentation methods such as thresholding or the k-means algorithm *** study,we propose a multimodal machine learning approach that combines intensity information obtained at differentelectron beam accelerating voltages to improve the three-dimensional(3D)reconstruction of *** treatingthe increased shine-through effect at higher accelerating voltages as a form of additional information,the proposed methodsignificantly improves segmentation accuracy and leads to more precise 3D reconstructions for real FIB tomography data.

关键词： Multimodal machine learning Multi-voltage images FIB-SEM Overdeterministic systems 3D reconstruction FIB tomography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

单分子结中的有机自由基（英文）

引用

Science China Materials 2024年

作者：张雅琦邱仁慧屈恺张成 j.Fraser stoddart 陈洪亮 Zhejiang-Israel joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation Centre Zhejiang University Department of Chemistry The University of Hong Kong stoddart Institute of Molecular Science Department of Chemistry Zhejiang University Beijing National Laboratory for Molecular Sciences Beijing 100871 China Department of Chemistry and Innovation Center of Pesticide Research China Agricultural University School of Chemistry University of New South Wales

空气稳定有机自由基的发现引起了人们对探究其在分子电子学和自旋电子学中应用的兴趣.这些自由基具有独特的开壳层电子结构,因而表现出特殊的电学特性.由于其较弱的旋轨耦合特性,也使得其成为自旋电子学的重要研究对象.此外,自由基还可...

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：