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Radiofrequency ablation combined with transcatheter arterial chemoembolization for recurrent liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1756-1764页

作者： Jin-You Guo Li-Li Zhao hui-Jun cai hui Zeng Wei-Dong Mei Department of Oncology The Second People's Hospital of Zhejiang Province Taizhou Yuhuan CityTaizhou 317605Zhejiang ProvinceChina Department of Interventional China's Zhejiang Province Tumor HospitalHangzhou 310000Zhejiang ProvinceChina

BACKGROUND The recurrence rate of liver cancer after surgery is *** ablation(RFA)combined with transcatheter arterial chemoembolization(TACE)is an effective treatment for liver cancer;however,its efficacy in recurrent liver cancer remains *** To investigate the clinical effect of TACE combined with RFA in the treatment of recurrent liver *** Ninety patients with recurrent liver cancer were divided into 2 groups according to treatment plan:Control(RFA alone);and experimental[TACE combined with RFA(TACE+RFA)].The incidence of increased alanine aminotransferase levels,complications,and other indices were compared between the two groups before and after the *** One month after the procedures,the short-term efficacy rate and Karnofsky Performance Status scores of the experimental group were significantly higher than those of the control group(P0.05).CONCLUSION TACE+RFA was effective for the treatment of recurrent liver cancer and significantly reduced AFP levels and improved various indices of liver function.

关键词： Transcatheter arterial chemoembolization Radiofrequency ablation Recurrent liver cancer Clinical efficacy Overall response rate Disease control rate

Application of in-situ characterization techniques in modern aqueous batteries

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Rare Metals 2024年第8期43卷 3553-3575页

作者： Jia-Hao Wu Hong-Wei cai Zhao-hui Deng Jean-Jacques Gaumet Yu Bao Wen Luo Department of Physics State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingSchool of Materials Science and EngineeringWuhan University of TechnologyWuhan430070China Laboratoire de Chimie Et Physique:Approche Multi-Echelles Des Milieux Complexes(LCP-A2MC)Institut Jean BarriolUniversitéde Lorraine57070MetzFrance Department of Medicinal Chemistry Hubei College of Chinese MedicineJingzhou 434020China

The development of high-performance aqueous batteries calls for an in-depth knowledge of their chargedischarge redox and failure mechanism,as well as a systematic understanding of the dynamic evolution of microstructure,phase composition,chemical composition,and local chemical environment of the materials for ***-situ characterization technology is expected to understand and reveal the problems faced by aqueous rechargeable batteries,such as the dissolution of electrode materials,the growth of metal negative electrode dendrites,passivation,corrosion,side reactions and a series of *** on this,typical in-situ characterization techniques and their basic mechanisms are summarized,including in-situ optical visualization,in-situ microscopy techniques(in-situ scanning electron microscopy(SEM),in-situ transmission electron microscopy(TEM)),in-situ X-ray techniques(in-situ X-ray diffraction(XRD),in-situ X-ray photoelectron spectroscopy(XPS),in-situ near-edge structural X-ray absorption spectroscopy(XANES)),and in-situ spectroscopy techniques(in-situ Raman spectroscopy,in-situ Fourier transform infrared(FTIR)).Moreover,some emerging techniques concerning aqueous battery research,especially gas evolution and materials dissolution issues,such as in-situ electrochemical quartz crystal microbalance(EQCM).in-situ fiber-optic sensing,in-situ gas chromatography(GC) are *** last,the applications of advanced in-situ characterizations in future research of aqueous batteries are emphasized and discussed,along with some of the remaining challenges and possible solutions.

关键词： Aqueous battery In-situ characterization Phase transformation Solid electrolyte interphase Zinc dendrite growth

Comprehensive analysis of the potential pathogenesis of COVID-19 infection and liver cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 436-457页

作者： Yao Rong Ming-Zheng Tang Song-Hua Liu Xiao-Feng Li hui cai First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina General Surgery Clinical Medical Center Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND A growing number of clinical examples suggest that coronavirus disease 2019(COVID-19)appears to have an impact on the treatment of patients with liver cancer compared to the normal population,and the prevalence of COVID-19 is significantly higher in patients with liver ***,this mechanism of action has not been *** sets for COVID-19(GSE180226)and liver cancer(GSE87630)were obtained from the Gene Expression Omnibus *** identifying the common differentially expressed genes(DEGs)of COVID-19 and liver cancer,functional enrichment analysis,protein-protein interaction network construction and scree-ning and analysis of hub genes were ***,the validation of the differential expression of hub genes in the disease was performed and the regulatory network of transcription factors and hub genes was *** Of 518 common DEGs were obtained by screening for functional *** hub genes including aurora kinase B,cyclin B2,cell division cycle 20,cell division cycle associated 8,nucleolar and spindle associated protein 1,etc.,were further identified from DEGs using the“cytoHubba”*** enrichment analysis of hub genes showed that these hub genes are associated with P53 signalling pathway regulation,cell cycle and other functions,and they may serve as potential molecular markers for COVID-19 and liver ***,we selected 10 of the hub genes for in vitro expression validation in liver cancer *** Our study reveals a common pathogenesis of liver cancer and *** common pathways and key genes may provide new ideas for further mechanistic studies.

关键词： COVID-19 Liver cancer Differentially expressed genes Hub genes Pathogenesis

Joint Design of ISAC Waveform Under PAPR Constraints

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China Communications 2024年第7期21卷 186-211页

作者： Chen Yating Wen cai Huang Yan Liang Le Li Jie Zhang hui Hong Wei State Key Lab of Millimeter Waves Southeast UniversityNanjing 211100China School of Information Science and Technology Northwest UniversityXi’an 710127China National Mobile Communications Research Laboratory Nanjing 211100China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211100China

In this paper,we formulate the precoding problem of integrated sensing and communication(ISAC)waveform as a non-convex quadratically constrained quadratic programming(QCQP),in which the weighted sum of communication multi-user interference(MUI)and the gap between dual-use waveform and ideal radar waveform is minimized with peak-toaverage power ratio(PAPR)*** propose an efficient algorithm based on alternating direction method of multipliers(ADMM),which is able to decouple multiple variables and provide a closed-form solution for each *** addition,to improve the sensing performance in both spatial and temporal domains,we propose a new criteria to design the ideal radar waveform,in which the beam pattern is made similar to the ideal one and the integrated sidelobe level of the ambiguity function in each target direction is minimized in the region of *** limited memory Broyden-Fletcher-Goldfarb-Shanno(LBFGS)algorithm is applied to the design of the ideal radar waveform which works as a reference in the design of the dual-function *** results indicate that the designed dual-function waveform is capable of offering good communication quality of service(QoS)and sensing performance.

关键词： ambiguity function integrated sensing and communication MIMO OFDM PAPR waveform design

Multistep continuous flow synthesis of Erlotinib

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Chinese Chemical Letters 2024年第4期35卷 371-375页

作者： hui Jin Qin cai Peiwen Liu Yan Chen Derong Wang Weiping Zhu Yufang Xu Xuhong Qian State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

Erlotinib is an orally administered, highly effective, specific epidermal growth factor receptor tyrosine kinase inhibitor, used to treat non-small cell lung cancer and pancreatic cancer. The traditional synthetic methods for Erlotinib exhibit long reaction time and safety concern. Herein, we describe a novel five-step route for the synthesis of Erlotinib in flow. These five steps comprise etherification, nitration, reduction,addition and cyclization reactions. All steps were optimized and converted to continuous flow process,which drastically reduces the reaction time and considerably improves the process safety as well as the total yield. Enabled by five continuous flow units, Erlotinib is efficiently afforded with an E-factor of 38,an overall yield of 83%, and a total residence time of 25.1 min. Majority steps in this process have been optimized for quantitative conversion, which offers the possibility of telescoping the entire process.

关键词： Erlotinib Continuous flow synthesis Microchannel flow reactor Process optimization Continuous nitration Continuous hydrogenation

Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第1期15卷 43-52页

作者： Sha-Sha cai Teng-Ye Zheng Kang-Yao Wang hui-Ping Zhu Department of Nephrology The First People’s Hospital of WenlingWenling 317500Zhejiang ProvinceChina

BACKGROUND Among older adults,type 2 diabetes mellitus(T2DM)is widely recognized as one of the most prevalent *** nephropathy(DN)is a frequent com-plication of DM,mainly characterized by renal microvascular *** detection,aggressive prevention,and cure of DN are key to improving *** a diagnostic and predictive model for DN is crucial in auxiliary *** To investigate the factors that impact T2DM complicated with DN and utilize this information to develop a predictive *** The clinical data of 210 patients diagnosed with T2DM and admitted to the First People’s Hospital of Wenling between August 2019 and August 2022 were retrospectively *** to whether the patients had DN,they were divided into the DN group(complicated with DN)and the non-DN group(without DN).Multivariate logistic regression analysis was used to explore factors affecting DN in patients with *** data were randomly split into a training set(n=147)and a test set(n=63)in a 7:3 ratio using a random *** training set was used to construct the nomogram,decision tree,and random forest models,and the test set was used to evaluate the prediction performance of the model by comparing the sensitivity,specificity,accuracy,recall,precision,and area under the receiver operating characteristic *** Among the 210 patients with T2DM,74(35.34%)had *** validation dataset showed that the accuracies of the nomogram,decision tree,and random forest models in predicting DN in patients with T2DM were 0.746,0.714,and 0.730,*** sensitivities were 0.710,0.710,and 0.806,respectively;the specificities were 0.844,0.875,and 0.844,respectively;the area under the receiver operating characteristic curve(AUC)of the patients were 0.811,0.735,and 0.850,*** Delong test results revealed that the AUC values of the decision tree model were lower than those of the random forest and nomogram models(P<0.05),whereas the differ

关键词： Type 2 diabetes mellitus Diabetic nephropathy Random forest Decision-making tree Nomogram Forecast

Natural products inspired[3+2]cycloaddition enables efficient construction of hydroxylated tetrahydrofuran acetals and concise syntheses of lignans

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Science China Chemistry 2024年第7期67卷 2306-2313页

作者： Dong-Yue cai Weiming Shi Zhao-hui Jin Zhi-Xiang Yu Jin-Xin Zhao Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Beijing National Laboratory for Molecular Sciences(BNLMS) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of ChemistryPeking UniversityBeijing 100871China

Mimicking biosynthetic pathways of hongkonoids led to the development of a new Cu(Ⅰ)-catalyzed[3+2]cycloaddition ofα-hydroxyketone andβ-keto enol ethers,affording tetrahydrofuran acetals in a highly diastereoselective manner and 100%atom *** studies on the mechanism disclosed a concerted but asynchronous Michael addition/aldol *** the same importance,this methodology provides a practical biomimetic approach for one-step construction of the dibenzylbutyrolactol lignan backbone starting from two phenyl propane derivatives,opening up a powerful new approach for lignan synthesis,which is showcased by succinct total syntheses of two biologically important aryltetralin-type lignans,β-apopicropodophyllin and *** the mild and operationally simple conditions,the developed chemistry might have a promising prospect in potential industrial applications.

关键词： [3+2]cycloaddition transition-metal catalysis tetrahydrofuran lignans natural products

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High-Performance Recyclable Furan-based Epoxy Resin and Its Carbon Fiber Composites with Dense Hydrogen Bonding

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Chinese Journal of Polymer Science 2024年第1期42卷 73-86,I0008页

作者： Chang-Bo Zhao Lu-Kun Feng hui Xie Ming-Liang Wang Bing Guo Zhi-Yong Xue cai-Zhen Zhu Jian Xu Advanced Materials Research Institute North China Electric Power UniversityBejing 102206China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology and Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive ApplicationHarbin Institute of TechnologyShenzhen 518055China

The emerging biomass-based epoxy vitrimers hold great potential to fulfill the requirements for sustainable development of *** the existence of dynamic chemical bonds in vitrimers often reduces both the thermal and mechanical properties of epoxy resins, it is challenging to produce recyclable epoxy vitrimers with both excellent mechanical properties and good thermal stability. Herein, a monomer 4-(((5-(hydroxymethyl)furan-2-yl)methylene)amino)phenol(FCN) containing furan ring with potential to form high density of hydrogen bonding among repeating units is designed and copolymerized with glycerol triglycidyl ether to yield epoxy resin(FCN-GTE), which intrinsically has dual hydrogen bond networks, dynamic imine structure and resultant high performance. Importantly, as compared to the BPA-GTE, the FCN-GTE exhibits significantly improved mechanical properties owing to the increased density of hydrogen bond network and physical crosslinking interaction. Furthermore, density functional theory(DFT) calculation and in situ FTIR analysis is conducted to decipher the formation mechanism of hydrogen bond network. In addition, the FCN-GTE possesses superior UV shielding, chemical degradation, and recyclability because of the existence of abundant imine bonds. Notably, the FCN-GTE-based carbon fiber composites could be completely recycled in an amine *** study provides a facile strategy for synthesizing recyclable biomass-based high-performance epoxy vitrimers and carbon fiber composites.

关键词： Furan Hydrogen bond network Dynamic Schiff base Carbon fiber composites Recycling

Enhancing Photovoltaic Performance of Nonfused-Ring Electron Acceptors via Asymmetric End-Group Engineering and Noncovalently Conformational Locks

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Chinese Journal of Chemistry 2024年第5期42卷 485-490页

作者： Bo Liu Congqi Li Xiaobin Gu Yinghui Han Zhixiang Wei Yunhao cai Xin Zhang hui Huang Yanping Huo School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhouGuangdong510006 China College of Materials Science and Opto-Electronic Technology & Center of Materials Science and Optoelectronics Engineering & CAS Center for Excellence in Topological Quantum Computation & CAS Key Laboratory of Vacuum Physics University of Chinese Academy of SciencesBeijing100049 China College Resources and Environment University of Chinese Academy of SciencesBeijing100049 China Center for Excellence in Nanoscience (CAS) & Key Laboratory of Nanosystem and Hierarchical Fabrication (CAS) National Center for Nanoscience and TechnologyBeijing100190 China

By employing the asymmetric end-group engineering,an asymmetric nonfused-ring electron acceptor(NFREA)was designed and *** with the symmetric analogs(NoCA-17 and NoCA-18),NoCA-19 possesses broader light absorption range,more coplanarπ-conjugated backbone,and appropriate crystallinity according to the experimental and theoretical *** organic solar cells based on J52:NoCA-19 exhibited a power conversion efficiency as high as 12.26%,which is much higher than those of J52:NoCA-17(9.50%)and J52:NoCA-18(11.77%),mainly due to more efficient exciton dissociation,better and balanced charge mobility,suppressed recombination loss,shorter charge extraction time,longer charge carrier lifetimes,and more favorable blend film *** findings demonstrate the great potential of asymmetric end-group engineering in exploring low-cost and high-performance NFREAs.

关键词： Organic solar cells Nonfused-ring electron acceptors Asymmetric end-group engineering Noncovalently conformational locks Low-cost acceptors