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Cancer Communications 2023年第6期43卷 720-725页

作者： Mikkel g.Terp martina Tuttolomondo Neil Portman Sidse Ehmsen Lene E.Johansen martin Bak Elgene Lim Henrik J.Ditzel Department of Cancer and Inflammation Research Institute of Molecular MedicineUniversity of Southern DenmarkOdenseDenmark garvan Institute of Medical Research DarlinghurstSydneyNew SouthWalesAustralia St.Vincent’s Clinical School Faculty of MedicineUniversity of New SouthWales SydneySydneyNew South WalesAustralia Department of Oncology Institute of Clinical ResearchOdense University HospitalOdenseDenmark Department of Pathology Sydvestjysk SygehusEsbjergDenmark Academy of geriatric Cancer Research(AgeCare) Odense University HospitalOdenseDenmark

Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a phosphoinositide 3-kinase inhibitor(PI3Ki),the disease will eventually progress,and the optimal treatment strategy upon progression remains undefined[1-4].To address this,we developed MCF-7-and T47D-derived PIK3CAmutated breast cancer cell lines[5]resistant to combined CDK4/6i palbociclib and fulvestrant(MPF-R and TPFR)or combined PI3Ki alpelisib and fulvestrant(MAF-R and TAF-R),respectively(Supplementary Materials and Methods).Drug-sensitive isogenic cells(M-S and T-S)grown in parallel with MPF-R and TPF-R cells and the original MCF-7/S0.5 and T47D cells were analyzed for comparison.

关键词： PIK3CA breast cancer

Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade Pereira Lucas Moraes Berneira Claudio martin Pereira de Pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean Carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter Janice Luehring giongo Rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (gC-MS) and thermal analyses (thermogravimetric analysis (TgA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

A risk table to address concerns external to stock assessments when developing fisheries harvest recommendations

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Ecosystem Health and Sustainability 2020年第1期6卷 46-56,45页

作者： martin W.Dorn Stephani g.Zador Resource Ecology and Fisheries Management Alaska Fisheries Science CenterSeattleWAUSA

This paper develops a risk table to facilitate incorporation of additional information into the fisheries stock assessment and management *** risk table is designed to evaluate unanticipated ecosystem and environmental impacts on marine resources that may require a rapid management *** risk table is a standardized framework to document concerns about the assessment model,population dynamics,and the ecosystem/environment that are not explicitly addressed within the stock assessment model.A scoring procedure is used to evaluate the severity of the *** concerns can then be evaluated in support for or against a reduction from the maximum Acceptable Biological Catch while providing reviewers and stakeholders transparent documentation of the *** risk table was applied successfully to several stocks on a trial basis during the 2018 groundfish assessment cycle for the North Pacific Fishery Management Council,and will be used for all full groundfish assessments in *** changes in climate are likely for Alaska marine ecosystems in coming decades,and these changes are not entirely ***,we avocate that the risk table approach should be included in the suite of management tools used to address the effects of climate change on Alaska marine resources.

关键词： Acceptable biological catch ecosystem-based management risk assessment stock assessment North Pacific Fishery Management Council

Exploiting Virtual Elasticity of Production Systems to Respect OTD—Part 3: Basic Considerations for Modelling CPPS Characterized by Non-Ergodic Order Entry and Non-Deterministic Product-Mix for Fully Flexible Addressable Workstations

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American Journal of Operations Research 2022年第2期12卷 19-63页

作者： Bruno g. Rüttimann martin T. Stöckli Eidgenö ssische Technische Hochschule Zürich IWF Zurich Switzerland Inspire Ag Zurich Switzerland

The recently experienced hype concerning the so-called “4th Industrial Revolution” of production systems has prompted several papers of various subtopics regarding Cyber-Phdysical Production Systems (CPPS). However, important aspects such as the modelling of CPPS to understand the theory regarding the performance of highly non-ergodic and non-deterministic flexible manufacturing systems in terms of Exit Rate (ER), Manufacturing Lead Time (MLT), and On-Time Delivery (OTD) have not yet been examined systematically and even less modeled analytically. To develop the topic, in this paper, the prerequisites for modelling such systems are defined in order to be able to derive an explicit and dedicated production mathematics-based understanding of CPPS and its dynamics: switching from explorative simulation to rational modelling of the manufacturing “physics” led to an own and specific manufacturing theory. The findings have led to enouncing, among others, the Theorem of Non-Ergodicity as well as the Batch Cycle Time Deviation Function giving important insights to model digital twin-based CPPS for complying with the mandatory OTD.

关键词： On-Time-Delivery Production System Industry 4.0 CPPS IoT Stochastic Arrival Rate Non-Ergodic Process Virtual Elasticity Production Capacity Nominal Mean Exit Rate Theorem of Non-Ergodicity Non-Deterministic Product-Mix TFL AgV Scheduling Algorithm Digital Twin

Chronic hepatitis C in hemodialysis patients:Prevalence and liver fibrosis impact in the National Center for Renal Health in Peru

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iLIVER 2022年第3期1卷 141-144页

作者： P.martin Padilla-Machaca Eduardo Luna-Victoria Ada Cabrera Juan-Carlos gómez-De la Torre Rocio galloso Pedro Montes guillermo Almenara National Hospital EsSaludLimaPerú National University of San Marcos LimaPerú National Renal Health Center EsSaludLimaPerú Laboratorio Clínico Roe LimaPerú Asociacion Peruana para el Estudio del Hígado(APEH) LimaPerú

Background:Hepatitis C(HCV)remains a serious public health problem in high-risk persons such as patients on chronic *** aimed to estimate the serological prevalence of HCV,the HCV viral load and genotype,and liver fibrosis stage among patients on chronic hemodialysis at the National Renal Health Center in Lima,***:From June 2019 to March 2021,all patients who received chronic hemodialysis were invited to *** who provided written informed consent were *** with HCV-positive serology underwent determination of HCV viral *** from subjects with detectable viral load,underwent determination of HCV ***,HCV infected subjects underwent determination of liver fibrosis using transitional elastography(Fibroscan 402):Metavir score:F0-F1:2.5-7.5 kPa,F2:7.6-9.5 Kpa,F3:9.6-12 Kpa,F4(Cirrhosis):12.1-75 ***:Of the 303 subjects invited to participate,174(57.4%)subjects gave their written *** age was 52 years(range 22-91)and 116(66.6%)were *** serology was positive in 35.1%of patients(61/174);however,the prevalence of positive serology with detectable viral load was 20.11%(35/174).genotype 1a was the most prevalent(85%).The majority(83.6%)of subjects with detectable viral load had values lower than 800.000 IU/***-nine of those 35 subjects underwent elastography evaluation,and 13(44.8%)of them were found to have stage F2-F4 ***:The prevalence of HCV at the largest reference center for hemodialysis in Lima remains high,with gT1a predominance,viral load usually below 800,000 IU/mL and significant liver fibrosis.

关键词： Hepatitis C Hemodialysis Liver fibrosis HCV genotype

Life-cycle Assessment of Carbon Dioxide Capture for Enhanced Oil Recovery

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Chinese Journal of Chemical Engineering 2008年第3期16卷 343-353页

作者： Edgar g. Hertwich martin Aaberg Bhawna Singh Anders H. StrФmman Industrial Ecology Programme Norwegian University of Technology （NTNU） 7491 Trondheim Norway Department of Energy and Process Engineering Norwegian University of Technology （NTNU） 7491 Trondheim Norway DNV Energy Region Nordic and Eurasia Veritasveien 11322 HФvik Norway

技术是的二氧化碳俘获和存储( CCS )的发展和推广挪威的政府工程的气候 strategy.A 数字的一块奠基石当前沿着挪威的韦斯特海岸被评估/计划，在从这个工程的 ***2 的将在 Halten 油田为提高的油的回收部分地被利用，在挪威的海。我们学... 详细信息

技术是的二氧化碳俘获和存储( CCS )的发展和推广挪威的政府工程的气候 strategy.A 数字的一块奠基石当前沿着挪威的韦斯特海岸被评估/计划，在从这个工程的 ***2 的将在 Halten 油田为提高的油的回收部分地被利用，在挪威的海。我们学习如此的 system.A 的一个潜在的图案有 832 MW 的粗野权力产量的联合周期动力厂作为溶剂用胺基于燃烧以后的俘获与 CO2 俘获植物被相结合。捕获的 CO2 被用于提高的油的回收(EOR ) 。我们采用一个混合生命周期评价(LCA ) 估计系统的环境影响的方法。站台的修正和操作的学习焦点在 *** 期间分配连接到 CO2 的俘获到连接到 CO2 的运输和存储到生产的油的电生产，和影响的影响。我们的学习由 80% ～ 75 g ·(kW · h 从权力生产显示出温室气体排出物的实质的减小)^(-1) 。它也显示与采油每单位量油生产了联系的排出物的减小，主要由于增加的采油。如果另外的力量需求从陆地由于 EOR 导致电源，减小是特别重要的。

关键词：石油回采捕集 CO2 全周期评估

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 46-69页

作者： Sarah Lépine Maria José Castellanos-Montiel Thomas martin Durcan The Neuro’s Early Drug Discovery Unit(EDDU) Department of Neurology and NeurosurgeryMontreal Neurological Institute-HospitalMcGill University3801 University StreetMontrealQC H3A 2B4Canada Faculty of Medicine and Health Sciences McGill University3605 De La MontagneMontrealQC H3G 2M1Canada

Amyotrophic lateral sclerosis(ALS)is a disease characterized by upper and lower motor neuron(MN)loss with a signature feature of cytoplasmic aggregates containing TDP-43,which are detected in nearly all *** in the gene that encodes TDP-43(TARBDP)are known to result in both familial and sporadic *** ALS,disruption of neuro-muscular junctions(NMJs)constitutes a critical event in disease pathogenesis,leading to denervation atrophy,motor impairments and *** defects and impaired synaptic transmission at NMJs have been reported in several TDP-43 animal models and in vitro,linking TDP-43 dysregulation to the loss of NMJ integrity in *** the lens of the dying-back and dying-forward hypotheses of ALS,this review discusses the roles of TDP-43 related to synaptic function,with a focus on the potential molecular mechanisms occurring within MNs,skeletal muscles and glial cells that may contribute to NMJ disruption in ALS.

关键词： Amyotrophic lateral sclerosis Denervation Neuromuscular junction TDP-43 Dying-back Dying-forward

Insect host-parasite coevolution in the light of experimental evolution

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Insect Science 2014年第4期21卷 401-414页

作者： Niels A. g. Kerstes Oliver Y. martin Experimental Ecology Institute for Integrative Biology D‐USYS ETH Zurich Zurich Switzerland

The many ways parasites can impact their host species have been the focus of intense study using a range of approaches. A particularly promising but under-used method in this context is experimental evolution, because it allows targeted manipulation of known populations exposed to contrasting conditions. The strong potential of applying this method to the study of insect hosts and their associated parasites is demonstrated by the few available long-term experiments where insects have been exposed to parasites. In this review, we summarize these studies, which have delivered valuable insights into the evolution of resistance in response to parasite pressure, the underlying mechanisms, as well as correlated genetic responses. We further assess findings from relevant artificial selection studies in the interrelated contexts of immunity, life history, and reproduction. In addition, we discuss a number of well-studied Tribolium castaneum-Nosema whitei coevolution experiments in more detail and provide suggestions for research. Specifically, we suggest that future experiments should also be performed using nonmodel hosts and should incorporate contrasting experimental conditions, such as population sizes or envi- ronments. Finally, we expect that adding a third partner, for example, a second parasite or symbiont, to a host-parasite system could strongly impact （co）evolutionary dynamics.

关键词： artificial selection immunity Nosema reproduction resistance Tribolium

In-process failure analysis of thin-wall structures made by laser powder bed fusion additive manufacturing

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Journal of Materials Science & Technology 2022年第3期98卷 233-243页

作者： Apratim Chakraborty Reza Tangestani Rasim Batmaz Waqas Muhammad Philippe Plamondon Andrew Wessman Lang Yuan Étienne martin University of Waterloo 200 University Avenue WestWaterlooON N2L 3G1Canada Polytechnique Montréal 2500 Chemin de PolytechniqueMontréalQC H3T 1J4Canada University of Arizona 1235 E.James E.Rogers WayTucsonAZ 85721-0012United States University of South Carolina 301 Main StreetColumbiaSC 29208United States

Fabrication of thin-wall components using the laser powder bed fusion(LPBF)additive manufacturing(AM)technology was investigated for two“hard-to-weld”high gamma prime Ni-based superalloys RENé65(R65)and RENé108(R108).Simple block parts with wall thicknesses of 0.25 mm,1.00 mm,and5.00 mm are printed using a bidirectional laser scanning strategy without layer-wise *** with walls thinner than 5 mm fail before reaching the designated build *** indicate that reduction of limiting build height(LBH)corresponds to the reduction of part thickness and is unaffected by alloy *** the contrary,the number of internal micro-cracks along columnar grain boundaries in the build direction(BD)increases with part thickness and is significantly higher in R108 than *** findings suggest that reduced LBH in parts with thinner walls is not caused by internal micro-crack *** and finite element analysis(FEA)of the in-process thermal stresses show that the LBH trend is not explained by the conventional cracking *** suggest that part thickness affects stress distribution leading to more substantial distortion and consequent failure to add layers for continued fabrication of thinner parts.

关键词： Laser powder bed fusion Superalloys Thin-wall Residual stress Additive manufacturing

Acid-treated Fe-doped TiO2 as a high performance photocatalyst used for degradation of phenol under visible light irradiation

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Journal of Environmental Sciences 2019年第9期31卷 183-194页

作者： Vahid Moradi Faysal Ahmed martin B.g. Jun Arthur Blackburn Rodney A. Herring Mechanical Engineering Department University of Victoria Victoria British Columbia V8W 2Y2 Canada Center for Advanced Materials and Related Technology University of Victoria Victoria British Columbia V8W 2Y2 Canada School of Mechanical Engineering Purdue University West Lafayette IN 47907-2088 USA

The photocatalytic activity of Fe-doped TiO2 nanoparticles is significantly increased by an acid-treatment process. The photocatalyst nanoparticles were prepared using sol–gel method with 0.5 mol% ratio of Fe:Ti in acidic pH of 3. The nanoparticles were structurally characterized by means of X-ray diffraction(XRD), high-resolution transmission electron microscope(HRTEM), energy-dispersive X-ray spectroscopy(EDX), X-ray photoelectron spectroscopy(XPS) and diffuse reflectance spectroscopy(DRS). It was observed that the photocatalytic activity suffered from an iron oxide contaminating layer deposited on the surface of the nanoparticles. This contamination layer was removed using an HCl acidtreatment process. The photocatalytic activity using 500 mg/L of Fe0.5-TiO2 in a 10 mg/L of phenol solution increased significantly from 33% to 57%(about 73% increase in the performance), within 90 min of reaction time under visible light irradiation. This significant improvement was achieved by removing the iron oxide contamination layer from the surface of the nanoparticles and adjusting p H to mild acidic and basic pHs.

关键词： Phenol degradation Visible light Photocatalyst Kinetics Iron doping