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Analysis of the combined effect of rs699 and rs5051 on angiotensinogen expression and hypertension

Chronic Diseases and Translational Medicine 2024年第2期10卷 102-117页

作者： Nicholas R.Powell Tyler Shugg Jacob Leighty Matthew martin Rolf P.Kreutz Michael T.Eadon Dongbing Lai Tao Lu Todd C.Skaar Division of Clinical Pharmacology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Pharmacology and Toxicology School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiology School of MedicineKrannert Institute of CardiologyIndiana UniversityIndianapolisIndianaUSA Division of Nephrology Department of MedicineSchool of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Medical and Molecular Genetics School of MedicineIndiana UniversityIndianapolisIndianaUSA

Background Hypertension(HTN)involves genetic variability in the renin-angiotensin system and influences antihypertensive *** previously reported that angiotensinogen(AGT)messenger RNA(mRNA)is endogenously bound by miR-122-5p and rs699 A>G decreases reporter mRNA in the microRNA functional-assay *** AGT promoter variant rs5051 C>T is in linkage disequilibrium(ld)with rs699 A>G and increases AGT *** independent effect of these variants is understudied due to their ld therefore we aimed to test the hypothesis that increased AGT by rs5051 C>T counterbalances AGT decreased by rs699 A>G,and when these variants occur independently,it translates to HTN-related *** We used in silico,in vitro,in vivo,and retrospective models to test this *** In silico,rs699 A>G is predicted to increase miR-122-5p binding affinity by 3%.Mir-eCLIP results show rs699 is 40–45 nucleotides from the strongest microRNA-binding site in the AGT ***,rs699 A>G increases AGT mRNA in an AGT-plasmid-cDNA HepG2 expression ***-Tissue Expression(GTEx)and UK Biobank analyses demonstrate liver AGT expression and HTN phenotypes are not different when rs699 A>G occurs independently from rs5051 C>***,GTEx and the in vitro experiments suggest rs699 A>G confers cell-type-specific effects on AGT mRNA abundance,and suggest paracrine renal renin-angiotensin-system perturbations could mediate the rs699 A>G associations with *** We found that rs5051 C>T and rs699 A>G significantly associate with systolic blood pressure in Black participants in the UK Biobank,demonstrating a fourfold larger effect than in White *** studies are warranted to determine if altered antihypertensive response in Black individuals might be due to rs5051 C>T or rs699 A>*** like this will help clinicians move beyond the use of race as a surrogate for genotype.

关键词： angiotensinogen genetic and genomic medicine hypertension rs699

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Phylogeny of the Acarosporaceae(Lecanoromycetes,Ascomycota,Fungi)and the evolution of carbonized ascomata

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Fungal Diversity 2015年第4期73卷 145-158页

作者： martin Westberg Ana M.Millanes Kerry Knudsen Mats Wedin Department of Botany Swedish Museum of Natural HistoryP.O.Box 50007SE-10405 StockholmSweden Departamento de Biología y Geología Universidad Rey Juan CarlosE-28933 MóstolesSpain Department of Ecology Faculty of Environmental SciencesKamýcká129Prague CZ-16521Czech Republic

The phylogeny of the Acarosporaceae(Lecanoromycetes,Acarosporomycetidae,Acarosporales)is investigated using data from three molecular markers;nuclear ITS-LSU rDNA,mitochondrial SSU andβ-*** is shown to be constituted by six main clades;Myriospora,Timdalia,Pleopsidium,a clade composed by BAcarospora^rhizobola and BA.^terricola,the poorly supported Sarcogyne clade(including several Polysporina and Acarospora species)and the Acarospora clade(including the type of Polysporina,***,and several other Polysporina species).The common ancestor of the Acarosporaceae did not produce strongly black pigmented(carbonized or melanized)ascomata,but this trait has arisen secondarily and independently numerous times in the evolution of the *** number of changes in character states of both carbonized epihymenium and carbonized exciple are considerably more than the minimum *** genera Sarcogyne and Polysporina—largely circumscribed based on the presence of black pigmented ascomata—are shown to be distinctly *** presence of green algae in the ascoma margin(lecanorine or lecideine ascomata)may vary even within single species.

关键词： Convergent evolution Lichens Lichenized fungi Lichenicolous

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12 W high power InGaAsP/AlGaInP 755 nm quantum well laser

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Chinese Optics Letters 2019年第6期17卷 49-53页

作者： H. martin Hu Jianyang Zhao Weimin Wang James Ho Langxing Kuang Wenbin Liu Research Institute of Tsinghua University in Shenzhen Shenzhen 518057China Guangdong Provincial Key Laboratory of Optomechatronics Shenzhen 518057China Shenzhen Raybow Optoelectronics Co. Ltd.Shenzhen 518055China

High power laser diodes(lds)with a lasing wavelength between 700 and 780 nm have great potential in various medical ***,we report our recent efforts in developing an InGaAsP/AlGaInP-based commercial high power edge-emitting ld,which has 755 nm emission peak with a world-record continuous wave output power of 12.7 W,the highest reported so *** lack of Al atoms in the active region significantly lowers the chance of catastrophic optical damage during high power laser ***,with an accumulated 3800 h running time,our ongoing aging tests reveal excellent reliability of our devices.

关键词： High power laser wavelength between

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Genomic regions and pathways associated with gastrointestinal parasites resistance in Santa Inês breed adapted to tropical climate

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Journal of Animal Science and Biotechnology 2018年第1期9卷 35-50页

作者： Mariana Piatto Berton Rafael Medeiros de Oliveira Silva Elisa Peripolli Nedenia Bonvino Stafuzza Jesús Fernández martin Maria Saura álvarez Beatriz Villanueva Gavina Miguel Angel Toro Georgget Banchero Priscila Silva Oliveira Joanir Pereira Eler Fernando Baldi José Bento Sterman Ferraz Departamento de Zootecnia Faculdade de Ciências Agrárias e VeterináriasUniversidade Estadual PaulistaVia de acesso Prof.Paulo Donato Castellane sno Jaboticabal SP CEP 14884 900 Brazil Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA Crta.de la Coruna km75 28040 Madrid Spain Departamento de Producción Agraria School of AgriculturalFood and Byosystems EngineeringUniversisdad Politécnica de MadridCampus Ciudad Universitaria Avda.Complutense 3-Avda.Puerta Hierro 28040 Madrid Spain Instituto Nacional de Investigación Agropecuária(INIA) Ruta 50 Kin. 12 Colonia Uruguay Faculdade de Zootecnia e Engenharia de Alimentos Nucleo de Apoio à Pesquisa em Melhoramento AnimalBiotecnologia e TransgeniaUniversidade de Sao Paulo Rua Duque de Caxias Norte 225 Pirassununga SP CEP 13635 900Brazil

Background： The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in a breed of sheep adapted to tropical climate. Phenotypes evaluations were performed to verify resistance to gastrointestinal parasites, and were divided into two categories： i） farm phenotypes, assessing body condition score（BCS）, degree of anemia assessed by the famacha chart（FAM）, fur score（FS） and feces consistency（FC）; and ii） lab phenotypes,comprising blood analyses for hematocrit（HCT）, white blood cell count（WBC）, red blood cell count（RBC）,hemoglobin（HGB）, platelets（PLT） and transformed（log10） egg per gram of feces（EPG_（log））. A total of 576 animals were genotyped with the Ovine SNP12k Bead Chip（Illumina, Inc.）, that contains 12,785 bialleleic SNP markers. The variance components were estimated using a single trait model by single step genomic BLUP ***： The overall linkage disequilibrium（ld） mean between pairs of markers measured by r2 was 0.23. The overall ld mean between markers considering windows up to 10 Mb was 0.07. The mean ld between adjacent SNPs across autosomes ranged from 0.02 to 0.10. Heritability estimates were low for EPG_（log）（0.11）, moderate for RBC（0.18）, PLT（0.17） HCT（0.20）, HGB（0.16） and WBC（0.22）, and high for FAM（0.35）. A total of 22, 21, 23, 20, 26, 25 and 23 windows for EPG_（log）for FAM, WBC, RBC, PLT, HCT and HGB traits were identified, respectively. Among the associated windows, 10 were shown to be common to HCT and HGB traits on OAR1, OAR2, OAR3, OAR5, OAR8 and ***： The traits indicating gastrointestinal parasites resistance presented an adequate genetic variability to respond to selection in Santa Inês breed, and it is expected a higher genetic gain for FAM trait when compared to the others. The level of ld estimated for markers separated by less than 1 Mb indicated that the Ovine SNP12k Bead Chip m

关键词： Gwas Linkage disequilibrium arasites resistance Santa Inês breed

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热融粘合法——粘合技术的另一种选择

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光盘技术 2000年第6期 46-49页

作者： martin Eichlseder 夏雨人

越来越多的光盘生产厂开始生产DVD光盘,对于大多数刚接触DVD光盘的生产者来说粘合是一个过去从未接触过的生产工艺,只有过去生产ld或MO的生产厂才累积有粘合的经验,这就是热融粘合法。现在UV固化粘合法有许多优势,但是Krauss-Maffei公司... 详细信息

越来越多的光盘生产厂开始生产DVD光盘,对于大多数刚接触DVD光盘的生产者来说粘合是一个过去从未接触过的生产工艺,只有过去生产ld或MO的生产厂才累积有粘合的经验,这就是热融粘合法。现在UV固化粘合法有许多优势,但是Krauss-Maffei公司(以下称KM公司)的martin Eichlseder先生提出了自己的观点,他认为不应忽视热融粘合法工艺,最新的研究成果将使它成为值得信赖的技术。

关键词：热融粘合法光盘 DVD 粘合技术

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Bootstrap重抽样方法

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英国医学杂志中文版 2016年第3期19卷 154-155页

作者： J martin Bland Douglas G Altman 徐晶许群 Department of Health Sciences University of YorkYork YO10 5DD UK Centre for Statisticsin Medicine Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal Sciences Universityof Oxford Oxford OX3 7LD UK 中国医学科学院基础医学研究所北京协和医学院基础学院流行病与卫生统计学系

医学研究中，我们通过研究一个由个体组成的样本来对目标人群进行推断。均数或构成比差异之类估计值的计算，通常伴随由标准误衍生的可信区间。这里，单个样本的数据用于量化从同一人群中抽取的（假设的）多个样本指标估计值的变异。由... 详细信息

医学研究中，我们通过研究一个由个体组成的样本来对目标人群进行推断。均数或构成比差异之类估计值的计算，通常伴随由标准误衍生的可信区间。这里，单个样本的数据用于量化从同一人群中抽取的（假设的）多个样本指标估计值的变异。由于我们只有一个样本，就需要对数据进行假设。

关键词： Bootstrap 重抽样方法个体组成样本目标人群均数构成比差异

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Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers

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Journal of Animal Science and Biotechnology 2019年第1期10卷 140-149页

作者： Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du State Key Lab of Animal Nutrition College of Animal Science and TechnologyChina Agricultural University Department of Animal Sciences Washington State University Department of Animal Sciences Louisiana State University College of Animal Science and Technology Gansu Agricultural University School of Food Science Washington State University College of Veterinary Science Washington State University

Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ *** impact on beef cattle muscle growth remains ***: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of *** 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle *** resulting steers were harvested at 14 months of ***: Vitamin A administration increased cattle growth at 2 *** 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and *** derived mononuclear cells were further isolated and induced myogenesis in *** myotubes and a higher degree of myogenesis was observed in vitamin A ***,vitamin A increased Latissimus dorsi(ld) muscle fiber size at *** addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX ***,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal ***: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers.

关键词： Cattle Muscle Fiber type Muscle growth Myogenesis PAX7 Satellite cells Vitamin A

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抽样误差以外的不确定性

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英国医学杂志中文版 2015年第4期18卷 218-219页

作者： Douglas G Altman J martin Bland 罗凯 Centre for Statistics in Medicine Nuffield Department of OrthopaedicsRheumatology and Musculoskeletal Sciences University of Oxford Oxford OX37LD UK Department of Health Sciences University of York York YO10 5DD UK 中国医学科学院基础医学研究所

研究结果的统计分析主要是利用可信区间及假设检验获知研究结果的不确定性，这种不确定性是在从研究人员主要关注的较大总体中抽取研究参加者样本而产生的’。但是，除抽样变异问题外，更重要的是需考虑其他来源的不确定性。在（研究结... 详细信息

研究结果的统计分析主要是利用可信区间及假设检验获知研究结果的不确定性，这种不确定性是在从研究人员主要关注的较大总体中抽取研究参加者样本而产生的’。但是，除抽样变异问题外，更重要的是需考虑其他来源的不确定性。在（研究结果）测量中，应区分精确性与准确性。精确性是指用同一方法在相同时间对同一个体进行的测量是如何不同，而准确性是指测量结果与我们想知道的真正结果是如何接近。

关键词：抽样误差不确定性医疗卫生行业医学研究

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